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Widespread loss of gelsolin in breast cancers of humans, mice, and rats.

Authors: Asch, HL  Head, K  Dong, Y  Natoli, F  Winston, JS  Connolly, JL  Asch, BB 
Citation: Asch HL, etal., Cancer Res. 1996 Nov 1;56(21):4841-5.
Pubmed: (View Article at PubMed) PMID:8895730

Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and benign, immortalized cell lines. Moreover, actin filaments were usually attenuated coincident with the reduction in gelsolin. Gelsolin was also missing or greatly decreased in 70% of 30 human sporadic, invasive breast carcinomas examined by immunocytochemistry and in 100% of virally induced mouse and chemically induced rat mammary carcinomas evaluated by Northern analysis. Southern analysis revealed no major mutations in the gelsolin gene of human breast cancer cells. Our results show that partial or total loss of gelsolin expression is common to the majority of breast cancers of diverse etiologies in three animal species and point to gelsolin as a candidate suppressor of breast cancer.


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RGD Object Information
RGD ID: 1599869
Created: 2007-02-19
Species: All species
Last Modified: 2007-02-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.