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Gelsolin immunoreactivity and development of the tectorial membrane in the cochlea of normal and hypothyroid rats.

Authors: Rabie, A  Ferraz, C  Clavel, MC  Legrand, C 
Citation: Rabie A, etal., Cell Tissue Res. 1988 Oct;254(1):241-5.
Pubmed: (View Article at PubMed) PMID:2848627

Gelsolin was localized by immunocytochemistry in the developing cochlea of the rat. In normal animals, the protein appeared at 18 th day in utero in cells of the Kolliker's organ, which are involved in the secretion of the tectorial membrane. The Kolliker's organ cells were not immunoreactive after the first postnatal week, which is when they cease their secretory activity. Gelsolin immunoreactivity was similar in thyroid-deficient rats until the second postnatal week but, at this age, Kolliker's organ did not transform and its gelsolin immunoreactivity persisted, together with its secretory activity. As a result, the tectorial membrane was greatly distorted and out of contact with the hair cells, which dramatically impaired the mechanical properties of the organ of Corti. The developing cochlea thus provides an example of the involvement of gelsolin in a secretory process that is of importance in the development of hearing.


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RGD ID: 1599872
Created: 2007-02-19
Species: All species
Last Modified: 2007-02-19
Status: ACTIVE


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