Lmcd1 (LIM and cysteine rich domains 1) - Rat Genome Database

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Gene: Lmcd1 (LIM and cysteine rich domains 1) Chinchilla lanigera
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Symbol: Lmcd1
Name: LIM and cysteine rich domains 1
RGD ID: 8848632
Description: ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of calcineurin-NFAT signaling cascade (ortholog); regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); coronary stenosis (ortholog); mitral valve insufficiency (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LIM and cysteine-rich domains 1; LIM and cysteine-rich domains protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561151,308 - 214,476 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955561151,315 - 213,904 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lmcd1Chinchillacoronary stenosis  ISOLMCD1 (Homo sapiens)9068941protein:increased expression:coronary arteryRGDPMID:32160773 and REF_RGD_ID:243065232
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lmcd1ChinchillaAtrioventricular Septal Defect 2  ISOLMCD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrioventricular septal defect more ...ClinVarPMID:28492532
Lmcd1ChinchillaNeurodevelopmental Disorders  ISOLMCD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lmcd1Chinchillamitral valve insufficiency  ISOLMCD1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26301497
Lmcd1Chinchillamitral valve prolapse  ISOLMCD1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26301497


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lmcd1Chinchillanucleus located_inISOLmcd1 (Mus musculus)9068941 PMID:16199866MGIPMID:16199866

Molecular Function

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074  



Lmcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561151,308 - 214,476 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955561151,315 - 213,904 (+)NCBIChiLan1.0ChiLan1.0
LMCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,501,823 - 8,574,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,501,807 - 8,574,668 (+)EnsemblGRCh38hg38GRCh38
GRCh3738,543,509 - 8,616,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,518,511 - 8,584,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 3438,518,510 - 8,584,805NCBI
Celera38,480,112 - 8,546,564 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,478,394 - 8,544,846 (+)NCBIHuRef
CHM1_138,493,836 - 8,560,461 (+)NCBICHM1_1
T2T-CHM13v2.038,492,967 - 8,566,009 (+)NCBIT2T-CHM13v2.0
Lmcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,250,747 - 112,307,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,250,719 - 112,307,386 (+)EnsemblGRCm39 Ensembl
GRCm386112,273,758 - 112,330,423 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,273,758 - 112,330,425 (+)EnsemblGRCm38mm10GRCm38
MGSCv376112,223,752 - 112,280,417 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,239,591 - 112,296,202 (+)NCBIMGSCv36mm8
Celera6114,110,587 - 114,167,245 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.14NCBI
Lmcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84146,948,993 - 147,007,878 (+)NCBIGRCr8
mRatBN7.24145,393,153 - 145,452,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,393,145 - 145,452,046 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,785,843 - 150,844,729 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,566,657 - 146,625,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,187,941 - 145,246,815 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,192,989 - 144,252,554 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,192,989 - 144,252,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,494,655 - 207,554,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,071,431 - 148,130,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,316,271 - 148,375,153 (+)NCBI
Celera4133,994,893 - 134,022,583 (+)NCBICelera
Cytogenetic Map4q41NCBI
LMCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,507,235 - 8,573,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,511,847 - 8,585,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,448,143 - 8,521,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.138,692,557 - 8,765,522 (+)NCBIpanpan1.1PanPan1.1panPan2
LMCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,524,393 - 9,582,939 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,524,413 - 9,583,529 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,557,871 - 9,616,422 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0209,555,858 - 9,614,448 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl209,555,878 - 9,614,921 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1209,276,475 - 9,335,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0209,622,849 - 9,681,370 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0209,595,563 - 9,654,153 (-)NCBIUU_Cfam_GSD_1.0
Lmcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,431,414 - 14,489,110 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,420,597 - 4,478,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366024,420,600 - 4,478,384 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1364,933,700 - 64,994,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11364,933,692 - 64,994,204 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,215,911 - 72,275,069 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,531,441 - 44,598,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041121,964,274 - 122,035,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmcd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,158,561 - 3,218,658 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,158,682 - 3,218,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000001749   ⟹   ENSCLAP00000001706
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955561151,308 - 214,476 (+)Ensembl
RefSeq Acc Id: XM_005412996   ⟹   XP_005413053
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955561151,315 - 213,904 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509111   ⟹   XP_013364565
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955561151,315 - 213,904 (+)NCBI
Sequence:
Protein RefSeqs XP_005413053 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001706
  ENSCLAP00000001706.1
RefSeq Acc Id: XP_005413053   ⟸   XM_005412996
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UMS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364565   ⟸   XM_013509111
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000001706   ⟸   ENSCLAT00000001749
LIM zinc-binding   PET



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000001274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001749 ENTREZGENE
  ENSCLAT00000001749.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
InterPro PET_domain UniProtKB/TrEMBL
  PET_testin UniProtKB/TrEMBL
  Pk/Esn/Tes UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
NCBI Gene Lmcd1 ENTREZGENE
PANTHER LIM AND CYSTEINE-RICH DOMAINS PROTEIN 1 UniProtKB/TrEMBL
  LIM DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
  PET UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
  PET UniProtKB/TrEMBL
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8C2UMS1 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Lmcd1  LIM and cysteine rich domains 1    LIM and cysteine-rich domains 1  Symbol and/or name change 5135510 APPROVED