GSN (gelsolin) - Rat Genome Database

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Gene: GSN (gelsolin) Canis lupus familiaris
Analyze
Symbol: GSN
Name: gelsolin
RGD ID: 12167877
Description: ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); myosin II binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament capping (ortholog); actin filament depolymerization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); amyloidosis (ortholog); Brain Injuries (ortholog); FOUND IN actin cap (ortholog); actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: gelsolin (amyloidosis, Finnish type); LOC102154209; LOW QUALITY PROTEIN: gelsolin; synapsin-1-like; uncharacterized LOC102154209; uncharacterized protein LOC102154209
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBI
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBI
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBI
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBI
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament capping  (ISO)
actin filament depolymerization  (ISO)
actin filament polymerization  (ISO)
actin filament reorganization  (ISO)
actin filament severing  (ISO)
actin polymerization or depolymerization  (ISO)
aging  (ISO)
amyloid fibril formation  (ISO)
apoptotic process  (ISO)
cardiac muscle cell contraction  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to interferon-gamma  (ISO)
cilium assembly  (ISO)
extracellular matrix disassembly  (ISO)
hepatocyte apoptotic process  (ISO)
negative regulation of viral entry into host cell  (ISO)
oligodendrocyte development  (ISO)
phagocytosis, engulfment  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of actin nucleation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of keratinocyte apoptotic process  (ISO)
positive regulation of protein processing in phagocytic vesicle  (ISO)
protein destabilization  (ISO)
regulation of cell adhesion  (ISO)
regulation of establishment of T cell polarity  (ISO)
regulation of plasma membrane raft polarization  (ISO)
regulation of podosome assembly  (ISO)
regulation of receptor clustering  (ISO)
relaxation of cardiac muscle  (ISO)
renal protein absorption  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to muscle stretch  (ISO)
sequestering of actin monomers  (ISO)
striated muscle atrophy  (ISO)
tissue regeneration  (ISO)
vesicle-mediated transport  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBI
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBI
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBI
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBI
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBI
GSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9121,207,794 - 121,332,843 (+)EnsemblGRCh38hg38GRCh38
GRCh389121,201,483 - 121,332,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,963,761 - 124,095,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
Gsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,146,371 - 35,197,914 (+)NCBIGRCm39mm39
GRCm39 Ensembl235,146,392 - 35,197,904 (+)Ensembl
GRCm38235,256,359 - 35,307,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,256,380 - 35,307,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,137,960 - 35,163,412 (+)NCBIGRCm37mm9NCBIm37
MGSCv36235,104,449 - 35,129,901 (+)NCBImm8
Celera234,977,113 - 35,002,613 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.5NCBI
Gsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2318,585,166 - 18,638,404 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl318,585,172 - 18,638,402 (+)Ensembl
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
Gsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
GSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19120,741,148 - 120,805,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,741,148 - 120,805,831 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0992,413,819 - 92,460,483 (+)NCBIMhudiblu_PPA_v0panPan3
Gsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,295,713 - 261,385,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,253,079 - 18,317,285 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,253,324 - 18,285,938 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603524,700,374 - 24,764,693 (+)NCBIVero_WHO_p1.0
Gsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476013,943,680 - 14,004,660 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 4 1 2
Medium 5 5 21 6 6 6 2 6 12 7 9 4
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022425034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038491125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038491126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038491127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038491128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000005907   ⟹   ENSCAFP00000005471
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1174,248,247 - 74,268,129 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000086601   ⟹   ENSCAFP00000046683
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089578   ⟹   ENSCAFP00000054392
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1174,248,253 - 74,268,129 (+)Ensembl
RefSeq Acc Id: XM_038491125   ⟹   XP_038347053
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11173,892,791 - 73,912,586 (+)NCBI
RefSeq Acc Id: XM_038491126   ⟹   XP_038347054
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11173,892,985 - 73,912,586 (+)NCBI
RefSeq Acc Id: XM_038491127   ⟹   XP_038347055
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBI
RefSeq Acc Id: XM_038491128   ⟹   XP_038347056
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11173,878,098 - 73,912,586 (+)NCBI
RefSeq Acc Id: XM_038553263   ⟹   XP_038409191
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBI
RefSeq Acc Id: XM_038617143   ⟹   XP_038473071
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01173,923,618 - 73,943,469 (+)NCBI
RefSeq Acc Id: XM_038617144   ⟹   XP_038473072
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01173,923,812 - 73,943,469 (+)NCBI
RefSeq Acc Id: XM_038617145   ⟹   XP_038473073
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBI
RefSeq Acc Id: XM_038617146   ⟹   XP_038473074
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01173,908,891 - 73,943,469 (+)NCBI
RefSeq Acc Id: XM_038656237   ⟹   XP_038512165
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1172,659,138 - 72,678,974 (+)NCBI
RefSeq Acc Id: XM_038656246   ⟹   XP_038512174
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1172,659,332 - 72,678,974 (+)NCBI
RefSeq Acc Id: XM_038656255   ⟹   XP_038512183
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBI
RefSeq Acc Id: XM_038656266   ⟹   XP_038512194
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1172,644,406 - 72,678,974 (+)NCBI
RefSeq Acc Id: XM_038682596   ⟹   XP_038538524
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01175,385,821 - 75,405,704 (+)NCBI
RefSeq Acc Id: XM_038682597   ⟹   XP_038538525
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01175,386,015 - 75,405,704 (+)NCBI
RefSeq Acc Id: XM_038682598   ⟹   XP_038538526
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBI
RefSeq Acc Id: XM_038682599   ⟹   XP_038538527
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01175,371,057 - 75,405,704 (+)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000005471   ⟸   ENSCAFT00000005907
RefSeq Acc Id: ENSCAFP00000046683   ⟸   ENSCAFT00000086601
RefSeq Acc Id: ENSCAFP00000054392   ⟸   ENSCAFT00000089578
RefSeq Acc Id: XP_038347055   ⟸   XM_038491127
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038347056   ⟸   XM_038491128
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038347053   ⟸   XM_038491125
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038347054   ⟸   XM_038491126
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038473073   ⟸   XM_038617145
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038473074   ⟸   XM_038617146
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038473071   ⟸   XM_038617143
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038473072   ⟸   XM_038617144
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038538526   ⟸   XM_038682598
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038538527   ⟸   XM_038682599
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038538524   ⟸   XM_038682596
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038538525   ⟸   XM_038682597
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038512183   ⟸   XM_038656255
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038512194   ⟸   XM_038656266
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038512165   ⟸   XM_038656237
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512174   ⟸   XM_038656246
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038409191   ⟸   XM_038553263
- Peptide Label: isoform X1

Promoters
RGD ID:13685319
Promoter ID:EPDNEW_C3386
Type:single initiation site
Name:GSN_1
Description:gelsolin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11174,248,236 - 74,248,296EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003663 Ensembl
NCBI Gene GSN ENTREZGENE
VGNC ID VGNC:41532 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 GSN  gelsolin  LOC102154209  synapsin-1-like  Data Merged 737654 PROVISIONAL
2017-09-12 LOC102154209  synapsin-1-like    uncharacterized LOC102154209  Symbol and/or name change 5135510 APPROVED