Thbs1 (thrombospondin 1) - Rat Genome Database

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Gene: Thbs1 (thrombospondin 1) Chinchilla lanigera
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Symbol: Thbs1
Name: thrombospondin 1
RGD ID: 8940744
Description: ENCODES a protein that exhibits collagen V binding (ortholog); extracellular matrix binding (ortholog); fibrinogen binding (ortholog); INVOLVED IN activation of MAPK activity (ortholog); behavioral response to pain (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Bloom syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: thrombospondin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (ISO)
behavioral response to pain  (ISO)
blood vessel morphogenesis  (ISO)
cell migration  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (ISO)
endocardial cushion development  (ISO)
engulfment of apoptotic cell  (ISO)
growth plate cartilage development  (ISO)
immune response  (ISO)
inflammatory response  (ISO)
monocyte aggregation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cGMP-mediated signaling  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of dendritic cell antigen processing and presentation  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of fibrinolysis  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (ISO)
negative regulation of nitric oxide mediated signal transduction  (ISO)
negative regulation of plasminogen activation  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
outflow tract morphogenesis  (ISO)
peptide cross-linking  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of translation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of cell cycle  (ISO)
response to calcium ion  (ISO)
response to drug  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to glucose  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (ISO)
response to testosterone  (ISO)
sprouting angiogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Thbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
THBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,010,501 (+)NCBICHM1_1
Thbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBImm8
MGSCv362117,803,363 - 117,818,574 (+)NCBImm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
Thbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,056,286 - 105,071,445 (+)NCBI
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
THBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11536,776,756 - 36,793,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1536,776,756 - 36,793,170 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01518,521,802 - 18,538,172 (+)NCBIMhudiblu_PPA_v0panPan3
THBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1306,770,212 - 6,786,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl306,769,470 - 6,784,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha306,824,809 - 6,841,468 (+)NCBI
ROS_Cfam_1.0306,896,290 - 6,912,963 (+)NCBI
UMICH_Zoey_3.1306,820,232 - 6,836,894 (+)NCBI
UNSW_CanFamBas_1.0306,926,083 - 6,942,777 (+)NCBI
UU_Cfam_GSD_1.0307,055,241 - 7,071,904 (+)NCBI
Thbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,216,385 - 85,233,062 (+)NCBI
SpeTri2.0NW_0049364713,064,466 - 3,081,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,728,781 - 131,746,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,728,781 - 131,746,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,905,998 - 146,923,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBI
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)Ensembl
Thbs1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248046,849,660 - 6,866,164 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015419   ⟹   ENSCLAP00000015259
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)Ensembl
RefSeq Acc Id: XM_013512591   ⟹   XP_013368045
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013368045 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013368045   ⟸   XM_013512591
- Sequence:
RefSeq Acc Id: ENSCLAP00000015259   ⟸   ENSCLAT00000015419


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010506 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000015259 ENTREZGENE
Ensembl Transcript ENSCLAT00000015419 ENTREZGENE
NCBI Gene Thbs1 ENTREZGENE