WRAP53 (WD repeat containing antisense to TP53) - Rat Genome Database

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Gene: WRAP53 (WD repeat containing antisense to TP53) Canis lupus familiaris
Analyze
Symbol: WRAP53 (Ensembl: EFNB3)
Name: WD repeat containing antisense to TP53
RGD ID: 12124119
Description: ENCODES a protein that exhibits histone binding (inferred); identical protein binding (inferred); protein carrier chaperone (inferred); INVOLVED IN positive regulation of telomere maintenance via telomerase (ortholog); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 3 (ortholog); Body Weight (ortholog); FOUND IN Cajal body (inferred); cytosol (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: telomerase Cajal body protein 1; WD repeat domain 79; WDR79
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,574,153 - 32,586,222 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,574,134 - 32,594,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,712,138 - 32,725,180 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,677,789 - 32,690,832 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,678,578 - 32,690,834 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,645,668 - 32,658,710 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,601,891 - 32,614,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,780,842 - 32,793,885 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WRAP53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,574,153 - 32,586,222 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,574,134 - 32,594,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,712,138 - 32,725,180 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,677,789 - 32,690,832 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,678,578 - 32,690,834 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,645,668 - 32,658,710 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,601,891 - 32,614,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,780,842 - 32,793,885 (+)NCBIUU_Cfam_GSD_1.0
WRAP53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,686,071 - 7,703,502 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,686,071 - 7,703,502 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,589,389 - 7,606,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,532,520 - 7,547,544 (+)NCBINCBI36Build 36hg18NCBI36
Celera177,615,750 - 7,633,180 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,482,804 - 7,500,156 (+)NCBIHuRef
CHM1_1177,598,524 - 7,615,973 (+)NCBICHM1_1
T2T-CHM13v2.0177,590,175 - 7,607,622 (+)NCBIT2T-CHM13v2.0
Wrap53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,452,580 - 69,471,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,452,584 - 69,471,081 (-)EnsemblGRCm39 Ensembl
GRCm381169,561,754 - 69,580,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,561,758 - 69,580,255 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,375,256 - 69,392,826 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,377,949 - 69,395,519 (-)NCBIMGSCv36mm8
Celera1176,524,707 - 76,542,284 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.81NCBI
Wrap53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,780,873 - 54,797,919 (-)NCBIGRCr8
mRatBN7.21054,282,092 - 54,299,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,282,105 - 54,298,929 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,944,501 - 58,961,275 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,433,045 - 58,449,818 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,940,731 - 53,957,518 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,169,024 - 56,185,800 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,169,025 - 56,185,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,914,380 - 55,931,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,380,914 - 56,398,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,394,537 - 56,412,124 (-)NCBI
Celera1053,436,325 - 53,453,155 (-)NCBICelera
Cytogenetic Map10q24NCBI
Wrap53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554679,225,506 - 9,240,756 (-)NCBIChiLan1.0ChiLan1.0
WRAP53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,280,889 - 15,298,965 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,246,094 - 17,265,011 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,715,897 - 7,735,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,707,220 - 7,723,410 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,707,221 - 7,723,394 (+)Ensemblpanpan1.1panPan2
Wrap53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,461,298 - 47,478,596 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595936,487 - 952,791 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595936,184 - 952,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WRAP53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,954,669 - 52,968,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,954,674 - 52,968,371 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,205,960 - 55,219,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WRAP53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,065,531 - 7,085,590 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,066,333 - 7,085,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,323,308 - 14,343,301 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wrap53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,283,984 - 10,296,729 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,283,721 - 10,296,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WRAP53
94 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026478   ⟹   ENSCAFP00000024592
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,574,134 - 32,586,202 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000036506   ⟹   ENSCAFP00000031891
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,575,344 - 32,586,202 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000042891   ⟹   ENSCAFP00000035853
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,588,333 - 32,594,333 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000045758   ⟹   ENSCAFP00000036919
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,588,333 - 32,593,021 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000069246   ⟹   ENSCAFP00000053849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,574,134 - 32,594,333 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000073485   ⟹   ENSCAFP00000057757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,574,134 - 32,585,929 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845043832   ⟹   ENSCAFP00845034349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,678,578 - 32,690,834 (+)Ensembl
RefSeq Acc Id: XM_005619990   ⟹   XP_005620047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,574,153 - 32,586,222 (+)NCBI
Dog10K_Boxer_Tasha532,712,138 - 32,725,180 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038475553   ⟹   XP_038331481
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,645,668 - 32,658,710 (+)NCBI
RefSeq Acc Id: XM_038536723   ⟹   XP_038392651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0532,780,842 - 32,793,885 (+)NCBI
RefSeq Acc Id: XM_038600897   ⟹   XP_038456825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,601,891 - 32,614,933 (+)NCBI
RefSeq Acc Id: XM_038665443   ⟹   XP_038521371
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,677,789 - 32,690,832 (+)NCBI
RefSeq Acc Id: XP_005620047   ⟸   XM_005619990
- UniProtKB: A0A8C0QER0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000053849   ⟸   ENSCAFT00000069246
Ensembl Acc Id: ENSCAFP00000036919   ⟸   ENSCAFT00000045758
Ensembl Acc Id: ENSCAFP00000057757   ⟸   ENSCAFT00000073485
Ensembl Acc Id: ENSCAFP00000035853   ⟸   ENSCAFT00000042891
Ensembl Acc Id: ENSCAFP00000024592   ⟸   ENSCAFT00000026478
Ensembl Acc Id: ENSCAFP00000031891   ⟸   ENSCAFT00000036506
RefSeq Acc Id: XP_038331481   ⟸   XM_038475553
RefSeq Acc Id: XP_038456825   ⟸   XM_038600897
RefSeq Acc Id: XP_038521371   ⟸   XM_038665443
- UniProtKB: A0A8C0QER0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392651   ⟸   XM_038536723
- UniProtKB: A0A8C0QER0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845034349   ⟸   ENSCAFT00845043832

Promoters
RGD ID:13683236
Promoter ID:EPDNEW_C1304
Type:single initiation site
Name:WRAP53_1
Description:WD repeat containing antisense to TP53
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,575,373 - 32,575,433EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031192 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040006355 UniProtKB/TrEMBL
  ENSCAFG00845024805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026478.6 UniProtKB/TrEMBL
  ENSCAFT00040012016.1 UniProtKB/TrEMBL
  ENSCAFT00845043832 ENTREZGENE
  ENSCAFT00845043832.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro SWT21/TCAB1_mRNA_Telomere UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene WRAP53 ENTREZGENE
PANTHER TELOMERASE CAJAL BODY PROTEIN 1 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A8C0QER0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PST8_CANLF UniProtKB/TrEMBL
  A0A8P0NI36_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48432 ENTREZGENE