RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Coronary Disease
Accession: DOID:9000528
browse the term
Definition: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Synonyms: exact_synonym: CHD; Coronary Diseases; coronary heart disease; coronary heart diseases
narrow_synonym: CORONARY ARTERY DISEASE, EARLY-ONSET; THREE VESSEL CORONARY DISEASE; chronic coronary heart disease
related_synonym: CHDS1; CHDS2; CHDS3; CHDS4; CHDS5; CHDS6; CHDS7; CHDS8; CHDS9; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 1; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 2; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 3; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 4; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 5; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 6; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 7; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 8; CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 9; Coronary artery disease, susceptibility to; Coronary heart disease in familial hypercholesterolemia, protection against
primary_id: MESH:D003327
alt_id: MIM:300464 ; MIM:607339 ; MIM:608316 ; MIM:608318 ; MIM:608901 ; MIM:610938 ; MIM:611139 ; MIM:612030 ; MIM:614466
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Abca1
ATP binding cassette subfamily A member 1
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
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Abcg5
ATP binding cassette subfamily G member 5
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004955441:10,964,588...10,987,771
Ensembl chrNW_004955441:10,964,858...10,986,967
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Abcg8
ATP binding cassette subfamily G member 8
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004955441:10,982,307...11,004,789
Ensembl chrNW_004955441:10,982,307...11,009,116
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Ace2
angiotensin converting enzyme 2
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :8790G>A (human)
RGD
PMID:18753062
RGD:2313798
NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
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Ada
adenosine deaminase
ISO
protein:increased expression:leukocyte
RGD
PMID:17259686
RGD:1624286
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif 13
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004955513:2,761,386...2,786,447
Ensembl chrNW_004955513:2,764,186...2,786,187
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Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif 7
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
NCBI chrNW_004955450:525,313...581,006
Ensembl chrNW_004955450:529,999...577,621
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Adipoq
adiponectin, C1Q and collagen domain containing
disease_progression
ISO
associated with Diabetes mellitus, Type2;
RGD
PMID:22019747 PMID:22207678
RGD:5686379 RGD:5686406
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Adrb2
adrenoceptor beta 2
susceptibility
ISO
DNA:polymorphism: :p.Q27E
RGD
PMID:12682000
RGD:1601128
NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
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Adrb3
adrenoceptor beta 3
susceptibility
ISO
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994(human)
RGD
PMID:10421225 PMID:20536507
RGD:1559326 RGD:5684776
NCBI chrNW_004955463:13,663,064...13,665,553
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Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
associated with Heart Failure; protein:increased expression:plasma (human) protein:decreased expression:plasma (human)
RGD
PMID:20685687 PMID:23396398
RGD:7243186 RGD:7244134
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Agtr1
angiotensin II receptor type 1
no_association susceptibility
ISO
DNA:polymorphism:3' utr:1166A>C (human)
RGD
PMID:9456365 PMID:9857918
RGD:1566499 RGD:1601152
NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
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Agxt2
alanine--glyoxylate aminotransferase 2
ISO
DNA:missense mutation:cds:V140I (rs37369)(human)
RGD
PMID:24834905
RGD:329961320
NCBI chrNW_004955426:20,102,368...20,142,596
Ensembl chrNW_004955426:20,101,620...20,142,620
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Apoa4
apolipoprotein A4
susceptibility no_association
ISO
DNA:missense mutation:cds:p.T347S (human)
RGD
PMID:9013087 PMID:12676816
RGD:1578411 RGD:5685683
NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
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Apob
apolipoprotein B
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424
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Apoc2
apolipoprotein C2
susceptibility
ISO
RGD
PMID:7590197
RGD:1601205
NCBI chrNW_004955555:2,019,547...2,021,543
Ensembl chrNW_004955555:2,016,217...2,021,830
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Apoc3
apolipoprotein C3
no_association susceptibility
ISO
DNA:polymorphism:promoter:-482C>T ClinVar Annotator: match by term: Coronary heart disease associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD ClinVar
PMID:11060345 PMID:16321685 PMID:17654446 PMID:19074352 PMID:20097930 PMID:23701270 PMID:24941081 PMID:24941082 PMID:25225788 PMID:25741868 PMID:25962519 PMID:27114411 PMID:28406212 PMID:28492532 PMID:28825717 PMID:29237685 PMID:30255797 PMID:32041611 PMID:34548093 PMID:36876364 More...
RGD:1601224 RGD:2306754
NCBI chrNW_004955412:18,165,667...18,168,015
Ensembl chrNW_004955412:18,165,667...18,168,015
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Apoe
apolipoprotein E
onset
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphisms, haplotype:promoter, cds:g.-219G>T, p.C112R, p.R158C (human)
CTD RGD
PMID:10736278 PMID:11862316
RGD:1578479
NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
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Ccdc92
coiled-coil domain containing 92
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004955482:5,196,238...5,206,210
Ensembl chrNW_004955482:5,197,515...5,206,210
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Cd14
CD14 molecule
ISO
protein:increased expression:monocyte
RGD
PMID:10831941
RGD:2314175
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd36
CD36 molecule (CD36 blood group)
ISO
ClinVar Annotator: match by term: CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 7
ClinVar OMIM
PMID:25741868 PMID:28960434 PMID:33116287
NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
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Cd40lg
CD40 ligand
treatment
ISO
RGD
PMID:23819214
RGD:7248750
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
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Cdkn2b
cyclin dependent kinase inhibitor 2B
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
NCBI chrNW_004955472:12,275,613...12,280,141
Ensembl chrNW_004955472:12,275,544...12,280,528
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Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 1
ClinVar OMIM
PMID:25741868
NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
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Dab2ip
DAB2 interacting protein
ISO
DNA:SNP:CDS:rs7025486 (human)
RGD
PMID:21444365
RGD:401938618
NCBI chrNW_004955419:6,229,437...6,416,619
Ensembl chrNW_004955419:6,228,591...6,416,402
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Dnah11
dynein axonemal heavy chain 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19060911
NCBI chrNW_004955410:24,045,333...24,352,626
Ensembl chrNW_004955410:24,044,886...24,352,626
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:16595607
RGD:1580981
NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572
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Esr2
estrogen receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17367797
NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
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F12
coagulation factor XII
ISO
protein:decreased activity::
RGD
PMID:18021303
RGD:11041785
NCBI chrNW_004955408:29,644,279...29,665,161
Ensembl chrNW_004955408:29,642,096...29,650,950
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F13a1
coagulation factor XIII A chain
ISO
RGD
PMID:11391716
RGD:1581030
NCBI chrNW_004955465:7,444,118...7,617,366
Ensembl chrNW_004955465:7,443,166...7,617,436
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Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus
RGD
PMID:15451784
RGD:2315870
NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773
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Flt1
fms related receptor tyrosine kinase 1
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472
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Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:SNP: :rs9939609 (human)
RGD
PMID:26555680
RGD:11555922
NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771
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G6pd
glucose-6-phosphate dehydrogenase
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 PMID:8471773 PMID:9589612 PMID:10502785 PMID:11601226 PMID:12064920 PMID:15727905 PMID:16329560 PMID:16607506 PMID:25741868 PMID:28492532 PMID:29300386 PMID:29339739 PMID:30045279 PMID:30315739 PMID:31489982 PMID:31863082 PMID:33051526 PMID:33072997 PMID:34659341 PMID:34762759 PMID:34895177 PMID:35313968 PMID:35840819 PMID:36353116 More...
NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083
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Ggt1
gamma-glutamyltransferase 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:serum
RGD
PMID:16772340
RGD:2315604
NCBI chrNW_004955455:8,082,578...8,099,523
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Glul
glutamate-ammonia ligase
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :rs10911021 (human)
RGD
PMID:23982368
RGD:401794410
NCBI chrNW_004955406:21,266,383...21,274,546
Ensembl chrNW_004955406:21,266,383...21,275,309
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Gp1ba
glycoprotein Ib platelet subunit alpha
ISO
RGD
PMID:14592833
RGD:1580433
NCBI chrNW_004955467:10,333,537...10,347,488
Ensembl chrNW_004955467:10,333,575...10,346,989
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
disease_progression
ISO
RGD
PMID:15809366
RGD:5508474
NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:15869055
RGD:1598404
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Hnf1a
HNF1 homeobox A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:12059985
RGD:1624217
NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419
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Igf1
insulin like growth factor 1
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Igfals
insulin like growth factor binding protein acid labile subunit
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004955442:15,469,602...15,482,115
Ensembl chrNW_004955442:15,478,202...15,482,115
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Igfbp3
insulin like growth factor binding protein 3
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845
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Igfbp5
insulin like growth factor binding protein 5
ISO
RGD
PMID:15521962
RGD:1626121
NCBI chrNW_004955453:16,530,110...16,550,733
Ensembl chrNW_004955453:16,530,110...16,550,733
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 PMID:8471773 PMID:9589612 PMID:10502785 PMID:11601226 PMID:12064920 PMID:15727905 PMID:16329560 PMID:16607506 PMID:25741868 PMID:28492532 PMID:29300386 PMID:29339739 PMID:30045279 PMID:30315739 PMID:31489982 PMID:31863082 PMID:33051526 PMID:33072997 PMID:34659341 PMID:34762759 PMID:34895177 PMID:35313968 PMID:35840819 PMID:36353116 More...
NCBI chrNW_004955580:1,053,823...1,069,802
Ensembl chrNW_004955580:1,053,823...1,069,802
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Il18
interleukin 18
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1b
interleukin 1 beta
ISO
DNA:polymorphism
RGD
PMID:15379752
RGD:1626636
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Irf8
interferon regulatory factor 8
susceptibility
ISO
DNA:SNPs:intron 4, intron 2: (rs925994,rs10514610) (human)
RGD
PMID:23661672
RGD:329902076
NCBI chrNW_004955541:973,004...988,493
Ensembl chrNW_004955541:973,022...990,106
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Irs1
insulin receptor substrate 1
ISO
ClinVar Annotator: match by term: Coronary artery disease, susceptibility to
ClinVar
PMID:1311924 PMID:7623569 PMID:8104271 PMID:8647950 PMID:10084586 PMID:10430617 PMID:10591678 PMID:10843189 PMID:12843189 PMID:14671192 PMID:14707024 PMID:15240653 More...
NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
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Itga2
integrin subunit alpha 2
no_association
ISO
RGD
PMID:9684730
RGD:1582306
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Itgam
integrin subunit alpha M
exacerbates
ISO
protein:increased expression:monocyte (human)
RGD
PMID:20876457
RGD:329901842
NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
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Itgb3
integrin subunit beta 3
ISO
DNA:polymorphism:exon
RGD
PMID:10583927
RGD:5128478
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
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Kalrn
kalirin RhoGEF kinase
ISO
ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 5
ClinVar
PMID:17357071 PMID:25741868
NCBI chrNW_004955427:23,184,751...23,823,128
Ensembl chrNW_004955427:23,184,739...23,816,811
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Kat2b
lysine acetyltransferase 2B
severity
ISO
DNA:snp:promoter:g.-2481G>C (human)
RGD
PMID:21062767
RGD:9590309
NCBI chrNW_004955430:12,109,493...12,196,102
Ensembl chrNW_004955430:12,128,069...12,198,117
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
no_association
ISO
RGD
PMID:12964027
RGD:1581699
NCBI chrNW_004955413:17,364,447...17,371,255
Ensembl chrNW_004955413:17,364,213...17,371,255
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Kdr
kinase insert domain receptor
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Ldlr
low density lipoprotein receptor
ISO
ClinVar Annotator: match by term: Early-onset coronary artery disease
ClinVar
PMID:9712531 PMID:10422804 PMID:11810272 PMID:11845603 PMID:17765246 PMID:19318025 PMID:20506408 PMID:21382890 PMID:21642693 PMID:22390909 PMID:23375686 PMID:24033266 PMID:25487149 PMID:25647241 PMID:25741868 PMID:28161202 PMID:28492532 PMID:28895539 PMID:29353225 PMID:30293936 PMID:30637778 PMID:30971288 PMID:32719484 PMID:33418990 PMID:33454241 PMID:33740630 PMID:34037665 PMID:35339733 PMID:35568682 PMID:36499307 More...
NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056
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Lepr
leptin receptor
onset
ISO
DNA:SNP: C>T (rs6656451) (human)
RGD
PMID:29848931
RGD:401799677
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Lgals2
galectin 2
susceptibility
ISO
RGD
PMID:17040205
RGD:1581853
NCBI chrNW_004955413:23,988,193...24,001,868
Ensembl chrNW_004955413:23,988,193...23,989,703
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Lipc
lipase C, hepatic type
susceptibility
ISO
associated with Obesity and Diabetes; DNA:transition:promoter:-514C>T (human)
RGD
PMID:16570154
RGD:2308824
NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766
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LOC102004641
cytochrome b-245 light chain
ISO
RGD
PMID:10488959
RGD:1580275
NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118
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Lpl
lipoprotein lipase
ISO
ClinVar Annotator: match by term: Coronary heart disease
ClinVar
PMID:8199176 PMID:8541837 PMID:8872057 PMID:10364086 PMID:10517255 PMID:21146168 PMID:24033266 PMID:25741868 PMID:28492532 More...
NCBI chrNW_004955403:43,646,084...43,672,116
Ensembl chrNW_004955403:43,646,084...43,673,967
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Lrp1
LDL receptor related protein 1
susceptibility
ISO
RGD
PMID:15121769
RGD:1581911
NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146
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Maco1
macoilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19060911
NCBI chrNW_004955452:4,966,357...5,030,868
Ensembl chrNW_004955452:4,968,500...5,030,868
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Mb
myoglobin
severity
ISO
RGD
PMID:15976963
RGD:1582388
NCBI chrNW_004955405:43,215,404...43,221,606
Ensembl chrNW_004955405:43,215,007...43,222,052
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Mgp
matrix Gla protein
susceptibility
ISO
RGD
PMID:16973975
RGD:1582502
NCBI chrNW_004955413:11,614,851...11,618,090
Ensembl chrNW_004955413:11,615,078...11,618,024
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Mif
macrophage migration inhibitory factor
ISO
coronary occlusion; mRNA:increased expression:myocardium
RGD
PMID:20367970
RGD:4890973
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Mlxip
MLX interacting protein
susceptibility
ISO
DNA:SNP:3'utr: (rs4758685) (human)
RGD
PMID:23840567
RGD:401794443
NCBI chrNW_004955482:6,410,182...6,456,582
Ensembl chrNW_004955482:6,411,890...6,456,580
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNP: (rs35493868); in younger than 55 years of age
RGD
PMID:29848931
RGD:401799677
NCBI chrNW_004955456:14,096,530...14,116,687
Ensembl chrNW_004955456:14,096,531...14,117,269
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Mras
muscle RAS oncogene homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004955501:615,303...670,404
Ensembl chrNW_004955501:615,303...670,782
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16792904
NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
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Mttp
microsomal triglyceride transfer protein
susceptibility
ISO
DNA:polymorphism:promoter:-493G>T
RGD
PMID:15136504
RGD:1625487
NCBI chrNW_004955496:7,963,323...8,022,393
Ensembl chrNW_004955496:7,963,262...8,009,838
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Myh15
myosin heavy chain 15
ISO
DNA:snp:exon:EX28T>C rs3900940 (human)
RGD
PMID:18073581
RGD:2317145
NCBI chrNW_004955427:9,257,716...9,400,526
Ensembl chrNW_004955427:9,259,811...9,400,526
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Nr1h3
nuclear receptor subfamily 1 group H member 3
exacerbates
ISO
mRNA:decreased expression:peripheral blood mononuclear cell (human) mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:16252156 PMID:19211025
RGD:401827902 RGD:401850788
NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049
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Oaz1
ornithine decarboxylase antizyme 1
susceptibility
ISO
DNA:SNP:intron:c.2222A>G (rs2074458) (human)
RGD
PMID:17761941
RGD:401851037
NCBI chrNW_004955495:5,871,418...5,874,200
Ensembl chrNW_004955495:5,871,418...5,874,200
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Pcsk9
proprotein convertase subtilisin/kexin type 9
susceptibility
ISO
DNA:missense mutation, nonsense mutations:cds:p.R46L, p.Y142X, p.C679X (human)
RGD
PMID:16554528
RGD:1581000
NCBI chrNW_004955464:4,424,583...4,439,805
Ensembl chrNW_004955464:4,425,435...4,439,842
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
ClinVar Annotator: match by term: Three Vessel Coronary Disease
ClinVar
PMID:8532023
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Phactr1
phosphatase and actin regulator 1
no_association susceptibility
ISO
DNA:SNP:intron 3: (rs12526453) (human) associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs12526453) (human)
RGD
PMID:22152955 PMID:28287809
RGD:11055500 RGD:401901081
NCBI chrNW_004955465:1,395,418...1,915,820
Ensembl chrNW_004955465:1,395,088...1,913,847
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Pla2g7
phospholipase A2 group VII
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15699277 PMID:21356620
RGD:6482780
NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1730212 PMID:9181759
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Pltp
phospholipid transfer protein
susceptibility
ISO
protein:increased expression:serum (human)
RGD
PMID:14695459
RGD:1581038
NCBI chrNW_004955445:11,384,723...11,399,217
Ensembl chrNW_004955445:11,384,723...11,399,217
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Pon1
paraoxonase 1
no_association severity
ISO
DNA:missense mutation:cds:p.Q192R (human) ClinVar Annotator: match by term: Coronary artery disease, susceptibility to protein:decreased expression:serum
RGD ClinVar
PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9011577 PMID:9215303 PMID:9385372 PMID:9443884 PMID:9661650 PMID:11238489 PMID:11335891 PMID:11788650 PMID:11810302 PMID:11888590 PMID:11889198 PMID:11918623 PMID:12082503 PMID:15214960 PMID:15241482 PMID:19005291 PMID:21170047 PMID:25741868 More...
RGD:2313267 RGD:8547675
NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
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Pon2
paraoxonase 2
susceptibility
ISO
DNA:missense mutation:cds:p.C311S (human)
RGD
PMID:9443862
RGD:1580216
NCBI chrNW_004955432:11,988,009...12,020,702
Ensembl chrNW_004955432:11,987,919...12,020,740
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Rbp4
retinol binding protein 4
ISO
protein:increased expression:blood plasma (human)
RGD
PMID:23584360
RGD:329845574
NCBI chrNW_004955507:112,342...120,050
Ensembl chrNW_004955507:108,669...120,584
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Retn
resistin
ISO
protein:increased expression:blood
RGD
PMID:17175295
RGD:7207156
NCBI chrNW_004955563:1,607,814...1,609,273
Ensembl chrNW_004955563:1,607,814...1,609,273
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Rtel1
regulator of telomere elongation helicase 1
ameliorates
ISO
DNA:SNP:cds:rs6010620|rs4809324 (human)
RGD
PMID:30623606
RGD:152985693
NCBI chrNW_004955528:531,680...578,003
Ensembl chrNW_004955528:532,385...572,398
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Scarb1
scavenger receptor class B member 1
ISO
RGD
PMID:15967843
RGD:1580004
NCBI chrNW_004955482:4,813,502...4,836,479
Ensembl chrNW_004955482:4,813,955...4,837,392
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Selp
selectin P
ISO
protein:altered expression:serum
RGD
PMID:11597943
RGD:1580074
NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
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Serpinf2
serpin family F member 2
ISO
protein:increased expression:blood
RGD
PMID:15771120
RGD:1625529
NCBI chrNW_004955481:1,441,262...1,449,078
Ensembl chrNW_004955481:1,442,010...1,449,242
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Tcf7l2
transcription factor 7 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004955431:18,020,309...18,207,926
Ensembl chrNW_004955431:18,020,409...18,209,134
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Tert
telomerase reverse transcriptase
ISO
ClinVar Annotator: match by term: Coronary artery disease, susceptibility to
ClinVar
PMID:16890917
NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589
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Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:17200788
RGD:2312456
NCBI chrNW_004955415:30,222,830...30,226,406
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Vegfa
vascular endothelial growth factor A
ISO
mRNA, protein:increased expression:ventricle myocardium
RGD
PMID:16139132
RGD:2313728
NCBI chrNW_004955437:9,527,445...9,541,908
G
Vkorc1
vitamin K epoxide reductase complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16549638
NCBI chrNW_004955493:7,928,516...7,931,265
G
Vwf
von Willebrand factor
ISO
RGD
PMID:11864703
RGD:1580647
NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571
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Zc3hc1
zinc finger C3HC-type containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28869590
NCBI chrNW_004955479:10,692,438...10,717,368
Ensembl chrNW_004955479:10,692,738...10,717,228
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Arhgap17
Rho GTPase activating protein 17
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955493:3,326,893...3,384,621
Ensembl chrNW_004955493:3,327,584...3,384,620
G
Bax
BCL2 associated X, apoptosis regulator
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
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C3
complement C3
ISO
RGD
PMID:26476955
RGD:11552746
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cacng4
calcium voltage-gated channel auxiliary subunit gamma 4
ISO
mRNA:decreased expression:blood:
RGD
PMID:27746059
RGD:13524557
NCBI chrNW_004955478:6,219,637...6,278,759
Ensembl chrNW_004955478:6,219,631...6,280,169
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Casp3
caspase 3
treatment
ISO
RGD
PMID:26550220
RGD:13782284
NCBI chrNW_004955403:24,315,712...24,326,271
G
Casp7
caspase 7
treatment
ISO
RGD
PMID:26550220
RGD:13782284
NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524
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Ccn1
cellular communication network factor 1
ameliorates
ISO
RGD
PMID:30371213
RGD:329845516
NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166
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Dsc2
desmocollin 2
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955402:18,465,631...18,496,948
Ensembl chrNW_004955402:18,464,989...18,489,475
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
treatment
ISO
RGD
PMID:23054911
RGD:405650598
NCBI chrNW_004955523:307,181...310,728
Ensembl chrNW_004955523:305,728...310,728
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
mRNA:increased expression:blood
RGD
PMID:35693610
RGD:329901852
NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771
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Gata5
GATA binding protein 5
susceptibility
ISO
DNA:SNPs:promoter:rs80197101, rs77067995 (human)
RGD
PMID:33684162
RGD:155260335
NCBI chrNW_004955528:1,595,231...1,604,979
Ensembl chrNW_004955528:1,595,231...1,604,979
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Gpx3
glutathione peroxidase 3
ISO
protein:increased expression:plasma
RGD
PMID:28374671
RGD:401827832
NCBI chrNW_004955408:2,622,162...2,629,088
Ensembl chrNW_004955408:2,622,741...2,629,032
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Gsk3b
glycogen synthase kinase 3 beta
treatment ameliorates
ISO
RGD
PMID:26591365 PMID:32068187
RGD:13792778 RGD:267358468
NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
ISO
ClinVar Annotator: match by term: Acute myocardial infarction
ClinVar
PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22616558 PMID:22898539 PMID:23949315 PMID:24606448 PMID:25157968 PMID:26619011 More...
NCBI chrNW_004955416:15,197,611...15,212,919
Ensembl chrNW_004955416:15,197,366...15,223,363
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Ifng
interferon gamma
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955580:1,053,823...1,069,802
Ensembl chrNW_004955580:1,053,823...1,069,802
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Il10
interleukin 10
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il17a
interleukin 17A
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1b
interleukin 1 beta
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rl1
interleukin 1 receptor like 1
ISO
RGD
PMID:24837094
RGD:40813741
NCBI chrNW_004955470:7,779,828...7,849,157
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Il33
interleukin 33
ISO
RGD
PMID:24837094
RGD:40813741
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Il4
interleukin 4
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955408:4,058,052...4,065,999
G
Il6
interleukin 6
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955410:25,079,835...25,084,390
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Itgam
integrin subunit alpha M
treatment
ISO
RGD
PMID:21238619
RGD:329901664
NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
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Kif6
kinesin family member 6
ISO
DNA:SNP: :p.W719R (rs20455) (human)
RGD
PMID:20044086
RGD:243048455
NCBI chrNW_004955437:6,353,318...6,597,196
Ensembl chrNW_004955437:6,352,316...6,671,934
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Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
ameliorates
ISO
associated with obesity
RGD
PMID:35257523
RGD:401794445
NCBI chrNW_004955420:8,778,271...8,793,634
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Plcg1
phospholipase C gamma 1
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955445:15,787,496...15,823,859
Ensembl chrNW_004955445:15,787,496...15,823,859
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Pten
phosphatase and tensin homolog
ameliorates
ISO
mRNA:decreased expression:heart left ventricle (rat) RNA:increased expression:serum
RGD
PMID:26973267 PMID:29990866 PMID:32595526
RGD:11526378 RGD:155882565 RGD:401851053
NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
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Rhoa
ras homolog family member A
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451
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Rit2
Ras like without CAAX 2
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955402:28,737,882...29,137,006
Ensembl chrNW_004955402:28,737,575...29,078,777
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Sdhb
succinate dehydrogenase complex iron sulfur subunit B
ameliorates
ISO
associated with obesity
RGD
PMID:35257523
RGD:401794445
NCBI chrNW_004955527:1,769,280...1,792,496
Ensembl chrNW_004955527:1,768,940...1,792,361
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Serping1
serpin family G member 1
ISO
mRNA:increased expression:heart
RGD
PMID:26476955
RGD:11552746
NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982
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Tbx1
T-box transcription factor 1
treatment
ISO
RGD
PMID:27422448
RGD:155882497
NCBI chrNW_004955442:18,320,674...18,327,062
Ensembl chrNW_004955442:18,319,762...18,325,337
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Tnf
tumor necrosis factor
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Zeb1
zinc finger E-box binding homeobox 1
ameliorates
ISO
RGD
PMID:32068187
RGD:267358468
NCBI chrNW_004955429:23,011,627...23,198,188
Ensembl chrNW_004955429:23,010,790...23,198,250
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Edn1
endothelin 1
ISO
protein:increased expression:aortic root, coronary sinus, plasma (human)
RGD
PMID:12581682
RGD:8661757
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Serpine1
serpin family E member 1
disease_progression
ISO
protein:decreased expression, decreased activity:heart:
RGD
PMID:12615902
RGD:13208541
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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F3
coagulation factor III, tissue factor
ISO
RGD
PMID:9916935
RGD:11341701
NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159
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Hnrnpk
heterogeneous nuclear ribonucleoprotein K
ISO
RGD
PMID:21489814
RGD:155260371
NCBI chrNW_004955432:3,246,090...3,257,774
Ensembl chrNW_004955432:3,246,092...3,257,774
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Pdgfd
platelet derived growth factor D
ISO
RGD
PMID:19213942
RGD:9854642
NCBI chrNW_004955412:6,868,995...7,093,353
Ensembl chrNW_004955412:6,866,869...7,093,998
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Epo
erythropoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19337937
NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1430592
NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21062213
NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
associated with Mucocutaneous Lymph Node Syndrome;protein:increased expression:serum
RGD
PMID:22683371
RGD:8694456
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Gja1
gap junction protein alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15548583
NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
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Itpkc
inositol-trisphosphate 3-kinase C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18084290
NCBI chrNW_004955578:597,105...614,081
Ensembl chrNW_004955578:598,351...614,081
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Mmp12
matrix metallopeptidase 12
susceptibility
ISO
RGD
PMID:12103254
RGD:1582363
NCBI chrNW_004955412:6,045,146...6,057,112
Ensembl chrNW_004955412:6,045,100...6,057,262
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Abca1
ATP binding cassette subfamily A member 1
ISO
RGD
PMID:11086027
RGD:1600951
NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
G
Abcc6
ATP binding cassette subfamily C member 6
ISO
DNA:nonsense mutation:exon:p.R1141X (3421C>T) (human)
RGD
PMID:12176944
RGD:11038788
NCBI chrNW_004955442:865,292...921,739
Ensembl chrNW_004955442:865,238...922,221
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Abcg5
ATP binding cassette subfamily G member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11099417 PMID:11138003
NCBI chrNW_004955441:10,964,588...10,987,771
Ensembl chrNW_004955441:10,964,858...10,986,967
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Abcg8
ATP binding cassette subfamily G member 8
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004955441:10,982,307...11,004,789
Ensembl chrNW_004955441:10,982,307...11,009,116
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Acat2
acetyl-CoA acetyltransferase 2
susceptibility
ISO
DNA:polymorphisms: :41A>G, 734C>T, IVS4-57_58ins48bp
RGD
PMID:16195894
RGD:1601112
NCBI chrNW_004955439:21,123,886...21,142,562
Ensembl chrNW_004955439:21,122,923...21,142,480
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Acp1
acid phosphatase 1
ISO
RGD
PMID:19246900
RGD:2313179
NCBI chrNW_004955487:290,434...302,405
Ensembl chrNW_004955487:290,557...302,547
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Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955450:525,313...581,006
Ensembl chrNW_004955450:529,999...577,621
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Adipoq
adiponectin, C1Q and collagen domain containing
susceptibility
ISO
protein:decreased expression:adipose tissue associated with type 2 diabetes mellitus; DNA:SNP: (rs2241766) +45T>G(human)
RGD
PMID:17878891 PMID:27218147
RGD:329956419 RGD:5686802
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
G
Adrb3
adrenoceptor beta 3
no_association
ISO
DNA:missense mutation:cds:p.W64R (human) DNA:missense mutation:cds:p.W64R rs4994 (human)
RGD
PMID:9126344 PMID:11229427
RGD:1559325 RGD:5684412
NCBI chrNW_004955463:13,663,064...13,665,553
G
Adtrp
androgen dependent TFPI regulating protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378986
NCBI chrNW_004955465:2,721,171...2,823,368
Ensembl chrNW_004955465:2,742,169...2,809,790
G
Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
associated with Mucocutaneous Lymph Node Syndrome DNA:polymorphism:cds:p.G82S (human)
RGD
PMID:20668462 PMID:22337222
RGD:6767569 RGD:8695960
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
G
Agtr1
angiotensin II receptor type 1
ISO
RGD
PMID:12975417
RGD:1566498
NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
G
Agxt2
alanine--glyoxylate aminotransferase 2
ISO
DNA:missense mutation:cds:rs37369, rs16899974 (human)
RGD
PMID:30284143
RGD:329961317
NCBI chrNW_004955426:20,102,368...20,142,596
Ensembl chrNW_004955426:20,101,620...20,142,620
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Ahsg
alpha 2-HS glycoprotein
susceptibility
ISO
associated with Diabetes Mellitus, Type 2;DNA:SNPs
RGD
PMID:17062776
RGD:1625792
NCBI chrNW_004955420:21,071,111...21,078,397
Ensembl chrNW_004955420:21,069,681...21,078,298
G
Akt1
AKT serine/threonine kinase 1
ISO
RGD
PMID:18054314
RGD:5509083
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
DNA:snps:multiple (human)
RGD
PMID:19596330
RGD:2313883
NCBI chrNW_004955431:15,071,535...15,097,496
Ensembl chrNW_004955431:15,069,089...15,097,580
G
Ampd1
adenosine monophosphate deaminase 1
susceptibility
ISO
DNA:SNP:exon 2:34C>T (human) DNA:SNP:exon:34C>T (human)
RGD
PMID:11028479 PMID:24508110
RGD:329349360 RGD:329412480
NCBI chrNW_004955435:17,962,487...17,991,625
Ensembl chrNW_004955435:17,962,514...17,991,556
G
Angptl4
angiopoietin like 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27135400
NCBI chrNW_004955563:1,024,163...1,030,816
Ensembl chrNW_004955563:1,021,414...1,029,894
G
Anks1a
ankyrin repeat and sterile alpha motif domain containing 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955437:2,916,598...3,070,771
Ensembl chrNW_004955437:2,916,598...3,070,771
G
Apcs
amyloid P component, serum
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12714198
NCBI chrNW_004955468:11,388,154...11,389,259
Ensembl chrNW_004955468:11,388,192...11,390,314
G
Aph1b
aph-1 homolog B, gamma-secretase subunit
ISO
DNA:SNP:CDS:p.F217L (rs1047552) (human)
RGD
PMID:18987747
RGD:13703124
NCBI chrNW_004955450:12,000,682...12,022,183
Ensembl chrNW_004955450:12,000,424...12,022,071
G
Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:2128269 PMID:27135400
RGD:1601188
NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298
G
Apoa2
apolipoprotein A2
ISO
protein:decreased expression:serum
RGD
PMID:17923573
RGD:2313956
NCBI chrNW_004955468:12,977,956...12,979,282
Ensembl chrNW_004955468:12,977,956...12,979,753
G
Apoa5
apolipoprotein A5
no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:promoter:-1131T>C (human) DNA:polymorphism:promoter:-1131T>C, c.56C>G (human)
CTD RGD
PMID:15177130 PMID:15306190 PMID:24097064
RGD:1578412 RGD:2313322
NCBI chrNW_004955412:18,128,861...18,131,752
Ensembl chrNW_004955412:18,129,603...18,131,115
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Apob
apolipoprotein B
no_association
ISO
DNA:SNP:CDS:rs1042031 (human)
RGD
PMID:1732399 PMID:9585673 PMID:28167353
RGD:1578417 RGD:1578418 RGD:329901772
NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424
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Apoc3
apolipoprotein C3
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:promoter:-482C>T, in women without Diabetes Mellitus, Type 2 (MeSH:D003924)
CTD RGD
PMID:14709372 PMID:15059615 PMID:24097064
RGD:1578443 RGD:1626412
NCBI chrNW_004955412:18,165,667...18,168,015
Ensembl chrNW_004955412:18,165,667...18,168,015
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Apoe
apolipoprotein E
susceptibility
ISO
DNA:snp, missense mutation:promoter, cds:g.-219G>T, p.C112R (human) associated with Diabetes Mellitus, Non-Insulin Dependent;DNA:SNP:promoter:-219G>T (human) DNA:missense mutation:cds:p.C112R (human)
RGD
PMID:12860263 PMID:14563588 PMID:15059615 PMID:28808185
RGD:13703132 RGD:1578449 RGD:1580039 RGD:1626412
NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
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Apom
apolipoprotein M
susceptibility
ISO
DNA:SNP:promoter:g.-778T>C(rs805296)(human)
RGD
PMID:17674965
RGD:2314241
NCBI chrNW_004955437:190,609...192,781
Ensembl chrNW_004955437:190,609...197,342
G
Arhgap31
Rho GTPase activating protein 31
susceptibility
ISO
associated with nicotine dependence;DNA:SNP: (rs10934490) (human)
RGD
PMID:19706030
RGD:329970276
NCBI chrNW_004955427:19,019,008...19,136,298
Ensembl chrNW_004955427:19,019,511...19,131,755
G
Atp2b1
ATPase plasma membrane Ca2+ transporting 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004955405:26,872,379...26,932,270
Ensembl chrNW_004955405:26,872,379...26,932,703
G
Bche
butyrylcholinesterase
susceptibility
ISO
DNA:polymorphism: :p.A539T (human)
RGD
PMID:17852836
RGD:2306777
NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
G
Brinp3
BMP/retinoic acid inducible neural specific 3
ISO
DNA:SNP: :rs12732361(human), associated with male.
RGD
PMID:27461004
RGD:14398490
NCBI chrNW_004955406:27,870,115...28,240,328
Ensembl chrNW_004955406:27,869,456...28,238,978
G
Btnl2
butyrophilin like 2
susceptibility
ISO
associated with Mucocutaneous Lymph Node Syndrome; DNA:SNP: :rs 2395158(human)
RGD
PMID:19882345
RGD:9685030
NCBI chrNW_004955437:1,084,330...1,101,751
Ensembl chrNW_004955437:1,083,745...1,101,730
G
Carf
calcium responsive transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955457:11,853,256...11,947,909
Ensembl chrNW_004955457:11,896,492...11,936,229
G
Cbs
cystathionine beta-synthase
ISO
CBS variant c.844ins68
RGD
PMID:12855221
RGD:1600626
NCBI chrNW_004955407:38,924,355...38,939,790
Ensembl chrNW_004955407:38,924,321...38,939,790
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Ccl26
C-C motif chemokine ligand 26
susceptibility
ISO
protein:decreased expression:plasma (human)
RGD
PMID:16620281
RGD:11081161
NCBI chrNW_004955456:14,554,583...14,558,967
G
Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:12426226
RGD:1581178
NCBI chrNW_004955420:25,641,184...25,664,413
G
Cd14
CD14 molecule
no_association
ISO
DNA:SNP:promoter
RGD
PMID:18157711
RGD:2314154
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd36
CD36 molecule (CD36 blood group)
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
G
Cd40lg
CD40 ligand
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum associated with Kidney Failure, Chronic associated with Mucocutaneous Lymph Node Syndrome;DNA:SNP: :rs4810485 (human) protein:increased expression:coronary artery, serum
CTD RGD
PMID:16368305 PMID:16494885 PMID:17635572 PMID:22645426 PMID:23819214
RGD:2314209 RGD:7248436 RGD:7248750 RGD:8547776
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
G
Cdh5
cadherin 5
ISO
RGD
PMID:14695457
RGD:1598391
NCBI chrNW_004955433:22,957,718...22,994,515
Ensembl chrNW_004955433:22,967,960...22,992,924
G
Cdkn2b
cyclin dependent kinase inhibitor 2B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23104008 PMID:34961328
NCBI chrNW_004955472:12,275,613...12,280,141
Ensembl chrNW_004955472:12,275,544...12,280,528
G
Celsr2
cadherin EGF LAG seven-pass G-type receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955435:12,671,759...12,695,070
Ensembl chrNW_004955435:12,671,759...12,695,564
G
Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:17627189
RGD:4892665
NCBI chrNW_004955406:39,195,101...39,201,808
Ensembl chrNW_004955406:39,191,073...39,202,020
G
Clcn6
chloride voltage-gated channel 6
susceptibility
ISO
DNA:SNP: :rs3737964(human)
RGD
PMID:26740945
RGD:14696742
NCBI chrNW_004955486:2,066,317...2,096,317
Ensembl chrNW_004955486:2,064,916...2,096,317
G
Clu
clusterin
ISO
associated with Mucocutaneous Lymph Node Syndrome;protein:decreased expression:plasma
RGD
PMID:20711835
RGD:9068393
NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
G
Cpe
carboxypeptidase E
severity
ISO
DNA:SNPs:CDS:intron 4, exon 4 (A2925G, G2855A) (human)
RGD
PMID:18080843
RGD:405650688
NCBI chrNW_004955403:39,862,893...39,971,902
Ensembl chrNW_004955403:39,862,191...39,971,902
G
Cst3
cystatin C
ISO
protein:increased expression:serum (human)
RGD
PMID:17983622
RGD:2314352
NCBI chrNW_004955415:30,507,972...30,512,109
G
Cubn
cubilin
susceptibility
ISO
DNA:SNP,haplotypes:intron: (rs2291521)G>A (human)
RGD
PMID:33004870
RGD:329901841
NCBI chrNW_004955429:10,789,674...11,038,297
Ensembl chrNW_004955429:10,788,959...11,038,845
G
CUNH1orf167
chromosome unknown C1orf167 homolog
ISO
DNA:SNP: :rs56001051(human)
RGD
PMID:31175347
RGD:14696712
NCBI chrNW_004955486:2,112,698...2,131,296
G
Cxcl12
C-X-C motif chemokine ligand 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955546:1,929,269...1,941,690
Ensembl chrNW_004955546:1,929,269...1,941,690
G
Dab2ip
DAB2 interacting protein
onset
ISO
DNA:SNP:CDS:rs7025486 (human)
RGD
PMID:30595311
RGD:401938617
NCBI chrNW_004955419:6,229,437...6,416,619
Ensembl chrNW_004955419:6,228,591...6,416,402
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
ISO
DNA:missense mutation:cds:rs997251 (human)
RGD
PMID:30284143
RGD:329961317
NCBI chrNW_004955423:8,637,116...8,673,881
Ensembl chrNW_004955423:8,636,756...8,676,790
G
Ddah2
DDAH family member 2, ADMA-independent
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17267746
NCBI chrNW_004955437:265,727...269,016
Ensembl chrNW_004955437:260,969...269,660
G
Ece1
endothelin converting enzyme 1
ISO
protein:increased expression:smooth muscle cell,macrophage
RGD
PMID:8994440 PMID:10973835
RGD:1580909 RGD:7244168
NCBI chrNW_004955452:1,653,783...1,704,619
Ensembl chrNW_004955452:1,651,316...1,751,489
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Edn1
endothelin 1
severity treatment
ISO
protein:increased expression:atherosclerotic lesions (human) associated with Hypertension;DNA:missense mutation:cds:p.L198N (human)
RGD
PMID:7968078 PMID:11927217 PMID:18923236
RGD:4144886 RGD:8661705 RGD:8662294
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Eng
endoglin
severity
ISO
protein:increased expression:plasma (human)
RGD
PMID:21667051
RGD:7248776
NCBI chrNW_004955419:818,797...853,319
Ensembl chrNW_004955419:818,932...852,694
G
Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:14732757
RGD:1580982
NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572
G
Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25245553
NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
susceptibility
ISO
DNA:SNP: :rs13181(human)
RGD
PMID:27566080
RGD:12880440
NCBI chrNW_004955555:2,355,005...2,369,599
Ensembl chrNW_004955555:2,355,005...2,369,599
G
Esr1
estrogen receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:9396482 PMID:16159931 PMID:20559769
RGD:1580335
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
G
Esr2
estrogen receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16099331 PMID:20559769
RGD:1581014
NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
G
F2
coagulation factor II, thrombin
treatment
ISO
RGD
PMID:14961168
RGD:10449426
NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
G
F7
coagulation factor VII
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human) DNA:polymorphisms:cds:R353Q (human)
RGD
PMID:8522401 PMID:10599031 PMID:11334615
RGD:2312397 RGD:2312400 RGD:2312408
NCBI chrNW_004955404:685,170...692,797
Ensembl chrNW_004955404:680,594...693,665
G
Fabp2
fatty acid binding protein 2
ISO
DNA:SNP:CDS:2445G>A, amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) in women
RGD
PMID:15059615
RGD:1626412
NCBI chrNW_004955428:20,930,512...20,933,950
Ensembl chrNW_004955428:20,930,479...20,933,950
G
Fes
FES proto-oncogene, tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955416:14,948,121...14,959,035
Ensembl chrNW_004955416:14,948,123...14,960,005
G
Fgb
fibrinogen beta chain
ISO
RGD
PMID:8565160
RGD:1580382
NCBI chrNW_004955471:8,824,901...8,832,836
Ensembl chrNW_004955471:8,822,965...8,832,884
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Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus
RGD
PMID:14585103
RGD:2315879
NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773
G
Fto
FTO alpha-ketoglutarate dependent dioxygenase
ISO
DNA:SNP: :rs9939609 (human) DNA:SNP:intron:rs9939609 (human)
RGD
PMID:24622111 PMID:28167353
RGD:329812039 RGD:329901772
NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771
G
Furin
furin, paired basic amino acid cleaving enzyme
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955416:14,915,031...14,947,634
Ensembl chrNW_004955416:14,936,546...14,949,252
G
Gck
glucokinase
susceptibility
ISO
DNA:SNP:promoter:-30G>A (human)
RGD
PMID:15173029
RGD:2301876
NCBI chrNW_004955456:7,784,269...7,838,260
Ensembl chrNW_004955456:7,783,760...7,842,129
G
Gdf15
growth differentiation factor 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20855664
NCBI chrNW_004955524:3,123,513...3,125,642
Ensembl chrNW_004955524:3,123,760...3,125,621
G
Gfod1
Gfo/Idh/MocA-like oxidoreductase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955465:1,235,917...1,338,072
Ensembl chrNW_004955465:1,235,917...1,332,775
G
Ggcx
gamma-glutamyl carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955424:1,926,924...1,952,635
Ensembl chrNW_004955424:1,936,772...1,952,635
G
Gja4
gap junction protein alpha 4
ISO
DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S in men only (p = 0.0047) in a Swiss population DNA:SNP:CDS:1019C>T, amino acid P319S, in men both with and without Diabetes Mellitus, Type 2 (MeSH:D003924)
RGD
PMID:15059615 PMID:16677656
RGD:1626412 RGD:1626615
NCBI chrNW_004955452:12,902,764...12,905,337
Ensembl chrNW_004955452:12,902,773...12,905,337
G
Gnb3
G protein subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16141801
NCBI chrNW_004955413:4,440,693...4,447,419
Ensembl chrNW_004955413:4,440,693...4,447,416
G
Gpx1
glutathione peroxidase 1
ISO
cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood DNA:repeat:exon
RGD
PMID:12655278 PMID:16338763
RGD:1600677 RGD:1600708
NCBI chrNW_004955532:1,298,336...1,298,830
G
Gpx3
glutathione peroxidase 3
ISO
mRNA:increased expression:epicardial fat
RGD
PMID:21679057
RGD:401827169
NCBI chrNW_004955408:2,622,162...2,629,088
Ensembl chrNW_004955408:2,622,741...2,629,032
G
Gsr
glutathione-disulfide reductase
ISO
cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood
RGD
PMID:16338763
RGD:1600708
NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
G
Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004955471:11,367,318...11,422,199
Ensembl chrNW_004955471:11,367,282...11,424,273
G
Hectd4
HECT domain E3 ubiquitin protein ligase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22751097
NCBI chrNW_004955482:8,714,100...8,847,975
Ensembl chrNW_004955482:8,716,092...8,847,979
G
Hfe
homeostatic iron regulator
no_association
ISO
RGD
PMID:12746412
RGD:1582673
NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
G
Hgf
hepatocyte growth factor
ISO
RGD
PMID:11669408
RGD:8548610
NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058
G
Hhipl1
HHIP like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955438:20,936,314...20,951,466
Ensembl chrNW_004955438:20,936,314...20,950,550
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:12742282
RGD:5508477
NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745
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Hmox1
heme oxygenase 1
no_association susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:repeat:promoter
CTD RGD
PMID:12136229 PMID:12377749 PMID:14691581
RGD:1580454 RGD:1580470 RGD:1598401
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Hnf1a
HNF1 homeobox A
susceptibility
ISO
DNA:SNPs,haplotypes:multiple DNA:SNP,haplotypes:intron: (rs55783344) C>T(human) DNA:SNP:intron 1: (rs7310409) G>A (human)
RGD
PMID:25202455 PMID:28035729 PMID:33004870
RGD:329901832 RGD:329901837 RGD:329901841
NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613
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Hs3st1
heparan sulfate-glucosamine 3-sulfotransferase 1
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:15266341 PMID:15965027 PMID:16024819 PMID:16410828 PMID:17179217 PMID:17558387 PMID:17568005 PMID:19122651 PMID:19303047 PMID:19858363 PMID:21152010 PMID:22090374 PMID:28126521 More...
NCBI chrNW_004955549:1,591,605...1,623,681
Ensembl chrNW_004955549:1,591,605...1,623,681
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
sexual_dimorphism
ISO
associated with obesity;mRNA,protein:increased expression:multiple (human)
RGD
PMID:23009206
RGD:329901914
NCBI chrNW_004955489:2,500,928...2,524,715
Ensembl chrNW_004955489:2,497,680...2,524,805
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Hspd1
heat shock protein family D (Hsp60) member 1
severity
ISO
RGD
PMID:11222468
RGD:1624218
NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419
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Ica1l
islet cell autoantigen 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955457:11,983,201...12,085,870
Ensembl chrNW_004955457:12,006,306...12,085,799
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Il10
interleukin 10
susceptibility no_association
ISO
DNA:SNP:promoter:-1082A>G (rs1800896) (human) DNA:SNPs:promoter:-592C>A (rs1800872), -819C>T (rs1800871) (human)
RGD
PMID:16460885 PMID:29525679
RGD:14975129 RGD:1598621
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il15
interleukin 15
ISO
associated with Hypertension;protein:increased expression:serum
RGD
PMID:16109314
RGD:1626610
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il1b
interleukin 1 beta
ISO
mRNA:increased expression:peripheral blood (human)
RGD
PMID:22780915
RGD:7175093
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rl1
interleukin 1 receptor like 1
severity
ISO
DNA:polymorphisms: :-27307T>A, -27614C>A (human)
RGD
PMID:20602249
RGD:5144241
NCBI chrNW_004955470:7,779,828...7,849,157
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Il6
interleukin 6
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
RGD
PMID:19368923
RGD:2307251
NCBI chrNW_004955410:25,079,835...25,084,390
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Irak1
interleukin 1 receptor associated kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20524934
NCBI chrNW_004955580:663,651...668,622
Ensembl chrNW_004955580:661,609...668,622
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Irs1
insulin receptor substrate 1
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:exon:G972R
CTD RGD
PMID:10591678
RGD:1624974
NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
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Itga2
integrin subunit alpha 2
no_association
ISO
RGD
PMID:15227729
RGD:1582294
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Jcad
junctional cadherin 5 associated
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378988
NCBI chrNW_004955429:21,954,274...22,038,953
Ensembl chrNW_004955429:21,954,149...22,035,754
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Kalrn
kalirin RhoGEF kinase
susceptibility onset severity
ISO
DNA:SNP:intron: (rs9289231) T>G (human) associated with nicotine dependence; DNA:SNPs:multiple DNA:SNP:intron: (rs9289231) (human) associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs9289231) T>G (human)
RGD
PMID:19706030 PMID:25316661 PMID:27218147 PMID:30483314
RGD:11076452 RGD:329955537 RGD:329956419 RGD:329970276
NCBI chrNW_004955427:23,184,751...23,823,128
Ensembl chrNW_004955427:23,184,739...23,816,811
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Kcne2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955407:33,734,969...33,736,609
Ensembl chrNW_004955407:33,735,148...33,735,513
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
OMIM:300464 | OMIM:607339 | OMIM:608316 | OMIM:608318 | OMIM:608320 | OMIM:608901 | OMIM:610938 | OMIM:610947 | OMIM:611139 | OMIM:612030 | OMIM:614293 | OMIM:614466
MouseDO
NCBI chrNW_004955413:17,364,447...17,371,255
Ensembl chrNW_004955413:17,364,213...17,371,255
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Kif6
kinesin family member 6
no_association treatment sexual_dimorphism
ISO
DNA:SNP: :rs20455 (human) DNA:SNP: :p.W719R (rs20455) (human) associated with type 2 diabetes mellitus;DNA:SNP: :p.W719R (rs20455) (human)
RGD
PMID:18222354 PMID:19371834 PMID:21458191 PMID:25629058 PMID:26443250 PMID:26997531 More...
RGD:11527801 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048451 RGD:243048454
NCBI chrNW_004955437:6,353,318...6,597,196
Ensembl chrNW_004955437:6,352,316...6,671,934
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Kl
klotho
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:promoter: -G395>A (human)
CTD RGD
PMID:12669274 PMID:16579981 PMID:16979405
RGD:1581721 RGD:1581723
NCBI chrNW_004955431:12,782,913...12,833,215
Ensembl chrNW_004955431:12,782,846...12,833,215
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Ldlr
low density lipoprotein receptor
no_association
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16459141 PMID:21378990 PMID:27135400
RGD:1581823
NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056
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Lepr
leptin receptor
susceptibility
ISO
DNA:missense mutation:CDS:p.Q223R (human)
RGD
PMID:27257426
RGD:21079462
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Lipa
lipase A, lysosomal acid type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378988 PMID:34961328 PMID:35590109
NCBI chrNW_004955425:3,718,291...3,755,942
Ensembl chrNW_004955425:3,718,206...3,756,142
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Lipc
lipase C, hepatic type
susceptibility no_association
ISO
associated with Diabetes Mellitus, Insulin-Dependent; DNA:transition:promoter:-480C>T (human) DNA:SNP,haplotypes: (rs17269397)A>G (human) 250G/A C514T
RGD
PMID:11916946 PMID:12689525 PMID:15099346 PMID:33004870
RGD:1600663 RGD:1600664 RGD:2308839 RGD:329901841
NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766
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Lipg
lipase G, endothelial type
ISO
RGD
PMID:16354105
RGD:1580865
NCBI chrNW_004955402:34,666,757...34,689,726
Ensembl chrNW_004955402:34,667,036...34,687,568
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Lmod1
leiomodin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28530674
NCBI chrNW_004955406:37,967,098...38,012,908
Ensembl chrNW_004955406:37,964,643...38,013,405
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LOC102004641
cytochrome b-245 light chain
ISO
RGD
PMID:14709372
RGD:1578443
NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118
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LOC102004889
sterol 26-hydroxylase, mitochondrial
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004955453:14,601,495...14,647,383
Ensembl chrNW_004955453:14,601,444...14,647,366
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LOC102021597
alpha-1-antiproteinase S-like
ISO
protein:increased expression:serum
RGD
PMID:7832094
RGD:1643149
NCBI chrNW_004955438:17,920,200...17,929,105
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LOC102024786
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS:rs10741657 (human)
RGD
PMID:25003556
RGD:401901077
NCBI chrNW_004955414:29,929,130...29,948,151
Ensembl chrNW_004955414:29,928,644...29,948,484
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Lox
lysyl oxidase
ISO
RGD
PMID:12393934
RGD:1581886
NCBI chrNW_004955521:178,290...193,926
Ensembl chrNW_004955521:185,792...193,926
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Lpl
lipoprotein lipase
ISO
RGD
PMID:8641022
RGD:1580537
NCBI chrNW_004955403:43,646,084...43,672,116
Ensembl chrNW_004955403:43,646,084...43,673,967
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Lrp6
LDL receptor related protein 6
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:28492532
NCBI chrNW_004955413:9,080,901...9,237,644
Ensembl chrNW_004955413:9,080,914...9,237,650
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Lrp8
LDL receptor related protein 8
no_association onset
ISO
DNA:missense mutation:cds:p.R952Q (human)
RGD
PMID:17847002 PMID:18592168
RGD:2306124 RGD:2306125
NCBI chrNW_004955464:5,837,002...5,912,178
Ensembl chrNW_004955464:5,837,009...5,911,672
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Lta
lymphotoxin alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15266304 PMID:15973460
RGD:1580414
NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529
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Lum
lumican
ISO
RGD
PMID:11890723
RGD:1582121
NCBI chrNW_004955405:28,299,966...28,307,982
Ensembl chrNW_004955405:28,298,988...28,308,054
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Map3k7
mitogen-activated protein kinase kinase kinase 7
ISO
associated with hypothyroidism;mRNA:decreased expression:venous blood (human)
RGD
PMID:32495070
RGD:155791451
NCBI chrNW_004955411:17,177,335...17,229,957
Ensembl chrNW_004955411:17,177,335...17,229,957
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Mat2a
methionine adenosyltransferase 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955424:1,953,623...1,961,164
Ensembl chrNW_004955424:1,953,623...1,961,164
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Mia3
MIA SH3 domain ER export factor 3
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:25741868
NCBI chrNW_004955520:1,853,145...1,890,338
Ensembl chrNW_004955520:1,850,942...1,890,390
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNP:cds: G771C, Q241H (rs381231) DNA:SNPs,haplotypes: (rs3812316) (human) DNA:SNP:cds: C771G, H241Q
RGD
PMID:19571538 PMID:21726544 PMID:25179879
RGD:401794579 RGD:401794581 RGD:401794582
NCBI chrNW_004955456:14,096,530...14,116,687
Ensembl chrNW_004955456:14,096,531...14,117,269
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Mmp12
matrix metallopeptidase 12
susceptibility
ISO
RGD
PMID:10807873
RGD:1582366
NCBI chrNW_004955412:6,045,146...6,057,112
Ensembl chrNW_004955412:6,045,100...6,057,262
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Mmp9
matrix metallopeptidase 9
treatment susceptibility
ISO
RGD
PMID:15191941 PMID:26261622
RGD:11344965 RGD:1582644
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Mras
muscle RAS oncogene homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:35590109
NCBI chrNW_004955501:615,303...670,404
Ensembl chrNW_004955501:615,303...670,782
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Mthfr
methylenetetrahydrofolate reductase
no_association susceptibility
ISO
DNA:transition:cds:g.677C>T (human) DNA:SNPs: (rs1801133, rs4846049) (Human)
RGD
PMID:12387655 PMID:15648053 PMID:24315498
RGD:1580579 RGD:401850782 RGD:6893453
NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
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Mylip
myosin regulatory light chain interacting protein
ISO
ClinVar Annotator: match by term: Coronary atherosclerosis
ClinVar
NCBI chrNW_004955483:9,725,343...9,745,041
Ensembl chrNW_004955483:9,723,023...9,745,062
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Mylk
myosin light chain kinase
susceptibility
ISO
associated with nicotine dependence; DNA:SNP: (rs16834817)
RGD
PMID:19706030
RGD:329970276
NCBI chrNW_004955427:22,760,432...23,008,432
Ensembl chrNW_004955427:22,762,221...22,970,508
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Nampt
nicotinamide phosphoribosyltransferase
ISO
RGD
PMID:17283255
RGD:1642340
NCBI chrNW_004955410:10,717,664...10,742,109
Ensembl chrNW_004955410:10,717,664...10,751,177
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Nbeal1
neurobeachin like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955457:11,671,565...11,839,357
Ensembl chrNW_004955457:11,671,565...11,839,211
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Ngf
nerve growth factor
ISO
RGD
PMID:11935372
RGD:1580935
NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
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Ngfr
nerve growth factor receptor
ISO
RGD
PMID:11935372
RGD:1580935
NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
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Nnmt
nicotinamide N-methyltransferase
severity
ISO
protein:increased expression:blood serum (human)
RGD
PMID:28174167
RGD:401793727
NCBI chrNW_004955412:15,892,906...15,916,166
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Nod2
nucleotide binding oligomerization domain containing 2
ISO
DNA:polymorphisms: :p.G908R, 3020_3021insC (human)
RGD
PMID:21565239
RGD:5508725
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Nos2
nitric oxide synthase 2
ISO
associated with Mucocutaneous Lymph Node Syndrome; protein:increased expression:neutrophil, monocyte
RGD
PMID:14764920
RGD:1580941
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
susceptibility
ISO
DNA:snp:cds:c.894G>T (human) DNA:duplication:intron:IVS4?-?+27 (human) DNA:snp:promoter:g.-786T>C (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8564837 PMID:10510054 PMID:14989558 PMID:16284093 PMID:17267746 PMID:19696404 PMID:19761682 More...
RGD:7421529 RGD:7771567 RGD:7771578
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Nppa
natriuretic peptide A
ISO
associated with Diabetes Mellitus, Type 2;DNA:SNP:exon: 2238T>C,rs5065 (human) DNA:snp:cds:c.2238T>C (human)
RGD
PMID:12514664 PMID:22170009
RGD:1579982 RGD:7247716
NCBI chrNW_004955486:2,061,196...2,062,805
Ensembl chrNW_004955486:2,060,735...2,063,003
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Nppb
natriuretic peptide B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18022110
NCBI chrNW_004955486:2,054,775...2,056,130
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Nr1h3
nuclear receptor subfamily 1 group H member 3
ISO
associated with type 2 diabetes mellitus;mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:28871240
RGD:401850555
NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049
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Nr3c1
nuclear receptor subfamily 3 group C member 1
ISO
DNA:missense mutation:cds:p.N363S (human)
RGD
PMID:12623935
RGD:1580790
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
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Ogg1
8-oxoguanine DNA glycosylase
susceptibility
ISO
DNA:SNP,haplotype: :p.S326C (rs1052133) (human)
RGD
PMID:23368530
RGD:401827273
NCBI chrNW_004955561:1,277,362...1,282,949
Ensembl chrNW_004955561:1,277,365...1,282,793
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Pappa
pappalysin 1
severity
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11586954 PMID:16055491
RGD:1642327
NCBI chrNW_004955419:11,415,666...11,645,994
Ensembl chrNW_004955419:11,420,638...11,646,145
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Parl
presenilin associated rhomboid like
susceptibility
ISO
DNA:missense mutation:cds:p.L262V (human)
RGD
PMID:18758826
RGD:12902623
NCBI chrNW_004955420:23,549,125...23,581,782
Ensembl chrNW_004955420:23,548,672...23,582,137
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Pcsk9
proprotein convertase subtilisin/kexin type 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:27135400
NCBI chrNW_004955464:4,424,583...4,439,805
Ensembl chrNW_004955464:4,425,435...4,439,842
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Pdgfd
platelet derived growth factor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378988 PMID:34961328
NCBI chrNW_004955412:6,868,995...7,093,353
Ensembl chrNW_004955412:6,866,869...7,093,998
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Pecam1
platelet and endothelial cell adhesion molecule 1
no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:missense mutation:cds:p.L125V (human) DNA:missense mutations:cds:p.N536S, p.G670R (human) DNA:polymorphism:5' utr:g.53G>A (human)
CTD RGD
PMID:10780329 PMID:11795274 PMID:12732396 PMID:28530674
RGD:1581010 RGD:2311656 RGD:6771225
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Phactr1
phosphatase and actin regulator 1
susceptibility sexual_dimorphism
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:exon: (rs4714955) (human) DNA:hypermethylation, hypomethylation:promoter, exon: (human) DNA:SNPs:intron: (rs9381439, rs9349379) (human) associated with familial hypercholesterolemia;DNA:SNP:intron: (rs12526453) (human) DNA:SNP:intron:g.12903957A>G (rs9349379) (human) DNA:SNP:intron:g.12903725A>G (rs9349379) (human)
CTD RGD
PMID:21378990 PMID:22751097 PMID:26098115 PMID:27066539 PMID:27517945 PMID:27893421 PMID:29784573 PMID:30777881 PMID:31499127 PMID:34961328 More...
RGD:401851919 RGD:401900135 RGD:401900687 RGD:401900688 RGD:401901243 RGD:401901251
NCBI chrNW_004955465:1,395,418...1,915,820
Ensembl chrNW_004955465:1,395,088...1,913,847
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Pik3c2g
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004955413:14,454,376...14,764,323
Ensembl chrNW_004955413:14,454,377...14,764,558
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Pla2g7
phospholipase A2 group VII
susceptibility disease_progression
ISO
DNA:polymorphism: :p.A379V (human)
RGD
PMID:15115767 PMID:17070179
RGD:6482777 RGD:6482781
NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996
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Plpp3
phospholipid phosphatase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955464:3,122,420...3,197,359
Ensembl chrNW_004955464:3,081,334...3,197,413
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Pnpla3
patatin like phospholipase domain containing 3
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :rs738409 (p.I148M) (human)
RGD
PMID:31377187
RGD:14981594
NCBI chrNW_004955413:28,879,646...28,896,224
Ensembl chrNW_004955413:28,879,748...28,893,938
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Pon1
paraoxonase 1
susceptibility
ISO
DNA:missense mutation:cds:p.Q192R (human) ClinVar Annotator: match by term: Coronary artery spasm 2, susceptibility to
RGD ClinVar
PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9215303 PMID:9385372 PMID:9443884 PMID:10729395 PMID:11238489 PMID:11810302 PMID:11888590 PMID:12082503 PMID:15241482 PMID:21170047 PMID:25741868 More...
RGD:1580196
NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
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Pon2
paraoxonase 2
severity
ISO
DNA:missense mutation:cds:p.C311S (human)
RGD
PMID:12454802
RGD:1580217
NCBI chrNW_004955432:11,988,009...12,020,702
Ensembl chrNW_004955432:11,987,919...12,020,740
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Ppara
peroxisome proliferator activated receptor alpha
susceptibility
ISO
DNA:snp:intron: (human)
RGD
PMID:16043164
RGD:1580228
NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
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Pparg
peroxisome proliferator activated receptor gamma
ISO
protein:decreased expression:carotid artery, macrophage, smooth muscle cell (human)
RGD
PMID:21709632
RGD:8552814
NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
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Ppp4c
protein phosphatase 4 catalytic subunit
ISO
mRNA:decreased expression:blood (human)
RGD
PMID:30015926
RGD:401901084
NCBI chrNW_004955493:6,894,849...6,901,344
Ensembl chrNW_004955493:6,894,849...6,901,344
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Prdm16
PR/SET domain 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35590109
NCBI chrNW_004955486:8,139,848...8,327,788
Ensembl chrNW_004955486:8,137,531...8,327,977
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Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004955491:5,852,534...6,048,820
Ensembl chrNW_004955491:5,852,082...6,019,318
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Procr
protein C receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28530674
NCBI chrNW_004955422:26,215,757...26,220,396
Ensembl chrNW_004955422:26,216,002...26,220,101
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Psrc1
proline and serine rich coiled-coil 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955435:12,697,179...12,702,021
Ensembl chrNW_004955435:12,697,733...12,700,628
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14642682
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Pth
parathyroid hormone
ISO
protein:increased expression:serum (human)
RGD
PMID:23460043
RGD:7242420
NCBI chrNW_004955414:28,828,389...28,831,417
Ensembl chrNW_004955414:28,825,651...28,831,117
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Ptpn1
protein tyrosine phosphatase non-receptor type 1
ISO
DNA:SNP:exon 8:g.981C>T (human)
RGD
PMID:21676396
RGD:401965429
NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275
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Ptpn22
protein tyrosine phosphatase non-receptor type 22
ISO
DNA: snp: cds: rs2476601
RGD
PMID:21846984
RGD:6484553
NCBI chrNW_004955435:17,082,762...17,139,067
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Ptprd
protein tyrosine phosphatase receptor type D
ISO
DNA:SNP:intron: (rs10115782) (human)
RGD
PMID:22216278
RGD:401976461
NCBI chrNW_004955434:12,033,825...14,132,636
Ensembl chrNW_004955434:12,031,420...12,428,774
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Rbp4
retinol binding protein 4
sexual_dimorphism susceptibility severity disease_progression
ISO
protein:increased expression:blood plasma (human) DNA:SNP:intron: (rs7094671) (human) associated with hypothyroidism;protein:increased expression:blood serum (human) protein:increased expression:epicardial fat (human)
RGD
PMID:18854400 PMID:21645024 PMID:25437889 PMID:25479076 PMID:31278889
RGD:329845573 RGD:329845584 RGD:329845843 RGD:329845849 RGD:329845882
NCBI chrNW_004955507:112,342...120,050
Ensembl chrNW_004955507:108,669...120,584
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Ryr2
ryanodine receptor 2
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004955492:2,647,597...3,275,512
Ensembl chrNW_004955492:2,648,956...3,076,509
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Sars1
seryl-tRNA synthetase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955435:12,642,485...12,659,833
Ensembl chrNW_004955435:12,641,776...12,660,682
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Sele
selectin E
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:mutation: :p.S128R (human) ClinVar Annotator: match by term: Coronary artery disease
RGD ClinVar
PMID:17578587 PMID:25741868
RGD:2313596
NCBI chrNW_004955462:7,564,437...7,575,297
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Selp
selectin P
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:insertion:promoter: (human)
RGD
PMID:9484978
RGD:1580190
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Serpinf2
serpin family F member 2
ISO
RGD
PMID:9184412
RGD:1625532
NCBI chrNW_004955481:1,441,262...1,449,078
Ensembl chrNW_004955481:1,442,010...1,449,242
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Sh2b3
SH2B adaptor protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955482:8,079,905...8,100,791
Ensembl chrNW_004955482:8,096,160...8,097,765
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Slc2a4
solute carrier family 2 member 4
ISO
mRNA:decreased expression:epicardial fat, subcutaneous adipose tissue (human)
RGD
PMID:21645024
RGD:329845584
NCBI chrNW_004955467:9,630,304...9,636,005
Ensembl chrNW_004955467:9,630,304...9,636,005
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Slc5a3
solute carrier family 5 member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955407:33,460,238...33,511,889
Ensembl chrNW_004955407:33,494,816...33,511,968
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Smad3
SMAD family member 3
ISO
ClinVar Annotator: match by term: Coronary artery disease
ClinVar
PMID:25741868
NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136
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Soat2
sterol O-acyltransferase 2
susceptibility
ISO
DNA:polymorphisms: :p.E41G, p.T734I, IVS4-57_-58ins48bp (human)
RGD
PMID:16195894
RGD:1601112
NCBI chrNW_004955458:383,123...394,003
Ensembl chrNW_004955458:382,892...394,749
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Sod1
superoxide dismutase 1
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD
PMID:16338763
RGD:1600708
NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
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Sod3
superoxide dismutase 3
ISO
RGD
PMID:10811593
RGD:1580853
NCBI chrNW_004955480:257,716...263,149
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Sort1
sortilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990 PMID:34961328
NCBI chrNW_004955435:12,725,952...12,819,280
Ensembl chrNW_004955435:12,730,270...12,819,029
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Spp1
secreted phosphoprotein 1
ISO
In type 2 diabetic patients
RGD
PMID:21034455
RGD:6903271
NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016
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Srebf1
sterol regulatory element binding transcription factor 1
susceptibility severity disease_progression
ISO
DNA:SNP, haplotype:: -36delG (human) mRNA:decreased expression:blood serum (human) associated with type 2 diabetes mellitus; mRNA:increased expression:epicardial fat (human)
RGD
PMID:12752570 PMID:28367087 PMID:31610782
RGD:401827912 RGD:401842364 RGD:401842368
NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
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Srebf2
sterol regulatory element binding transcription factor 2
disease_progression
ISO
associated with type 2 diabetes mellitus;mRNA:increased expression:epicardial fat (human)
RGD
PMID:28367087
RGD:401842368
NCBI chrNW_004955413:27,271,717...27,326,655
Ensembl chrNW_004955413:27,271,953...27,326,759
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Tbx2
T-box transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35590109
NCBI chrNW_004955451:2,458,612...2,466,264
Ensembl chrNW_004955451:2,457,568...2,466,639
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Tcf21
transcription factor 21
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP: (rs12190287) (human)
CTD RGD
PMID:21378990 PMID:22751097 PMID:26909569
RGD:329337364
NCBI chrNW_004955439:2,617,562...2,620,613
Ensembl chrNW_004955439:2,617,492...2,620,644
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Tek
TEK receptor tyrosine kinase
ISO
protein:increased expression:plasma
RGD
PMID:12814387
RGD:1601489
NCBI chrNW_004955472:7,633,790...7,748,130
Ensembl chrNW_004955472:7,633,721...7,748,386
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Tert
telomerase reverse transcriptase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16890917
NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589
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Thbd
thrombomodulin
severity
ISO
RGD
PMID:17012137
RGD:1601638
NCBI chrNW_004955415:30,222,830...30,226,406
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Tll1
tolloid like 1
severity
ISO
associated with type 2 diabetes:DNA:SNP:CDS:rs1503298 (human)
RGD
PMID:21911782
RGD:155883159
NCBI chrNW_004955403:39,299,461...39,491,638
Ensembl chrNW_004955403:39,299,461...39,491,638
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Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15632890 PMID:20524934
RGD:1580736
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnf
tumor necrosis factor
ISO
DNA:SNP:promoter:-863C>A, in men without Diabetes Mellitus, Type 2 (MeSH:D003924)
RGD
PMID:15059615
RGD:1626412
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfrsf11b
TNF receptor superfamily member 11b
ISO
protein:increased expression:serum
RGD
PMID:15926884
RGD:1620893
NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894
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Tnfrsf1a
TNF receptor superfamily member 1A
severity
ISO
RGD
PMID:19845893
RGD:5131425
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnni3
troponin I3, cardiac type
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004955567:1,037,325...1,042,102
Ensembl chrNW_004955567:1,037,462...1,042,039
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Tp53
tumor protein p53
ISO
DNA:misssense mutation: :p.R72P (rs1042522) (human)
RGD
PMID:29482350
RGD:14995930
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
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Traf6
TNF receptor associated factor 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20524934
NCBI chrNW_004955422:9,925,765...9,950,354
Ensembl chrNW_004955422:9,932,680...9,949,100
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Trib1
tribbles pseudokinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24097064
NCBI chrNW_004955461:494,003...501,928
Ensembl chrNW_004955461:494,003...501,990
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Ttn
titin
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004955403:18,057,344...18,328,389
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Twist1
twist family bHLH transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955410:22,003,981...22,005,483
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Vamp5
vesicle associated membrane protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955424:1,911,711...1,912,865
Ensembl chrNW_004955424:1,911,711...1,912,874
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Vamp8
vesicle associated membrane protein 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34961328
NCBI chrNW_004955424:1,922,830...1,926,844
Ensembl chrNW_004955424:1,923,092...1,926,728
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Vdr
vitamin D receptor
severity
ISO
DNA:SNP (human)
RGD
PMID:9761785
RGD:4889864
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:14668888 PMID:15754021 PMID:15937083
RGD:1580569
NCBI chrNW_004955437:9,527,445...9,541,908
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Vim
vimentin
ISO
protein:increased expression:monocyte
RGD
PMID:21938407
RGD:6480617
NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554
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Vtn
vitronectin
ISO
RGD
PMID:15678274
RGD:1580816
NCBI chrNW_004955481:4,765,078...4,768,027
Ensembl chrNW_004955481:4,765,193...4,771,019
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Wdr12
WD repeat domain 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955457:11,947,816...11,970,066
Ensembl chrNW_004955457:11,947,915...11,971,805
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Wrn
WRN RecQ like helicase
ISO
RGD
PMID:11186893
RGD:1580824
NCBI chrNW_004955463:7,495,243...7,633,532
Ensembl chrNW_004955463:7,525,100...7,633,596
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Xrcc1
X-ray repair cross complementing 1
onset
ISO
DNA:polymorphism:: (rs1799782) (human)
RGD
PMID:24315498
RGD:401850782
NCBI chrNW_004955555:1,293,416...1,315,839
Ensembl chrNW_004955555:1,293,416...1,315,839
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Xrcc3
X-ray repair cross complementing 3
susceptibility
ISO
DNA:SNP,haplotypes:exon 7: p.T241M (rs861539) (Human)
RGD
PMID:23368530
RGD:401827273
NCBI chrNW_004955538:2,499,297...2,511,898
Ensembl chrNW_004955538:2,501,607...2,509,778
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Zc3hc1
zinc finger C3HC-type containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21378990
NCBI chrNW_004955479:10,692,438...10,717,368
Ensembl chrNW_004955479:10,692,738...10,717,228
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Zfyve21
zinc finger FYVE-type containing 21
ISO
ClinVar Annotator: match by term: Premature coronary artery atherosclerosis
ClinVar
PMID:25741868
NCBI chrNW_004955538:2,509,506...2,519,682
Ensembl chrNW_004955538:2,509,506...2,519,676
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Zhx3
zinc fingers and homeoboxes 3
ISO
ClinVar Annotator: match by term: Coronary atherosclerosis
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004955445:15,632,723...15,785,238
Ensembl chrNW_004955445:15,632,995...15,785,238
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Mef2a
myocyte enhancer factor 2A
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant, 1 | ClinVar Annotator: match by term: Coronary artery disease/myocardial infarction
OMIM ClinVar
PMID:14645853 PMID:15496429 PMID:15841183 PMID:25741868
NCBI chrNW_004955416:26,926,753...27,051,171
Ensembl chrNW_004955416:26,953,798...27,051,171
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Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2
ClinVar
PMID:25741868 PMID:28492532
NCBI chrNW_004955469:9,203,433...9,227,526
Ensembl chrNW_004955469:9,203,434...9,227,865
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Lrp6
LDL receptor related protein 6
ISO
ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2
OMIM ClinVar
PMID:17332414 PMID:23703864 PMID:25741868 PMID:28492532
NCBI chrNW_004955413:9,080,901...9,237,644
Ensembl chrNW_004955413:9,080,914...9,237,650
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Arhgap9
Rho GTPase activating protein 9
ISO
ClinVar Annotator: match by term: Coronary artery spasm 3, susceptibility to
ClinVar
PMID:19911011
NCBI chrNW_004955458:5,193,708...5,201,625
Ensembl chrNW_004955458:5,193,816...5,199,067
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Nos3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Coronary artery spasm 1, susceptibility to
ClinVar
PMID:9737779 PMID:9894802 PMID:10359729 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11810302
NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
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Aldh1a2
aldehyde dehydrogenase 1 family member A2
disease_progression
ISO
RGD
PMID:26315408
RGD:14367880
NCBI chrNW_004955450:16,406,578...16,453,048
Ensembl chrNW_004955450:16,406,436...16,453,180
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12138120
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Ahsp
alpha hemoglobin stabilizing protein
ISO
mRNA:decreased expression:blood (human)
RGD
PMID:35144391
RGD:329961301
NCBI chrNW_004955493:8,337,761...8,344,497
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Bche
butyrylcholinesterase
susceptibility
ISO
DNA:polymorphism: :p.A539T (human)
RGD
PMID:17275003
RGD:2306778
NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
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Cdh13
cadherin 13
ISO
protein:increased expression:artery, smooth muscle cell
RGD
PMID:12376824
RGD:2293553
NCBI chrNW_004955564:407,120...1,549,880
Ensembl chrNW_004955564:408,730...1,426,841
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:plasma
RGD
PMID:14578618
RGD:1598500
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:14578618
RGD:1598500
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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Hmox1
heme oxygenase 1
susceptibility
ISO
RGD
PMID:16020495
RGD:1598402
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Itgb2
integrin subunit beta 2
ISO
RGD
PMID:11703955
RGD:1581185
NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
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Lox
lysyl oxidase
ISO
RGD
PMID:15218472
RGD:1581881
NCBI chrNW_004955521:178,290...193,926
Ensembl chrNW_004955521:185,792...193,926
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Mapk1
mitogen-activated protein kinase 1
ISO
RGD
PMID:15583728
RGD:1582284
NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphisms:5' utr, exon:multiple (human)
RGD
PMID:15790942
RGD:1582150
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mmp7
matrix metallopeptidase 7
treatment
ISO
RGD
PMID:21139058
RGD:9685362
NCBI chrNW_004955412:5,780,772...5,792,485
Ensembl chrNW_004955412:5,778,502...5,792,445
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Mthfr
methylenetetrahydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16489563
NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
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Myc
MYC proto-oncogene, bHLH transcription factor
treatment
ISO
RGD
PMID:7955204
RGD:10059621
NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982
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Npy5r
neuropeptide Y receptor Y5
ISO
mRNA, protein:increased expression:carotid artery
RGD
PMID:12689918
RGD:1625501
NCBI chrNW_004955403:41,667,632...41,675,619
Ensembl chrNW_004955403:41,667,632...41,675,619
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Oaz1
ornithine decarboxylase antizyme 1
susceptibility
ISO
DNA:SNP:intron:c.2222A>G (rs2074458) (human)
RGD
PMID:17761941
RGD:401851037
NCBI chrNW_004955495:5,871,418...5,874,200
Ensembl chrNW_004955495:5,871,418...5,874,200
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:12114325 PMID:16373617
RGD:1581358 RGD:1581366
NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16319143
RGD:1580322
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tp53
tumor protein p53
ISO
RGD
PMID:14740296
RGD:1580742
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
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Ucp3
uncoupling protein 3
susceptibility
ISO
DNA:polymorphism:promoter:-55C>T (human)
RGD
PMID:17786284
RGD:2313513
NCBI chrNW_004955414:17,558,889...17,578,108
Ensembl chrNW_004955414:17,558,889...17,578,737
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Apln
apelin
ISO
protein:decreased expression:plasma
RGD
PMID:19015606
RGD:2313942
NCBI chrNW_004955473:5,346,822...5,356,359
Ensembl chrNW_004955473:5,346,747...5,356,359
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Edn1
endothelin 1
treatment
ISO
RGD
PMID:10854676
RGD:8661796
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Hrh2
histamine receptor H2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721106
NCBI chrNW_004955408:28,186,316...28,225,146
Ensembl chrNW_004955408:28,186,249...28,229,411
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Igf1
insulin like growth factor 1
ISO
mRNA:increased expression:myocyte:
RGD
PMID:8102103
RGD:10046053
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Igf1r
insulin like growth factor 1 receptor
ISO
mRNA:increased expression:myocyte:
RGD
PMID:8102103
RGD:10046053
NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666
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Itgav
integrin subunit alpha V
ISO
RGD
PMID:11922905
RGD:1582454
NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297
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Lmcd1
LIM and cysteine rich domains 1
ISO
protein:increased expression:coronary artery
RGD
PMID:32160773
RGD:243065232
NCBI chrNW_004955561:151,315...213,904
Ensembl chrNW_004955561:151,308...214,476
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LOC102024786
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS: (Rs6486205|rs10741657|rs2060793)
RGD
PMID:34262949
RGD:401901074
NCBI chrNW_004955414:29,929,130...29,948,151
Ensembl chrNW_004955414:29,928,644...29,948,484
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Mdk
midkine
ISO
RGD
PMID:10683378
RGD:1299187
NCBI chrNW_004955422:1,655,351...1,657,026
Ensembl chrNW_004955422:1,655,358...1,657,044
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Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12721106
NCBI chrNW_004955486:2,061,196...2,062,805
Ensembl chrNW_004955486:2,060,735...2,063,003
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
DNA:missense mutations:cds:p.L125V, p.S563N (human)
RGD
PMID:10571959
RGD:1598382
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Phactr1
phosphatase and actin regulator 1
susceptibility
ISO
DNA:SNP::g.13011943A>G (rs9349379) (human)
RGD
PMID:22745674
RGD:401900726
NCBI chrNW_004955465:1,395,418...1,915,820
Ensembl chrNW_004955465:1,395,088...1,913,847
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Prkce
protein kinase C epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16782078
NCBI chrNW_004955441:12,642,703...13,142,396
Ensembl chrNW_004955441:12,642,697...13,139,372
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Tnfrsf11b
TNF receptor superfamily member 11b
ISO
protein:increased expression:serum
RGD
PMID:15569000
RGD:1624167
NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894
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Itgb3
integrin subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8598867
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1452937 PMID:8172379 PMID:15301905
NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
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Nos3
nitric oxide synthase 3
ISO
ClinVar Annotator: match by term: Hypertension resistant to conventional therapy
ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Ptprd
protein tyrosine phosphatase receptor type D
susceptibility
ISO
associated with coronary artery disease;DNA:SNP:intron: (rs324498) (human)
RGD
PMID:30237584
RGD:401976431
NCBI chrNW_004955434:12,033,825...14,132,636
Ensembl chrNW_004955434:12,031,420...12,428,774
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Agt
angiotensinogen
ISO
mRNA:increased expression:myocardium
RGD
PMID:11451295
RGD:8548894
NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
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Agtr1
angiotensin II receptor type 1
ISO
mRNA:increased expression:myocardium
RGD
PMID:11451295
RGD:8548894
NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
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Akt1
AKT serine/threonine kinase 1
ISO
protein:increased serine phosphorylation:platelet
RGD
PMID:20467748
RGD:5509094
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Apoa4
apolipoprotein A4
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:20367977
RGD:5685646
NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
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Bdnf
brain derived neurotrophic factor
ISO
RGD
PMID:16186425
RGD:4891111
NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
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Cxcl8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10660968
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Edn1
endothelin 1
ISO
associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human)
RGD
PMID:14556009
RGD:8661755
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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F7
coagulation factor VII
ISO
protein:increased expression:plasma (human)
RGD
PMID:10653827
RGD:2312399
NCBI chrNW_004955404:685,170...692,797
Ensembl chrNW_004955404:680,594...693,665
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:18333374
RGD:5508458
NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745
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Itga2
integrin subunit alpha 2
susceptibility
ISO
RGD
PMID:15104219
RGD:1582303
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Itgam
integrin subunit alpha M
ameliorates
ISO
protein:decreased expression:neutrophil (human)
RGD
PMID:18043994
RGD:329901840
NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
RGD
PMID:10486281
RGD:1582334
NCBI chrNW_004955430:2,772,064...2,787,912
Ensembl chrNW_004955430:2,770,373...2,789,131
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Pappa
pappalysin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11586954
NCBI chrNW_004955419:11,415,666...11,645,994
Ensembl chrNW_004955419:11,420,638...11,646,145
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:2382605
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Pten
phosphatase and tensin homolog
ISO
RNA:increased expression:serum
RGD
PMID:32595526
RGD:401851053
NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
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Selp
selectin P
ISO
protein:increased expression:serum
RGD
PMID:21162967
RGD:6219003
NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
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Serpinc1
serpin family C member 1
treatment
ISO
RGD
PMID:8122184
RGD:11035255
NCBI chrNW_004955406:14,024,183...14,036,206
Ensembl chrNW_004955406:14,024,313...14,035,948
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Sod3
superoxide dismutase 3
ISO
RGD
PMID:14592844
RGD:1580841
NCBI chrNW_004955480:257,716...263,149
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Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
ISO
ClinVar Annotator: match by term: Coronary sclerosis, medial, of infancy
ClinVar
PMID:9536098 PMID:15940697 PMID:17576681 PMID:25741868 PMID:28492532
NCBI chrNW_004955436:12,416,147...12,477,214
Ensembl chrNW_004955436:12,415,737...12,480,359
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Abcc9
ATP binding cassette subfamily C member 9
ISO
ClinVar Annotator: match by term: Myocardial infarction
ClinVar
PMID:16563363 PMID:18239147 PMID:20474083 PMID:21846889 PMID:23739550 PMID:23861362 PMID:24033266 PMID:24439875 PMID:25333069 PMID:25741868 PMID:26636822 PMID:26656175 PMID:26764160 PMID:28492532 More...
NCBI chrNW_004955413:17,385,966...17,510,220
Ensembl chrNW_004955413:17,382,564...17,510,132
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Ace2
angiotensin converting enzyme 2
treatment
ISO
mRNA:increased expression:myocardium
RGD
PMID:15671045 PMID:23959549
RGD:1558664 RGD:9685449
NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
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Acta2
actin alpha 2, smooth muscle
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004955425:4,023,001...4,039,980
Ensembl chrNW_004955425:4,026,430...4,040,747
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Acvr2a
activin A receptor type 2A
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004955440:13,849,926...13,931,374
Ensembl chrNW_004955440:13,849,926...13,931,374
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Acvr2b
activin A receptor type 2B
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004955427:25,438,652...25,467,360
Ensembl chrNW_004955427:25,438,652...25,467,360
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif 1
ISO
RGD
PMID:15625312
RGD:9681751
NCBI chrNW_004955407:26,524,487...26,533,038
Ensembl chrNW_004955407:26,524,130...26,533,038
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Add1
adducin 1
no_association
ISO
DNA:missense mutation:cds:p.G460W (human)
RGD
PMID:16420563 PMID:17082469
RGD:5147995 RGD:5148001
NCBI chrNW_004955514:1,784,302...1,812,845
Ensembl chrNW_004955514:1,783,814...1,815,917
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Adipoq
adiponectin, C1Q and collagen domain containing
disease_progression
ISO
RGD
PMID:21326342
RGD:5686351
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Adipor1
adiponectin receptor 1
ISO
mRNA, protein:decreased expression:heart left ventricle
RGD
PMID:16415076
RGD:1625764
NCBI chrNW_004955406:38,939,167...38,955,647
Ensembl chrNW_004955406:38,936,588...38,955,352
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Adipor2
adiponectin receptor 2
ISO
mRNA, protein:decreased expression:heart left ventricle
RGD
PMID:16415076
RGD:1625764
NCBI chrNW_004955454:4,243,898...4,327,255
Ensembl chrNW_004955454:4,243,898...4,327,308
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Adora1
adenosine A1 receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12160945
NCBI chrNW_004955406:39,148,811...39,183,577
Ensembl chrNW_004955406:39,149,689...39,187,688
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Adra2b
adrenoceptor alpha 2B
ISO
RGD
PMID:12535806
RGD:1559314
NCBI chrNW_004955470:3,711,075...3,714,450
Ensembl chrNW_004955470:3,711,031...3,714,241
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Adrb1
adrenoceptor beta 1
ISO
RGD
PMID:17143192
RGD:7241557
NCBI chrNW_004955431:19,025,663...19,027,026
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Adrb2
adrenoceptor beta 2
susceptibility
ISO
DNA:polymorphisms: :p.G16R, p.Q27E, p.T164I mRNA:decreased expression:heart
RGD
PMID:12400771 PMID:15520258
RGD:1601126 RGD:8548519
NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
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Ager
advanced glycosylation end-product specific receptor
susceptibility
ISO
DNA:polymorphism:promoter:-429T>C (human) mRNA:increased expression:left ventricle myocardium (rat)
RGD
PMID:16728681 PMID:19910580
RGD:1625333 RGD:2325647
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Agt
angiotensinogen
susceptibility
ISO
associated with hypertension;DNA:polymorphism: :p.M235T associated with Coronary Artery Disease;DNA:polymorphism: :p.M235T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:1668233 PMID:11393670 PMID:16413583 PMID:17299437 PMID:21167013
RGD:1566452 RGD:1601132 RGD:5129191
NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
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Agtr1
angiotensin II receptor type 1
no_association susceptibility
ISO
DNA:polymorphism:3' utr:1166A>C (human)
RGD
PMID:9652322 PMID:9857918 PMID:16061119
RGD:10047101 RGD:1566499 RGD:1601150
NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
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Ahsg
alpha 2-HS glycoprotein
ISO
protein:increased expression:plasma
RGD
PMID:19029462
RGD:2313810
NCBI chrNW_004955420:21,071,111...21,078,397
Ensembl chrNW_004955420:21,069,681...21,078,298
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Aimp1
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
ISO
RGD
PMID:14732363
RGD:1580021
NCBI chrNW_004955496:3,073,480...3,108,012
Ensembl chrNW_004955496:3,072,341...3,108,672
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Ak1
adenylate kinase 1
treatment
ISO
RGD
PMID:22229508
RGD:11100025
NCBI chrNW_004955419:799,415...807,138
Ensembl chrNW_004955419:799,410...811,029
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Akt1
AKT serine/threonine kinase 1
ISO
protein:decreased serine phosphorylation:heart protein:increased serine phosphorylation:platelet
RGD
PMID:20352476 PMID:20467748
RGD:10041035 RGD:5509094
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Aldh2
aldehyde dehydrogenase 2 family member
ISO
DNA:missense mutation: :p.E487K (human)
RGD
PMID:12452318
RGD:2311152
NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899
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Alox5ap
arachidonate 5-lipoxygenase activating protein
no_association
ISO
DNA:snps:multiple (human)
RGD
PMID:14770184 PMID:19046748
RGD:1578317 RGD:2313891
NCBI chrNW_004955431:15,071,535...15,097,496
Ensembl chrNW_004955431:15,069,089...15,097,580
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Angpt1
angiopoietin 1
ISO
mRNA, protein:decreased expression:myocardium
RGD
PMID:15364619
RGD:1626168
NCBI chrNW_004955417:30,199,508...30,386,695
Ensembl chrNW_004955417:30,198,842...30,386,266
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Angpt2
angiopoietin 2
ISO
protein:increased expression:left ventricular wall, heart septum (rat)
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004955403:54,139,823...54,193,740
Ensembl chrNW_004955403:54,139,823...54,195,032
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Anxa5
annexin A5
no_association susceptibility
ISO
protein:altered localization:cardiac muscle cell, sarcolemma protein:increased expression:plasma DNA:polymorphism: :-1C>T (human)
RGD
PMID:8814351 PMID:12200370 PMID:16025836 PMID:16501019
RGD:1578384 RGD:2317541 RGD:2317542 RGD:2317543
NCBI chrNW_004955428:18,873,782...18,907,955
Ensembl chrNW_004955428:18,873,782...18,907,955
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
susceptibility
ISO
DNA:polymorphism:exon 5: G>A (human)
RGD
PMID:18712175
RGD:401827276
NCBI chrNW_004955550:1,273,170...1,275,843
Ensembl chrNW_004955550:1,273,284...1,279,743
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Apoa1
apolipoprotein A1
no_association
ISO
DNA:polymorphisms
RGD
PMID:10428310 PMID:20176799
RGD:1578442 RGD:2325759
NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298
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Apoa4
apolipoprotein A4
susceptibility no_association
ISO
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.Q360H (human) DNA:mutation:intron:IVS2 (human)
RGD
PMID:7958503 PMID:10428310
RGD:1578442 RGD:5685678
NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
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Apoc3
apolipoprotein C3
no_association
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
RGD ClinVar
PMID:10428310
RGD:1578442
NCBI chrNW_004955412:18,165,667...18,168,015
Ensembl chrNW_004955412:18,165,667...18,168,015
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Apoe
apolipoprotein E
susceptibility
ISO
DNA:missense mutations, haplotypes:cds:p.C112R, p.R158C (human) CTD Direct Evidence: marker/mechanism DNA:missense mutations, haplotype:cds:p.C112R, p.C158R (human)
RGD CTD
PMID:10090925 PMID:10587578 PMID:17217375
RGD:10449412 RGD:1601229
NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
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Apoh
apolipoprotein H
ISO
RGD
PMID:12826288 PMID:15322656
RGD:10054111 RGD:2313985
NCBI chrNW_004955478:5,612,258...5,626,061
Ensembl chrNW_004955478:5,610,164...5,626,020
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Atg7
autophagy related 7
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004955429:14,076,976...14,301,034
Ensembl chrNW_004955429:14,076,960...14,304,236
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Atm
ATM serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:24358288
RGD:10053570
NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29702141
NCBI chrNW_004955435:19,537,224...19,563,631
Ensembl chrNW_004955435:19,536,634...19,564,580
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Atp5f1d
ATP synthase F1 subunit delta
treatment
ISO
protein:decreased expression:myocardium (rat)
RGD
PMID:23809007 PMID:29300489
RGD:13792656 RGD:13792681
NCBI chrNW_004955495:6,664,394...6,666,693
Ensembl chrNW_004955495:6,664,394...6,666,693
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Atp5po
ATP synthase peripheral stalk subunit OSCP
treatment
ISO
RGD
PMID:24692845
RGD:13801194
NCBI chrNW_004955407:33,288,194...33,298,817
Ensembl chrNW_004955407:33,286,178...33,299,420
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Avpr1a
arginine vasopressin receptor 1A
ISO
RGD
PMID:16423716
RGD:2300376
NCBI chrNW_004955458:10,245,325...10,253,209
Ensembl chrNW_004955458:10,245,111...10,253,209
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Bak1
BCL2 antagonist/killer 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29122578
NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997
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Bax
BCL2 associated X, apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20079142 PMID:25450231
NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
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Bcl2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
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Bcl2l1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17467744 PMID:20079142
RGD:1643494
NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
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Bdkrb1
bradykinin receptor B1
ISO
mRNA:increased expression:heart
RGD
PMID:12489796
RGD:704379
NCBI chrNW_004955438:16,500,219...16,505,394
Ensembl chrNW_004955438:16,500,633...16,501,691
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Bdkrb2
bradykinin receptor B2
ISO
mRNA:increased expression:heart
RGD
PMID:12489796
RGD:704379
NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172
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Becn1
beclin 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20079142
RGD:11561913
NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
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Bnip3
BCL2 interacting protein 3
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
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Brap
BRCA1 associated protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198608
NCBI chrNW_004955482:8,254,709...8,282,416
Ensembl chrNW_004955482:8,254,709...8,282,416
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Brinp3
BMP/retinoic acid inducible neural specific 3
susceptibility
ISO
DNA:SNPs:3' end:
RGD
PMID:18430236
RGD:14398488
NCBI chrNW_004955406:27,870,115...28,240,328
Ensembl chrNW_004955406:27,869,456...28,238,978
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C3
complement C3
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16996480
RGD:1600605
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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C7
complement C7
ISO
Protein:increased activity:serum, myocardium
RGD
PMID:15724448
RGD:1599522
NCBI chrNW_004955426:25,173,463...25,230,897
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C8a
complement C8 alpha chain
ISO
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004955464:2,806,859...2,874,444
G
C8b
complement C8 beta chain
ISO
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004955464:2,754,655...2,796,423
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Cacybp
calcyclin binding protein
ISO
mRNA:increased expression:heart
RGD
PMID:16440310
RGD:2326117
NCBI chrNW_004955406:14,823,509...14,840,127
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Camk2d
calcium/calmodulin dependent protein kinase II delta
treatment
ISO
mRNA, protein:splice variants, increased expression:heart left ventricle (rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004955428:25,583,501...25,880,395
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Casp3
caspase 3
treatment ameliorates
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:25450231 PMID:27904666 PMID:28622474
RGD:13782309 RGD:329333030
NCBI chrNW_004955403:24,315,712...24,326,271
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Casr
calcium sensing receptor
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:22527939
RGD:7205672
NCBI chrNW_004955427:21,486,608...21,574,017
Ensembl chrNW_004955427:21,486,427...21,575,210
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Cat
catalase
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:14575298 PMID:21600015
RGD:1581148
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Cav3
caveolin 3
ISO
Protein:increased expression:cytosol mRNA, protein; increased expression; myocardium (rat)
RGD
PMID:12566108 PMID:29438664
RGD:126925221 RGD:1599542
NCBI chrNW_004955561:326,008...335,911
Ensembl chrNW_004955561:325,944...335,914
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Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:heart (rat)
RGD
PMID:18954648
RGD:4890013
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Ccn1
cellular communication network factor 1
ISO
mRNA,protein:increased expression:myocardium (mouse)
RGD
PMID:15117851
RGD:329845570
NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166
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Ccn2
cellular communication network factor 2
treatment
ISO
mRNA:increased expression:left ventricle (rat)
RGD
PMID:18167060 PMID:29849775
RGD:2314623 RGD:35673318
NCBI chrNW_004955436:12,523,602...12,526,986
Ensembl chrNW_004955436:12,522,944...12,526,480
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Ccna2
cyclin A2
ISO
protein:increased expression:cardiomyocyte:
RGD
PMID:23634243
RGD:10054471
NCBI chrNW_004955428:18,725,969...18,732,478
Ensembl chrNW_004955428:18,726,062...18,732,211
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Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:12719858 PMID:12853162
RGD:1581174 RGD:1581177
NCBI chrNW_004955420:25,641,184...25,664,413
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:18954648
RGD:4890013
NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
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Cct7
chaperonin containing TCP1 subunit 7
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
ClinVar
PMID:24213632
NCBI chrNW_004955424:12,379,222...12,402,161
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Cd14
CD14 molecule
no_association
ISO
associated with Coronary Artery Disease;DNA:SNP:promoter
RGD
PMID:10195920 PMID:14587643 PMID:17436151
RGD:1580252 RGD:1580255 RGD:2314155
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd36
CD36 molecule (CD36 blood group)
severity
ISO
RGD
PMID:22128087
RGD:6893560
NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
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Cd40lg
CD40 ligand
ISO
protein:increased expression:serum
RGD
PMID:17635572
RGD:2314209
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
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Cd59
CD59 molecule (CD59 blood group)
ISO
protein:decreased expression:myocardium
RGD
PMID:7515561
RGD:1600501
NCBI chrNW_004955422:12,500,572...12,528,738
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Cdkn1b
cyclin dependent kinase inhibitor 1B
treatment
ISO
RGD
PMID:22492676
RGD:10045366
NCBI chrNW_004955413:9,615,542...9,620,542
Ensembl chrNW_004955413:9,615,542...9,620,542
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Cfl1
cofilin 1
treatment
ISO
RGD
PMID:24292258
RGD:11570534
NCBI chrNW_004955422:19,479,181...19,482,571
Ensembl chrNW_004955422:19,479,181...19,482,571
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Cftr
CF transmembrane conductance regulator
ISO
associated with Myocardial Reperfusion Injury
RGD
PMID:23221371
RGD:11566046
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:18480670
RGD:4892633
NCBI chrNW_004955406:39,195,101...39,201,808
Ensembl chrNW_004955406:39,191,073...39,202,020
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Ciita
class II major histocompatibility complex transactivator
susceptibility no_association
ISO
DNA:polymorphism:promoter:-168A>G
RGD
PMID:15821736 PMID:17183695
RGD:1358146 RGD:5491201
NCBI chrNW_004955442:7,600,903...7,647,619
Ensembl chrNW_004955442:7,603,893...7,647,624
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Ckb
creatine kinase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12359538
NCBI chrNW_004955538:2,379,868...2,380,771
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Ckm
creatine kinase, M-type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:3279722 PMID:12359538
NCBI chrNW_004955555:2,318,072...2,330,733
Ensembl chrNW_004955555:2,318,072...2,336,811
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Clu
clusterin
treatment
ISO
RGD
PMID:20854280
RGD:9068409
NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
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Col1a1
collagen type I alpha 1 chain
treatment
ISO
RGD
PMID:25636075
RGD:11041598
NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073
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Col3a1
collagen type III alpha 1 chain
treatment
ISO
RGD
PMID:25636075
RGD:11041598
NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887
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Col4a1
collagen type IV alpha 1 chain
susceptibility
ISO
DNA:polymorphism: :p.Q1334H (human)
RGD
PMID:18077766
RGD:2311341
NCBI chrNW_004955404:2,196,193...2,327,324
Ensembl chrNW_004955404:2,260,029...2,326,074
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Col6a3
collagen type VI alpha 3 chain
ISO
DNA:SNP:CDS:E1386K (rs146092501) (human)
RGD
PMID:30226566
RGD:401851058
NCBI chrNW_004955542:2,869,183...2,950,569
Ensembl chrNW_004955542:2,887,723...2,949,062
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Creb1
cAMP responsive element binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149
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Crem
cAMP responsive element modulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004955462:2,491,504...2,547,587
Ensembl chrNW_004955462:2,491,504...2,536,385
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Cs
citrate synthase
severity
ISO
protein:decreased expression:diaphragm, mitochondrion
RGD
PMID:1877670 PMID:34416105
RGD:243048469 RGD:243048471
NCBI chrNW_004955458:3,881,798...3,913,044
Ensembl chrNW_004955458:3,881,798...3,893,401
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Csf2
colony stimulating factor 2
ISO
RGD
PMID:21326109
RGD:5131507
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:15639484
RGD:11039417
NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126
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Csnk2a1
casein kinase 2 alpha 1
ISO
RGD
PMID:15090263
RGD:11565830
NCBI chrNW_004955597:326,601...397,112
G
Csnk2b
casein kinase 2 beta
ISO
RGD
PMID:15090263
RGD:11565830
NCBI chrNW_004955437:210,541...215,725
Ensembl chrNW_004955437:210,838...219,694
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Ctla4
cytotoxic T-lymphocyte associated protein 4
ISO
DNA:SNP:CDS:49A>G (human)
RGD
PMID:17652883
RGD:2301976
NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460
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Ctsb
cathepsin B
ISO
protein:increased activity:serum, heart (rat)
RGD
PMID:19958779
RGD:2315501
NCBI chrNW_004955403:53,086,236...53,100,217
Ensembl chrNW_004955403:53,085,574...53,093,809
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Cxcl12
C-X-C motif chemokine ligand 12
ISO
mRNA:increased expression:heart left ventricle
RGD
PMID:11820456 PMID:19187644
RGD:2306567 RGD:632503
NCBI chrNW_004955546:1,929,269...1,941,690
Ensembl chrNW_004955546:1,929,269...1,941,690
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Dab2
DAB adaptor protein 2
ISO
protein:increased expression:cardiomyocyte
RGD
PMID:20666606 PMID:21762377
RGD:7243156 RGD:7243158
NCBI chrNW_004955426:23,852,752...23,883,030
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Dab2ip
DAB2 interacting protein
onset
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP:CDS:intron 1 (rs7025486) (human)
CTD RGD
PMID:20622881
RGD:401901599
NCBI chrNW_004955419:6,229,437...6,416,619
Ensembl chrNW_004955419:6,228,591...6,416,402
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Dag1
dystroglycan 1
treatment
ISO
RGD
PMID:12034665
RGD:11541047
NCBI chrNW_004955532:1,446,553...1,465,310
Ensembl chrNW_004955532:1,397,900...1,466,312
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Dcn
decorin
ISO
RGD
PMID:16311904
RGD:1598497
NCBI chrNW_004955405:28,335,493...28,371,912
Ensembl chrNW_004955405:28,332,545...28,372,323
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Ddit3
DNA damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25450231
NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513
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Dgkz
diacylglycerol kinase zeta
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17071729
NCBI chrNW_004955422:1,658,237...1,687,000
Ensembl chrNW_004955422:1,657,926...1,695,404
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Dvl1
dishevelled segment polarity protein 1
ISO
RGD
PMID:15256074
RGD:1580899
NCBI chrNW_004955486:9,464,390...9,469,984
Ensembl chrNW_004955486:9,464,313...9,469,984
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Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
treatment
ISO
associated with heart failure; protein:increased expression, increased activity:heart left ventricle (rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004955407:36,456,628...36,588,940
Ensembl chrNW_004955407:36,453,098...36,589,382
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Ece1
endothelin converting enzyme 1
ISO
RGD
PMID:9607404
RGD:1580912
NCBI chrNW_004955452:1,653,783...1,704,619
Ensembl chrNW_004955452:1,651,316...1,751,489
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Edn1
endothelin 1
severity
ISO
protein:increased secretion:plasma (human) mRNA:increased expression:heart left ventricle (rat)
RGD
PMID:10573185 PMID:17893002
RGD:1580921 RGD:4144880
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Edn2
endothelin 2
ISO
RGD
PMID:10573185
RGD:1580921
NCBI chrNW_004955537:1,228,062...1,233,784
Ensembl chrNW_004955537:1,228,070...1,233,797
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Ednra
endothelin receptor type A
ISO
RGD
PMID:12524016
RGD:1580948
NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761
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Ednrb
endothelin receptor type B
ISO
RGD
PMID:12524016
RGD:1580948
NCBI chrNW_004955404:29,394,253...29,425,358
Ensembl chrNW_004955404:29,394,164...29,425,358
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Egln1
egl-9 family hypoxia inducible factor 1
ISO
RGD
PMID:16765982
RGD:11252084
NCBI chrNW_004955492:7,407,800...7,454,851
Ensembl chrNW_004955492:7,407,800...7,454,842
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Egln3
egl-9 family hypoxia inducible factor 3
ISO
RGD
PMID:16765982
RGD:11252084
NCBI chrNW_004955409:26,939,933...26,967,156
Ensembl chrNW_004955409:26,939,933...26,967,156
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Epas1
endothelial PAS domain protein 1
ISO
RGD
PMID:15247145 PMID:18484163
RGD:1580977 RGD:5147886
NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369
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Ephb1
EPH receptor B1
ameliorates
ISO
RGD
PMID:28622474
RGD:329333030
NCBI chrNW_004955501:3,424,112...3,821,727
Ensembl chrNW_004955501:3,423,977...3,821,890
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:19716829
RGD:5688358
NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572
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Epo
erythropoietin
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19337937 PMID:21415704
RGD:10400907
NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355
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Epor
erythropoietin receptor
ISO
RGD
PMID:21415704
RGD:10400907
NCBI chrNW_004955495:2,293,587...2,299,302
Ensembl chrNW_004955495:2,293,540...2,298,715
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Erbb2
erb-b2 receptor tyrosine kinase 2
treatment
ISO
RGD
PMID:26892146
RGD:11522702
NCBI chrNW_004955451:14,442,816...14,456,009
Ensembl chrNW_004955451:14,442,816...14,459,379
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Erbb4
erb-b2 receptor tyrosine kinase 4
treatment
ISO
RGD
PMID:26892146
RGD:11522702
NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558
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Esr1
estrogen receptor 1
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
ClinVar OMIM
PMID:11894143 PMID:11919305 PMID:14600184 PMID:15133719 PMID:25741868
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
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F10
coagulation factor X
ISO
ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to
ClinVar
PMID:10984565 PMID:12181036 PMID:25741868
NCBI chrNW_004955404:666,142...682,598
Ensembl chrNW_004955404:666,165...682,538
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F12
coagulation factor XII
susceptibility
ISO
DNA:polymorphism:promoter:-46C>T(human)
RGD
PMID:16411408
RGD:11041803
NCBI chrNW_004955408:29,644,279...29,665,161
Ensembl chrNW_004955408:29,642,096...29,650,950
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F13a1
coagulation factor XIII A chain
ISO
ClinVar Annotator: match by term: Myocardial infarction, protection against
ClinVar OMIM
PMID:8025280 PMID:9459313 PMID:9550516 PMID:10365735 PMID:10910914 PMID:12072871 PMID:12456499 PMID:17393027 PMID:25741868 More...
NCBI chrNW_004955465:7,444,118...7,617,366
Ensembl chrNW_004955465:7,443,166...7,617,436
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F2
coagulation factor II, thrombin
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism::20210G>A(human)
CTD RGD
PMID:9292507 PMID:9531249 PMID:10027711 PMID:12480694
RGD:1581022
NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
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F3
coagulation factor III, tissue factor
treatment
ISO
RGD
PMID:21229253
RGD:11062083
NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159
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F5
coagulation factor V
susceptibility no_association
ISO
DNA:mutation:cds:1691G>A (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9531249 PMID:10590188 PMID:15131548
RGD:11564335 RGD:11564337
NCBI chrNW_004955462:7,695,004...7,757,832
Ensembl chrNW_004955462:7,694,939...7,757,463
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F7
coagulation factor VII
susceptibility
ISO
ClinVar Annotator: match by term: F7-related condition | ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to DNA:missense mutation, repeat:cds, intron:p.R353Q, (human)
ClinVar RGD OMIM
PMID:1634227 PMID:2070047 PMID:6812354 PMID:7919338 PMID:7981691 PMID:8242057 PMID:8844208 PMID:8883260 PMID:9420338 PMID:10554827 PMID:10862079 PMID:10984565 PMID:11129332 PMID:11931672 PMID:12181036 PMID:12903033 PMID:12935978 PMID:15142120 PMID:15456489 PMID:15735798 PMID:18282149 PMID:18669152 PMID:18976247 PMID:20040857 PMID:20735728 PMID:20958793 PMID:21902896 PMID:22180436 PMID:25582404 PMID:25741868 PMID:25828579 PMID:25952977 PMID:26105150 PMID:28492532 PMID:31064749 PMID:34355501 More...
RGD:11049521
NCBI chrNW_004955404:685,170...692,797
Ensembl chrNW_004955404:680,594...693,665
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Fabp3
fatty acid binding protein 3
ISO
RGD
PMID:8326460
RGD:1582401
NCBI chrNW_004955452:9,851,182...9,858,735
Ensembl chrNW_004955452:9,846,689...9,861,971
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Fgb
fibrinogen beta chain
ISO
RGD
PMID:9437197
RGD:1580381
NCBI chrNW_004955471:8,824,901...8,832,836
Ensembl chrNW_004955471:8,822,965...8,832,884
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Fgf1
fibroblast growth factor 1
treatment
ISO
RGD
PMID:24200746
RGD:10449026
NCBI chrNW_004955415:11,151,330...11,245,554
Ensembl chrNW_004955415:11,151,266...11,247,344
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Fgfr1
fibroblast growth factor receptor 1
ISO
RGD
PMID:17439742
RGD:10402087
NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
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Fgfr2
fibroblast growth factor receptor 2
ameliorates
ISO
RGD
PMID:19358330
RGD:155663664
NCBI chrNW_004955551:2,321,190...2,427,000
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Fis1
fission, mitochondrial 1
ISO
protein:increased expression:plantaris (rat)
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004955456:16,057,158...16,060,623
Ensembl chrNW_004955456:16,038,221...16,060,623
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Flt1
fms related receptor tyrosine kinase 1
ISO
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472
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Flt3lg
fms related receptor tyrosine kinase 3 ligand
treatment
ISO
RGD
PMID:24184252
RGD:11049498
NCBI chrNW_004955559:1,364,056...1,371,245
Ensembl chrNW_004955559:1,365,938...1,370,002
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Fn1
fibronectin 1
ISO
protein:decreased expression:heart
RGD
PMID:19695229
RGD:2325720
NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased expression:paraventricular nucleus hypothalamus, paraventricular nucleus thalamus
RGD
PMID:27601012
RGD:405649741
NCBI chrNW_004955523:307,181...310,728
Ensembl chrNW_004955523:305,728...310,728
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Fto
FTO alpha-ketoglutarate dependent dioxygenase
treatment
ISO
DNA:SNP: :rs17817449 (human) associated with type 2 diabetes mellitus;DNA:SNP:intron:rs9939609 (human) mRNA, protein:decreased expression:heart
RGD
PMID:20031593 PMID:26772723 PMID:29997116
RGD:11555187 RGD:329812009 RGD:329901766
NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771
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Fzd2
frizzled class receptor 2
ISO
mRNA:increased expression:heart left ventricle
RGD
PMID:9142123
RGD:4107058
NCBI chrNW_004955451:17,501,410...17,503,726
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G6pd
glucose-6-phosphate dehydrogenase
treatment
ISO
RGD
PMID:20462747
RGD:10449173
NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083
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Gata4
GATA binding protein 4
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:20200331 PMID:23948075
RGD:7327215
NCBI chrNW_004955403:52,958,318...53,029,267
Ensembl chrNW_004955403:52,987,644...53,029,267
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Gatm
glycine amidinotransferase
ISO
RGD
PMID:31972362
RGD:329961305
NCBI chrNW_004955409:8,068,524...8,084,603
Ensembl chrNW_004955409:8,068,476...8,084,603
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Gch1
GTP cyclohydrolase 1
treatment
ISO
RGD
PMID:26192027 PMID:32782412
RGD:329961570 RGD:329970290
NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614
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Gclc
glutamate-cysteine ligase catalytic subunit
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
ClinVar OMIM
PMID:12598062
NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539
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Gclm
glutamate-cysteine ligase modifier subunit
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:12081989 PMID:12975258
NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384
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Ggt1
gamma-glutamyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19419996
NCBI chrNW_004955455:8,082,578...8,099,523
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Ghrh
growth hormone releasing hormone
treatment
ISO
RGD
PMID:24373935
RGD:10401242
NCBI chrNW_004955422:24,481,246...24,490,529
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Gja1
gap junction protein alpha 1
treatment
ISO
protein:decreased phosphorylation
RGD
PMID:22841862 PMID:22969867 PMID:29428663
RGD:13592597 RGD:7207261 RGD:7207262
NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
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Gja4
gap junction protein alpha 4
ISO
DNA:SNP:CDS:T allele of 1019C>T in Japanese men (p<0.001) associated with coronary artery disease; DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S (p = 0.0026) in a Swiss population
RGD
PMID:12477941 PMID:15982495 PMID:16677656
RGD:1580400 RGD:1626615 RGD:1626626
NCBI chrNW_004955452:12,902,764...12,905,337
Ensembl chrNW_004955452:12,902,773...12,905,337
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Gja5
gap junction protein alpha 5
treatment
ISO
RGD
PMID:29428663
RGD:13592597
NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349
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Gp1ba
glycoprotein Ib platelet subunit alpha
ISO
RGD
PMID:15269835
RGD:1580432
NCBI chrNW_004955467:10,333,537...10,347,488
Ensembl chrNW_004955467:10,333,575...10,346,989
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Gpt
glutamic--pyruvic transaminase
treatment
ISO
RGD
PMID:32026788
RGD:401793703
NCBI chrNW_004955454:3,127,997...3,132,459
Ensembl chrNW_004955454:3,127,997...3,132,459
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Gpx1
glutathione peroxidase 1
susceptibility
ISO
RGD
PMID:14573732
RGD:1600662
NCBI chrNW_004955532:1,298,336...1,298,830
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Gsk3b
glycogen synthase kinase 3 beta
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16565311 PMID:16716347
RGD:10045368
NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
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Gsn
gelsolin
ameliorates
ISO
protein:decreased expression:blood serum (human)
RGD
PMID:9142022 PMID:28622474
RGD:329333022 RGD:329333030
NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361
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Gsr
glutathione-disulfide reductase
treatment
ISO
RGD
PMID:25119867
RGD:10401898
NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
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Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
ClinVar
PMID:24213632
NCBI chrNW_004955471:11,367,318...11,422,199
Ensembl chrNW_004955471:11,367,282...11,424,273
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Hadh
hydroxyacyl-CoA dehydrogenase
ISO
RGD
PMID:11481570
RGD:2302229
NCBI chrNW_004955496:1,835,034...1,861,410
Ensembl chrNW_004955496:1,835,034...1,861,407
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Hamp
hepcidin antimicrobial peptide
ISO
mRNA:increased expression:heart
RGD
PMID:19615879
RGD:11041636
NCBI chrNW_004955468:4,576,080...4,577,591
Ensembl chrNW_004955468:4,575,510...4,577,649
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Hfe
homeostatic iron regulator
no_association susceptibility
ISO
RGD
PMID:10491370 PMID:12850485
RGD:1582672 RGD:1582697
NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
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Hgf
hepatocyte growth factor
treatment
ISO
protein:increased expression:serum:
RGD
PMID:12419930 PMID:16570015
RGD:8548609 RGD:8548632
NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058
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Hif1a
hypoxia inducible factor 1 subunit alpha
treatment ameliorates
ISO
human gene in a rat model mRNA:increased expression:heart left ventricle
RGD
PMID:15247145 PMID:15999059 PMID:18484163 PMID:28622474
RGD:1580977 RGD:329333030 RGD:5147886 RGD:9068466
NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497
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Hmgb1
high mobility group box 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21113057 PMID:23188125
RGD:10402174
NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:12392996 PMID:20925964
RGD:1598393 RGD:4145134
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
ameliorates
ISO
RGD
PMID:26465199 PMID:28522730
RGD:11087531 RGD:329902054
NCBI chrNW_004955489:2,500,928...2,524,715
Ensembl chrNW_004955489:2,497,680...2,524,805
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Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:heart
CTD RGD
PMID:17587755
RGD:2308939
NCBI chrNW_004955484:9,206,681...9,212,356
Ensembl chrNW_004955484:9,206,681...9,212,356
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25450231
NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:17202668
RGD:1624230
NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419
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Icam1
intercellular adhesion molecule 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10070497 PMID:23139358
RGD:8547733
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Igf1
insulin like growth factor 1
severity
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16635594 PMID:19295919
RGD:1598421 RGD:2306696
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Igf1r
insulin like growth factor 1 receptor
ISO
mRNA,protein:increased expression:myocyte:
RGD
PMID:8682060
RGD:10046050
NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666
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Il10
interleukin 10
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15466015 PMID:15883752 PMID:16310260
RGD:1598480
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il17a
interleukin 17A
ISO
mRNA, protein:increased expression:heart left ventricle (rat)
RGD
PMID:23096364
RGD:9095344
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il18
interleukin 18
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il18bp
interleukin 18 binding protein
ISO
RGD
PMID:19805173
RGD:4889400
NCBI chrNW_004955414:19,327,828...19,332,577
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Il1b
interleukin 1 beta
ameliorates
ISO
protein:increased expression:serum (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11743230 PMID:15883752 PMID:16310260 PMID:23143013 PMID:23237935 PMID:33389498 More...
RGD:242905187 RGD:7175553 RGD:7204425
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18474815 PMID:19005744
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il4r
interleukin 4 receptor
ISO
mRNA:increased expression:heart
RGD
PMID:10807530
RGD:4889985
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15883752 PMID:16310260
NCBI chrNW_004955410:25,079,835...25,084,390
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Il6r
interleukin 6 receptor
ISO
RGD
PMID:12123772
RGD:1625444
NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762
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Inhba
inhibin subunit beta A
ISO
mRNA:increased expression:heart (rat) mRNA:increased expression:myocardium (mouse)
RGD
PMID:14993131 PMID:32427381
RGD:1580888 RGD:329849118
NCBI chrNW_004955460:2,054,879...2,066,628
Ensembl chrNW_004955460:2,046,588...2,066,609
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Inhbb
inhibin subunit beta B
ISO
mRNA:increased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004955459:9,482,998...9,488,489
Ensembl chrNW_004955459:9,482,873...9,488,489
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Isl1
ISL LIM homeobox 1
ameliorates
ISO
RGD
PMID:22727192 PMID:29482621
RGD:243048463 RGD:243048464
NCBI chrNW_004955446:15,824,956...15,835,000
Ensembl chrNW_004955446:15,824,035...15,835,046
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Itga2
integrin subunit alpha 2
susceptibility no_association
ISO
RGD
PMID:10194421 PMID:15227729 PMID:16697311
RGD:1581029 RGD:1582294 RGD:1582296
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Itga3
integrin subunit alpha 3
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:19041328
RGD:2325287
NCBI chrNW_004955451:11,563,120...11,590,119
Ensembl chrNW_004955451:11,561,704...11,589,727
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Itgam
integrin subunit alpha M
treatment
ISO
RGD
PMID:29933226
RGD:329853753
NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
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Itgb1
integrin subunit beta 1
treatment
ISO
RGD
PMID:28367125
RGD:13602094
NCBI chrNW_004955462:4,454,809...4,483,227
Ensembl chrNW_004955462:4,454,809...4,484,842
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Itgb3
integrin subunit beta 3
no_association susceptibility
ISO
DNA:polymorphism:exon: ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
RGD OMIM ClinVar
PMID:2014236 PMID:7570918 PMID:8598867 PMID:8667943 PMID:8838346 PMID:9700201 PMID:9716140 PMID:10531147 PMID:10583927 PMID:10727448 PMID:11723016 PMID:17264806 PMID:25728920 PMID:25741868 PMID:28492532 More...
RGD:5128481 RGD:5128498
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
RGD
PMID:10486281
RGD:1582334
NCBI chrNW_004955430:2,772,064...2,787,912
Ensembl chrNW_004955430:2,770,373...2,789,131
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Jak2
Janus kinase 2
susceptibility
ISO
associated with Myocardial Reperfusion Injury
RGD
PMID:22749532
RGD:10403083
NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208
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Kcnj2
potassium inwardly rectifying channel subfamily J member 2
treatment
ISO
RGD
PMID:23647964
RGD:7247426
NCBI chrNW_004955478:2,734,795...2,745,217
Ensembl chrNW_004955478:2,734,795...2,745,217
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Kcnk2
potassium two pore domain channel subfamily K member 2
ISO
mRNA:decreased expression:heart left ventricle, epicardium, endocardium (rat)
RGD
PMID:21683547
RGD:9831182
NCBI chrNW_004955406:2,793,493...2,975,322
Ensembl chrNW_004955406:2,791,803...2,975,322
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Kcnn4
potassium calcium-activated channel subfamily N member 4
susceptibility
ISO
DNA:SNPs,haplotypes:introns:multiple
RGD
PMID:19644414
RGD:329969896
NCBI chrNW_004955555:1,493,600...1,509,113
Ensembl chrNW_004955555:1,490,052...1,509,113
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Kdm5b
lysine demethylase 5B
ameliorates
ISO
RGD
PMID:36481938
RGD:329901769
NCBI chrNW_004955406:38,755,220...38,823,094
Ensembl chrNW_004955406:38,755,220...38,823,088
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Kdm6a
lysine demethylase 6A
ISO
mRNA:increased expression:myocardium (rat)
RGD
PMID:30887465
RGD:151665136
NCBI chrNW_004955516:3,151,350...3,346,832
Ensembl chrNW_004955516:3,149,948...3,346,832
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Kdr
kinase insert domain receptor
treatment
ISO
RGD
PMID:16698275 PMID:25936512
RGD:126925214 RGD:1581717
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Kif6
kinesin family member 6
no_association treatment
ISO
DNA:SNP: :p.W719R (rs20455) (human) CTD Direct Evidence: marker/mechanism DNA:SNP: :rs20455 (human)
RGD CTD
PMID:18222354 PMID:19371834 PMID:20403483 PMID:20927332 PMID:21943003 PMID:26997531 More...
RGD:11097528 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048450
NCBI chrNW_004955437:6,353,318...6,597,196
Ensembl chrNW_004955437:6,352,316...6,671,934
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Klf13
KLF transcription factor 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29122578
NCBI chrNW_004955416:30,087,705...30,137,437
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Klk1
kallikrein 1
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12411458 PMID:17022964
RGD:1641799
NCBI chrNW_004955559:457,030...461,086
Ensembl chrNW_004955559:456,932...465,704
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Lamp2
lysosomal associated membrane protein 2
ISO
mRNA:increased expression:plantaris
RGD
PMID:24427319
RGD:11557988
NCBI chrNW_004955572:1,423,048...1,464,443
Ensembl chrNW_004955572:1,422,981...1,462,622
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Lcat
lecithin-cholesterol acyltransferase
ISO
RGD
PMID:16640830
RGD:1581773
NCBI chrNW_004955484:8,772,692...8,776,122
Ensembl chrNW_004955484:8,772,692...8,776,122
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Ldha
lactate dehydrogenase A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:3279722
NCBI chrNW_004955414:33,087,745...33,100,846
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Lgals2
galectin 2
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:15129282
NCBI chrNW_004955413:23,988,193...24,001,868
Ensembl chrNW_004955413:23,988,193...23,989,703
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Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29769800
NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438
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Lipg
lipase G, endothelial type
susceptibility
ISO
DNA:polymorphism: :584C>T (human)
RGD
PMID:17526978
RGD:1641818
NCBI chrNW_004955402:34,666,757...34,689,726
Ensembl chrNW_004955402:34,667,036...34,687,568
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LOC102004641
cytochrome b-245 light chain
ISO
mRNA:increase expression:ventricle myocardium: mRNA:increased expression:myocardium
RGD
PMID:11243862 PMID:18762777
RGD:1599690 RGD:2317860
NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118
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LOC102009223
cytochrome P450 1B1
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004955441:5,803,397...5,812,131
Ensembl chrNW_004955441:5,803,032...5,812,131
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LOC102012042
cytochrome b-245 heavy chain
ISO
mRNA:increase expression:ventricle myocardium
RGD
PMID:11243862
RGD:1599690
NCBI chrNW_004955587:781,533...818,149
Ensembl chrNW_004955587:781,388...819,912
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LOC102024786
vitamin D 25-hydroxylase
ISO
DNA:SNP:CDS:rs2060793, rs1993116, rs10766197 (human)
RGD
PMID:29804528
RGD:401901167
NCBI chrNW_004955414:29,929,130...29,948,151
Ensembl chrNW_004955414:29,928,644...29,948,484
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Lox
lysyl oxidase
ISO
RGD
PMID:14553832
RGD:1581883
NCBI chrNW_004955521:178,290...193,926
Ensembl chrNW_004955521:185,792...193,926
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Lpl
lipoprotein lipase
susceptibility
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :p.D9N (rs1801177) (human)
RGD
PMID:18823627
RGD:2313302
NCBI chrNW_004955403:43,646,084...43,672,116
Ensembl chrNW_004955403:43,646,084...43,673,967
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Lrp1
LDL receptor related protein 1
susceptibility
ISO
RGD
PMID:12402342
RGD:1581913
NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146
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Lrp8
LDL receptor related protein 8
susceptibility onset no_association
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1 DNA:missense mutation:cds:p.R952Q (human)
OMIM ClinVar RGD
PMID:17847002 PMID:18592168
RGD:2306124 RGD:2306125
NCBI chrNW_004955464:5,837,002...5,912,178
Ensembl chrNW_004955464:5,837,009...5,911,672
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Lrpap1
LDL receptor related protein associated protein 1
susceptibility
ISO
RGD
PMID:12394648
RGD:1581922
NCBI chrNW_004955514:2,195,228...2,208,258
Ensembl chrNW_004955514:2,195,228...2,208,688
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Lta
lymphotoxin alpha
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to DNA:SNP:exon:804C>A (p.T26N) (human)
OMIM ClinVar RGD
PMID:12426569 PMID:12746914 PMID:14681301 PMID:15175864 PMID:15266304 PMID:23398946 PMID:25741868 More...
RGD:1581940 RGD:8548841
NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529
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Map1lc3a
microtubule associated protein 1 light chain 3 alpha
treatment
ISO
RGD
PMID:20079142
RGD:11561913
NCBI chrNW_004955422:26,774,466...26,776,024
Ensembl chrNW_004955422:26,774,922...26,775,884
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Map3k5
mitogen-activated protein kinase kinase kinase 5
treatment
ISO
RGD
PMID:22635076
RGD:10412335
NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808
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Map3k7
mitogen-activated protein kinase kinase kinase 7
treatment
ISO
mRNA, protein:increased expression:myocardium (rat)
RGD
PMID:16183734 PMID:27121011
RGD:11073666 RGD:2298758
NCBI chrNW_004955411:17,177,335...17,229,957
Ensembl chrNW_004955411:17,177,335...17,229,957
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Mapk1
mitogen-activated protein kinase 1
ISO
RGD
PMID:15653762
RGD:1582282
NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
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Mapk14
mitogen-activated protein kinase 14
ameliorates
ISO
RGD
PMID:33409963
RGD:401794430
NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083
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Mapk8
mitogen-activated protein kinase 8
ameliorates
ISO
RGD
PMID:28622474
RGD:329333030
NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
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Mdh2
malate dehydrogenase 2
ISO
RGD
PMID:9753871
RGD:1582468
NCBI chrNW_004955456:14,819,406...14,833,547
Ensembl chrNW_004955456:14,819,406...14,837,142
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Mdk
midkine
ISO
RGD
PMID:9568069
RGD:1582488
NCBI chrNW_004955422:1,655,351...1,657,026
Ensembl chrNW_004955422:1,655,358...1,657,044
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Mef2c
myocyte enhancer factor 2C
treatment
ISO
RGD
PMID:23948075
RGD:7327215
NCBI chrNW_004955418:22,537,388...22,701,434
Ensembl chrNW_004955418:22,537,285...22,701,434
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Meox2
mesenchyme homeobox 2
ISO
protein:decreased expression:heart (rat)
RGD
PMID:24155330
RGD:155882536
NCBI chrNW_004955410:18,924,669...18,988,478
Ensembl chrNW_004955410:18,924,605...18,988,478
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Mff
mitochondrial fission factor
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23867156
RGD:12879458
NCBI chrNW_004955453:7,221,244...7,256,029
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Mfn2
mitofusin 2
treatment
ISO
RGD
PMID:20886221
RGD:12738232
NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772
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Mgp
matrix Gla protein
susceptibility
ISO
RGD
PMID:11073842
RGD:1582503
NCBI chrNW_004955413:11,614,851...11,618,090
Ensembl chrNW_004955413:11,615,078...11,618,024
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Mia3
MIA SH3 domain ER export factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198609
NCBI chrNW_004955520:1,853,145...1,890,338
Ensembl chrNW_004955520:1,850,942...1,890,390
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Mif
macrophage migration inhibitory factor
ISO
mRNA, protein:increased expression:myocardium protein:increased expression:plasma
RGD
PMID:11589847 PMID:12704210
RGD:1642003 RGD:1642008
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Mlxipl
MLX interacting protein like
susceptibility
ISO
DNA:SNP:cd: C771G, p.Q241H (rs3812316) (human)
RGD
PMID:24448738
RGD:401799621
NCBI chrNW_004955456:14,096,530...14,116,687
Ensembl chrNW_004955456:14,096,531...14,117,269
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Mmp13
matrix metallopeptidase 13
ISO
RGD
PMID:15782494
RGD:1582556
NCBI chrNW_004955412:6,106,994...6,118,760
Ensembl chrNW_004955412:6,106,994...6,118,760
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Mmp14
matrix metallopeptidase 14
ISO
RGD
PMID:10773235 PMID:16461815
RGD:1582569 RGD:1582587
NCBI chrNW_004955409:37,438,924...37,448,704
Ensembl chrNW_004955409:37,440,541...37,448,437
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10773235 PMID:11179039 PMID:16310260 PMID:24358288
RGD:1582587 RGD:7207136
NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
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Mmp7
matrix metallopeptidase 7
ISO
RGD
PMID:16769909
RGD:1582373
NCBI chrNW_004955412:5,780,772...5,792,485
Ensembl chrNW_004955412:5,778,502...5,792,445
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Mmp9
matrix metallopeptidase 9
susceptibility
ISO
protein:increased expression:heart left ventricle protein:increased expression, increased activity:heart left ventricle (rat) protein:increased expression:coronary artery, plasma (human) CTD Direct Evidence: marker/mechanism DNA:snps:promoter, exon:g.-1562C>T, p.R279Q (rs3918242, rs2664538) (human)
RGD CTD
PMID:8531210 PMID:14729404 PMID:15118287 PMID:16310260 PMID:16845718 PMID:17893005 PMID:24358288 PMID:25520329 More...
RGD:13204799 RGD:1582639 RGD:1582645 RGD:1582653 RGD:7207049 RGD:7207198
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Mstn
myostatin
ISO
mRNA:decreased expression:myocardium (mouse)
RGD
PMID:32427381
RGD:329849118
NCBI chrNW_004955403:8,914,505...8,921,190
Ensembl chrNW_004955403:8,914,482...8,923,465
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Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNP: :677C>T (human) associated with Kidney Failure, Chronic; DNA:transition:cds:g.677C>T rs1801133 (human)
RGD
PMID:10090925 PMID:19272686
RGD:10449412 RGD:6893548
NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
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Mtor
mechanistic target of rapamycin kinase
treatment
ISO
protein:decreased serine phosphorylation:heart associated with Diabetes Mellitus, Experimental
RGD
PMID:20352476 PMID:23773982
RGD:10041035 RGD:10041040
NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
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Ncam1
neural cell adhesion molecule 1
ISO
mRNA, protein:increased expression:heart protein:alternative form, increased expression:myocardium
RGD
PMID:19853610 PMID:23462508
RGD:2325979 RGD:40924663
NCBI chrNW_004955412:14,630,109...14,923,847
Ensembl chrNW_004955412:14,630,443...14,923,926
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Ndufb5
NADH:ubiquinone oxidoreductase subunit B5
treatment
ISO
RGD
PMID:24692845
RGD:13801194
NCBI chrNW_004955420:8,778,271...8,793,634
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:23290949 PMID:24915518
RGD:10412734 RGD:10412738
NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
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Nfkbia
NFKB inhibitor alpha
treatment
ISO
RGD
PMID:19616538
RGD:10413879
NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
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Ngf
nerve growth factor
treatment
ISO
protein:increased expression:myocardium
RGD
PMID:20360245
RGD:405100231
NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
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Nlk
nemo like kinase
ISO
mRNA, protein:decreased expression:heart
RGD
PMID:26861724
RGD:242905213
NCBI chrNW_004955481:4,828,441...4,973,734
Ensembl chrNW_004955481:4,828,448...4,973,734
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Nlrp3
NLR family pyrin domain containing 3
ameliorates
ISO
RGD
PMID:33389498
RGD:242905187
NCBI chrNW_004955581:597,952...616,903
Ensembl chrNW_004955581:597,667...617,410
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Nono
non-POU domain containing octamer binding
ameliorates
ISO
RGD
PMID:35247074
RGD:155882458
NCBI chrNW_004955475:10,833,514...10,853,460
Ensembl chrNW_004955475:10,833,189...10,853,519
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Nos2
nitric oxide synthase 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10090345 PMID:11489778 PMID:26192027
RGD:329970290
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
susceptibility treatment
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:aorta (rat) DNA:duplication:intron:IVS4?-?+27 (human) human gene in rat model DNA:repeats:intron
CTD RGD
PMID:10510054 PMID:10531147 PMID:11903359 PMID:12362496 PMID:16337503 PMID:17637430 PMID:22012955 PMID:28980197 PMID:29311930 More...
RGD:13450930 RGD:13503346 RGD:1580283 RGD:1580284 RGD:5128481 RGD:7771561 RGD:7771563
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Npm1
nucleophosmin 1
ISO
protein:increased expression:cardiomyocyte:
RGD
PMID:21444791
RGD:11535018
NCBI chrNW_004955408:24,151,070...24,218,783
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Nppa
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism|therapeutic DNA:snp:cds:c.2238T>C (human)
CTD RGD
PMID:9527094 PMID:11743230 PMID:12514664 PMID:16087130
RGD:1579982 RGD:1580000
NCBI chrNW_004955486:2,061,196...2,062,805
Ensembl chrNW_004955486:2,060,735...2,063,003
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Nppb
natriuretic peptide B
ISO
RGD
PMID:17256064 PMID:17639095 PMID:19858735
RGD:1642266 RGD:2324680 RGD:7247724
NCBI chrNW_004955486:2,054,775...2,056,130
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Npr1
natriuretic peptide receptor 1
susceptibility
ISO
DNA:missense mutation:cds:p.M341I (human)
RGD
PMID:14646971
RGD:1580174
NCBI chrNW_004955545:323,386...338,654
Ensembl chrNW_004955545:323,956...338,097
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Nr1h3
nuclear receptor subfamily 1 group H member 3
susceptibility
ISO
DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)
RGD
PMID:21903943
RGD:401842365
NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049
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Nr3c2
nuclear receptor subfamily 3 group C member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16413583 PMID:17587755
NCBI chrNW_004955471:3,059,210...3,397,894
Ensembl chrNW_004955471:3,061,735...3,395,520
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Nrg1
neuregulin 1
treatment
ISO
RGD
PMID:24200746 PMID:26892146 PMID:27993643
RGD:10449026 RGD:11522702 RGD:405145704
NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116
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Nrip1
nuclear receptor interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22503866
NCBI chrNW_004955407:16,740,253...16,820,297
Ensembl chrNW_004955407:16,740,253...16,820,297
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Opa1
OPA1 mitochondrial dynamin like GTPase
treatment
ISO
RGD
PMID:20886221
RGD:12738232
NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081
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Oprd1
opioid receptor delta 1
ISO
RGD
PMID:12798419 PMID:15076225
RGD:2316587 RGD:9831425
NCBI chrNW_004955452:7,866,790...7,913,399
Ensembl chrNW_004955452:7,866,758...7,913,399
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Oprk1
opioid receptor kappa 1
ISO
RGD
PMID:15076225
RGD:9831425
NCBI chrNW_004955454:12,741,577...12,751,282
Ensembl chrNW_004955454:12,744,765...12,752,226
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P2ry12
purinergic receptor P2Y12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19334620
NCBI chrNW_004955448:2,442,368...2,488,567
Ensembl chrNW_004955448:2,442,368...2,488,567
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Pappa
pappalysin 1
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:intron
CTD RGD
PMID:11586954 PMID:17700210
RGD:1642324
NCBI chrNW_004955419:11,415,666...11,645,994
Ensembl chrNW_004955419:11,420,638...11,646,145
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Parp1
poly(ADP-ribose) polymerase 1
ISO
protein:altered processing:left ventricle (mouse)
RGD
PMID:21282286
RGD:5684012
NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
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Pcsk2
proprotein convertase subtilisin/kexin type 2
ISO
DNA:SNP:intron: (rs6080699) (human)
RGD
PMID:20036365
RGD:6483554
NCBI chrNW_004955415:26,266,513...26,496,905
Ensembl chrNW_004955415:26,266,484...26,497,001
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Pde3a
phosphodiesterase 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19027736
NCBI chrNW_004955413:16,340,827...16,642,731
Ensembl chrNW_004955413:16,340,918...16,643,214
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Pde5a
phosphodiesterase 5A
ISO
RGD
PMID:17339532
RGD:2314468
NCBI chrNW_004955428:20,785,497...20,904,717
Ensembl chrNW_004955428:20,785,423...20,904,717
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Pdgfd
platelet derived growth factor D
ISO
mRNA,protein:altered expression:myocardium:
RGD
PMID:21767547
RGD:9854703
NCBI chrNW_004955412:6,868,995...7,093,353
Ensembl chrNW_004955412:6,866,869...7,093,998
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Pebp1
phosphatidylethanolamine binding protein 1
ISO
protein:decreased expression:right heart ventricle, ventricular septum
RGD
PMID:17089028
RGD:2302667
NCBI chrNW_004955455:13,217,012...13,222,370
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Pecam1
platelet and endothelial cell adhesion molecule 1
onset no_association
ISO
DNA:missense mutation:cds:p.R643G (human) DNA:polymorphisms: :p.N563S, p.G670R (human) DNA:missense mutations:cds:p.L125V, p.S563N (human)
RGD
PMID:11795274 PMID:15265022 PMID:15488875
RGD:1581009 RGD:2311656 RGD:6771224
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Pgf
placental growth factor
ISO
RGD
PMID:20649603 PMID:21329947 PMID:22114497
RGD:6483584 RGD:6483773 RGD:6483777
NCBI chrNW_004955523:616,196...627,055
Ensembl chrNW_004955523:616,154...627,713
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Phactr1
phosphatase and actin regulator 1
susceptibility severity no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:multiple (human) DNA:SNP:intron:(rs12526453) (human) DNA:SNP:intron: (rs9369640) (human) DNA:SNPs:intron 3: (rs9349379, rs2026458, rs2876300) (human) mRNA:increased expression:peripheral blood mononuclear cells (human) DNA:SNP:intron:g.13035530G>C (rs12526453) (human) mRNA, protein:decreased expression:heart left ventricle (rat)
CTD RGD
PMID:19198609 PMID:25738804 PMID:25838425 PMID:26086777 PMID:26098115 PMID:33460763 More...
RGD:11052493 RGD:11052994 RGD:11053274 RGD:11056926 RGD:401851907 RGD:401900171
NCBI chrNW_004955465:1,395,418...1,915,820
Ensembl chrNW_004955465:1,395,088...1,913,847
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Phlda3
pleckstrin homology like domain family A member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34351043
NCBI chrNW_004955406:37,579,006...37,582,230
Ensembl chrNW_004955406:37,579,006...37,582,230
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:20056919
RGD:6482688
NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
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Pla2g7
phospholipase A2 group VII
ISO
protein:decreased expression:serum
RGD
PMID:19644070
RGD:6482786
NCBI chrNW_004955437:11,534,251...11,577,942
Ensembl chrNW_004955437:11,534,173...11,555,996
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Plat
plasminogen activator, tissue type
treatment
ISO
CTD Direct Evidence: therapeutic DNA:snp:enhancer:g.-7351C>T (human)
CTD RGD
PMID:1430592 PMID:1492007 PMID:1898952 PMID:1899364 PMID:1900011 PMID:2104561 PMID:2105625 PMID:2494454 PMID:2505604 PMID:2521976 PMID:3089627 PMID:3121335 PMID:7488445 PMID:7723950 PMID:7775709 PMID:7902905 PMID:7994806 PMID:8328192 PMID:8554022 PMID:8598594 PMID:9183334 PMID:10171637 PMID:10505926 PMID:10645301 PMID:10914357 PMID:11382373 PMID:11489769 PMID:11848437 PMID:12074692 PMID:12227717 PMID:12848087 PMID:15215796 PMID:15301905 PMID:18195371 PMID:19341228 PMID:20122609 More...
RGD:11541077 RGD:1580881
NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
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Plau
plasminogen activator, urokinase
ISO
mRNA, protein:increased expression:myocardium CTD Direct Evidence: marker/mechanism|therapeutic DNA:SNP:3' utr:c.*141C>T (rs4065) (human)
RGD CTD
PMID:1908371 PMID:2174952 PMID:2382605 PMID:3068399 PMID:3984876 PMID:8416330 PMID:17653104 PMID:20518747 PMID:20952728 More...
RGD:6484126 RGD:6484133 RGD:6484145
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Plaur
plasminogen activator, urokinase receptor
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:12393744 PMID:20952728
RGD:1580897 RGD:6484133
NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324
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Plcb1
phospholipase C beta 1
ISO
protein:increased expression:heart
RGD
PMID:9521338
RGD:2314514
NCBI chrNW_004955415:18,210,608...18,915,099
Ensembl chrNW_004955415:18,210,662...18,915,158
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Plcb3
phospholipase C beta 3
ISO
protein:increased expression:heart
RGD
PMID:9521338
RGD:2314514
NCBI chrNW_004955422:20,810,871...20,827,267
Ensembl chrNW_004955422:20,810,544...20,827,267
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Pln
phospholamban
treatment
ISO
protein:decreased expression:heart left ventricle (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16026515 PMID:16162791 PMID:23781262 PMID:26067684
RGD:11097969 RGD:7327176
NCBI chrNW_004955436:1,439,098...1,447,070
Ensembl chrNW_004955436:1,439,098...1,447,070
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Pon1
paraoxonase 1
ISO
RGD
PMID:10610741 PMID:10978258
RGD:1580198 RGD:1580202
NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
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Postn
periostin
ISO
protein:increased expression:heart:
RGD
PMID:24212842
RGD:10041024
NCBI chrNW_004955431:8,510,646...8,544,901
Ensembl chrNW_004955431:8,510,624...8,544,971
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Ppara
peroxisome proliferator activated receptor alpha
ISO
DNA:SNP:intron:rs4253623, minor allele associated with increased risk
RGD
PMID:18549840
RGD:5562819
NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
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Ppargc1a
PPARG coactivator 1 alpha
ISO
protein:decreased expression:heart (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:22087236 PMID:22503866
RGD:6484266 RGD:7242181
NCBI chrNW_004955480:543,397...1,188,376
Ensembl chrNW_004955480:1,078,322...1,188,435
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Prkce
protein kinase C epsilon
ISO
CTD Direct Evidence: therapeutic RNA:decreased expression:myocardium:
CTD RGD
PMID:16782078 PMID:28887629
RGD:155882580
NCBI chrNW_004955441:12,642,703...13,142,396
Ensembl chrNW_004955441:12,642,697...13,139,372
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Prkd1
protein kinase D1
treatment
ISO
RGD
PMID:26064267
RGD:289474908
NCBI chrNW_004955409:30,554,095...30,860,588
Ensembl chrNW_004955409:30,554,013...30,860,649
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
ISO
RGD
PMID:10936861
RGD:11100014
NCBI chrNW_004955459:3,097,229...3,105,566
Ensembl chrNW_004955459:3,094,120...3,104,135
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Psma6
proteasome 20S subunit alpha 6
susceptibility
ISO
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
OMIM ClinVar
PMID:16845397 PMID:19282875 PMID:25741868
NCBI chrNW_004955409:25,751,578...25,787,533
Ensembl chrNW_004955409:25,750,270...25,787,533
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Ptgis
prostaglandin I2 synthase
susceptibility
ISO
DNA:SNP::1117C>A (human) DNA:silent mutation:exon 8:1117C>A (human) DNA:SNP:CDS: (rs5629) (human)
RGD
PMID:12040339 PMID:19040046 PMID:19046748 PMID:19327107
RGD:2313891 RGD:401901147 RGD:401901155 RGD:401901268
NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:15138244
RGD:1581289
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Ptn
pleiotrophin
ISO
protein:increased expression:myocardium (rat)
RGD
PMID:17925408
RGD:10044023
NCBI chrNW_004955494:5,580,264...5,681,848
Ensembl chrNW_004955494:5,580,422...5,684,190
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Rad50
RAD50 double strand break repair protein
treatment
ISO
RGD
PMID:15623426
RGD:9831390
NCBI chrNW_004955408:3,953,801...4,035,494
Ensembl chrNW_004955408:3,953,800...4,035,494
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Ranbp1
RAN binding protein 1
ISO
protein:decreased expression:heart ventricle, cytoplasm (rat)
RGD
PMID:25341891
RGD:9835001
NCBI chrNW_004955442:17,985,456...17,992,945
Ensembl chrNW_004955442:17,985,544...17,992,759
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Rbp4
retinol binding protein 4
ISO
protein:increased expression:blood serum (human)
RGD
PMID:25142320
RGD:329845867
NCBI chrNW_004955507:112,342...120,050
Ensembl chrNW_004955507:108,669...120,584
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Ren
renin
susceptibility
ISO
associated with Hypertension; protein:increased activity:plasma (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:1668233 PMID:1759997
RGD:6892687
NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286
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Retn
resistin
ISO
protein:increased expression:plasma
RGD
PMID:18997620
RGD:7207152
NCBI chrNW_004955563:1,607,814...1,609,273
Ensembl chrNW_004955563:1,607,814...1,609,273
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Rps6kb1
ribosomal protein S6 kinase B1
ISO
protein:increased threonine phosphorylation:heart left ventricle
RGD
PMID:16540832
RGD:1642998
NCBI chrNW_004955451:3,181,085...3,225,610
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Ryr1
ryanodine receptor 1
ISO
protein:hyperphosphorylation:extensor digitorum longus:
RGD
PMID:12824280
RGD:329813076
NCBI chrNW_004955468:879,807...1,000,118
Ensembl chrNW_004955468:879,951...1,000,036
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S100b
S100 calcium binding protein B
ISO
mRNA, protein:increased expression:left ventricle myocardium, plasma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9788975 PMID:19910580
RGD:2325647
NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510
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Sdc1
syndecan 1
ISO
mRNA:increased expression:myocardium
RGD
PMID:9237025
RGD:2311712
NCBI chrNW_004955469:2,762,696...2,773,697
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Sdc4
syndecan 4
ISO
protein:increased expression:plasma
RGD
PMID:11372670
RGD:2312328
NCBI chrNW_004955445:11,990,916...12,009,178
Ensembl chrNW_004955445:11,990,792...12,011,553
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Sell
selectin L
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10070497
NCBI chrNW_004955462:7,591,997...7,611,408
Ensembl chrNW_004955462:7,591,366...7,612,846
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Selp
selectin P
susceptibility
ISO
protein:increased expression:serum associated with Hypertension;protein:increased expression:plasma DNA:polymorphisms, haplotypes:cds:p.S290N, p.N562D, p.T715P (human)
RGD
PMID:12165563 PMID:17391113 PMID:21162967 PMID:21567088
RGD:1580075 RGD:2312304 RGD:6218991 RGD:6219003
NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:deletion:promoter:g.-676_-674delG (human)
RGD
PMID:12477941 PMID:16053971
RGD:1626626 RGD:8547882
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Sfrp2
secreted frizzled related protein 2
ISO
RGD
PMID:19079247 PMID:19109969
RGD:155883169 RGD:4107088
NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321
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Sh2b3
SH2B adaptor protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chrNW_004955482:8,079,905...8,100,791
Ensembl chrNW_004955482:8,096,160...8,097,765
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Shh
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:20052412
RGD:12879408
NCBI chrNW_004955491:8,647,133...8,657,381
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Sirt1
sirtuin 1
ISO
protein:altered localization:nucleus
RGD
PMID:20089851
RGD:2316169
NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
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Sirt3
sirtuin 3
treatment
ISO
RGD
PMID:24471974
RGD:9586050
NCBI chrNW_004955476:11,794,951...11,826,244
Ensembl chrNW_004955476:11,794,951...11,826,237
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Slc27a1
solute carrier family 27 member 1
ISO
protein:decreased expression:infarcted heart
RGD
PMID:17034771
RGD:1642800
NCBI chrNW_004955524:803,793...821,920
Ensembl chrNW_004955524:805,014...821,838
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Slc27a6
solute carrier family 27 member 6
ISO
protein:decreased expression:heart
RGD
PMID:17034771
RGD:1642800
NCBI chrNW_004955415:1,973,308...2,041,800
Ensembl chrNW_004955415:1,973,308...2,041,866
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Smad2
SMAD family member 2
treatment ameliorates
ISO
RGD
PMID:11087260 PMID:33409963
RGD:12903276 RGD:401794430
NCBI chrNW_004955402:33,131,760...33,217,144
Ensembl chrNW_004955402:33,136,778...33,216,844
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Smad3
SMAD family member 3
ameliorates
ISO
RGD
PMID:33409963
RGD:401794430
NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136
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Smad4
SMAD family member 4
treatment
ISO
RGD
PMID:11087260
RGD:12903276
NCBI chrNW_004955402:35,956,080...36,001,746
Ensembl chrNW_004955402:35,961,165...35,994,538
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Socs1
suppressor of cytokine signaling 1
ISO
protein:increased expression:heart
RGD
PMID:16377761
RGD:2298918
NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109
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Sod1
superoxide dismutase 1
treatment
ISO
CTD Direct Evidence: therapeutic human gene in a rat model
RGD CTD
PMID:11864929 PMID:21600015 PMID:22006090
RGD:1581222 RGD:8655953
NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:2313102 PMID:9250167 PMID:12160945 PMID:14575298
RGD:1580839 RGD:1580840 RGD:1581148
NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
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Sod3
superoxide dismutase 3
ISO
RGD
PMID:14592844
RGD:1580841
NCBI chrNW_004955480:257,716...263,149
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Sparc
secreted protein acidic and cysteine rich
ISO
mRNA:increased expression:heart
RGD
PMID:12826287
RGD:2300056
NCBI chrNW_004955408:6,100,123...6,122,460
Ensembl chrNW_004955408:6,099,003...6,122,459
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Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:12939547 PMID:14500723
RGD:1581325 RGD:1581386
NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016
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Srsf1
serine and arginine rich splicing factor 1
treatment
ISO
protein:increased phosphorylation:heart left ventricle(rat)
RGD
PMID:26067684
RGD:11097969
NCBI chrNW_004955451:4,992,634...4,996,619
Ensembl chrNW_004955451:4,992,634...4,999,029
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Tbx3
T-box transcription factor 3
ISO
RGD
PMID:19341743
RGD:5132891
NCBI chrNW_004955455:15,988,153...16,000,156
Ensembl chrNW_004955455:15,988,663...16,000,063
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Tbx5
T-box transcription factor 5
treatment
ISO
RGD
PMID:23948075
RGD:7327215
NCBI chrNW_004955455:16,133,130...16,217,894
Ensembl chrNW_004955455:16,132,975...16,217,953
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Tek
TEK receptor tyrosine kinase
ISO
protein:increased expression:ventricle myocardium
RGD
PMID:16714360
RGD:1601493
NCBI chrNW_004955472:7,633,790...7,748,130
Ensembl chrNW_004955472:7,633,721...7,748,386
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Tfpi
tissue factor pathway inhibitor
treatment
ISO
mRNA,protein:increased expression:heart:
RGD
PMID:14656922 PMID:15630488 PMID:21229253
RGD:11060131 RGD:11060139 RGD:11062083
NCBI chrNW_004955403:10,925,155...11,004,229
Ensembl chrNW_004955403:10,924,893...11,004,284
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Tgfb1
transforming growth factor beta 1
susceptibility
ISO
CTD Direct Evidence: marker/mechanism associated with Coronary Disease;DNA:polymorphism:promoter:-509C>T (human) mRNA,protein:increased expression:heart:
CTD RGD
PMID:16310260 PMID:16543493 PMID:27121011
RGD:11073666 RGD:1601560
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Tgfb2
transforming growth factor beta 2
ISO
RGD
PMID:14575314
RGD:2302107
NCBI chrNW_004955406:174,949...249,248
Ensembl chrNW_004955406:172,814...249,248
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Tgfbr1
transforming growth factor beta receptor 1
ISO
RGD
PMID:10198196
RGD:1601617
NCBI chrNW_004955419:26,490,899...26,546,349
Ensembl chrNW_004955419:26,490,899...26,547,017
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Tgfbr2
transforming growth factor beta receptor 2
ISO
protein:increased expression:myocardium
RGD
PMID:10198196
RGD:1601617
NCBI chrNW_004955430:21,919,338...21,999,688
Ensembl chrNW_004955430:21,932,553...22,001,837
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Th
tyrosine hydroxylase
no_association
ISO
DNA:polymorphism:intron:g.1170_1173dupTCAT (human)
RGD
PMID:16139102
RGD:1580048
NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137
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Thbd
thrombomodulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9843165 PMID:10627464
NCBI chrNW_004955415:30,222,830...30,226,406
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Thbs1
thrombospondin 1
ISO
mRNA, protein:increased expression:myocardium
RGD
PMID:16179730
RGD:2317960
NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419
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Timp2
TIMP metallopeptidase inhibitor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004955506:3,769,113...3,812,896
Ensembl chrNW_004955506:3,768,646...3,813,820
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Tlr4
toll like receptor 4
ISO
DNA:SNP:intron:rs1927911, minor allele associated with decreased risk
RGD
PMID:15864121 PMID:18549840
RGD:1580734 RGD:5562819
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tm6sf2
transmembrane 6 superfamily member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24633158
NCBI chrNW_004955524:2,586,201...2,593,123
Ensembl chrNW_004955524:2,585,797...2,593,105
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Tnc
tenascin C
ISO
protein:increased expression:heart, fibroblast
RGD
PMID:11454990
RGD:4889618
NCBI chrNW_004955419:12,569,620...12,662,897
Ensembl chrNW_004955419:12,569,547...12,662,958
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Tnf
tumor necrosis factor
ISO
mRNA, protein:increased expression:left ventricle myocardium, plasma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15883752 PMID:16310260 PMID:21362018
RGD:5130892
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfrsf11b
TNF receptor superfamily member 11b
ISO
RGD
PMID:15926884
RGD:1620893
NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894
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Tnfrsf12a
TNF receptor superfamily member 12A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20082609
NCBI chrNW_004955442:14,320,159...14,322,146
Ensembl chrNW_004955442:14,320,159...14,322,146
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Tnfrsf14
TNF receptor superfamily member 14
ISO
protein:increased expression:heart, cardiomyocyte, endothelial cell (rat)
RGD
PMID:18353719
RGD:2317281
NCBI chrNW_004955486:8,670,182...8,684,677
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
mRNA, protein:increased expression:left ventricle myocardium (rat)
RGD
PMID:15117889 PMID:20651834 PMID:21362018
RGD:1624194 RGD:5130892 RGD:5130975
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
mRNA, protein:decreased expression:left ventricle myocardium (rat)
RGD
PMID:21362018
RGD:5130892
NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
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Tnfsf11
TNF superfamily member 11
ISO
protein:increased expression:serum
RGD
PMID:18298349
RGD:2302363
NCBI chrNW_004955518:431,401...462,063
Ensembl chrNW_004955518:430,642...462,705
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Tnfsf4
TNF superfamily member 4
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
OMIM RGD CTD
PMID:15750594
RGD:1580396
NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309
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Tnni3
troponin I3, cardiac type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12359538
NCBI chrNW_004955567:1,037,325...1,042,102
Ensembl chrNW_004955567:1,037,462...1,042,039
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Tnnt2
troponin T2, cardiac type
ISO
RGD
PMID:15226628
RGD:1580441
NCBI chrNW_004955406:37,491,462...37,507,360
Ensembl chrNW_004955406:37,487,154...37,507,639
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Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24358288
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
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Trpv1
transient receptor potential cation channel subfamily V member 1
ISO
RGD
PMID:27671317
RGD:13792689
NCBI chrNW_004955467:13,221,391...13,239,089
Ensembl chrNW_004955467:13,221,391...13,239,089
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Ttn
titin
ISO
RGD
PMID:12221049
RGD:1580780
NCBI chrNW_004955403:18,057,344...18,328,389
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Txnrd1
thioredoxin reductase 1
ISO
mRNA:decreased expression:heart left ventricle (rat)
RGD
PMID:18515646
RGD:5134341
NCBI chrNW_004955405:38,863,762...38,928,615
Ensembl chrNW_004955405:38,903,918...38,927,410
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Ubd
ubiquitin D
ISO
mRNA, protein; increased expression; myocardium (rat)
RGD
PMID:29438664
RGD:126925221
NCBI chrNW_004955583:29,438...29,873
Ensembl chrNW_004955583:29,438...31,555
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Uts2
urotensin 2
ISO
associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle
RGD
PMID:15549273
RGD:2306846
NCBI chrNW_004955486:5,052,045...5,056,610
Ensembl chrNW_004955486:5,052,045...5,056,610
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Uts2r
urotensin 2 receptor
ISO
associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle
RGD
PMID:15549273
RGD:2306846
NCBI chrNW_004955506:756,859...761,891
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Vcan
versican
ISO
RGD
PMID:16311904
RGD:1598497
NCBI chrNW_004955418:26,967,595...27,078,430
G
Vdac1
voltage dependent anion channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25488258
NCBI chrNW_004955408:5,260,444...5,275,972
Ensembl chrNW_004955408:5,260,353...5,275,990
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Vdac2
voltage dependent anion channel 2
treatment
ISO
RGD
PMID:20601275
RGD:10003049
NCBI chrNW_004955437:16,857,715...16,871,717
Ensembl chrNW_004955437:16,853,433...16,872,345
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Vegfa
vascular endothelial growth factor A
treatment
ISO
protein:increased expression:serum,platelet:
RGD
PMID:10652191 PMID:25936512
RGD:126925214 RGD:7483604
NCBI chrNW_004955437:9,527,445...9,541,908
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Vegfb
vascular endothelial growth factor B
ISO
RGD
PMID:17975666
RGD:2314324
NCBI chrNW_004955422:20,840,055...20,843,182
Ensembl chrNW_004955422:20,840,055...20,843,225
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Vwf
von Willebrand factor
ISO
protein:increased expression:heart:
RGD
PMID:19435557
RGD:11080745
NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571
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Wdr12
WD repeat domain 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198609 PMID:25915632
NCBI chrNW_004955457:11,947,816...11,970,066
Ensembl chrNW_004955457:11,947,915...11,971,805
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Wrn
WRN RecQ like helicase
ISO
RGD
PMID:9021029
RGD:1580821
NCBI chrNW_004955463:7,495,243...7,633,532
Ensembl chrNW_004955463:7,525,100...7,633,596
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Xrcc3
X-ray repair cross complementing 3
susceptibility
ISO
DNA:polymorphism:: (human)
RGD
PMID:18712175
RGD:401827276
NCBI chrNW_004955538:2,499,297...2,511,898
Ensembl chrNW_004955538:2,501,607...2,509,778
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Zeb2
zinc finger E-box binding homeobox 2
ISO
protein:increased expression:heart (rat)
RGD
PMID:24155330
RGD:155882536
NCBI chrNW_004955440:10,755,658...10,881,044
Ensembl chrNW_004955440:10,756,014...10,795,491
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16317512
NCBI chrNW_004955482:7,233,336...7,295,754
Ensembl chrNW_004955482:7,233,336...7,295,754
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11927517
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Pln
phospholamban
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16317512
NCBI chrNW_004955436:1,439,098...1,447,070
Ensembl chrNW_004955436:1,439,098...1,447,070
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11927517
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Cdh5
cadherin 5
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004955433:22,957,718...22,994,515
Ensembl chrNW_004955433:22,967,960...22,992,924
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Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449
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Jup
junction plakoglobin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16824628
NCBI chrNW_004955451:15,993,055...16,004,152
Ensembl chrNW_004955451:15,989,180...16,004,155
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:plasma
RGD
PMID:9415270
RGD:8547713
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Kcnj8
potassium inwardly rectifying channel subfamily J member 8
ISO
RGD
PMID:11984590
RGD:1581700
NCBI chrNW_004955413:17,364,447...17,371,255
Ensembl chrNW_004955413:17,364,213...17,371,255
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Abcb1
ATP binding cassette subfamily B member 1
treatment
ISO
DNA:SNPs: :rs1045642,rs7779562(human)
RGD
PMID:25217066
RGD:14700903
NCBI chrNW_004955432:4,911,774...5,085,349
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Atp5mc2
ATP synthase membrane subunit c locus 2
severity
ISO
RGD
PMID:27441480
RGD:14696800
NCBI chrNW_004955458:952,817...960,963
Ensembl chrNW_004955458:952,817...959,962
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Ccn1
cellular communication network factor 1
sexual_dimorphism
ISO
protein:increased expression:blood serum (human)
RGD
PMID:34597881
RGD:329845519
NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166
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Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29769800
NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all