SKP2 (S-phase kinase associated protein 2) - Rat Genome Database

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Gene: SKP2 (S-phase kinase associated protein 2) Canis lupus familiaris
Analyze
Symbol: SKP2
Name: S-phase kinase associated protein 2
RGD ID: 12159505
Description: ENCODES a protein that exhibits identical protein binding (inferred); ubiquitin ligase-substrate adaptor activity (inferred); INVOLVED IN cellular response to cell-matrix adhesion (ortholog); G1/S transition of mitotic cell cycle (ortholog); G2/M transition of mitotic cell cycle (ortholog); PARTICIPATES IN Notch signaling pathway; p53 signaling pathway; ASSOCIATED WITH Brain Injuries (ortholog); breast cancer (ortholog); cervix uteri carcinoma in situ (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,352,966 - 72,386,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,352,986 - 72,386,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha471,962,697 - 71,996,249 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0472,860,285 - 72,892,402 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl472,861,375 - 72,892,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,606,024 - 72,639,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0472,729,654 - 72,763,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0473,263,074 - 73,296,649 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SKP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,352,966 - 72,386,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,352,986 - 72,386,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha471,962,697 - 71,996,249 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0472,860,285 - 72,892,402 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl472,861,375 - 72,892,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,606,024 - 72,639,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0472,729,654 - 72,763,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0473,263,074 - 73,296,649 (-)NCBIUU_Cfam_GSD_1.0
SKP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38536,152,111 - 36,193,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl536,151,989 - 36,196,849 (+)EnsemblGRCh38hg38GRCh38
GRCh37536,152,213 - 36,184,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,187,946 - 36,219,904 (+)NCBINCBI36Build 36hg18NCBI36
Celera536,037,882 - 36,069,833 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef536,103,294 - 36,135,146 (+)NCBIHuRef
CHM1_1536,154,887 - 36,186,889 (+)NCBICHM1_1
T2T-CHM13v2.0536,400,405 - 36,441,818 (+)NCBIT2T-CHM13v2.0
Skp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,112,070 - 9,155,512 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,112,073 - 9,155,512 (-)EnsemblGRCm39 Ensembl
GRCm38159,111,982 - 9,155,425 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,111,985 - 9,155,425 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,041,742 - 9,070,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,038,867 - 9,067,333 (-)NCBIMGSCv36mm8
Celera158,929,103 - 8,957,934 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.84NCBI
Skp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,888,406 - 59,916,471 (-)NCBIGRCr8
mRatBN7.2258,161,226 - 58,189,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,161,229 - 58,189,338 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx265,259,097 - 65,287,393 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,371,360 - 63,399,422 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,372,679 - 58,400,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,506,146 - 58,534,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,506,151 - 58,534,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,593,574 - 77,621,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,769,164 - 58,797,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera253,770,002 - 53,798,066 (-)NCBICelera
Cytogenetic Map2q16NCBI
Skp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,972,663 - 20,999,769 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542620,972,663 - 20,999,769 (+)NCBIChiLan1.0ChiLan1.0
SKP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,145,802 - 74,177,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,299,431 - 72,331,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,179,608 - 74,211,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,460,989 - 79,493,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl579,461,018 - 79,492,311 (-)Ensemblpanpan1.1panPan2
Skp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,707,776 - 225,735,425 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365185,637,331 - 5,664,778 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365185,635,856 - 5,664,057 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,463,012 - 21,509,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11621,463,270 - 21,500,925 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,480,017 - 22,517,706 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,009,114 - 35,040,518 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl435,009,076 - 35,042,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607125,339,782 - 25,375,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475918,830,323 - 18,858,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475918,796,055 - 18,858,692 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SKP2
362 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 5 22 6 6 6 6 6 12 8 10 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000029721   ⟹   ENSCAFP00000027621
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl472,354,649 - 72,386,307 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068233   ⟹   ENSCAFP00000065130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl472,354,649 - 72,386,307 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087166   ⟹   ENSCAFP00000061362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl472,352,986 - 72,386,307 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089810   ⟹   ENSCAFP00000057460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl472,354,649 - 72,371,265 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845007999   ⟹   ENSCAFP00845006294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl472,861,375 - 72,892,173 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008011   ⟹   ENSCAFP00845006304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl472,861,375 - 72,892,173 (-)Ensembl
RefSeq Acc Id: XM_038474199   ⟹   XP_038330127
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1472,606,024 - 72,639,558 (-)NCBI
RefSeq Acc Id: XM_038535323   ⟹   XP_038391251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0473,263,074 - 73,296,649 (-)NCBI
RefSeq Acc Id: XM_038599591   ⟹   XP_038455519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0472,729,654 - 72,763,206 (-)NCBI
RefSeq Acc Id: XM_038662388   ⟹   XP_038518316
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0472,860,285 - 72,892,402 (-)NCBI
RefSeq Acc Id: XM_546346   ⟹   XP_546346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1472,352,966 - 72,386,469 (-)NCBI
Dog10K_Boxer_Tasha471,962,697 - 71,996,249 (-)NCBI
Sequence:
RefSeq Acc Id: XP_546346   ⟸   XM_546346
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KVD7 (UniProtKB/TrEMBL),   A0A8C0QQM8 (UniProtKB/TrEMBL),   A0A8P0TD43 (UniProtKB/TrEMBL),   A0A8I3MXJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027621   ⟸   ENSCAFT00000029721
RefSeq Acc Id: ENSCAFP00000061362   ⟸   ENSCAFT00000087166
RefSeq Acc Id: ENSCAFP00000065130   ⟸   ENSCAFT00000068233
RefSeq Acc Id: ENSCAFP00000057460   ⟸   ENSCAFT00000089810
RefSeq Acc Id: XP_038330127   ⟸   XM_038474199
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038455519   ⟸   XM_038599591
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038518316   ⟸   XM_038662388
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MXJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391251   ⟸   XM_038535323
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KVD7 (UniProtKB/TrEMBL),   A0A8C0QQM8 (UniProtKB/TrEMBL),   A0A8I3MXJ5 (UniProtKB/TrEMBL),   A0A8P0TD43 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845006294   ⟸   ENSCAFT00845007999
RefSeq Acc Id: ENSCAFP00845006304   ⟸   ENSCAFT00845008011
Protein Domains
F-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018725 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001480 UniProtKB/TrEMBL
  ENSCAFG00040008787 UniProtKB/TrEMBL
  ENSCAFG00845004397 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000068233.2 UniProtKB/TrEMBL
  ENSCAFT00000087166.2 UniProtKB/TrEMBL
  ENSCAFT00000089810.2 UniProtKB/TrEMBL
  ENSCAFT00030002646.1 UniProtKB/TrEMBL
  ENSCAFT00030002657.1 UniProtKB/TrEMBL
  ENSCAFT00030002666.1 UniProtKB/TrEMBL
  ENSCAFT00030002675.1 UniProtKB/TrEMBL
  ENSCAFT00040016384.1 UniProtKB/TrEMBL
  ENSCAFT00040016457.1 UniProtKB/TrEMBL
  ENSCAFT00040016597.1 UniProtKB/TrEMBL
  ENSCAFT00040016614.1 UniProtKB/TrEMBL
  ENSCAFT00845007999.1 UniProtKB/TrEMBL
  ENSCAFT00845008011.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:489228 UniProtKB/TrEMBL
NCBI Gene SKP2 ENTREZGENE
PANTHER PROTEIN ARABIDILLO 1 UniProtKB/TrEMBL
  PROTEIN ARABIDILLO 1-RELATED UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
  LRR_CC UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A8C0KVD7 ENTREZGENE
  A0A8C0LZC5_CANLF UniProtKB/TrEMBL
  A0A8C0QN40_CANLF UniProtKB/TrEMBL
  A0A8C0QQM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S1B1_CANLF UniProtKB/TrEMBL
  A0A8I3MTR3_CANLF UniProtKB/TrEMBL
  A0A8I3MXJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TD43 ENTREZGENE
UniProt Secondary A0A8P0P6P7 UniProtKB/TrEMBL
  A0A8P0PDR5 UniProtKB/TrEMBL
  A0A8P0TD43 UniProtKB/TrEMBL
VGNC ID VGNC:51910 ENTREZGENE