Nod2 (nucleotide binding oligomerization domain containing 2) - Rat Genome Database

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Gene: Nod2 (nucleotide binding oligomerization domain containing 2) Chinchilla lanigera
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Symbol: Nod2
Name: nucleotide binding oligomerization domain containing 2
RGD ID: 8720074
Description: ENCODES a protein that exhibits actin binding (ortholog); CARD domain binding (ortholog); enzyme binding (ortholog); INVOLVED IN activation of immune response (ortholog); biosynthetic process of antibacterial peptides active against Gram-positive bacteria (ortholog); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN anchored component of plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
familial Mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (ISO)
Granuloma  (ISO)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (ISO)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (ISO)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (ISO)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
PFAPA Syndrome  (ISO)
Pneumococcal Meningitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (ISO)
systemic lupus erythematosus  (ISO)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
YAO SYNDROME  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (ISO)
biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to muramyl dipeptide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to peptidoglycan  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of bacterium  (ISO)
detection of muramyl dipeptide  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of localization in cell  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
innate immune response  (ISO)
innate immune response in mucosa  (ISO)
intracellular signal transduction  (ISO)
JNK cascade  (ISO)
maintenance of gastrointestinal epithelium  (ISO)
MAPK cascade  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-18 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of T cell mediated immunity  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
NIK/NF-kappaB signaling  (ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
pattern recognition receptor signaling pathway  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phagocytosis  (ISO)
positive regulation of antibacterial peptide biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of prostaglandin-E synthase activity  (ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (ISO)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type 2 immune response  (ISO)
positive regulation of xenophagy  (ISO)
regulation of inflammatory response  (ISO)
regulation of neutrophil chemotaxis  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
response to nutrient  (ISO)
response to peptidoglycan  (ISO)
stress-activated MAPK cascade  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
xenophagy  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,693,606 - 50,733,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1650,693,588 - 50,734,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBImm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,379,720 - 18,422,817 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)Ensembl
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0panPan3
NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBI
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBI
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBI
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBI
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBI
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBI
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBIVero_WHO_p1.0
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000013222   ⟹   ENSCLAP00000013071
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)Ensembl
RefSeq Acc Id: XM_005388272   ⟹   XP_005388329
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005388273   ⟹   XP_005388330
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554338,746,213 - 8,777,507 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005388329 (Get FASTA)   NCBI Sequence Viewer  
  XP_005388330 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005388329   ⟸   XM_005388272
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005388330   ⟸   XM_005388273
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000013071   ⟸   ENSCLAT00000013222


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000013071 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013222 ENTREZGENE, UniProtKB/TrEMBL
NCBI Gene Nod2 ENTREZGENE
UniProt A0A8C2VBW8_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nod2  nucleotide binding oligomerization domain containing 2    nucleotide-binding oligomerization domain containing 2  Symbol and/or name change 5135510 APPROVED