Cfl1 (cofilin 1) - Rat Genome Database

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Gene: Cfl1 (cofilin 1) Chinchilla lanigera
Analyze
Symbol: Cfl1
Name: cofilin 1
RGD ID: 8826230
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); phosphatidylinositol bisphosphate binding (ortholog); INVOLVED IN actin filament depolymerization (ortholog); actin filament fragmentation (ortholog); actin filament organization (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; ASSOCIATED WITH brain compression (ortholog); Breast Neoplasms (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN cell leading edge (ortholog); cell-cell junction (ortholog); cofilin-actin rod (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cofilin 1 (non-muscle); cofilin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,479,181 - 19,482,571 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,479,181 - 19,482,571 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament depolymerization  (ISO)
actin filament fragmentation  (ISO)
actin filament organization  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to ether  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to tumor necrosis factor  (ISO)
cytoskeleton organization  (ISO)
establishment of cell polarity  (ISO)
establishment of spindle localization  (ISO)
hippocampus development  (ISO)
mitotic cytokinesis  (ISO)
modification of postsynaptic actin cytoskeleton  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of actin filament depolymerization  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of lamellipodium assembly  (ISO)
negative regulation of postsynaptic density organization  (ISO)
negative regulation of unidimensional cell growth  (ISO)
neural crest cell migration  (ISO)
neural fold formation  (ISO)
positive regulation by host of viral process  (ISO)
positive regulation of actin filament depolymerization  (ISO)
positive regulation of barbed-end actin filament capping  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of embryonic development  (ISO)
positive regulation of establishment of cell polarity regulating cell shape  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein localization to cell leading edge  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of synaptic plasticity  (ISO)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
regulation of cell morphogenesis  (ISO)
regulation of dendritic spine morphogenesis  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to organic cyclic compound  (ISO)
response to virus  (ISO)

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Cfl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,479,181 - 19,482,571 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,479,181 - 19,482,571 (+)NCBIChiLan1.0ChiLan1.0
CFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,823,022 - 65,862,026 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,854,673 - 65,858,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,622,144 - 65,625,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,378,858 - 65,382,380 (-)NCBINCBI36hg18NCBI36
Build 341165,378,862 - 65,382,380NCBI
Celera1162,946,188 - 62,949,710 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,948,799 - 61,952,321 (-)NCBIHuRef
CHM1_11165,506,695 - 65,510,217 (-)NCBICHM1_1
Cfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,540,483 - 5,544,059 (+)NCBIGRCm39mm39
GRCm39 Ensembl195,540,483 - 5,545,229 (+)Ensembl
GRCm38195,490,455 - 5,494,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,490,455 - 5,495,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,490,455 - 5,494,031 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,490,525 - 5,495,201 (+)NCBImm8
Celera195,362,154 - 5,365,730 (+)NCBICelera
Cytogenetic Map19ANCBI
Cfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,796,012 - 202,801,337 (+)NCBI
Rnor_6.0 Ensembl1220,869,805 - 220,873,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01220,869,805 - 220,873,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,799,126 - 227,802,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,133,876 - 208,137,408 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11208,287,328 - 208,290,861 (+)NCBI
Celera1200,333,275 - 200,336,807 (+)NCBICelera
Cytogenetic Map1q43NCBI
CFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,544,275 - 64,548,372 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,544,275 - 64,550,806 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01161,215,092 - 61,218,628 (-)NCBIMhudiblu_PPA_v0panPan3
CFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,404,649 - 51,408,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,401,659 - 51,408,212 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,013,157 - 50,016,753 (+)NCBI
ROS_Cfam_1.01852,442,507 - 52,446,103 (+)NCBI
UMICH_Zoey_3.11851,542,563 - 51,546,159 (+)NCBI
UNSW_CanFamBas_1.01851,116,937 - 51,120,532 (+)NCBI
UU_Cfam_GSD_1.01851,906,246 - 51,909,842 (+)NCBI
Cfl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,236,442 - 7,239,965 (+)NCBI
SpeTri2.0NW_0049365993,678,724 - 3,682,314 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,469,254 - 6,475,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,471,558 - 6,475,019 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,575,587 - 5,579,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,408,560 - 8,410,564 (+)NCBI
Vero_WHO_p1.0NW_023666038105,687,711 - 105,692,145 (+)NCBI
Cfl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476720,574,884 - 20,578,413 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023650   ⟹   ENSCLAP00000023429
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542219,479,181 - 19,482,571 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000023651   ⟹   ENSCLAP00000023430
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542219,481,090 - 19,482,234 (+)Ensembl
RefSeq Acc Id: XM_013513851   ⟹   XP_013369305
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542219,479,181 - 19,482,571 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013369305 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013369305   ⟸   XM_013513851
- Sequence:
RefSeq Acc Id: ENSCLAP00000023429   ⟸   ENSCLAT00000023650
RefSeq Acc Id: ENSCLAP00000023430   ⟸   ENSCLAT00000023651


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016067 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023429 ENTREZGENE
Ensembl Transcript ENSCLAT00000023650 ENTREZGENE
NCBI Gene Cfl1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Cfl1  cofilin 1    cofilin 1 (non-muscle)  Symbol and/or name change 5135510 APPROVED