RGD Reference Report - Plasma gelsolin levels and outcomes after aneurysmal subarachnoid hemorrhage. - Rat Genome Database

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Plasma gelsolin levels and outcomes after aneurysmal subarachnoid hemorrhage.

Authors: Pan, Jian-Wei  He, Ling-Na  Xiao, Feng  Shen, Jian  Zhan, Ren-Ya 
Citation: Pan JW, etal., Crit Care. 2013 Jul 23;17(4):R149. doi: 10.1186/cc12828.
RGD ID: 329333027
Pubmed: PMID:23880145   (View Abstract at PubMed)
PMCID: PMC4057205   (View Article at PubMed Central)
DOI: DOI:10.1186/cc12828   (Journal Full-text)


INTRODUCTION: Lower gelsolin levels have been associated with the severity and poor outcome of critical illness. Nevertheless, their link with clinical outcomes of aneurysmal subarachnoid hemorrhage is unknown. Therefore, we aimed to investigate the relationship between plasma gelsolin levels and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage.
METHODS: A total of 262 consecutive patients and 150 healthy subjects were included. Plasma gelsolin levels were measured by enzyme-linked immunosorbent assay. Mortality and poor long-term outcome (Glasgow Outcome Scale score of 1-3) at 6 months were recorded.
RESULTS: Plasma gelsolin levels on admission were substantially lower in patients than in healthy controls (66.9 (26.4) mg/L vs. 126.4 (35.4) mg/L, P < 0.001), and negatively associated with World Federation of Neurological Surgeons score (r = -0.554, P < 0.001) and Fisher score (r = -0.538, P < 0.001), and identified as an independent predictor of poor functional outcome (odds ratio, 0.957; 95% confidence interval (CI), 0.933-0.983; P = 0.001) and death (odds ratio, 0.953; 95% CI, 0.917-0.990; P = 0.003) after 6 months. The areas under the ROC curve of gelsolin for functional outcome and mortality were similar to those of World Federation of Neurological Surgeons score and Fisher score (all P > 0.05). Gelsolin improved the predictive values of World Federation of Neurological Surgeons score and Fisher score for functional outcome (both P < 0.05), but not for mortality (both P > 0.05).
CONCLUSIONS: Gelsolin levels are a useful, complementary tool to predict functional outcome and mortality 6 months after aneurysmal subarachnoid hemorrhage.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSNHumanSubarachnoid Hemorrhage severityIEP protein:decreased expression:blood plasma (human)RGD 
GsnRatSubarachnoid Hemorrhage severityISOGSN (Homo sapiens)protein:decreased expression:blood plasma (human)RGD 
GsnMouseSubarachnoid Hemorrhage severityISOGSN (Homo sapiens)protein:decreased expression:blood plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsn  (gelsolin)

Genes (Mus musculus)
Gsn  (gelsolin)

Genes (Homo sapiens)
GSN  (gelsolin)


Additional Information