Tlr4 (toll like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll like receptor 4) Chinchilla lanigera
Analyze
Symbol: Tlr4
Name: toll like receptor 4
RGD ID: 9012315
Description: ENCODES a protein that exhibits identical protein binding (ortholog); lipopolysaccharide binding (ortholog); lipopolysaccharide immune receptor activity (ortholog); INVOLVED IN activation of innate immune response (ortholog); astrocyte development (ortholog); B cell proliferation involved in immune response (ortholog); PARTICIPATES IN titanium dioxide nanoparticle response pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH Acanthamoeba Keratitis (ortholog); Acne Conglobata (ortholog); Acute Coronary Syndrome (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: toll-like receptor 4; toll-like receptor 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (ISO)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
acute pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
age related macular degeneration 10  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Angina, Stable  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
esophagus adenocarcinoma  (ISO)
eumycotic mycetoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (ISO)
Fungal Keratitis  (ISO)
glomerulonephritis  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Meningitis, Escherichia Coli  (ISO)
meningococcal meningitis  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Onchocerciasis, Ocular  (ISO)
Optic Nerve Injuries  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
pulpitis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
sporotrichosis  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
astrocyte development  (ISO)
B cell proliferation involved in immune response  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
detection of lipopolysaccharide  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
I-kappaB phosphorylation  (ISO)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (ISO)
innate immune response-activating signal transduction  (ISO)
intestinal epithelial structure maintenance  (ISO)
leukotriene metabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage activation  (ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-23 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
nitric oxide production involved in inflammatory response  (ISO)
phagocytosis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet activation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of dendritic cell cytokine production  (ISO)
regulation of inflammatory response  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to activity  (ISO)
response to bacterium  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to oxidative stress  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
skeletal muscle contraction  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (ISO)
wound healing involved in inflammatory response  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBImm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19117,180,250 - 117,193,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0panPan3
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBI
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBI
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBI
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBI
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBI
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBI
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,059,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBI
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)Ensembl
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBI
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017058   ⟹   ENSCLAP00000016892
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)Ensembl
RefSeq Acc Id: XM_005382606   ⟹   XP_005382663
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382663 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005382663   ⟸   XM_005382606
- Sequence:
RefSeq Acc Id: ENSCLAP00000016892   ⟸   ENSCLAT00000017058


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011591 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000016892 ENTREZGENE
Ensembl Transcript ENSCLAT00000017058 ENTREZGENE
NCBI Gene Tlr4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tlr4  toll like receptor 4    toll-like receptor 4  Symbol and/or name change 5135510 APPROVED