Bcl2 (BCL2 apoptosis regulator) - Rat Genome Database

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Gene: Bcl2 (BCL2 apoptosis regulator) Chinchilla lanigera
Symbol: Bcl2
Name: BCL2 apoptosis regulator
RGD ID: 8830182
Description: ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); channel activity (ortholog); INVOLVED IN actin filament organization (ortholog); aging (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; erythropoietin signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; BCL2, apoptosis regulator
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adrenal Insufficiency  (ISO)
AIDS-Related Kaposi Sarcoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
azoospermia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-Cell CLL/Lymphoma 2  (ISO)
bilirubin metabolic disorder  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 18q deletion syndrome  (ISO)
Chronic Intermittent Hypoxia  (ISO)
clear cell adenocarcinoma  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
dementia  (ISO)
Diabetic Cardiomyopathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fetal Growth Retardation  (ISO)
follicular lymphoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
Head and Neck Neoplasms  (ISO)
Hemorrhagic Shock  (ISO)
Huntington's disease  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypothermia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
intestinal disease  (ISO)
Intestinal Neoplasms  (ISO)
intracranial aneurysm  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
learning disability  (ISO)
leiomyoma  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
mesenchymal chondrosarcoma  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multi-Infarct Dementia  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
oral mucosa leukoplakia  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
Ovarian Neoplasms  (ISO)
plasmacytoma  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
Premature Aging  (ISO)
priapism  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Sarcopenia  (ISO)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
synovial sarcoma  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Testis Reperfusion Injury  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
aging  (ISO)
animal organ morphogenesis  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
axonogenesis  (ISO)
B cell differentiation  (ISO)
B cell homeostasis  (ISO)
B cell lineage commitment  (ISO)
B cell receptor signaling pathway  (ISO)
behavioral fear response  (ISO)
brain development  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
CD8-positive, alpha-beta T cell lineage commitment  (ISO)
cell aging  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to fluoride  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cerebral cortex development  (ISO)
cochlear nucleus development  (ISO)
defense response to virus  (ISO)
developmental growth  (ISO)
developmental pigmentation  (ISO)
digestive tract morphogenesis  (ISO)
ear development  (ISO)
endoplasmic reticulum calcium ion homeostasis  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
focal adhesion assembly  (ISO)
gland morphogenesis  (ISO)
glial cell apoptotic process  (ISO)
glomerulus development  (ISO)
hair follicle morphogenesis  (ISO)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immune system development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
liver regeneration  (ISO)
lymphocyte homeostasis  (ISO)
lymphoid progenitor cell differentiation  (ISO)
male gonad development  (ISO)
melanin metabolic process  (ISO)
melanocyte differentiation  (ISO)
mesenchymal cell development  (ISO)
metanephros development  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular pH reduction  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of retinal cell programmed cell death  (ISO)
neuron apoptotic process  (ISO)
oligodendrocyte differentiation  (ISO)
oocyte development  (ISO)
organ growth  (ISO)
ossification  (ISO)
ovarian follicle development  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
pigment granule organization  (ISO)
pigmentation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of melanocyte differentiation  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of skeletal muscle fiber development  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
post-embryonic development  (ISO)
protein dephosphorylation  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of apoptotic process  (ISO)
regulation of autophagy  (ISO)
regulation of catalytic activity  (ISO)
regulation of cell cycle  (ISO)
regulation of cell-matrix adhesion  (ISO)
regulation of developmental pigmentation  (ISO)
regulation of gene expression  (ISO)
regulation of glycoprotein biosynthetic process  (ISO)
regulation of growth  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of nitrogen utilization  (ISO)
regulation of programmed cell death  (ISO)
regulation of protein localization  (ISO)
regulation of protein stability  (ISO)
regulation of transmembrane transporter activity  (ISO)
regulation of viral genome replication  (ISO)
release of cytochrome c from mitochondria  (ISO)
renal system process  (ISO)
response to aluminum ion  (ISO)
response to amyloid-beta  (ISO)
response to caffeine  (ISO)
response to cAMP  (ISO)
response to copper ion  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to erythropoietin  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to iron ion  (ISO)
response to ischemia  (ISO)
response to L-ascorbic acid  (ISO)
response to monosaccharide  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to peptide hormone  (ISO)
response to phenylpropanoid  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to UV-B  (ISO)
response to vitamin E  (ISO)
spleen development  (ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
T cell lineage commitment  (ISO)
thymus development  (ISO)
ureteric bud development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1863,123,346 - 63,320,128 (-)EnsemblGRCh38hg38GRCh38
GRCh381863,123,346 - 63,320,280 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371860,790,579 - 60,987,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,941,559 - 59,137,593 (-)NCBINCBI36hg18NCBI36
Build 341858,941,558 - 59,136,910NCBI
Celera1857,509,356 - 57,706,116 (-)NCBI
Cytogenetic Map18q21.33NCBI
HuRef1857,487,199 - 57,684,751 (-)NCBIHuRef
CHM1_11860,786,149 - 60,982,536 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391106,465,906 - 106,642,020 (-)NCBIGRCm39mm39
GRCm39 Ensembl1106,465,908 - 106,642,004 (-)Ensembl
GRCm381106,538,176 - 106,714,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,538,178 - 106,714,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,434,756 - 108,610,867 (-)NCBIGRCm37mm9NCBIm37
MGSCv361108,365,740 - 108,541,849 (-)NCBImm8
Celera1109,386,734 - 109,563,656 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.76NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21322,689,783 - 22,853,920 (-)NCBI
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11859,797,184 - 59,993,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1859,802,443 - 59,992,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01856,481,212 - 56,679,012 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1113,733,849 - 13,900,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBI
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBI
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBI
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBI
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494426,970,171 - 27,134,608 (+)NCBI
SpeTri2.0NW_0049364972,209,136 - 2,373,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1158,288,544 - 158,518,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,337,403 - 158,518,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,824,218 - 175,994,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11816,440,560 - 16,643,187 (+)NCBI
ChlSab1.1 Ensembl1816,441,733 - 16,637,895 (+)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247928,854,345 - 9,032,727 (-)NCBI



Reference Sequences
RefSeq Acc Id: ENSCLAT00000016302   ⟹   ENSCLAP00000016138
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)Ensembl
RefSeq Acc Id: XM_013511218   ⟹   XP_013366672
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBI
Protein Sequences
Protein RefSeqs XP_013366672 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013366672   ⟸   XM_013511218
- Sequence:
RefSeq Acc Id: ENSCLAP00000016138   ⟸   ENSCLAT00000016302

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011104 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000016138 ENTREZGENE
Ensembl Transcript ENSCLAT00000016302 ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Bcl2  BCL2 apoptosis regulator    BCL2, apoptosis regulator  Symbol and/or name change 5135510 APPROVED
2016-08-03 Bcl2  BCL2, apoptosis regulator    B-cell CLL/lymphoma 2  Symbol and/or name change 5135510 APPROVED