Gsn (gelsolin) - Rat Genome Database

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Gene: Gsn (gelsolin) Ictidomys tridecemlineatus
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Symbol: Gsn
Name: gelsolin
RGD ID: 12518844
Description: ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); myosin II binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament capping (ortholog); actin filament depolymerization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); amyloidosis (ortholog); Brain Injuries (ortholog); FOUND IN actin cap (ortholog); actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: gelsolin, transcript variant X1; gelsolin, transcript variant X2; gelsolin, transcript variant X3; gelsolin, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament capping  (ISO)
actin filament depolymerization  (ISO)
actin filament polymerization  (ISO)
actin filament reorganization  (ISO)
actin filament severing  (ISO)
actin polymerization or depolymerization  (ISO)
aging  (ISO)
amyloid fibril formation  (ISO)
apoptotic process  (ISO)
cardiac muscle cell contraction  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to interferon-gamma  (ISO)
cilium assembly  (ISO)
extracellular matrix disassembly  (ISO)
hepatocyte apoptotic process  (ISO)
negative regulation of viral entry into host cell  (ISO)
oligodendrocyte development  (ISO)
phagocytosis, engulfment  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of actin nucleation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of keratinocyte apoptotic process  (ISO)
positive regulation of protein processing in phagocytic vesicle  (ISO)
protein destabilization  (ISO)
regulation of cell adhesion  (ISO)
regulation of establishment of T cell polarity  (ISO)
regulation of plasma membrane raft polarization  (ISO)
regulation of podosome assembly  (ISO)
regulation of receptor clustering  (ISO)
relaxation of cardiac muscle  (ISO)
renal protein absorption  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to muscle stretch  (ISO)
sequestering of actin monomers  (ISO)
striated muscle atrophy  (ISO)
tissue regeneration  (ISO)
vesicle-mediated transport  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Gsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9121,207,794 - 121,332,843 (+)EnsemblGRCh38hg38GRCh38
GRCh389121,201,483 - 121,332,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,963,761 - 124,095,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
Gsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,146,371 - 35,197,914 (+)NCBIGRCm39mm39
GRCm39 Ensembl235,146,392 - 35,197,904 (+)Ensembl
GRCm38235,256,359 - 35,307,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,256,380 - 35,307,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,137,960 - 35,163,412 (+)NCBIGRCm37mm9NCBIm37
MGSCv36235,104,449 - 35,129,901 (+)NCBImm8
Celera234,977,113 - 35,002,613 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.5NCBI
Gsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2318,585,166 - 18,638,404 (+)NCBI
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
Gsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
GSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19120,741,148 - 120,805,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,741,148 - 120,805,831 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0992,413,819 - 92,460,483 (+)NCBIMhudiblu_PPA_v0panPan3
GSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBI
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBI
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBI
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBI
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBI
GSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,295,713 - 261,385,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,253,079 - 18,317,285 (-)NCBI
ChlSab1.1 Ensembl1218,253,324 - 18,285,938 (-)Ensembl
Vero_WHO_p1.0NW_02366603524,700,374 - 24,764,693 (+)NCBI
Gsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476013,943,680 - 14,004,660 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005320912   ⟹   XP_005320969
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947190,008,514 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,777,019 - 9,802,787 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005320915   ⟹   XP_005320972
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049364879,777,275 - 9,802,779 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005320916   ⟹   XP_005320973
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947189,981,163 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,749,755 - 9,802,779 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021723500   ⟹   XP_021579175
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947189,996,437 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,764,949 - 9,802,779 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040286238   ⟹   XP_040142172
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
RefSeq Acc Id: XM_040286239   ⟹   XP_040142173
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
RefSeq Acc Id: XM_040286240   ⟹   XP_040142174
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947189,981,221 - 190,034,252 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005320973   ⟸   XM_005320916
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005320969   ⟸   XM_005320912
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005320972   ⟸   XM_005320915
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021579175   ⟸   XM_021723500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040142172   ⟸   XM_040286238
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040142173   ⟸   XM_040286239
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040142174   ⟸   XM_040286240
- Peptide Label: isoform X4
Protein Domains
Gelsolin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005409 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000004846 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005416 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Gelsolin UniProtKB/TrEMBL
  Gelsolin-like_dom UniProtKB/TrEMBL
  Villin/Gelsolin UniProtKB/TrEMBL
NCBI Gene Gsn ENTREZGENE
PANTHER PTHR11977 UniProtKB/TrEMBL
  PTHR11977:SF27 UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/TrEMBL
PRINTS GELSOLIN UniProtKB/TrEMBL
SMART GEL UniProtKB/TrEMBL
UniProt I3M611_ICTTR UniProtKB/TrEMBL