TCL1B (TCL1 family AKT coactivator B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: TCL1B (TCL1 family AKT coactivator B) Canis lupus familiaris
Analyze
Symbol: TCL1B
Name: TCL1 family AKT coactivator B
RGD ID: 12268391
Description: ENCODES a protein that exhibits protein kinase binding (inferred); protein serine/threonine kinase activator activity (inferred); INVOLVED IN intracellular signal transduction (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Neoplasm Metastasis (ortholog); Parkinson's disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T cell leukemia/lymphoma 1B; T-cell leukemia/lymphoma 1B; T-cell leukemia/lymphoma protein 1B
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,497,560 - 64,500,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,497,560 - 64,500,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,076,224 - 64,079,263 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0864,766,393 - 64,769,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,766,393 - 64,769,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,440,626 - 64,443,479 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,501,936 - 64,504,788 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,825,329 - 64,828,387 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TCL1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,497,560 - 64,500,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,497,560 - 64,500,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,076,224 - 64,079,263 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0864,766,393 - 64,769,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,766,393 - 64,769,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,440,626 - 64,443,479 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,501,936 - 64,504,788 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,825,329 - 64,828,387 (+)NCBIUU_Cfam_GSD_1.0
TCL1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381495,686,426 - 95,692,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,686,426 - 95,692,628 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,152,763 - 96,158,965 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,222,516 - 95,228,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,222,515 - 95,228,719NCBI
Celera1476,208,508 - 76,214,717 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1476,338,317 - 76,344,548 (+)NCBIHuRef
CHM1_11496,090,663 - 96,096,959 (+)NCBICHM1_1
T2T-CHM13v2.01489,918,003 - 89,924,209 (+)NCBIT2T-CHM13v2.0
Tcl1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,125,963 - 105,132,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,125,949 - 105,132,884 (+)EnsemblGRCm39 Ensembl
GRCm3812105,159,704 - 105,166,625 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,159,690 - 105,166,625 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,397,914 - 106,404,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,560,754 - 105,567,675 (+)NCBIMGSCv36mm8
Celera12106,392,293 - 106,399,180 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.21NCBI
TCL1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21596,842,185 - 96,847,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,058,650 - 96,064,573 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,315,855 - 76,322,054 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11495,639,798 - 95,645,999 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1495,639,798 - 95,645,999 (+)Ensemblpanpan1.1panPan2
Tcl1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,999,209 - 10,004,227 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493660478,241 - 83,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCL1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7116,912,976 - 116,917,934 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17116,912,974 - 116,917,940 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,127,971 - 124,132,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCL1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12473,548,086 - 73,554,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2473,548,165 - 73,552,726 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605360,717,114 - 60,722,999 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TCL1B
48 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00000085303   ⟹   ENSCAFP00000064469
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl864,497,560 - 64,500,412 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006142   ⟹   ENSCAFP00845004886
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl864,766,393 - 64,769,248 (+)Ensembl
RefSeq Acc Id: XM_038484433   ⟹   XP_038340361
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1864,440,626 - 64,443,479 (+)NCBI
RefSeq Acc Id: XM_038545981   ⟹   XP_038401909
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0864,825,329 - 64,828,387 (+)NCBI
RefSeq Acc Id: XM_038608205   ⟹   XP_038464133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0864,501,936 - 64,504,788 (+)NCBI
RefSeq Acc Id: XM_038673008   ⟹   XP_038528936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0864,766,393 - 64,769,248 (+)NCBI
RefSeq Acc Id: XM_850149   ⟹   XP_855242
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1864,497,560 - 64,500,412 (+)NCBI
Dog10K_Boxer_Tasha864,076,224 - 64,079,263 (+)NCBI
Sequence:
RefSeq Acc Id: XP_855242   ⟸   XM_850149
- UniProtKB: A0A8C0KMN4 (UniProtKB/TrEMBL),   A0A8C0MUM1 (UniProtKB/TrEMBL),   A0A8P0PD74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000064469   ⟸   ENSCAFT00000085303
RefSeq Acc Id: XP_038340361   ⟸   XM_038484433
RefSeq Acc Id: XP_038464133   ⟸   XM_038608205
RefSeq Acc Id: XP_038528936   ⟸   XM_038673008
- UniProtKB: A0A8C0KMN4 (UniProtKB/TrEMBL),   A0A8C0PT42 (UniProtKB/TrEMBL),   A0A8I3RSV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401909   ⟸   XM_038545981
- UniProtKB: A0A8C0KMN4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845004886   ⟸   ENSCAFT00845006142


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000043952 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009109 UniProtKB/TrEMBL
  ENSCAFG00040000071 UniProtKB/TrEMBL
  ENSCAFG00845003461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000085303.2 UniProtKB/TrEMBL
  ENSCAFT00030016849.1 UniProtKB/TrEMBL
  ENSCAFT00040000110.1 UniProtKB/TrEMBL
  ENSCAFT00845006142 ENTREZGENE
  ENSCAFT00845006142.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.15.10 UniProtKB/TrEMBL
InterPro TCL1_MTCP1 UniProtKB/TrEMBL
  TCL1_MTCP1_sf UniProtKB/TrEMBL
KEGG Report cfa:612418 UniProtKB/TrEMBL
NCBI Gene TCL1B ENTREZGENE
PANTHER PTHR14060 UniProtKB/TrEMBL
  T-CELL LEUKEMIA/LYMPHOMA PROTEIN 1B UniProtKB/TrEMBL
Pfam TCL1_MTCP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50904 UniProtKB/TrEMBL
UniProt A0A8C0KMN4 ENTREZGENE
  A0A8C0MUM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PT42 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RSV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PD74 ENTREZGENE
UniProt Secondary A0A8P0PD74 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-05 TCL1B  TCL1 family AKT coactivator B  TCL1B  T cell leukemia/lymphoma 1B  Symbol and/or name change 5135510 APPROVED
2017-12-19 TCL1B  T cell leukemia/lymphoma 1B    T-cell leukemia/lymphoma 1B  Symbol and/or name change 5135510 APPROVED