Fgfr1 (fibroblast growth factor receptor 1) - Rat Genome Database

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Gene: Fgfr1 (fibroblast growth factor receptor 1) Chinchilla lanigera
Analyze
Symbol: Fgfr1
Name: fibroblast growth factor receptor 1
RGD ID: 8760138
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); fibroblast growth factor binding (ortholog); fibroblast growth factor-activated receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); auditory receptor cell development (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acrocephalosyndactylia (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acrocephalosyndactylia  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
Alzheimer's disease  (ISO)
atypical chronic myeloid leukemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
cerebellar hypoplasia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Congenital Foot Deformities  (ISO)
Craniofacial Abnormalities  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Delayed Puberty  (ISO)
demyelinating disease  (ISO)
disease of cellular proliferation  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
Femoral Fractures  (ISO)
fibrolamellar carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Head Injuries, Penetrating  (ISO)
heart valve disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
holoprosencephaly  (ISO)
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/Palate  (ISO)
Hypoglossal Nerve Injuries  (ISO)
hypogonadotropic hypogonadism 2 with or without anosmia  (ISO)
hypogonadotropic hypogonadism 7 with or without anosmia  (ISO)
Hypogonadotropic Hypogonadism and Anosmia, Autosomal Dominant  (ISO)
infertility  (ISO)
Jackson-Weiss syndrome  (ISO)
Kallmann syndrome  (ISO)
Limb Ischemia  (ISO)
Liver Metastasis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
medulloblastoma  (ISO)
mental depression  (ISO)
mesangial proliferative glomerulonephritis  (ISO)
mouth disease  (ISO)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Nonsyndromic Trigonocephaly  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoglophonic dysplasia  (ISO)
Pfeiffer syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
retinal detachment  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
squamous cell carcinoma  (ISO)
Stargardt Disease 3  (ISO)
T-Cell Lymphoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Trigonocephaly 1  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (ISO)
umbilical hernia  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
auditory receptor cell development  (ISO)
blood vessel morphogenesis  (ISO)
brain development  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell maturation  (ISO)
cellular response to histamine  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
central nervous system neuron development  (ISO)
chondrocyte differentiation  (ISO)
ear development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO)
female pregnancy  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (ISO)
generation of neurons  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung-associated mesenchyme development  (ISO)
mesenchymal cell differentiation  (ISO)
midbrain development  (ISO)
middle ear morphogenesis  (ISO)
motogenic signaling involved in postnatal olfactory bulb interneuron migration  (ISO)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron projection development  (ISO)
orbitofrontal cortex development  (ISO)
organ induction  (ISO)
outer ear morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic cell cycle DNA replication  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of parathyroid hormone secretion  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
protein autophosphorylation  (ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of cell population proliferation  (ISO)
regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
regulation of gene expression  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of phosphate transport  (ISO)
regulation of phosphorus metabolic process  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of stem cell proliferation  (ISO)
response to ischemia  (ISO)
response to nutrient levels  (ISO)
salivary gland morphogenesis  (ISO)
sensory perception of sound  (ISO)
stem cell population maintenance  (ISO)
ureteric bud development  (ISO)
ventricular zone neuroblast division  (ISO)
vitamin D3 metabolic process  (ISO)
wound healing  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Fgfr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBIChiLan1.0ChiLan1.0
FGFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl838,400,215 - 38,468,834 (-)EnsemblGRCh38hg38GRCh38
GRCh38838,411,143 - 38,468,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37838,268,661 - 38,326,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,387,813 - 38,445,509 (-)NCBINCBI36hg18NCBI36
Build 34838,389,448 - 38,445,293NCBI
Celera837,221,633 - 37,279,334 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,802,638 - 36,860,684 (-)NCBIHuRef
CHM1_1838,470,562 - 38,528,261 (-)NCBICHM1_1
Fgfr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,008,775 - 26,065,734 (+)NCBIGRCm39mm39
GRCm39 Ensembl826,003,670 - 26,065,734 (+)Ensembl
GRCm38825,518,759 - 25,575,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,513,654 - 25,575,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,629,244 - 26,686,186 (+)NCBIGRCm37mm9NCBIm37
MGSCv36826,997,826 - 27,039,466 (+)NCBImm8
Celera826,986,822 - 27,044,074 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.12NCBI
Fgfr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21666,492,445 - 66,546,731 (-)NCBI
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Celera1664,402,647 - 64,442,189 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
FGFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1834,890,147 - 34,948,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,890,147 - 34,948,904 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0837,713,133 - 37,773,098 (-)NCBIMhudiblu_PPA_v0panPan3
FGFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,029,902 - 27,080,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,031,588 - 27,078,261 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,547,259 - 27,597,845 (+)NCBI
ROS_Cfam_1.01628,928,146 - 28,978,790 (+)NCBI
UMICH_Zoey_3.11627,151,667 - 27,202,222 (+)NCBI
UNSW_CanFamBas_1.01627,728,739 - 27,779,306 (+)NCBI
UU_Cfam_GSD_1.01627,767,626 - 27,818,261 (+)NCBI
Fgfr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,645,976 - 49,698,868 (+)NCBI
SpeTri2.0NW_0049367101,760,365 - 1,815,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,053,340 - 48,106,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,053,895 - 48,106,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,216,111 - 55,269,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,426,116 - 36,485,683 (-)NCBI
ChlSab1.1 Ensembl836,427,110 - 36,485,508 (-)Ensembl
Vero_WHO_p1.0NW_0236660525,502,205 - 5,561,763 (+)NCBI
Fgfr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,161,245 - 5,212,641 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000003407   ⟹   ENSCLAP00000003340
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003408   ⟹   ENSCLAP00000003341
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,042 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003409   ⟹   ENSCLAP00000003342
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546314,015,341 - 14,054,924 (-)Ensembl
RefSeq Acc Id: XM_005398449   ⟹   XP_005398506
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,044 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521506   ⟹   XP_013376960
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,044 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521508   ⟹   XP_013376962
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,045 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521509   ⟹   XP_013376963
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521510   ⟹   XP_013376964
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521511   ⟹   XP_013376965
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521512   ⟹   XP_013376966
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005398506   ⟸   XM_005398449
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013376966   ⟸   XM_013521512
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013376965   ⟸   XM_013521511
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013376962   ⟸   XM_013521508
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013376960   ⟸   XM_013521506
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013376964   ⟸   XM_013521510
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013376963   ⟸   XM_013521509
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSCLAP00000003342   ⟸   ENSCLAT00000003409
RefSeq Acc Id: ENSCLAP00000003340   ⟸   ENSCLAT00000003407
RefSeq Acc Id: ENSCLAP00000003341   ⟸   ENSCLAT00000003408


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002395 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000003340 ENTREZGENE
  ENSCLAP00000003341 ENTREZGENE
  ENSCLAP00000003342 ENTREZGENE
Ensembl Transcript ENSCLAT00000003407 ENTREZGENE
  ENSCLAT00000003408 ENTREZGENE
  ENSCLAT00000003409 ENTREZGENE
NCBI Gene Fgfr1 ENTREZGENE