Fn1 (fibronectin 1) - Rat Genome Database
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Gene: Fn1 (fibronectin 1) Chinchilla lanigera
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Symbol: Fn1
Name: fibronectin 1
RGD ID: 8845050
Description: ENCODES a protein that exhibits chaperone binding (ortholog); disordered domain specific binding (ortholog); enzyme binding (ortholog); INVOLVED IN biological process involved in interaction with symbiont (ortholog); calcium-independent cell-matrix adhesion (ortholog); cell activation (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Acute Otitis Media; acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN extracellular matrix; apical plasma membrane (ortholog); basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: fibronectin
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Otitis Media  (IEP)
Animal Mammary Neoplasms  (ISO)
aortic valve insufficiency  (ISO)
brain disease  (ISO)
Breast Neoplasms  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
chronic kidney disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Glomerulopathy with Giant Fibrillar Deposits  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
iron deficiency anemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Mammary Neoplasms, Experimental  (ISO)
membranoproliferative glomerulonephritis  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renovascular hypertension  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Pneumonia  (ISO)
Sturge-Weber syndrome  (ISO)
submandibular gland disease  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
VACTERL association  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological process involved in interaction with symbiont  (ISO)
calcium-independent cell-matrix adhesion  (ISO)
cell activation  (ISO)
cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate junction assembly  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to angiotensin  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mercury ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (ISO)
glial cell migration  (ISO)
integrin activation  (ISO)
integrin-mediated signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
neural crest cell migration involved in autonomic nervous system development  (ISO)
peptide cross-linking  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of gene expression  (ISO)
regulation of protein phosphorylation  (ISO)
response to activity  (ISO)
response to drug  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to ischemia  (ISO)
response to ozone  (ISO)
response to wounding  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
wound healing  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Fn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBIChiLan1.0ChiLan1.0
FN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2215,360,440 - 215,436,073 (-)EnsemblGRCh38hg38GRCh38
GRCh382215,360,862 - 215,436,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,225,177 - 216,300,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,933,422 - 216,009,036 (-)NCBINCBI36hg18NCBI36
Build 342216,050,686 - 216,126,297NCBI
Celera2209,994,808 - 210,070,377 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,082,209 - 208,158,070 (-)NCBIHuRef
CHM1_12216,231,063 - 216,306,652 (-)NCBICHM1_1
Fn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,624,632 - 71,692,439 (-)NCBIGRCm39mm39
GRCm38171,585,473 - 71,653,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,585,520 - 71,653,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37171,632,097 - 71,699,745 (-)NCBIGRCm37mm9NCBIm37
MGSCv36171,518,731 - 71,586,379 (-)NCBImm8
Celera172,141,007 - 72,208,976 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.05NCBI
Fn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
Cytogenetic Map9q33NCBI
RH 3.4 Map9673.9RGD
FN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B221,208,431 - 221,284,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,208,431 - 221,284,003 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B102,623,568 - 102,698,747 (-)NCBIMhudiblu_PPA_v0panPan3
FN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3722,420,428 - 22,523,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13722,456,854 - 22,522,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,357,895 - 130,430,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,177,867 - 101,254,613 (-)NCBI
ChlSab1.1 Ensembl10101,176,789 - 101,254,633 (-)Ensembl
Fn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624765707,872 - 775,056 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006931   ⟹   ENSCLAP00000006819
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000006932   ⟹   ENSCLAP00000006820
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000006933   ⟹   ENSCLAP00000006821
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955457629,599 - 694,948 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000006934   ⟹   ENSCLAP00000006822
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955457629,843 - 638,337 (+)Ensembl
RefSeq Acc Id: XM_005396902   ⟹   XP_005396959
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396903   ⟹   XP_005396960
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396904   ⟹   XP_005396961
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396905   ⟹   XP_005396962
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396909   ⟹   XP_005396966
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396910   ⟹   XP_005396967
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396911   ⟹   XP_005396968
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396912   ⟹   XP_005396969
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396913   ⟹   XP_005396970
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520687   ⟹   XP_013376141
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520688   ⟹   XP_013376142
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520689   ⟹   XP_013376143
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955457629,706 - 694,948 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005396959   ⟸   XM_005396902
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005396962   ⟸   XM_005396905
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005396968   ⟸   XM_005396911
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_005396960   ⟸   XM_005396903
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005396961   ⟸   XM_005396904
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005396969   ⟸   XM_005396912
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_005396966   ⟸   XM_005396909
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_005396967   ⟸   XM_005396910
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005396970   ⟸   XM_005396913
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_013376142   ⟸   XM_013520688
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013376143   ⟸   XM_013520689
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013376141   ⟸   XM_013520687
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000006822   ⟸   ENSCLAT00000006934
RefSeq Acc Id: ENSCLAP00000006821   ⟸   ENSCLAT00000006933
RefSeq Acc Id: ENSCLAP00000006820   ⟸   ENSCLAT00000006932
RefSeq Acc Id: ENSCLAP00000006819   ⟸   ENSCLAT00000006931


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004804 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000006819 ENTREZGENE
  ENSCLAP00000006820 ENTREZGENE
  ENSCLAP00000006821 ENTREZGENE
Ensembl Transcript ENSCLAT00000006931 ENTREZGENE
  ENSCLAT00000006932 ENTREZGENE
  ENSCLAT00000006933 ENTREZGENE
NCBI Gene Fn1 ENTREZGENE