Wrap53 (WD repeat containing antisense to TP53)

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Gene: Wrap53 (WD repeat containing antisense to TP53) Ictidomys tridecemlineatus

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Symbol:

Wrap53

Name:

WD repeat containing antisense to TP53

RGD ID:

12557324

Description:

ENCODES a protein that exhibits histone binding (inferred); identical protein binding (inferred); protein carrier chaperone (inferred); INVOLVED IN positive regulation of telomere maintenance via telomerase (ortholog); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 3 (ortholog); Body Weight (ortholog); FOUND IN Cajal body (inferred); cytosol (inferred); nuclear body (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

telomerase Cajal body protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,461,298 - 47,478,596 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	936,487 - 952,791 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	936,184 - 952,784 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Dyskeratosis Congenita (ISO)

autosomal recessive dyskeratosis congenita 3 (ISO)

Body Weight (ISO)

breast cancer (ISO)

colorectal cancer (ISO)

common variable immunodeficiency (ISO)

congenital myasthenic syndrome 2A (ISO)

Diamond-Blackfan anemia (ISO)

dyskeratosis congenita (ISO)

esophagus squamous cell carcinoma (ISO)

glottis squamous cell carcinoma (ISO)

head and neck squamous cell carcinoma (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

Li-Fraumeni syndrome (ISO)

Li-Fraumeni syndrome 1 (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

nasopharynx carcinoma (ISO)

ovarian cancer (ISO)

rectal benign neoplasm (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Cajal body organization (IEA)

positive regulation of DNA repair (IEA)

positive regulation of double-strand break repair (IEA)

positive regulation of double-strand break repair via homologous recombination (IEA)

positive regulation of double-strand break repair via nonhomologous end joining (IEA)

positive regulation of establishment of protein localization to telomere (IEA)

positive regulation of telomere maintenance via telomerase (IEA,ISO)

protein localization to Cajal body (IEA)

RNA folding (IEA)

scaRNA localization to Cajal body (IEA)

telomerase RNA localization to Cajal body (IEA)

telomere formation via telomerase (IEA)

telomere maintenance via telomerase (IEA)

Cellular Component

Cajal body (IEA)

cytosol (IEA)

nuclear body (IEA)

nucleoplasm (IEA)

site of double-strand break (IEA)

telomerase holoenzyme complex (IEA)

Molecular Function

histone binding (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein carrier chaperone (IEA)

protein-containing complex binding (IEA)

protein-folding chaperone binding (IEA)

RNA binding (IEA)

RNA folding chaperone (IEA)

telomerase RNA binding (IEA)

ubiquitin protein ligase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Wrap53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,461,298 - 47,478,596 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	936,487 - 952,791 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	936,184 - 952,784 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WRAP53
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,686,071 - 7,703,502 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,686,071 - 7,703,502 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,589,389 - 7,606,820 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,532,520 - 7,547,544 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	7,615,750 - 7,633,180 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,482,804 - 7,500,156 (+)	NCBI		HuRef
CHM1_1	17	7,598,524 - 7,615,973 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,590,175 - 7,607,622 (+)	NCBI		T2T-CHM13v2.0

Wrap53
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,452,580 - 69,471,076 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,452,584 - 69,471,081 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,561,754 - 69,580,250 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,561,758 - 69,580,255 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,375,256 - 69,392,826 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	69,377,949 - 69,395,519 (-)	NCBI		MGSCv36	mm8
Celera	11	76,524,707 - 76,542,284 (-)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.81	NCBI

Wrap53
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,780,873 - 54,797,919 (-)	NCBI		GRCr8
mRatBN7.2	10	54,282,092 - 54,299,908 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,282,105 - 54,298,929 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	58,944,501 - 58,961,275 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,433,045 - 58,449,818 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	53,940,731 - 53,957,518 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,169,024 - 56,185,800 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,169,025 - 56,185,857 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	55,914,380 - 55,931,438 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,380,914 - 56,398,501 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,394,537 - 56,412,124 (-)	NCBI
Celera	10	53,436,325 - 53,453,155 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Wrap53
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955467	9,225,506 - 9,240,756 (-)	NCBI	ChiLan1.0	ChiLan1.0

WRAP53
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,280,889 - 15,298,965 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,246,094 - 17,265,011 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,715,897 - 7,735,873 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,707,220 - 7,723,410 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,707,221 - 7,723,394 (+)	Ensembl	panpan1.1		panPan2

WRAP53
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,574,153 - 32,586,222 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,574,134 - 32,594,333 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,712,138 - 32,725,180 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,677,789 - 32,690,832 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,678,578 - 32,690,834 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,645,668 - 32,658,710 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,601,891 - 32,614,933 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,780,842 - 32,793,885 (+)	NCBI		UU_Cfam_GSD_1.0

WRAP53
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,954,669 - 52,968,364 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,954,674 - 52,968,371 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,205,960 - 55,219,648 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WRAP53
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	7,065,531 - 7,085,590 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	7,066,333 - 7,085,625 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,323,308 - 14,343,301 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wrap53
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,283,984 - 10,296,729 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,283,721 - 10,296,568 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040269368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002479 ⟹ ENSSTOP00000002217

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936595	936,487 - 952,791 (+)	Ensembl

RefSeq Acc Id:

XM_005332820 ⟹ XP_005332877

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	47,461,298 - 47,478,596 (+)	NCBI
SpeTri2.0	NW_004936595	936,184 - 952,784 (+)	NCBI

Sequence:

show sequence

AAATCTGATCCGGGATTCCGAAGGCCAATCGGAAGCCGGGCCCAAGTCCCGCGAGAACAAGAGG
CGCGGAGCGGCCCAGGGTTCTTAGCAGAGTTGTGCCTTTACTATTGATGTCCTTCTGTTCTCGC
CGGCCGGGGGTCTTCTGCCTCCCCCACGGAAAAGGAAAGAAGGCACTGGTGGGTTTCCCCACTT
CTGATCCCTGAGAACTTTGAAGCAGTTCCGGCAGTCCTGTGCGTCGGGCCGTCCATAGGCAGTA
GAGAGTTGCCCGGCTTAGGCCAATGTCTGCCGCGCTTCCTCTGCAGCATGAAGACGTCGGAGGA
GCAACTCTTGGCTCCAGACAGCCTTCCTTTAGACCAGGCCCCTGTACCAGCCTGTCCCTCTCCC
CACGCTTCTCCGATGGATAAAAATACAGACCCTGAATTTATACCACCGCCACCTGGTGGAGATG
ATCTGCCCCAGAGGTCCCCAGATCCCGTGGCTGGCTCAGCTTCGACCCAGGAGCTGGGGGAGGA
GAACCCAGCATCTCTCTCCACTCCCTTGGAAACCGAGTTTGATACTCCTCATGAGTTGAGTCCT
CAAATCAAGAAGCAAGAACTTGATGAAAATGCTAGCTCTCCTGCAGAAAAAATGAGTGTTCCGG
AGTTGGGGTCTGAAGAAGCCATGGAAGGCGTGTCTGAGGAAGCTGCTCCAGAGGATGAGGAAGA
CACCACTTGGAACTACAGCTTCTCCCGGATACCTCGGTTTCTCAGTGGTTCCTGGTCTGAGTTT
AGCACCCAACCTGAGAACTTCTTGAAAGGCTGTAAGTGGGCCCCAGATGGTTCCTGCATCTTGA
CCAATAGTGCTGATAACATCCTGCGGATTTATAACCTGCCCCCAGAGCTGTATAATGAGGGAGA
GCAAGTGGAATACACAGAAATGGCCCCTGTCCTTCGAATGATGGAGGGTGATACCATATATGAT
TACTGCTGGTATTCGCTGATGTCTTCAGCCCAACCAGACACCTCCTACGTGGCCAGCAGCAGTC
GGGAGAACCCAATTCACATCTGGGATGCATTCACTGGAGAGCTCCGGGCTTCCTTTCGTGCCTA
CAACCACCTGGATGAGCTGACGGCAGCCCACTCACTCTGCTTCTCCCCGGATGGCTCCCAACTC
TTCTGTGGCTTCAACCGGACCGTTCGAGTCTTCTCCACATCCCGACCTGGCCGAGACTGTGAGG
TGCGAGCCACATTTGCAAAAAAACAAGGTCAGAGTGGCATCATCTCCTGCATAGCCTTCAGCCC
AGCCCAGCCCCTCTATGCCTGTGGCTCCTATGGCCGCTCCCTGGGCCTGTATGCCTGGGATGAT
GGCTCCCATCTTGCCTTGCTTGGAGGGCATCAAGGGGGCATCACCCACCTCTGCTTTCACCCTG
ATGGCAACCGCTTCTTCTCAGGAGCCCGCAAGGATGCTGAGCTCCTCTGCTGGGACCTCCGGCA
GCCTGGTCATCCGCTTTGGTCCTTGAGTCGGGAGGTAACCACCAATCAGCGCATCTACTTTGAT
CTGGACCCGAGCGGCCAGTTCCTAGCAAGTGGCAGCACTAGCGGGGCTGTCTCTGTGTGGAACA
TCAGTGAGACTGGCAAGGATGGGAGTCCAGAGCCTGTGCTGAGTTTTCTGCCCCAGAAGGACTG
CACCAATGGAGTGAGCCTACACCCTAGCCTGCCTCTGCTGGCCACTGCCTCTGGTCAGCGTGTG
TTTCCGGAGCCCACTGACAGTGGGGATGAAGGGGAACAGGAGCCAGACCTCCCCCTGCTCTCCT
TTCGACACGTCCACCTGGAATGTCGGCTTCAGCTCTGGTGGTGTGGGGGTGGCCCAGATCCCAG
TATCCCTGATGATCACCAGGATGAGAAGGGACAAGGAGGGACTGAGGGAAGTGGGAGTGAACTT
ATATAAAAAGATTTTATATGATA

hide sequence

RefSeq Acc Id:

XM_040269368 ⟹ XP_040125302

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	47,461,298 - 47,478,486 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005332877	(Get FASTA)	NCBI Sequence Viewer
	XP_040125302	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002217.2
GenBank Protein	KAG3269894	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332877 ⟸ XM_005332820
- Peptide Label:	isoform X1
- UniProtKB:	I3M0H9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTSEEQLLAPDSLPLDQAPVPACPSPHASPMDKNTDPEFIPPPPGGDDLPQRSPDPVAGSAST QELGEENPASLSTPLETEFDTPHELSPQIKKQELDENASSPAEKMSVPELGSEEAMEGVSEEAA PEDEEDTTWNYSFSRIPRFLSGSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPE LYNEGEQVEYTEMAPVLRMMEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELR ASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIIS CIAFSPAQPLYACGSYGRSLGLYAWDDGSHLALLGGHQGGITHLCFHPDGNRFFSGARKDAELL CWDLRQPGHPLWSLSREVTTNQRIYFDLDPSGQFLASGSTSGAVSVWNISETGKDGSPEPVLSF LPQKDCTNGVSLHPSLPLLATASGQRVFPEPTDSGDEGEQEPDLPLLSFRHVHLECRLQLWWCG GGPDPSIPDDHQDEKGQGGTEGSGSELI hide sequence

RefSeq Acc Id:	XP_040125302 ⟸ XM_040269368
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000002217 ⟸ ENSSTOT00000002479

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002484	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002479.3	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	SWT21/TCAB1_mRNA_Telomere	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Wrap53	ENTREZGENE
PANTHER	TELOMERASE CAJAL BODY PROTEIN 1	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	I3M0H9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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