Gsn (gelsolin) - Rat Genome Database
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Gene: Gsn (gelsolin) Chinchilla lanigera
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Symbol: Gsn
Name: gelsolin
RGD ID: 8767145
Description: ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); myosin II binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament capping (ortholog); actin filament depolymerization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); amyloidosis (ortholog); Brain Injuries (ortholog); FOUND IN actin cap (ortholog); actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: plasma gelsolin
Orthologs:
Homo sapiens (human) : GSN (gelsolin)  HGNC  Alliance
Mus musculus (house mouse) : Gsn (gelsolin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsn (gelsolin)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GSN (gelsolin)
Canis lupus familiaris (dog) : GSN (gelsolin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsn (gelsolin)
Sus scrofa (pig) : GSN (gelsolin)
Chlorocebus sabaeus (African green monkey) : GSN (gelsolin)
Heterocephalus glaber (naked mole-rat) : Gsn (gelsolin)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament capping  (ISO)
actin filament depolymerization  (ISO)
actin filament polymerization  (ISO)
actin filament reorganization  (ISO)
actin filament severing  (ISO)
actin polymerization or depolymerization  (ISO)
aging  (ISO)
amyloid fibril formation  (ISO)
apoptotic process  (ISO)
cardiac muscle cell contraction  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to interferon-gamma  (ISO)
cilium assembly  (ISO)
extracellular matrix disassembly  (ISO)
hepatocyte apoptotic process  (ISO)
negative regulation of viral entry into host cell  (ISO)
oligodendrocyte development  (ISO)
phagocytosis, engulfment  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of actin nucleation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of keratinocyte apoptotic process  (ISO)
positive regulation of protein processing in phagocytic vesicle  (ISO)
protein destabilization  (ISO)
regulation of cell adhesion  (ISO)
regulation of establishment of T cell polarity  (ISO)
regulation of plasma membrane raft polarization  (ISO)
regulation of podosome assembly  (ISO)
regulation of receptor clustering  (ISO)
relaxation of cardiac muscle  (ISO)
renal protein absorption  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to muscle stretch  (ISO)
sequestering of actin monomers  (ISO)
striated muscle atrophy  (ISO)
tissue regeneration  (ISO)
vesicle-mediated transport  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Gsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
GSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9121,207,794 - 121,332,843 (+)EnsemblGRCh38hg38GRCh38
GRCh389121,201,483 - 121,332,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379124,030,380 - 124,095,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
Gsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,146,371 - 35,197,914 (+)NCBI
GRCm38235,256,359 - 35,307,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,256,380 - 35,307,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,137,960 - 35,163,412 (+)NCBIGRCm37mm9NCBIm37
MGSCv36235,104,449 - 35,129,901 (+)NCBImm8
Celera234,977,113 - 35,002,613 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.5NCBI
Gsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
GSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19120,741,148 - 120,805,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,741,148 - 120,805,831 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0992,413,819 - 92,460,483 (+)NCBIMhudiblu_PPA_v0panPan3
GSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,295,713 - 261,385,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1218,253,324 - 18,285,938 (-)Ensembl
ChlSab1.11218,253,079 - 18,317,285 (-)NCBI
Gsn
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476013,943,680 - 14,004,660 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013941   ⟹   ENSCLAP00000013786
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013942   ⟹   ENSCLAP00000013787
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,706,604 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000013943   ⟹   ENSCLAP00000013788
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,682,441 - 6,706,433 (-)Ensembl
RefSeq Acc Id: XM_005382570   ⟹   XP_005382627
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,682,202 - 6,706,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513254   ⟹   XP_013368708
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513255   ⟹   XP_013368709
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382627 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368708 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368709 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS59421 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005382627   ⟸   XM_005382570
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368709   ⟸   XM_013513255
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013368708   ⟸   XM_013513254
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000013786   ⟸   ENSCLAT00000013941
RefSeq Acc Id: ENSCLAP00000013787   ⟸   ENSCLAT00000013942
RefSeq Acc Id: ENSCLAP00000013788   ⟸   ENSCLAT00000013943


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009527 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000013787 ENTREZGENE
  ENSCLAP00000013788 ENTREZGENE
Ensembl Transcript ENSCLAT00000013942 ENTREZGENE
  ENSCLAT00000013943 ENTREZGENE
NCBI Gene Gsn ENTREZGENE