BAG1 (BAG cochaperone 1) - Rat Genome Database

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Gene: BAG1 (BAG cochaperone 1) Canis lupus familiaris
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Symbol: BAG1
Name: BAG cochaperone 1
RGD ID: 12220552
Description: ENCODES a protein that exhibits phosphoprotein binding (ortholog); INVOLVED IN apoptotic process (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of motor neuron apoptotic process (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); breast cancer (ortholog); Breast Neoplasms (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BAG family molecular chaperone regulator 1; BCL2 associated athanogene 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,348,833 - 50,363,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,350,999 - 50,363,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1148,978,818 - 48,993,481 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,288,922 - 51,303,809 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,288,044 - 51,303,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,953,304 - 49,967,917 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,820,251 - 49,835,112 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,585,344 - 50,600,226 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,348,833 - 50,363,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,350,999 - 50,363,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1148,978,818 - 48,993,481 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,288,922 - 51,303,809 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,288,044 - 51,303,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,953,304 - 49,967,917 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,820,251 - 49,835,112 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,585,344 - 50,600,226 (-)NCBIUU_Cfam_GSD_1.0
BAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,252,471 - 33,264,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,247,820 - 33,264,720 (-)EnsemblGRCh38hg38GRCh38
GRCh37933,252,469 - 33,264,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,242,469 - 33,254,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 34933,245,025 - 33,254,737NCBI
Celera933,182,605 - 33,194,897 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,209,370 - 33,221,664 (-)NCBIHuRef
CHM1_1933,251,269 - 33,264,545 (-)NCBICHM1_1
T2T-CHM13v2.0933,271,122 - 33,283,355 (-)NCBIT2T-CHM13v2.0
Bag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,936,398 - 40,948,294 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,936,398 - 40,948,294 (-)EnsemblGRCm39 Ensembl
GRCm38440,936,398 - 40,948,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,936,398 - 40,948,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv37440,883,431 - 40,895,327 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,125,088 - 41,136,908 (-)NCBIMGSCv36mm8
Celera440,597,072 - 40,608,972 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.67NCBI
Bag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,864,476 - 60,877,059 (-)NCBIGRCr8
mRatBN7.2556,068,494 - 56,081,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,068,494 - 56,081,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,035,035 - 58,047,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,854,186 - 59,866,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,848,377 - 59,861,135 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,254,421 - 57,267,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,254,421 - 57,267,002 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,785,751 - 61,798,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,329,720 - 58,342,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,329,898 - 58,342,460 (-)NCBI
Celera554,680,341 - 54,692,922 (-)NCBICelera
Cytogenetic Map5q22NCBI
Bag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554722,394,317 - 2,405,199 (+)NCBIChiLan1.0ChiLan1.0
BAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,339,036 - 91,348,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,345,096 - 91,354,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,033,267 - 33,043,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,841,254 - 33,851,242 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl933,841,449 - 33,851,167 (-)Ensemblpanpan1.1panPan2
Bag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,245,421 - 165,256,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,791,119 - 1,804,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,793,001 - 1,804,145 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,227,338 - 33,240,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,227,530 - 33,240,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,484,543 - 37,497,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,006,177 - 47,016,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,900,059 - 43,910,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473638,015,044 - 38,025,079 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,015,150 - 38,025,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BAG1
186 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000002906   ⟹   ENSCAFP00000002694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1150,350,999 - 50,363,581 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845035967   ⟹   ENSCAFP00845028147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1151,288,044 - 51,303,858 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845036025   ⟹   ENSCAFP00845028195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1151,288,925 - 51,303,503 (-)Ensembl
RefSeq Acc Id: XM_038491203   ⟹   XP_038347131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11149,953,304 - 49,967,917 (-)NCBI
RefSeq Acc Id: XM_038553286   ⟹   XP_038409214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01150,585,344 - 50,600,226 (-)NCBI
RefSeq Acc Id: XM_038617172   ⟹   XP_038473100
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01149,820,251 - 49,835,112 (-)NCBI
RefSeq Acc Id: XM_038668201   ⟹   XP_038524129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1148,978,818 - 48,993,481 (-)NCBI
RefSeq Acc Id: XM_038682623   ⟹   XP_038538551
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01151,288,922 - 51,303,809 (-)NCBI
RefSeq Acc Id: ENSCAFP00000002694   ⟸   ENSCAFT00000002906
RefSeq Acc Id: XP_038347131   ⟸   XM_038491203
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038473100   ⟸   XM_038617172
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038538551   ⟸   XM_038682623
- Peptide Label: isoform X1
- UniProtKB: A0A9E7V469 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524129   ⟸   XM_038668201
- Peptide Label: isoform X2
- UniProtKB: A0A9E7V469 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409214   ⟸   XM_038553286
- Peptide Label: isoform X1
- UniProtKB: A0A9E7V469 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845028147   ⟸   ENSCAFT00845035967
RefSeq Acc Id: ENSCAFP00845028195   ⟸   ENSCAFT00845036025
Protein Domains
BAG   Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001844 Ensembl
  ENSCAFG00000054031 UniProtKB/TrEMBL
  ENSCAFG00845020411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000094467.1 UniProtKB/TrEMBL
  ENSCAFT00000107244.1 UniProtKB/TrEMBL
  ENSCAFT00845035967 ENTREZGENE
  ENSCAFT00845035967.1 UniProtKB/TrEMBL
  ENSCAFT00845036025.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.120 UniProtKB/TrEMBL
InterPro BAG-1 UniProtKB/TrEMBL
  BAG_chaperone_regulator UniProtKB/TrEMBL
  BAG_dom_sf UniProtKB/TrEMBL
  BAG_domain UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene BAG1 ENTREZGENE
PANTHER PTHR12329 UniProtKB/TrEMBL
  PTHR12329:SF16 UniProtKB/TrEMBL
Pfam BAG UniProtKB/TrEMBL
  ubiquitin UniProtKB/TrEMBL
PIRSF BAG_1 UniProtKB/TrEMBL
PROSITE BAG UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART BAG UniProtKB/TrEMBL
  UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF63491 UniProtKB/TrEMBL
UniProt A0A8I3PHM1_CANLF UniProtKB/TrEMBL
  A0A8I3S1R1_CANLF UniProtKB/TrEMBL
  A0A8P0PNP8_CANLF UniProtKB/TrEMBL
  A0A8P0TNK9_CANLF UniProtKB/TrEMBL
  A0A9E7V469 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38363 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 BAG1  BAG cochaperone 1  BAG1  BCL2 associated athanogene 1  Symbol and/or name change 5135510 APPROVED