ALOX5 (arachidonate 5-lipoxygenase) - Rat Genome Database

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Gene: ALOX5 (arachidonate 5-lipoxygenase) Canis lupus familiaris
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Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
RGD ID: 12252833
Description: ENCODES a protein that exhibits dioxygenase activity (inferred); iron ion binding (inferred); metal ion binding (inferred); INVOLVED IN acute inflammatory response (ortholog); dendritic cell migration (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); adenoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog); INTERACTS WITH zileuton
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: polyunsaturated fatty acid 5-lipoxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBI
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBI
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)Ensembl
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBI
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBI
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zileuton  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
arachidonic acid metabolic process  (IBA)
coenzyme A biosynthetic process  (IEA)
dendritic cell migration  (ISO)
fatty acid biosynthetic process  (IEA)
glucose homeostasis  (ISO)
hepoxilin biosynthetic process  (IBA)
humoral immune response  (ISO)
inflammatory response  (ISO)
leukocyte chemotaxis involved in inflammatory response  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
leukotriene A4 biosynthetic process  (ISO)
leukotriene biosynthetic process  (ISO)
leukotriene metabolic process  (ISO)
leukotriene production involved in inflammatory response  (ISO)
linoleic acid metabolic process  (IBA)
lipid metabolic process  (IEA)
lipid oxidation  (IBA)
lipoxin biosynthetic process  (ISO)
lipoxygenase pathway  (IBA)
negative regulation of angiogenesis  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of response to endoplasmic reticulum stress  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of vascular wound healing  (ISO)
negative regulation of wound healing  (ISO)
oxidative phosphorylation  (IEA)
positive regulation of bone mineralization  (ISO)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of inflammatory response  (ISO)
regulation of inflammatory response to wounding  (ISO)
regulation of insulin secretion  (ISO)
regulation of reactive oxygen species biosynthetic process  (ISO)
response to hyperoxia  (ISO)
response to nutrient  (ISO)
sensory perception of pain  (ISO)
tetrahydrofolate biosynthetic process  (IEA)
tetrahydrofolate interconversion  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18978352   PMID:19274754   PMID:21616545  


Genomics

Comparative Map Data
ALOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBI
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBI
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)Ensembl
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBI
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBI
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBI
ALOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,374,216 - 45,446,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBI
Alox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBImm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
Alox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24149,531,329 - 149,578,696 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4149,531,515 - 149,578,743 (-)Ensembl
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,398,892 - 148,446,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
Alox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555462,494,819 - 2,550,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555462,495,226 - 2,550,909 (+)NCBIChiLan1.0ChiLan1.0
ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11045,639,946 - 45,710,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,639,946 - 45,710,016 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01042,461,398 - 42,531,576 (+)NCBIMhudiblu_PPA_v0panPan3
Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,798,191 - 81,858,352 (-)NCBI
SpeTri2.0NW_0049365547,807,914 - 7,848,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,859,016 - 90,907,094 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,085,257 - 41,145,760 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl941,085,361 - 41,145,331 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048764,154 - 824,908 (+)NCBIVero_WHO_p1.0
Alox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 3 5 5 8 5
Low 5 1 17 6 3 6 1 7 5 6
Below cutoff 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011163   ⟹   ENSCAFP00000010341
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000059504   ⟹   ENSCAFP00000049744
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl282,171,437 - 2,218,766 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046482   ⟹   ENSCAFP00845036492
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046566   ⟹   ENSCAFP00845036558
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845046655   ⟹   ENSCAFP00845036621
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl282,350,367 - 2,407,125 (-)Ensembl
RefSeq Acc Id: NM_001205113   ⟹   NP_001192042
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1282,170,920 - 2,218,765 (-)NCBI
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBI
ROS_Cfam_1.0282,349,850 - 2,407,091 (-)NCBI
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBI
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBI
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038439629   ⟹   XP_038295557
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBI
RefSeq Acc Id: XM_038439630   ⟹   XP_038295558
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0282,349,844 - 2,399,307 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001192042 (Get FASTA)   NCBI Sequence Viewer  
  XP_038295557 (Get FASTA)   NCBI Sequence Viewer  
  XP_038295558 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADV36116 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001192042   ⟸   NM_001205113
- UniProtKB: E7ECW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010341   ⟸   ENSCAFT00000011163
RefSeq Acc Id: ENSCAFP00000049744   ⟸   ENSCAFT00000059504
RefSeq Acc Id: XP_038295557   ⟸   XM_038439629
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038295558   ⟸   XM_038439630
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845036558   ⟸   ENSCAFT00845046566
RefSeq Acc Id: ENSCAFP00845036492   ⟸   ENSCAFT00845046482
RefSeq Acc Id: ENSCAFP00845036621   ⟸   ENSCAFT00845046655
Protein Domains
Lipoxygenase   PLAT

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
28 2184399 2184400 C T snv Jack Russell Terrier (JR0034)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006948 Ensembl
  ENSCAFG00030019943 UniProtKB/TrEMBL
  ENSCAFG00040025543 UniProtKB/TrEMBL
  ENSCAFG00845026331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030032001.1 UniProtKB/TrEMBL
  ENSCAFP00030032026.1 UniProtKB/TrEMBL
  ENSCAFP00040041617 UniProtKB/TrEMBL
  ENSCAFP00040041618 UniProtKB/TrEMBL
  ENSCAFP00040041619 UniProtKB/TrEMBL
  ENSCAFP00845036492 ENTREZGENE
  ENSCAFP00845036492.1 UniProtKB/TrEMBL
  ENSCAFP00845036558.1 UniProtKB/TrEMBL
  ENSCAFP00845036621.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030036684.1 UniProtKB/TrEMBL
  ENSCAFT00030036712.1 UniProtKB/TrEMBL
  ENSCAFT00040047675 UniProtKB/TrEMBL
  ENSCAFT00040047676 UniProtKB/TrEMBL
  ENSCAFT00040047677 UniProtKB/TrEMBL
  ENSCAFT00845046482 ENTREZGENE
  ENSCAFT00845046482.1 UniProtKB/TrEMBL
  ENSCAFT00845046566.1 UniProtKB/TrEMBL
  ENSCAFT00845046655.1 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/TrEMBL
KEGG Report cfa:477753 UniProtKB/TrEMBL
NCBI Gene ALOX5 ENTREZGENE
PANTHER PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A8C0NZM6_CANLF UniProtKB/TrEMBL
  A0A8C0RP82_CANLF UniProtKB/TrEMBL
  A0A8C0TX58_CANLF UniProtKB/TrEMBL
  A0A8I3PPI3_CANLF UniProtKB/TrEMBL
  A0A8I3PTZ0_CANLF UniProtKB/TrEMBL
  A0A8I3SA30_CANLF UniProtKB/TrEMBL
  E7ECW0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37813 ENTREZGENE