Lrp6 (LDL receptor related protein 6) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lrp6 (LDL receptor related protein 6) Chinchilla lanigera
Analyze
Symbol: Lrp6
Name: LDL receptor related protein 6
RGD ID: 8871925
Description: ENCODES a protein that exhibits apolipoprotein binding (ortholog); coreceptor activity involved in Wnt signaling pathway (ortholog); frizzled binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); axis elongation (ortholog); axis elongation involved in somitogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Coronary Artery Disease, Autosomal Dominant 2 (ortholog); Experimental Liver Cirrhosis (ortholog); Germ Cell and Embryonal Neoplasms (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,080,914 - 9,237,650 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,080,901 - 9,237,644 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
axis elongation  (ISO)
axis elongation involved in somitogenesis  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development  (ISO)
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  (ISO)
cell migration involved in gastrulation  (ISO)
cell-cell adhesion  (ISO)
cellular response to cholesterol  (ISO)
cerebellum morphogenesis  (ISO)
cerebral cortex cell migration  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (ISO)
convergent extension  (ISO)
dopaminergic neuron differentiation  (ISO)
dorsal/ventral axis specification  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
embryonic pattern specification  (ISO)
embryonic retina morphogenesis in camera-type eye  (ISO)
external genitalia morphogenesis  (ISO)
face morphogenesis  (ISO)
forebrain development  (ISO)
forebrain generation of neurons  (ISO)
forebrain radial glial cell differentiation  (ISO)
formation of radial glial scaffolds  (ISO)
gastrulation with mouth forming second  (ISO)
generation of neurons  (ISO)
heart looping  (ISO)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
mammary placode formation  (ISO)
midbrain development  (ISO)
midbrain-hindbrain boundary development  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of non-canonical Wnt signaling pathway  (ISO)
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  (ISO)
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis  (ISO)
negative regulation of planar cell polarity pathway involved in neural tube closure  (ISO)
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis  (ISO)
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis  (ISO)
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
neural crest cell differentiation  (ISO)
neural crest formation  (ISO)
neural tube closure  (ISO)
neural tube development  (ISO)
Norrin signaling pathway  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
pericardium morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of ossification  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-anal tail morphogenesis  (ISO)
primitive streak formation  (ISO)
protein localization to plasma membrane  (ISO)
receptor-mediated endocytosis involved in cholesterol transport  (ISO)
regulation of cell development  (ISO)
regulation of cell population proliferation  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to folic acid  (ISO)
response to peptide hormone  (ISO)
retina morphogenesis in camera-type eye  (ISO)
roof of mouth development  (ISO)
skeletal system morphogenesis  (ISO)
somitogenesis  (ISO)
thalamus development  (ISO)
trachea cartilage morphogenesis  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway involved in forebrain neuroblast division  (ISO)
Wnt signaling pathway involved in somitogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Lrp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,080,914 - 9,237,650 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,080,901 - 9,237,644 (-)NCBIChiLan1.0ChiLan1.0
LRP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1212,116,025 - 12,267,044 (-)EnsemblGRCh38hg38GRCh38
GRCh381212,116,025 - 12,267,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,268,959 - 12,419,978 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,160,226 - 12,311,078 (-)NCBINCBI36hg18NCBI36
Build 341212,164,957 - 12,311,013NCBI
Celera1217,412,009 - 17,562,835 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,034,207 - 12,184,947 (-)NCBIHuRef
CHM1_11212,234,005 - 12,384,830 (-)NCBICHM1_1
Lrp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,423,439 - 134,543,876 (-)NCBIGRCm39mm39
GRCm39 Ensembl6134,423,439 - 134,543,928 (-)Ensembl
GRCm386134,446,476 - 134,566,913 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,446,476 - 134,566,965 (-)EnsemblGRCm38mm10GRCm38
MGSCv376134,400,434 - 134,516,931 (-)NCBIGRCm37mm9NCBIm37
MGSCv366134,415,902 - 134,532,475 (-)NCBImm8
Celera6137,380,826 - 137,512,292 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.37NCBI
Lrp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24167,266,581 - 167,400,155 (-)NCBI
Rnor_6.0 Ensembl4168,194,927 - 168,323,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04168,194,054 - 168,323,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04232,475,530 - 232,606,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,337,114 - 171,444,932 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14171,582,253 - 171,717,580 (-)NCBI
Celera4155,870,415 - 155,972,673 (-)NCBICelera
Cytogenetic Map4q43NCBI
LRP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11212,508,108 - 12,658,074 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,508,108 - 12,657,973 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01212,121,411 - 12,288,590 (-)NCBIMhudiblu_PPA_v0panPan3
LRP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2734,003,539 - 34,161,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12734,003,334 - 34,166,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365875,065,200 - 5,143,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl560,149,028 - 60,314,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1560,149,041 - 60,318,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2563,564,404 - 63,674,461 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRP6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,016,542 - 12,170,496 (-)NCBI
ChlSab1.1 Ensembl1112,021,560 - 12,170,663 (-)Ensembl
Lrp6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475225,605,444 - 25,756,573 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023578   ⟹   ENSCLAP00000023357
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554139,080,914 - 9,237,650 (-)Ensembl
RefSeq Acc Id: XM_005378957   ⟹   XP_005379014
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554139,080,901 - 9,237,644 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005379014 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005379014   ⟸   XM_005378957
- Sequence:
RefSeq Acc Id: ENSCLAP00000023357   ⟸   ENSCLAT00000023578


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016021 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023357 ENTREZGENE
Ensembl Transcript ENSCLAT00000023578 ENTREZGENE
NCBI Gene Lrp6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Lrp6  LDL receptor related protein 6    low density lipoprotein receptor-related protein 6  Symbol and/or name change 5135510 APPROVED