Akt1 (AKT serine/threonine kinase 1) - Rat Genome Database

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Gene: Akt1 (AKT serine/threonine kinase 1) Chinchilla lanigera
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Symbol: Akt1
Name: AKT serine/threonine kinase 1
RGD ID: 8990541
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP binding (ortholog); calmodulin binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); aging (ortholog); apoptotic mitochondrial changes (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); acute promyelocytic leukemia (ortholog); adult hepatocellular carcinoma (ortholog); FOUND IN cell-cell junction (ortholog); ciliary basal body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: RAC-alpha serine/threonine-protein kinase; v-akt murine thymoma viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adult hepatocellular carcinoma  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
Aortic Valve, Calcification of  (ISO)
atherosclerosis  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bipolar disorder  (ISO)
bladder urothelial carcinoma  (ISO)
bone osteosarcoma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
cannabis abuse  (ISO)
Carcinogenesis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
coronary artery disease  (ISO)
Cowden Syndrome 6  (ISO)
diabetic retinopathy  (ISO)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
impotence  (ISO)
in situ carcinoma  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Macrocephaly Mesodermal Hamartoma Spectrum  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Meningeal Neoplasms  (ISO)
meningioma  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
paraplegia  (ISO)
Parkinson's disease  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
Stroke  (ISO)
substance-induced psychosis  (ISO)
T-Cell Lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
vulva cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to peptide  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of protein localization to mitochondrion  (ISO)
execution phase of apoptosis  (ISO)
gene expression  (ISO)
germ cell development  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycogen biosynthetic process  (ISO)
glycogen cell differentiation involved in embryonic placenta development  (ISO)
glycogen metabolic process  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
inflammatory response  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-18-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
labyrinthine layer blood vessel development  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
maintenance of protein location in mitochondrion  (ISO)
maternal placenta development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of calcium import into the mitochondrion  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of endopeptidase activity  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (ISO)
negative regulation of lymphocyte migration  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of superoxide anion generation  (ISO)
NIK/NF-kappaB signaling  (ISO)
osteoblast differentiation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
peripheral nervous system myelin maintenance  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endodeoxyribonuclease activity  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (ISO)
protein catabolic process  (ISO)
protein import into nucleus  (ISO)
protein kinase B signaling  (ISO)
protein phosphorylation  (ISO)
protein ubiquitination  (ISO)
regulation of aerobic respiration  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell migration  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of myelination  (ISO)
regulation of neuron projection development  (ISO)
regulation of protein localization  (ISO)
response to fluid shear stress  (ISO)
response to food  (ISO)
response to growth factor  (ISO)
response to hormone  (ISO)
response to ischemia  (ISO)
response to organic substance  (ISO)
response to UV-A  (ISO)
signal transduction  (ISO)
sphingosine-1-phosphate receptor signaling pathway  (ISO)
spinal cord development  (ISO)
striated muscle cell differentiation  (ISO)
translation  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Akt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
AKT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14104,769,349 - 104,795,751 (-)EnsemblGRCh38hg38GRCh38
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,235,686 - 105,262,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBINCBI36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
Akt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,620,255 - 112,641,318 (-)NCBIGRCm39mm39
GRCm39 Ensembl12112,620,255 - 112,641,318 (-)Ensembl
GRCm3812112,653,821 - 112,674,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,653,821 - 112,674,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712113,892,032 - 113,912,487 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612113,101,629 - 113,121,998 (-)NCBImm8
Celera12113,867,449 - 113,888,183 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Akt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26131,713,716 - 131,735,319 (-)NCBI
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
AKT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114105,211,645 - 105,236,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,208,128 - 105,236,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01485,417,229 - 85,444,722 (-)NCBIMhudiblu_PPA_v0panPan3
AKT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,317,399 - 72,335,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,317,869 - 72,335,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,823,163 - 71,843,039 (-)NCBI
ROS_Cfam_1.0872,592,378 - 72,612,252 (-)NCBI
UMICH_Zoey_3.1872,275,001 - 72,294,850 (-)NCBI
UNSW_CanFamBas_1.0872,318,256 - 72,338,331 (-)NCBI
UU_Cfam_GSD_1.0872,717,834 - 72,737,716 (-)NCBI
Akt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,791,300 - 1,810,158 (+)NCBI
SpeTri2.0NW_004936621620,163 - 639,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT1
(Sus scrofa - pig)
No map positions available.
AKT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,704,087 - 82,730,711 (-)NCBI
ChlSab1.1 Ensembl2482,704,068 - 82,727,698 (-)Ensembl
Akt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734507,880 - 525,295 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008918   ⟹   ENSCLAP00000008790
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000008919   ⟹   ENSCLAP00000008791
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555383,209,548 - 3,224,288 (-)Ensembl
RefSeq Acc Id: XM_005410844   ⟹   XP_005410901
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005410901 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005410901   ⟸   XM_005410844
- Sequence:
RefSeq Acc Id: ENSCLAP00000008790   ⟸   ENSCLAT00000008918
RefSeq Acc Id: ENSCLAP00000008791   ⟸   ENSCLAT00000008919


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006147 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000008790 ENTREZGENE
Ensembl Transcript ENSCLAT00000008918 ENTREZGENE
NCBI Gene Akt1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Akt1  AKT serine/threonine kinase 1    v-akt murine thymoma viral oncogene homolog 1  Symbol and/or name change 5135510 APPROVED