IL13 (interleukin 13) - Rat Genome Database

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Gene: IL13 (interleukin 13) Canis lupus familiaris
Analyze
Symbol: IL13
Name: interleukin 13
RGD ID: 12404079
Description: ENCODES a protein that exhibits interleukin-13 receptor binding (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); allergic conjunctivitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH cannabidiol; luteolin; masitinib
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-13; interleukin-13
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,957,870 - 20,961,391 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,759,917 - 19,762,847 (+)NCBI
ROS_Cfam_1.01121,744,389 - 21,747,318 (+)NCBI
ROS_Cfam_1.0 Ensembl1121,744,389 - 21,747,315 (+)Ensembl
UMICH_Zoey_3.11120,462,871 - 20,465,798 (+)NCBI
UNSW_CanFamBas_1.01120,310,464 - 20,313,371 (+)NCBI
UU_Cfam_GSD_1.01120,952,917 - 20,955,847 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
chlamydia  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diffuse scleroderma  (ISO)
drug allergy  (ISO)
Eczema  (ISO)
egg allergy  (ISO)
Endotoxemia  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
food allergy  (ISO)
Fungal Lung Diseases  (ISO)
Graves' disease  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
lipoid nephrosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
mastocytosis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
milk allergy  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
occupational dermatitis  (ISO)
onchocerciasis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
peanut allergy  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Picornaviridae Infections  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumonia  (ISO)
prostatic hypertrophy  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
purpura  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
Respiratory Tract Infections  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Schistosomiasis Mansoni  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
T-Cell Lymphoma  (ISO)
Transplant Rejection  (ISO)
uveitis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cannabidiol  (EXP)
luteolin  (EXP)
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cytokine stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
macrophage activation  (IEA)
microglial cell activation  (ISO)
negative regulation of complement-dependent cytotoxicity  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of connective tissue growth factor production  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of immunoglobulin production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of ion transport  (ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of mast cell degranulation  (IEA,ISO)
positive regulation of pancreatic stellate cell proliferation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of proton transport  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11032397  


Genomics

Comparative Map Data
IL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,957,870 - 20,961,391 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,759,917 - 19,762,847 (+)NCBI
ROS_Cfam_1.01121,744,389 - 21,747,318 (+)NCBI
ROS_Cfam_1.0 Ensembl1121,744,389 - 21,747,315 (+)Ensembl
UMICH_Zoey_3.11120,462,871 - 20,465,798 (+)NCBI
UNSW_CanFamBas_1.01120,310,464 - 20,313,371 (+)NCBI
UU_Cfam_GSD_1.01120,952,917 - 20,955,847 (+)NCBI
IL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,656,522 - 132,661,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,656,263 - 132,661,110 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,992,214 - 131,996,802 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,021,764 - 132,024,700 (+)NCBINCBI36hg18NCBI36
Build 345132,021,763 - 132,024,700NCBI
Celera5128,123,995 - 128,126,931 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,186,169 - 127,189,105 (+)NCBIHuRef
CHM1_15131,427,162 - 131,430,098 (+)NCBICHM1_1
T2T-CHM13v2.05133,176,323 - 133,180,911 (+)NCBI
Il13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,522,150 - 53,525,529 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,522,151 - 53,525,529 (-)Ensembl
GRCm381153,631,323 - 53,634,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,631,324 - 53,634,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,444,825 - 53,448,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,474,747 - 53,478,125 (-)NCBImm8
Celera1158,210,849 - 58,214,228 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
Il13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,790,130 - 37,792,687 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1037,790,130 - 37,792,737 (-)Ensembl
Rnor_6.01038,982,909 - 38,985,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,982,909 - 38,985,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,764,639 - 38,767,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,093,512 - 39,096,069 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,102,758 - 39,105,316 (-)NCBI
Celera1037,134,342 - 37,136,897 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,046,406 - 4,049,795 (+)NCBIChiLan1.0ChiLan1.0
IL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,235,788 - 134,240,548 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,235,788 - 134,240,548 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,073,863 - 128,078,453 (+)NCBIMhudiblu_PPA_v0panPan3
Il13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,527,018 - 115,529,671 (-)NCBI
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,441,025 - 140,444,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,475,762 - 35,479,419 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,476,490 - 35,478,869 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603442,463,847 - 42,466,277 (-)NCBIVero_WHO_p1.0
Il13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,428,095 - 39,429,843 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473339,427,189 - 39,430,019 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1 1
Low 8 5 4 5 1 6 1
Below cutoff 4 5 10 2 5 2 8 8 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001364   ⟹   ENSCAFP00000001250
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019361   ⟹   ENSCAFP00845015137
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1121,744,389 - 21,747,315 (+)Ensembl
RefSeq Acc Id: NM_001003384   ⟹   NP_001003384
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11120,958,464 - 20,961,391 (+)NCBI
Dog10K_Boxer_Tasha1119,759,917 - 19,762,847 (+)NCBI
ROS_Cfam_1.01121,744,389 - 21,747,318 (+)NCBI
UMICH_Zoey_3.11120,462,871 - 20,465,798 (+)NCBI
UNSW_CanFamBas_1.01120,310,464 - 20,313,371 (+)NCBI
UU_Cfam_GSD_1.01120,952,917 - 20,955,847 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003384 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF63204 (Get FASTA)   NCBI Sequence Viewer  
  Q9N0W9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003384   ⟸   NM_001003384
- Peptide Label: precursor
- UniProtKB: Q9N0W9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001250   ⟸   ENSCAFT00000001364
RefSeq Acc Id: ENSCAFP00845015137   ⟸   ENSCAFT00845019361

Promoters
RGD ID:13685171
Promoter ID:EPDNEW_C3239
Type:single initiation site
Name:IL13_1
Description:interleukin 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11120,958,442 - 20,958,502EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 20960082 20960083 A G snv Australian Cattle dog (AC023), Australian Cattle dog (AC108), Alpine Dachsbracke (AD009), Yorkshire Terrier (YT003), Australian Shepherd (AU178), Bavarian Hound (BG064), Miniature Bullterrier (BT007), Bullterrier (BT012), Cocker Spaniel (CP003), Great Dane (DD116), Dachshund (DH098), Dachshund (DH126), Chinese indigenous dogs (DQ1), Chinese indigenous dogs (DQ10), Chinese indigenous dogs (DQ2), Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ5), Chinese indigenous dogs (DQ6), Chinese indigenous dogs (DQ7), Chinese indigenous dogs (DQ8), Chinese indigenous dogs (DQ9), German Shepherd/Mixed breed (DS032), German Shepherd/Mixed breed (DS041), German Shepherd/Mixed breed (DS042), Entlebucher Sennenhund (EN091), Entlebucher Sennenhund (EN154), Entlebucher Sennenhund (EN221), Entlebucher Sennenhund (EN247), Entlebucher Sennenhund (EN261), Entlebucher Sennenhund (EN262), Entlebucher Sennenhund (EN263), Entlebucher Sennenhund (EN264), French Bulldog (FB065), Golden Retriever (GR1078), German Wirehaired (GW004), Greyhound (GY432), Jack Russell Terrier (JR0034), German Hunting Terrier (JT007), Jagdterrier (JT011), Kromfohrländer (KF042), Kunming Dog (KM10), Leonberger (LB1919), Chinese indigenous dogs (LJ9), Landseer (LN048), Norwich Terrier (NW206), Norwich Terrier (NW255), Spanish Water Dog (PE002), Poodle (PL116), Rottweiler (RO2), Rhodesian Ridgeback (RR098), Rhodesian Ridgeback (RR123), Rhodesian Ridgeback (RR224), Sloughi (SG005), Sloughi (SG006), Sloughi (SG008), Greater Swiss Mountain Dog (SH008), Pembroke Welsh Corgi (SRS732551), Black Russian Terrier (SRS833812), Shetland Sheepdog (SRS932138), Alaskan Husky (SY001), Siberian Husky (SY046), Tibetan Mastiff (TM2), Tibetan Mastiff (TM5), Tibetan Mastiff (TM7), Tibetan Mastiff (TM9), Weimaraner (WE008), Whippet (WH083), West Highland White Terrier (WW174), West Highland White Terrier (WW361), West Highland White Terrier (WW362), West Highland White Terrier (WW363), West Highland White Terrier (WW364)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000878 Ensembl
  ENSCAFG00030011676 UniProtKB/Swiss-Prot
  ENSCAFG00040006314 UniProtKB/TrEMBL
  ENSCAFG00845010953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00030018820 UniProtKB/Swiss-Prot
  ENSCAFP00040010202 UniProtKB/TrEMBL
  ENSCAFP00040010219 UniProtKB/TrEMBL
  ENSCAFP00845015137 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00030021587 UniProtKB/Swiss-Prot
  ENSCAFT00040011771 UniProtKB/TrEMBL
  ENSCAFT00040011792 UniProtKB/TrEMBL
  ENSCAFT00845019361 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:442990 UniProtKB/Swiss-Prot
NCBI Gene IL13 ENTREZGENE
Pfam IL13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0QE97_CANLF UniProtKB/TrEMBL
  A0A8C0RZ01_CANLF UniProtKB/TrEMBL
  IL13_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41936 ENTREZGENE