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Gene: AZIN1 (antizyme inhibitor 1) Canis lupus familiaris
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Symbol: AZIN1
Name: antizyme inhibitor 1
RGD ID: 12331093
Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Orthologs:
Homo sapiens (human) : AZIN1 (antizyme inhibitor 1)  HGNC  Alliance
Mus musculus (house mouse) : Azin1 (antizyme inhibitor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Azin1 (antizyme inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Azin1 (antizyme inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AZIN1 (antizyme inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Azin1 (antizyme inhibitor 1)
Sus scrofa (pig) : AZIN1 (antizyme inhibitor 1)
Chlorocebus sabaeus (African green monkey) : AZIN1 (antizyme inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Azin1 (antizyme inhibitor 1)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - uncurated

Genomics

Comparative Map Data

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on AZIN1
NCBI Gene
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 12331093
Created: 2017-01-24
Species: Canis lupus familiaris
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.