Nr3c1 (nuclear receptor subfamily 3 group C member 1) - Rat Genome Database

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Pathways
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Gene: Nr3c1 (nuclear receptor subfamily 3 group C member 1) Chinchilla lanigera
Analyze
Symbol: Nr3c1
Name: nuclear receptor subfamily 3 group C member 1
RGD ID: 8875061
Description: ENCODES a protein that exhibits chromatin binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN adrenal gland development (ortholog); androgen metabolic process (ortholog); astrocyte differentiation (ortholog); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; ASSOCIATED WITH 46, XX Disorders of Sex Development (ortholog); anorexia nervosa (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glucocorticoid receptor; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cataract  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cushing Syndrome  (ISO)
depressive disorder  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis 1  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Malocclusion  (ISO)
mood disorder  (ISO)
muscular atrophy  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
opioid abuse  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
status epilepticus  (ISO)
stress-related disorder  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
androgen metabolic process  (ISO)
astrocyte differentiation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin remodeling  (ISO)
circadian rhythm  (ISO)
female pregnancy  (ISO)
gene expression  (ISO)
glucocorticoid metabolic process  (ISO)
intracellular corticosteroid receptor signaling pathway  (ISO)
intracellular glucocorticoid receptor signaling pathway  (ISO)
lung development  (ISO)
mammary gland duct morphogenesis  (ISO)
maternal behavior  (ISO)
microglia differentiation  (ISO)
motor behavior  (ISO)
muscle atrophy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular permeability  (ISO)
neuroinflammatory response  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of glucocorticoid biosynthetic process  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of glucose metabolic process  (ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to mercury ion  (ISO)
synaptic transmission, glutamatergic  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Nr3c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
NR3C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5143,277,931 - 143,435,512 (-)EnsemblGRCh38hg38GRCh38
GRCh375142,657,496 - 142,815,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36Build 36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
T2T-CHM13v2.05143,809,293 - 143,966,896 (-)NCBIT2T-CHM13v2.0
Nr3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 Ensembl
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
Nr3c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81831,522,783 - 31,644,508 (-)NCBIGRCr8
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
NR3C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24138,522,276 - 138,977,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15136,661,826 - 137,116,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15144,741,452 - 144,865,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)Ensemblpanpan1.1panPan2
NR3C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha235,173,176 - 35,283,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,573,084 - 38,692,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,573,084 - 38,690,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,654,977 - 35,765,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0236,468,553 - 36,579,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,270,194 - 37,380,458 (-)NCBIUU_Cfam_GSD_1.0
Nr3c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213149,386,116 - 149,482,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650410,959,192 - 11,056,856 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,822,939 - 144,956,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12345,904,926 - 46,031,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603431,810,840 - 31,935,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr3c1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247742,495,304 - 2,602,632 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014082   ⟹   ENSCLAP00000013926
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)Ensembl
RefSeq Acc Id: XM_005380692   ⟹   XP_005380749
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005380694   ⟹   XP_005380751
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380749 (Get FASTA)   NCBI Sequence Viewer  
  XP_005380751 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013926
  ENSCLAP00000013926.1
Reference Protein Sequences
RefSeq Acc Id: XP_005380749   ⟸   XM_005380692
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005380751   ⟸   XM_005380694
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VH73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000013926   ⟸   ENSCLAT00000014082
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009640 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014082 ENTREZGENE
  ENSCLAT00000014082.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro Glcrtcd_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr3c1 ENTREZGENE
PANTHER GLUCOCORTICOID RECEPTOR UniProtKB/TrEMBL
  KNIRPS-RELATED PROTEIN-RELATED UniProtKB/TrEMBL
Pfam GCR UniProtKB/TrEMBL
  Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS GLCORTICOIDR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A8C2VH73 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nr3c1  nuclear receptor subfamily 3 group C member 1    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)  Symbol and/or name change 5135510 APPROVED