Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Chinchilla lanigera
Analyze
Symbol: Sirt1
Name: sirtuin 1
RGD ID: 8766123
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); caspase binding (ortholog); deacetylase activity (ortholog); INVOLVED IN angiogenesis (ortholog); behavioral response to starvation (ortholog); cell aging (ortholog); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); chromatin silencing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: NAD-dependent protein deacetylase sirtuin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Binge Drinking  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
behavioral response to starvation  (ISO)
cell aging  (ISO)
cellular glucose homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to antibiotic  (ISO)
cellular response to curcumin  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to rotenone  (ISO)
cellular response to starvation  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (ISO)
cellular triglyceride homeostasis  (ISO)
cholesterol homeostasis  (ISO)
chromatin organization  (ISO)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
DNA synthesis involved in DNA repair  (ISO)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
heterochromatin assembly  (ISO)
heterochromatin maintenance  (ISO)
histone deacetylation  (ISO)
histone H3 deacetylation  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (ISO)
macrophage differentiation  (ISO)
mitochondrion organization  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cAMP-dependent protein kinase activity  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (ISO)
negative regulation of helicase activity  (ISO)
negative regulation of histone H3-K14 acetylation  (ISO)
negative regulation of histone H3-K9 trimethylation  (ISO)
negative regulation of histone H4-K16 acetylation  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostaglandin biosynthetic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
ovulation from ovarian follicle  (ISO)
peptidyl-lysine acetylation  (ISO)
peptidyl-lysine deacetylation  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of histone H3-K9 methylation  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of macrophage apoptotic process  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein deacetylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle cell proliferation  (ISO)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of thyroid-stimulating hormone secretion  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (ISO)
protein depropionylation  (ISO)
protein destabilization  (ISO)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (ISO)
rDNA heterochromatin assembly  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of glucose metabolic process  (ISO)
regulation of lipid storage  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
regulation of protein serine/threonine kinase activity  (ISO)
regulation of smooth muscle cell apoptotic process  (ISO)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to kainic acid  (ISO)
response to leptin  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to resveratrol  (ISO)
single strand break repair  (ISO)
spermatogenesis  (ISO)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (ISO)
UV-damage excision repair  (ISO)
vasodilation  (ISO)
white fat cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Sirt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBIChiLan1.0ChiLan1.0
SIRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
Sirt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391063,154,784 - 63,174,814 (-)NCBIGRCm39mm39
GRCm39 Ensembl1063,154,784 - 63,217,483 (-)Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,319,005 - 63,381,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBImm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
Sirt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,307,143 - 25,329,260 (+)NCBI
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
SIRT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11066,681,983 - 66,714,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,681,598 - 66,715,069 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01064,368,878 - 64,401,684 (+)NCBIMhudiblu_PPA_v0panPan3
SIRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,188,616 - 19,220,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBI
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBI
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBI
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBI
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBI
Sirt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,803,376 - 61,829,477 (-)NCBI
SpeTri2.0NW_00493652110,296,097 - 10,316,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,091,157 - 71,123,299 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,091,167 - 71,126,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,182,651 - 77,184,716 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21477,053,991 - 77,079,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1963,463,059 - 63,497,893 (-)NCBI
ChlSab1.1 Ensembl963,462,389 - 63,497,867 (-)Ensembl
Vero_WHO_p1.0NW_02366604824,231,602 - 24,266,452 (-)NCBI
Sirt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247542,304,476 - 2,332,705 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022817   ⟹   ENSCLAP00000022609
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000022818   ⟹   ENSCLAP00000022610
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542520,297,069 - 20,305,906 (+)Ensembl
RefSeq Acc Id: XM_013514840   ⟹   XP_013370294
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370294 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013370294   ⟸   XM_013514840
- Sequence:
RefSeq Acc Id: ENSCLAP00000022610   ⟸   ENSCLAT00000022818
RefSeq Acc Id: ENSCLAP00000022609   ⟸   ENSCLAT00000022817


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015502 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000022609 ENTREZGENE
Ensembl Transcript ENSCLAT00000022817 ENTREZGENE
NCBI Gene Sirt1 ENTREZGENE