Pde3a (phosphodiesterase 3A) - Rat Genome Database

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Gene: Pde3a (phosphodiesterase 3A) Chinchilla lanigera
Analyze
Symbol: Pde3a
Name: phosphodiesterase 3A
RGD ID: 8793209
Description: ENCODES a protein that exhibits 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity (ortholog); 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to cGMP (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); hypertension and brachydactyly syndrome (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cGMP-inhibited 3',5'-cyclic phosphodiesterase A; phosphodiesterase 3A, cGMP-inhibited
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,340,918 - 16,643,214 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,340,827 - 16,642,731 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pde3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,340,918 - 16,643,214 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,340,827 - 16,642,731 (+)NCBIChiLan1.0ChiLan1.0
PDE3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,368,537 - 20,688,583 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,368,537 - 20,688,583 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,521,471 - 20,841,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,413,464 - 20,725,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 341220,413,485 - 20,725,646NCBI
Celera1225,677,589 - 25,989,565 (+)NCBICelera
Cytogenetic Map12p12.2NCBI
HuRef1220,294,054 - 20,609,054 (+)NCBIHuRef
CHM1_11220,487,485 - 20,802,952 (+)NCBICHM1_1
T2T-CHM13v2.01220,246,943 - 20,567,173 (+)NCBIT2T-CHM13v2.0
Pde3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396141,194,995 - 141,452,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6141,194,995 - 141,453,174 (+)EnsemblGRCm39 Ensembl
GRCm386141,249,269 - 141,506,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6141,249,269 - 141,507,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv376141,197,790 - 141,447,872 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366141,211,675 - 141,461,757 (+)NCBIMGSCv36mm8
Celera6144,313,875 - 144,561,276 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map671.87NCBI
Pde3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84175,904,276 - 176,170,531 (+)NCBIGRCr8
mRatBN7.24174,172,804 - 174,443,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,172,868 - 174,438,274 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4180,468,046 - 180,732,053 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,252,313 - 176,516,321 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04174,872,874 - 175,136,859 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04175,431,904 - 175,703,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,431,904 - 175,700,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04239,659,270 - 239,921,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44178,658,896 - 178,930,417 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14178,904,019 - 179,175,541 (+)NCBI
Celera4162,714,211 - 162,977,642 (+)NCBICelera
Cytogenetic Map4q44NCBI
PDE3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21025,825,418 - 26,141,755 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,821,163 - 26,138,472 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,380,213 - 20,690,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11220,763,999 - 21,068,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1220,763,999 - 21,064,391 (+)Ensemblpanpan1.1panPan2
PDE3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,555,558 - 26,878,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,560,547 - 26,878,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2719,575,517 - 19,894,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,888,527 - 27,207,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,892,255 - 27,208,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,750,810 - 27,069,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,736,440 - 27,052,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,282,366 - 19,598,748 (+)NCBIUU_Cfam_GSD_1.0
Pde3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,831,481 - 88,147,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,762,507 - 6,070,576 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,758,634 - 6,072,195 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,409,882 - 52,738,406 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,413,503 - 52,737,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,777,634 - 55,969,591 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,235,814 - 20,545,740 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,236,430 - 20,540,900 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606914,610,757 - 14,913,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,781,647 - 17,829,771 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,773,803 - 18,088,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000023090   ⟹   ENSCLAP00000022878
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541316,340,918 - 16,643,214 (+)Ensembl
RefSeq Acc Id: XM_005379045   ⟹   XP_005379102
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541316,340,827 - 16,642,731 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005379102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022878
  ENSCLAP00000022878.1
RefSeq Acc Id: XP_005379102   ⟸   XM_005379045
- UniProtKB: A0A8C2YTV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000022878   ⟸   ENSCLAT00000023090
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023090 ENTREZGENE
  ENSCLAT00000023090.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene Pde3a ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
  PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A8C2YTV1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Pde3a  phosphodiesterase 3A    phosphodiesterase 3A, cGMP-inhibited  Symbol and/or name change 5135510 APPROVED