Bax (BCL2 associated X, apoptosis regulator) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bax (BCL2 associated X, apoptosis regulator) Chinchilla lanigera
Analyze
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
RGD ID: 9028540
Description: ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); channel activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; intrinsic apoptotic pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN BAK complex (ortholog); BAX complex (ortholog); Bcl-2 family protein complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: apoptosis regulator BAX
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Insufficiency  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
ataxia telangiectasia  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
Cerebral Hemorrhage  (ISO)
cervical squamous cell carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Intermittent Hypoxia  (ISO)
clear cell renal cell carcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
cutaneous T cell lymphoma  (ISO)
dementia  (ISO)
dilated cardiomyopathy  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
heart disease  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
intermittent claudication  (ISO)
intestinal disease  (ISO)
Intestinal Neoplasms  (ISO)
ischemia  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mental depression  (ISO)
Microsatellite Instability  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multi-Infarct Dementia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (ISO)
prion disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Sarcopenia  (ISO)
scrapie  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
teratoma  (ISO)
Testis Reperfusion Injury  (ISO)
thyroiditis  (ISO)
toxoplasmosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
apoptotic signaling pathway  (ISO)
B cell apoptotic process  (ISO)
B cell homeostasis  (ISO)
B cell homeostatic proliferation  (ISO)
B cell negative selection  (ISO)
B cell receptor apoptotic signaling pathway  (ISO)
blood vessel remodeling  (ISO)
brain development  (ISO)
cell population proliferation  (ISO)
cellular respiration  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to UV  (ISO)
cellular response to virus  (ISO)
cerebral cortex development  (ISO)
development of secondary sexual characteristics  (ISO)
ectopic germ cell programmed cell death  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
fertilization  (ISO)
germ cell development  (ISO)
glial cell apoptotic process  (ISO)
glycosphingolipid metabolic process  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (ISO)
hypothalamus development  (ISO)
inner mitochondrial membrane organization  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
male gonad development  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrial fusion  (ISO)
mitochondrion morphogenesis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of protein binding  (ISO)
nervous system development  (ISO)
neuron apoptotic process  (ISO)
neuron migration  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
outer mitochondrial membrane organization  (ISO)
ovarian follicle development  (ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic process involved in mammary gland involution  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
post-embryonic development  (ISO)
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
regulation of mammary gland epithelial cell proliferation  (ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of nitrogen utilization  (ISO)
release of cytochrome c from mitochondria  (ISO)
release of matrix enzymes from mitochondria  (ISO)
response to axon injury  (ISO)
response to cocaine  (ISO)
response to copper ion  (ISO)
response to corticosterone  (ISO)
response to drug  (ISO)
response to gamma radiation  (ISO)
response to ionizing radiation  (ISO)
response to salt stress  (ISO)
response to toxic substance  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
retinal cell programmed cell death  (ISO)
Sertoli cell proliferation  (ISO)
sex differentiation  (ISO)
spermatid differentiation  (ISO)
spermatogenesis  (ISO)
T cell homeostatic proliferation  (ISO)
thymocyte apoptotic process  (ISO)
vagina development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Bax
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBIChiLan1.0ChiLan1.0
BAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,954,815 - 48,961,798 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,954,825 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,458,132 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBINCBI36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
Bax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,111,119 - 45,116,344 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,111,121 - 45,116,322 (-)Ensembl
GRCm38745,461,695 - 45,466,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,461,697 - 45,466,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,717,065 - 52,722,268 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,329,744 - 45,334,864 (-)NCBImm8
Celera740,917,745 - 40,922,946 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Bax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,940,001 - 95,945,407 (-)NCBI
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Celera190,195,913 - 90,201,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
BAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,793,594 - 54,800,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,793,594 - 54,800,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,955,926 - 45,962,870 (+)NCBIMhudiblu_PPA_v0panPan3
BAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,423,388 - 107,426,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,422,424 - 107,426,464 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,945,329 - 106,949,006 (-)NCBI
ROS_Cfam_1.01107,947,413 - 107,951,165 (-)NCBI
UMICH_Zoey_3.11107,614,952 - 107,618,629 (-)NCBI
UNSW_CanFamBas_1.01107,261,311 - 107,264,988 (-)NCBI
UU_Cfam_GSD_1.01108,096,913 - 108,100,590 (-)NCBI
Bax
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,349,880 - 21,355,462 (+)NCBI
SpeTri2.0NW_0049366642,968,103 - 2,973,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,187,260 - 54,228,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,100,514 - 50,106,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,186,028 - 42,193,105 (+)NCBI
Bax
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,050,222 - 5,068,565 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000016184   ⟹   ENSCLAP00000016020
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000016185   ⟹   ENSCLAP00000016021
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555591,699,389 - 1,700,244 (-)Ensembl
RefSeq Acc Id: XM_005412921   ⟹   XP_005412978
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005412978 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005412978   ⟸   XM_005412921
- Sequence:
RefSeq Acc Id: ENSCLAP00000016021   ⟸   ENSCLAT00000016185
RefSeq Acc Id: ENSCLAP00000016020   ⟸   ENSCLAT00000016184


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011028 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000016020 ENTREZGENE
Ensembl Transcript ENSCLAT00000016184 ENTREZGENE
NCBI Gene Bax ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Bax  BCL2 associated X, apoptosis regulator    BCL2-associated X protein  Symbol and/or name change 5135510 APPROVED