Angpt1 (angiopoietin 1) - Rat Genome Database

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Pathways
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Gene: Angpt1 (angiopoietin 1) Chinchilla lanigera
Analyze
Symbol: Angpt1
Name: angiopoietin 1
RGD ID: 9050136
Description: ENCODES a protein that exhibits identical protein binding (ortholog); receptor tyrosine kinase binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ regeneration (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); PARTICIPATES IN angiopoietin signaling pathway; ASSOCIATED WITH brain ischemia (ortholog); diabetic retinopathy (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN extracellular space (ortholog); membrane raft (ortholog); microvillus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiopoietin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541730,198,842 - 30,386,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541730,199,508 - 30,386,695 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ regeneration  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cell-substrate adhesion  (ISO)
glomerulus vasculature development  (ISO)
hemopoiesis  (ISO)
heparin biosynthetic process  (ISO)
in utero embryonic development  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of vascular permeability  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle development  (ISO)
positive chemotaxis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of blood-brain barrier permeability  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of receptor internalization  (ISO)
protein localization to cell surface  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of macrophage migration inhibitory factor signaling pathway  (ISO)
regulation of skeletal muscle satellite cell proliferation  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to vitamin B3  (ISO)
sprouting angiogenesis  (ISO)
Tie signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Angpt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541730,198,842 - 30,386,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541730,199,508 - 30,386,695 (-)NCBIChiLan1.0ChiLan1.0
ANGPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388107,249,482 - 107,497,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8107,249,482 - 107,498,055 (-)EnsemblGRCh38hg38GRCh38
GRCh378108,261,710 - 108,510,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368108,330,886 - 108,579,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 348108,330,885 - 108,579,430NCBI
Celera8104,448,513 - 104,696,524 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8103,581,813 - 103,830,178 (-)NCBIHuRef
CHM1_18108,301,960 - 108,550,507 (-)NCBICHM1_1
T2T-CHM13v2.08108,377,097 - 108,625,564 (-)NCBIT2T-CHM13v2.0
Angpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391542,288,063 - 42,540,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1542,288,119 - 42,540,373 (-)EnsemblGRCm39 Ensembl
GRCm381542,424,667 - 42,676,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1542,424,723 - 42,676,977 (-)EnsemblGRCm38mm10GRCm38
MGSCv371542,256,269 - 42,508,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361542,254,797 - 42,506,869 (-)NCBIMGSCv36mm8
Celera1542,923,801 - 43,172,633 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1516.69NCBI
Angpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8775,415,959 - 75,668,696 (-)NCBIGRCr8
mRatBN7.2773,528,345 - 73,783,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx775,390,636 - 75,634,234 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,593,123 - 77,836,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0777,461,245 - 77,704,839 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0781,338,327 - 81,592,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0781,364,881 - 81,618,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4778,195,504 - 78,451,471 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera770,543,119 - 70,792,915 (-)NCBICelera
Cytogenetic Map7q31NCBI
ANGPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27124,617,718 - 124,863,319 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18100,139,400 - 100,383,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08103,893,234 - 104,137,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18106,039,873 - 106,287,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8106,042,041 - 106,286,783 (-)Ensemblpanpan1.1panPan2
ANGPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1138,068,920 - 8,312,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl138,048,205 - 8,311,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha138,012,976 - 8,253,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0138,330,622 - 8,573,873 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl138,330,895 - 8,573,753 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1138,089,554 - 8,329,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,207,290 - 8,447,896 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0138,284,694 - 8,525,154 (-)NCBIUU_Cfam_GSD_1.0
Angpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530329,679,371 - 29,900,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647037,105,466 - 37,328,190 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647037,105,469 - 37,328,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl429,933,135 - 30,233,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1429,925,203 - 30,233,434 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2432,833,909 - 32,855,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,433,135 - 32,433,409 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,646,874 - 32,751,649 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18102,020,346 - 102,268,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603938,309,531 - 38,560,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angpt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476322,646,231 - 22,718,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476322,645,807 - 22,818,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021560   ⟹   ENSCLAP00000021357
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541730,198,842 - 30,386,266 (-)Ensembl
RefSeq Acc Id: XM_005381965   ⟹   XP_005382022
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541730,199,508 - 30,386,695 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382022 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021357
  ENSCLAP00000021357.1
Reference Protein Sequences
RefSeq Acc Id: XP_005382022   ⟸   XM_005381965
- UniProtKB: A0A8C2VXZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021357   ⟸   ENSCLAT00000021560
Protein Domains
Fibrinogen C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014625 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021560 ENTREZGENE
  ENSCLAT00000021560.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/TrEMBL
NCBI Gene Angpt1 ENTREZGENE
PANTHER FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/TrEMBL
  PTHR19143:SF156 UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_1 UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/TrEMBL
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/TrEMBL
UniProt A0A8C2VXZ0 ENTREZGENE, UniProtKB/TrEMBL