ALOX5 (arachidonate 5-lipoxygenase)

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Gene: ALOX5 (arachidonate 5-lipoxygenase) Canis lupus familiaris

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Symbol:

ALOX5

Name:

arachidonate 5-lipoxygenase

RGD ID:

12252833

Description:

ENCODES a protein that exhibits arachidonate 5-lipoxygenase activity (inferred); dioxygenase activity (inferred); iron ion binding (inferred); INVOLVED IN inflammatory response (ortholog); leukotriene biosynthetic process (ortholog); leukotriene metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); adenoma (ortholog); FOUND IN dendrite (ortholog); nuclear envelope (ortholog); sarcolemma (ortholog); INTERACTS WITH zileuton

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

polyunsaturated fatty acid 5-lipoxygenase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	2,170,920 - 2,218,765 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	2,170,920 - 2,219,609 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	2,405,370 - 2,462,571 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	2,349,844 - 2,407,164 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	2,349,846 - 2,407,125 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	2,147,070 - 2,204,281 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	2,183,953 - 2,241,179 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	2,315,780 - 2,373,040 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

adenocarcinoma (ISO)

adenoma (ISO)

aortic aneurysm (ISO)

arteriosclerosis (ISO)

asthma (ISO)

atherosclerosis (ISO)

Bone Fractures (ISO)

brain ischemia (ISO)

breast ductal carcinoma (ISO)

cholangiocarcinoma (ISO)

chronic myeloid leukemia (ISO)

Closed Fractures (ISO)

colitis (ISO)

Colonic Neoplasms (ISO)

Colonic Polyps (ISO)

common cold (ISO)

Drug Eruptions (ISO)

Endotoxemia (ISO)

exercise-induced bronchoconstriction (ISO)

genetic disease (ISO)

Hyperalgesia (ISO)

Hyperoxia (ISO)

hypertension (ISO)

in situ carcinoma (ISO)

Inflammation (ISO)

invasive ductal carcinoma (ISO)

lung adenocarcinoma (ISO)

lung disease (ISO)

middle cerebral artery infarction (ISO)

Multiple Organ Failure (ISO)

Myocardial Reperfusion Injury (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

nephrosclerosis (ISO)

nephrotic syndrome (ISO)

Ovarian Neoplasms (ISO)

Pain (ISO)

pancreatic cancer (ISO)

pleurisy (ISO)

pleuropneumonia (ISO)

Pneumococcal Pneumonia (ISO)

portal hypertension (ISO)

Prostatic Neoplasms (ISO)

pulmonary edema (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

pulmonary tuberculosis (ISO)

Radiation Pneumonitis (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

rheumatoid arthritis (ISO)

Seasonal Allergic Rhinitis (ISO)

Stomach Neoplasms (ISO)

Testicular Germ Cell Tumor (ISO)

urticaria (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

zileuton (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dendritic cell migration (IEA)

glucose homeostasis (IEA)

humoral immune response (IEA)

inflammatory response (IEA,ISO)

leukocyte chemotaxis involved in inflammatory response (IEA)

leukocyte migration involved in inflammatory response (IEA)

leukotriene A4 biosynthetic process (IEA)

leukotriene biosynthetic process (IEA,ISO)

leukotriene metabolic process (IEA,ISO)

leukotriene production involved in inflammatory response (IEA,ISO)

lipid metabolic process (IEA)

lipid oxidation (IEA)

lipoxin biosynthetic process (IEA)

negative regulation of angiogenesis (IEA)

negative regulation of endothelial cell proliferation (IEA)

negative regulation of inflammatory response (IEA)

negative regulation of response to endoplasmic reticulum stress (IEA)

negative regulation of sprouting angiogenesis (IEA)

negative regulation of vascular wound healing (IEA)

negative regulation of wound healing (IEA)

positive regulation of bone mineralization (IEA)

positive regulation of cytochrome-c oxidase activity (ISO)

positive regulation of leukocyte adhesion to arterial endothelial cell (IEA)

positive regulation of vasoconstriction (ISO)

regulation of cellular response to oxidative stress (IEA)

regulation of cytokine production involved in inflammatory response (IEA)

regulation of fat cell differentiation (IEA)

regulation of inflammatory response (IEA)

regulation of inflammatory response to wounding (IEA)

regulation of insulin secretion (IEA)

regulation of reactive oxygen species biosynthetic process (IEA)

response to hyperoxia (ISO)

response to nutrient (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

dendrite (ISO)

nuclear envelope (IEA,ISO)

nuclear envelope lumen (IEA)

nuclear matrix (IEA)

nuclear membrane (IEA)

nucleoplasm (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

sarcolemma (ISO)

Molecular Function

arachidonate 5-lipoxygenase activity (IEA)

dioxygenase activity (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

leukotriene metabolic pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:18978352	PMID:19274754	PMID:21616545	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ALOX5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	2,170,920 - 2,218,765 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	2,170,920 - 2,219,609 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	2,405,370 - 2,462,571 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	2,349,844 - 2,407,164 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	2,349,846 - 2,407,125 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	2,147,070 - 2,204,281 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	2,183,953 - 2,241,179 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	2,315,780 - 2,373,040 (-)	NCBI		UU_Cfam_GSD_1.0

ALOX5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	45,374,216 - 45,446,117 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	45,374,176 - 45,446,119 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	45,869,664 - 45,941,565 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	45,189,635 - 45,261,571 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	45,189,691 - 45,261,567	NCBI
Celera	10	41,889,257 - 41,939,521 (+)	NCBI		Celera
Cytogenetic Map	10	q11.21	NCBI
HuRef	10	42,394,884 - 42,467,216 (+)	NCBI		HuRef
CHM1_1	10	45,908,843 - 45,980,778 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	46,255,243 - 46,327,106 (+)	NCBI		T2T-CHM13v2.0

Alox5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	116,387,030 - 116,438,139 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	116,387,038 - 116,438,139 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	116,410,071 - 116,461,178 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	116,410,077 - 116,461,178 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	116,360,089 - 116,411,196 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	116,375,696 - 116,426,797 (-)	NCBI		MGSCv36	mm8
Celera	6	118,247,670 - 118,299,116 (-)	NCBI		Celera
Cytogenetic Map	6	E3	NCBI
cM Map	6	53.79	NCBI

Alox5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	151,203,948 - 151,251,126 (-)	NCBI		GRCr8
mRatBN7.2	4	149,531,329 - 149,578,696 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	149,531,515 - 149,578,743 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	155,763,428 - 155,810,585 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	151,547,462 - 151,594,624 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	150,170,360 - 150,217,527 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	148,398,004 - 148,446,308 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	148,398,892 - 148,446,303 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	214,345,956 - 214,393,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	152,610,283 - 152,657,891 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	152,855,123 - 152,902,732 (-)	NCBI
Celera	4	138,415,564 - 138,454,485 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

Alox5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955546	2,494,819 - 2,550,909 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955546	2,495,226 - 2,550,909 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	58,201,690 - 58,271,880 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	58,207,019 - 58,277,209 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	42,461,398 - 42,531,576 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	45,639,946 - 45,710,016 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	45,639,946 - 45,710,016 (+)	Ensembl	panpan1.1		panPan2

Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	81,798,191 - 81,858,352 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936554	7,808,355 - 7,867,931 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936554	7,807,914 - 7,848,691 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALOX5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	90,859,016 - 90,907,094 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	90,859,209 - 90,907,084 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	98,902,267 - 98,950,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALOX5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	41,085,257 - 41,145,760 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	41,085,361 - 41,145,331 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	764,154 - 824,908 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alox5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624966	168,250 - 220,522 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624966	168,244 - 220,430 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ALOX5
537 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001205113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038439629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038439630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HQ657323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000011163 ⟹ ENSCAFP00000010341

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	2,170,920 - 2,219,609 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000059504 ⟹ ENSCAFP00000049744

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	2,171,437 - 2,218,766 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845046482 ⟹ ENSCAFP00845036492

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	2,349,846 - 2,407,125 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845046566 ⟹ ENSCAFP00845036558

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	2,349,846 - 2,407,125 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845046655 ⟹ ENSCAFP00845036621

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	2,350,367 - 2,407,125 (-)	Ensembl

RefSeq Acc Id:

NM_001205113 ⟹ NP_001192042

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	28	2,170,920 - 2,218,765 (-)	NCBI
Dog10K_Boxer_Tasha	28	2,405,370 - 2,462,571 (-)	NCBI
ROS_Cfam_1.0	28	2,349,850 - 2,407,091 (-)	NCBI
UMICH_Zoey_3.1	28	2,147,070 - 2,204,281 (-)	NCBI
UNSW_CanFamBas_1.0	28	2,183,953 - 2,241,179 (-)	NCBI
UU_Cfam_GSD_1.0	28	2,315,780 - 2,373,040 (-)	NCBI

Sequence:

show sequence

AGCCCTCCGCCATGCCGTCCTACACGGTCACCGTGGCCACCGGCAGCCAGTGGTTCGCTGGCAC
CGACGACTACATCTACCTCAGCCTCGTGGGCTCCGCCGGCTGCAGCGAGAAGCACCTGCTGGAC
AAGCCCTTCTACAACGACTTTGAGCGCGGCGCGGTTGATTCTTATGATGTGACCGTAGATGAAG
AACTGGGCGACATCCAACTGGTCAAAATCGAGAAGCGTAAGTATTGGCTCCATGACGACTGGTA
CCTAAAGTATATCACGCTGAAGACGCCCTGTGGAGATTACATCGAGTTCCCTTGCTACCGCTGG
ATCACTGGTGAGGGCGAGATTGTCCTGAGAGATGGACGTGCAAAGTTGGCCTGCGATGACCAAA
TTCACATCCTCAAGCAGCACAGACGTAAAGAGCTGGAAACACGGCAAAAACAGTATCGGTGGAT
GGAGTGGAACCCTGGCTTCCCTTTGAGTATTGATGCCAAATGTCACAAGGATTTACCCCGAGAC
ATCCAGTTTGATAGCGAGAAGGGTGTGGACTTCGTTCTGAACTACTCTAAAGCGATGGAGAACC
TGTTCATCAACCGCTTCATGCACATGTTCCAGTCTTCTTGGAGTGACTTCGCTGATTTTGAGAA
GATCTTCGTCAAGATCAGCAACACTATTTCTGAGCGTGTCATGAACCACTGGCAGGAAGACCTC
ATGTTTGGCTACCAGTTCCTGAATGGCTGCAACCCAGTGTTGATCCAGCGCTGCAAGAAGCTAC
CCGAGAAGCTCCCTGTGACCACAGAGATGGTGGAGTGCAGTCTGGAGCGGCAGCTCACCTTGGA
GCAAGAGGTCGAGCAAGGAAACATCTTCATCGTGGACTTTGACCTGCTGGATGGTATCGATGCC
AACAAAACAGACCCCTGTACTCTGCAGTTCCTGGCAGCGCCCATCTGCTTGCTGTACAAGAATC
TGGCCAACAAGATTGTCCCCATTGCCATCCAGCTCAACCAAGTCCCAGGAGATGAAAACCCAAT
TTTTCTCCCTTCGGATGCAAAATATGACTGGCTTCTGGCCAAAATCTGGGTGCGCTCCAGTGAC
TTCCACATCCACCAGACCATCACTCACCTTCTGCGCACACATCTGGTGTCTGAAGTCTTGGTCT
TTGGCATTGCCATGTACCGCCACCTGCCCGCAGTGCACCCCATTTTCAAGCTTCTGGTGGCACA
CGTGCGGTTCACCATTGCCATCAACACCAAGGCCCGTGAACAGCTCATCTGCGAGTATGGACTC
TTTGACAAGGCCAACGCCACAGGGGGCGGTGGACACGTGCAGATGGTGCAGAGGGCCATGCAGG
ACCTGACCTACATCTCCCTGTGCTTCCCCGAGGCCATCAAAGCTCGGGGAATGGACAGCACAGA
GGACATTCCCTACTACTTCTACCGGGATGACGGGCTCCTGGTGTGGGAGGCCATCAAGACGTTC
ACGGCCGAGGTGGTAGGCATCTACTACAAGAGTGACCAGATGGTGGTAGAGGACCAGGAGCTGC
AGGACTTTGTGAAGGATGTTTATGTGTACGGCATGCGGGGCAAGAAGACCTCAGGTTTCCCCAA
GTCCATCAAGACCAGAGAGAAGCTGTCGGAGTACCTAACAGTAGTGATCTTCACGGCCTCAGCC
CAGCATGCAGCGGTGAACTTCGGCCAGTATGACTGGTGCTCCTGGATCCCCAATGCCCCCCCAA
CCATGCGGGCCCCACCACCGACGGCCAAGGGTGTCGTCACCATCGAGCAGATTGTGGACACGCT
GCCAGACCGTGGCCGCTCCTGCTGGCATCTGGGCGCAGTATGGGCACTGAGCCAGTTTCAAGAA
AATGAGCTGTTCCTGGGCATGTATCCAGAAGAGCATTTCATCGAGAAGCCTGTAAAAGAGGCCA
TTGCCCGGTTCCACAAGAACCTTGACACCATCGTCAGCATGATTGCTGAGCGCAACAAGAACAA
GAAGCTGCCATATTATTACTTGTCCCCAGACCGGATTCCCAATAGTGTAGCCATCTAAGAAGCC
ACCGGAGTCAGTCTCACTTGGATATGGCCAGATGCTTGAGGCTAAGCTCAGGTCCCAGACTCCA
GCCTGCCCAGGTGGGCAGGCACCCAGGTGGCCCTGGGGCAGACCTTGCAGCTTGCTTTTCTGTG
GCTGCCACGATTCCTCAGGCCCAGGCTTACTGGCTTCAAACCAAAGGATGTCCAAGTTGGGCCA
TGTTATGCCTAAGCTTCAGTGCATTCTAAAAGTTTTTCCCTCAATCTTTAGTGAATCCCATACT
CTGATCAGAGTGGGTACACTGCACAAATCCGTCTGACGCAGAGTAGGACTGTGTGGCCTCCTGC
CCTGCACCCAGCTCAGTGCTTCCACACCAGACAGCAACAAGAAGACAACTGATAGACATCTGTT
CTCATTGGGAGGCATGATTATTTCTGTTCTATTTATGCTTAGTCCAATTTCTTGCATATACTAG
ATGCCCAAATACATCCTTGTTGAATAAATTAGGAATTGTCATAAAAATAAAGAAGTGCATTCA

hide sequence

RefSeq Acc Id:

XM_038439629 ⟹ XP_038295557

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	28	2,349,844 - 2,407,164 (-)	NCBI

RefSeq Acc Id:

XM_038439630 ⟹ XP_038295558

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	28	2,349,844 - 2,399,307 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001192042	(Get FASTA)	NCBI Sequence Viewer
	XP_038295557	(Get FASTA)	NCBI Sequence Viewer
	XP_038295558	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ADV36116	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000010341.5
	ENSCAFP00000049744.2
	ENSCAFP00000070269.1
	ENSCAFP00030032001.1
	ENSCAFP00030032026.1
	ENSCAFP00040041617.1
	ENSCAFP00040041618.1
	ENSCAFP00040041619.1
	ENSCAFP00845036492
	ENSCAFP00845036492.1
	ENSCAFP00845036558.1
	ENSCAFP00845036621.1

RefSeq Acc Id:

NP_001192042 ⟸ NM_001205113

- UniProtKB:

E7ECW0 (UniProtKB/TrEMBL), A0A8C0NZM6 (UniProtKB/TrEMBL), A0A8P0TP16 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGD
IQLVKIEKRKYWLHDDWYLKYITLKTPCGDYIEFPCYRWITGEGEIVLRDGRAKLACDDQIHIL
KQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFIN
RFMHMFQSSWSDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIQRCKKLPEKL
PVTTEMVECSLERQLTLEQEVEQGNIFIVDFDLLDGIDANKTDPCTLQFLAAPICLLYKNLANK
IVPIAIQLNQVPGDENPIFLPSDAKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVLVFGIA
MYRHLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAMQDLTY
ISLCFPEAIKARGMDSTEDIPYYFYRDDGLLVWEAIKTFTAEVVGIYYKSDQMVVEDQELQDFV
KDVYVYGMRGKKTSGFPKSIKTREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRA
PPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAIARF
HKNLDTIVSMIAERNKNKKLPYYYLSPDRIPNSVAI

hide sequence

Ensembl Acc Id:

ENSCAFP00000010341 ⟸ ENSCAFT00000011163

Ensembl Acc Id:

ENSCAFP00000049744 ⟸ ENSCAFT00000059504

RefSeq Acc Id:	XP_038295557 ⟸ XM_038439629
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NZM6 (UniProtKB/TrEMBL), A0A8P0TP16 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038295558 ⟸ XM_038439630
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NZM6 (UniProtKB/TrEMBL), A0A8P0TP16 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845036558 ⟸ ENSCAFT00845046566

Ensembl Acc Id:

ENSCAFP00845036492 ⟸ ENSCAFT00845046482

Ensembl Acc Id:

ENSCAFP00845036621 ⟸ ENSCAFT00845046655

Protein Domains

Lipoxygenase PLAT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000006948	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030019943	UniProtKB/TrEMBL
	ENSCAFG00040025543	UniProtKB/TrEMBL
	ENSCAFG00845026331	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011163.5	UniProtKB/TrEMBL
	ENSCAFT00000059504.2	UniProtKB/TrEMBL
	ENSCAFT00000097947.1	UniProtKB/TrEMBL
	ENSCAFT00030036684.1	UniProtKB/TrEMBL
	ENSCAFT00030036712.1	UniProtKB/TrEMBL
	ENSCAFT00040047675.1	UniProtKB/TrEMBL
	ENSCAFT00040047676.1	UniProtKB/TrEMBL
	ENSCAFT00040047677.1	UniProtKB/TrEMBL
	ENSCAFT00845046482	ENTREZGENE
	ENSCAFT00845046482.1	UniProtKB/TrEMBL
	ENSCAFT00845046566.1	UniProtKB/TrEMBL
	ENSCAFT00845046655.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.60	UniProtKB/TrEMBL
	PLAT/LH2 domain	UniProtKB/TrEMBL
InterPro	LipOase	UniProtKB/TrEMBL
	LipOase_C	UniProtKB/TrEMBL
	LipOase_C_sf	UniProtKB/TrEMBL
	LipOase_CS	UniProtKB/TrEMBL
	LipOase_Fe_BS	UniProtKB/TrEMBL
	LipOase_mml	UniProtKB/TrEMBL
	PLAT/LH2_dom	UniProtKB/TrEMBL
	PLAT/LH2_dom_sf	UniProtKB/TrEMBL
	PLAT_LOX_verte	UniProtKB/TrEMBL
KEGG Report	cfa:477753	UniProtKB/TrEMBL
NCBI Gene	ALOX5	ENTREZGENE
PANTHER	POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE	UniProtKB/TrEMBL
	PTHR11771	UniProtKB/TrEMBL
Pfam	Lipoxygenase	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
PRINTS	LIPOXYGENASE	UniProtKB/TrEMBL
	MAMLPOXGNASE	UniProtKB/TrEMBL
PROSITE	LIPOXYGENASE_1	UniProtKB/TrEMBL
	LIPOXYGENASE_2	UniProtKB/TrEMBL
	LIPOXYGENASE_3	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
SMART	LH2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48484	UniProtKB/TrEMBL
	SSF49723	UniProtKB/TrEMBL
UniProt	A0A8C0NZM6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RP82_CANLF	UniProtKB/TrEMBL
	A0A8C0TX58_CANLF	UniProtKB/TrEMBL
	A0A8I3PPI3_CANLF	UniProtKB/TrEMBL
	A0A8I3PTZ0_CANLF	UniProtKB/TrEMBL
	A0A8I3SA30_CANLF	UniProtKB/TrEMBL
	A0A8P0TP16	ENTREZGENE
	E7ECW0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8P0NZL5	UniProtKB/TrEMBL
	A0A8P0SC91	UniProtKB/TrEMBL
	A0A8P0TP16	UniProtKB/TrEMBL
VGNC ID	VGNC:37813	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB