Oprk1 (opioid receptor kappa 1) - Rat Genome Database

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Gene: Oprk1 (opioid receptor kappa 1) Chinchilla lanigera
Analyze
Symbol: Oprk1
Name: opioid receptor kappa 1
RGD ID: 8741988
Description: ENCODES a protein that exhibits dynorphin receptor activity (ortholog); G protein-coupled opioid receptor activity (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN positive regulation of neuronal action potential; response to auditory stimulus; adenylate cyclase-inhibiting opioid receptor signaling pathway (ortholog); PARTICIPATES IN nalbuphine pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); Alcohol-Related Disorders (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN axon terminus (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kappa-type opioid receptor; opioid receptor, kappa 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545412,744,765 - 12,752,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545412,741,577 - 12,751,282 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. Improvement in auditory function following pentazocine suggests a role for dynorphins in auditory sensitivity. Sahley TL and Nodar RH, Ear Hear. 1994 Dec;15(6):422-31.
3. Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist. Sahley TL, etal., Eur J Pharmacol. 2008 Feb 2;580(1-2):100-15. Epub 2007 Oct 25.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Oprk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545412,744,765 - 12,752,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545412,741,577 - 12,751,282 (-)NCBIChiLan1.0ChiLan1.0
OPRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38853,225,724 - 53,251,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl853,225,724 - 53,251,637 (-)EnsemblGRCh38hg38GRCh38
GRCh37854,138,284 - 54,164,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36854,300,829 - 54,326,747 (-)NCBINCBI36Build 36hg18NCBI36
Build 34854,304,325 - 54,326,525NCBI
Celera850,129,111 - 50,155,030 (-)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef849,605,704 - 49,631,623 (-)NCBIHuRef
CHM1_1854,189,898 - 54,215,806 (-)NCBICHM1_1
T2T-CHM13v2.0853,602,209 - 53,628,122 (-)NCBIT2T-CHM13v2.0
Oprk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,658,673 - 5,676,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,658,689 - 5,676,354 (+)EnsemblGRCm39 Ensembl
GRCm3815,588,450 - 5,606,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,588,466 - 5,606,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715,578,574 - 5,592,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615,578,574 - 5,592,947 (+)NCBIMGSCv36mm8
Celera15,572,638 - 5,587,007 (+)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
Oprk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8518,657,866 - 18,675,671 (-)NCBIGRCr8
mRatBN7.2513,860,016 - 13,877,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx516,035,098 - 16,052,904 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0517,669,824 - 17,687,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0517,369,783 - 17,387,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBICelera
Cytogenetic Map5q12NCBI
OPRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2768,862,192 - 68,888,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1844,587,073 - 44,612,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0849,650,844 - 49,677,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1847,030,643 - 47,056,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl847,029,313 - 47,056,577 (-)Ensemblpanpan1.1panPan2
OPRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1295,022,270 - 5,054,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl295,025,786 - 5,051,919 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha295,465,554 - 5,491,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0295,094,906 - 5,125,355 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl295,094,910 - 5,125,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1295,025,124 - 5,051,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0295,246,074 - 5,272,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,327,765 - 5,353,862 (-)NCBIUU_Cfam_GSD_1.0
Oprk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,479,528 - 74,505,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936496280,558 - 305,904 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936496280,593 - 305,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,399,183 - 77,426,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1477,399,298 - 77,429,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,469,581 - 84,499,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1849,337,308 - 49,364,724 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl849,341,427 - 49,362,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603992,601,556 - 92,627,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,301,101 - 2,325,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247352,301,248 - 2,325,678 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014446   ⟹   ENSCLAP00000014288
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545412,744,765 - 12,752,226 (-)Ensembl
RefSeq Acc Id: XM_005396062   ⟹   XP_005396119
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545412,741,577 - 12,751,282 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005396119 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014288.1
Reference Protein Sequences
RefSeq Acc Id: XP_005396119   ⟸   XM_005396062
- UniProtKB: A0A8C2VGF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014288   ⟸   ENSCLAT00000014446
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009850 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014446.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Kappa_opi_rcpt UniProtKB/TrEMBL
  Opioid_rcpt UniProtKB/TrEMBL
NCBI Gene Oprk1 ENTREZGENE
PANTHER KAPPA-TYPE OPIOID RECEPTOR UniProtKB/TrEMBL
  NEUROPEPTIDES RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  KAPPAOPIOIDR UniProtKB/TrEMBL
  OPIOIDR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2VGF6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Oprk1  opioid receptor kappa 1    opioid receptor, kappa 1  Symbol and/or name change 5135510 APPROVED