AZIN1 (antizyme inhibitor 1) - Rat Genome Database

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Gene: AZIN1 (antizyme inhibitor 1) Canis lupus familiaris
Analyze
Symbol: AZIN1
Name: antizyme inhibitor 1
RGD ID: 12331093
Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,523,405 - 4,555,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20095969   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AZIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,523,405 - 4,555,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBIUU_Cfam_GSD_1.0
AZIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,826,111 - 102,893,864 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBINCBI36Build 36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,803 - 103,916,656 (-)NCBICHM1_1
T2T-CHM13v2.08103,954,549 - 103,992,441 (-)NCBIT2T-CHM13v2.0
Azin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,487,674 - 38,523,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,487,671 - 38,519,510 (-)EnsemblGRCm39 Ensembl
GRCm381538,487,430 - 38,519,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,487,427 - 38,519,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,417,185 - 38,449,021 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361538,432,019 - 38,463,855 (-)NCBIMGSCv36mm8
Celera1539,113,891 - 39,145,734 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.17NCBI
Azin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,539,711 - 71,566,515 (-)NCBIGRCr8
mRatBN7.2769,654,773 - 69,681,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,654,663 - 69,681,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,536,617 - 71,563,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,739,154 - 73,765,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,607,179 - 73,633,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
Azin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,231,696 - 27,259,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,231,695 - 27,259,564 (-)NCBIChiLan1.0ChiLan1.0
AZIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27120,193,169 - 120,231,424 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,729,217 - 95,767,340 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0899,483,027 - 99,521,151 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,639,950 - 101,678,604 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,639,950 - 101,678,604 (-)Ensemblpanpan1.1panPan2
Azin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,375,842 - 33,406,444 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,801,943 - 40,834,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647040,801,943 - 40,832,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,234,679 - 34,257,134 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,221,368 - 34,257,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,079,181 - 37,109,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,679,775 - 97,717,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,679,468 - 97,696,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603942,881,918 - 42,921,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,643,980 - 19,667,125 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,643,980 - 19,667,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AZIN1
248 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 17 1 6 1 6 1 12 8 10 5
Low 1 5 5 5 5 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014118509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM537953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK995910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX012289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN359470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN441562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN442648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN873824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000990   ⟹   ENSCAFP00000000907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl134,363,688 - 4,396,040 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076279   ⟹   ENSCAFP00000048265
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl134,363,996 - 4,396,040 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089464   ⟹   ENSCAFP00000054782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091877   ⟹   ENSCAFP00000064600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl134,363,996 - 4,396,040 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014198   ⟹   ENSCAFP00845011008
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl134,523,405 - 4,555,498 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014241   ⟹   ENSCAFP00845011041
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl134,524,266 - 4,555,488 (-)Ensembl
RefSeq Acc Id: NM_001291425   ⟹   NP_001278354
RefSeq Status: REVIEWED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1134,363,996 - 4,396,040 (-)NCBI
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBI
ROS_Cfam_1.0134,523,492 - 4,555,485 (-)NCBI
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBI
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBI
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038684529   ⟹   XP_038540457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBI
RefSeq Acc Id: XM_038684530   ⟹   XP_038540458
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBI
RefSeq Acc Id: XM_038684531   ⟹   XP_038540459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001278354   ⟸   NM_001291425
- UniProtKB: A0A8C0MTP9 (UniProtKB/TrEMBL),   A0A8C0QUD8 (UniProtKB/TrEMBL),   A0A8I3MWX9 (UniProtKB/TrEMBL),   A0A8C0QJ62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000907   ⟸   ENSCAFT00000000990
RefSeq Acc Id: ENSCAFP00000064600   ⟸   ENSCAFT00000091877
RefSeq Acc Id: ENSCAFP00000048265   ⟸   ENSCAFT00000076279
RefSeq Acc Id: ENSCAFP00000054782   ⟸   ENSCAFT00000089464
RefSeq Acc Id: XP_038540459   ⟸   XM_038684531
- Peptide Label: isoform X2
- UniProtKB: A0A8I3N3M2 (UniProtKB/TrEMBL),   A0A8P0NYB4 (UniProtKB/TrEMBL),   A0A8C0QJ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540457   ⟸   XM_038684529
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MTP9 (UniProtKB/TrEMBL),   A0A8C0QUD8 (UniProtKB/TrEMBL),   A0A8I3MWX9 (UniProtKB/TrEMBL),   A0A8C0QJ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540458   ⟸   XM_038684530
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MTP9 (UniProtKB/TrEMBL),   A0A8C0QUD8 (UniProtKB/TrEMBL),   A0A8I3MWX9 (UniProtKB/TrEMBL),   A0A8C0QJ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011041   ⟸   ENSCAFT00845014241
RefSeq Acc Id: ENSCAFP00845011008   ⟸   ENSCAFT00845014198
Protein Domains
Orn/DAP/Arg decarboxylase 2 C-terminal   Orn/DAP/Arg decarboxylase 2 N-terminal

Promoters
RGD ID:13685564
Promoter ID:EPDNEW_C3632
Type:single initiation site
Name:AZIN1_1
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1134,395,834 - 4,395,894EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000643 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010362 UniProtKB/TrEMBL
  ENSCAFG00040005933 UniProtKB/TrEMBL
  ENSCAFG00845008052 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000990.5 UniProtKB/TrEMBL
  ENSCAFT00000076279.2 UniProtKB/TrEMBL
  ENSCAFT00030019168.1 UniProtKB/TrEMBL
  ENSCAFT00040011092.1 UniProtKB/TrEMBL
  ENSCAFT00040011123.1 UniProtKB/TrEMBL
  ENSCAFT00040011153.1 UniProtKB/TrEMBL
  ENSCAFT00845014198 ENTREZGENE
  ENSCAFT00845014198.1 UniProtKB/TrEMBL
  ENSCAFT00845014241 ENTREZGENE
  ENSCAFT00845014241.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.10 UniProtKB/TrEMBL
InterPro Ala_racemase/Decarboxylase_C UniProtKB/TrEMBL
  Azin1 UniProtKB/TrEMBL
  De-COase2_C UniProtKB/TrEMBL
  De-COase2_CS UniProtKB/TrEMBL
  De-COase2_N UniProtKB/TrEMBL
  Orn/DAP/Arg_de-COase UniProtKB/TrEMBL
  Orn_de-COase UniProtKB/TrEMBL
  PLP-binding_barrel UniProtKB/TrEMBL
KEGG Report cfa:475058 UniProtKB/TrEMBL
NCBI Gene AZIN1 ENTREZGENE
PANTHER PTHR11482 UniProtKB/TrEMBL
  PTHR11482:SF7 UniProtKB/TrEMBL
Pfam Orn_Arg_deC_N UniProtKB/TrEMBL
  Orn_DAP_Arg_deC UniProtKB/TrEMBL
PRINTS ODADCRBXLASE UniProtKB/TrEMBL
  ORNDCRBXLASE UniProtKB/TrEMBL
PROSITE ODR_DC_2_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF50621 UniProtKB/TrEMBL
  SSF51419 UniProtKB/TrEMBL
UniProt A0A8C0MTP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QJ62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QM47_CANLF UniProtKB/TrEMBL
  A0A8C0QUD8 ENTREZGENE
  A0A8I3MWX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N3M2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NYB4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38329 ENTREZGENE