Epas1 (endothelial PAS domain protein 1) - Rat Genome Database

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Gene: Epas1 (endothelial PAS domain protein 1) Chinchilla lanigera
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Symbol: Epas1
Name: endothelial PAS domain protein 1
RGD ID: 8967431
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); cobalt ion binding (ortholog); DNA binding (ortholog); INVOLVED IN angiogenesis (ortholog); blood vessel remodeling (ortholog); cell differentiation (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute kidney failure (ortholog); azoospermia (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (ortholog); nuclear speck (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endothelial PAS domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Epas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBIChiLan1.0ChiLan1.0
EPAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,297,407 - 46,386,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,293,667 - 46,386,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37246,524,546 - 46,613,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,378,067 - 46,467,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34246,436,213 - 46,525,486NCBI
Celera246,363,267 - 46,452,583 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,262,570 - 46,351,445 (+)NCBIHuRef
CHM1_1246,455,122 - 46,544,416 (+)NCBICHM1_1
T2T-CHM13v2.0246,302,427 - 46,391,719 (+)NCBIT2T-CHM13v2.0
Epas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,061,292 - 87,140,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)EnsemblGRCm39 Ensembl
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBIMGSCv36mm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
Epas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,543,252 - 13,626,147 (-)NCBIGRCr8
mRatBN7.267,790,236 - 7,871,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,790,647 - 7,871,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,070,313 - 8,149,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,379,714 - 8,459,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,907,014 - 7,986,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
EPAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21280,015,546 - 80,104,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A80,019,514 - 80,108,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,403,411 - 46,492,734 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,332,286 - 47,421,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,332,308 - 47,421,560 (+)Ensemblpanpan1.1panPan2
EPAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,550,836 - 48,636,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,422,316 - 49,508,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBIUU_Cfam_GSD_1.0
Epas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,427,139 - 34,510,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,855,732 - 5,938,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,855,748 - 5,938,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,165,816 - 94,254,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,167,759 - 94,253,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,157,832 - 100,211,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,823,110 - 60,912,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,822,815 - 60,912,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604550,944,448 - 51,034,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473827,747,696 - 27,834,054 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473827,747,770 - 27,831,213 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000013553   ⟹   ENSCLAP00000013400
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)Ensembl
RefSeq Acc Id: XM_005390973   ⟹   XP_005391030
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005391030 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013400
  ENSCLAP00000013400.1
RefSeq Acc Id: XP_005391030   ⟸   XM_005390973
- UniProtKB: A0A8C2VEF4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000013400   ⟸   ENSCLAT00000013553
Protein Domains
bHLH   PAS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013553 ENTREZGENE
  ENSCLAT00000013553.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HIF-1_TAD_C UniProtKB/TrEMBL
  HIF_alpha_subunit UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Nuc_translocat UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Epas1 ENTREZGENE
PANTHER ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/TrEMBL
Pfam HIF-1 UniProtKB/TrEMBL
  HIF-1a_CTAD UniProtKB/TrEMBL
  PAS_11 UniProtKB/TrEMBL
  PAS_9 UniProtKB/TrEMBL
PRINTS NCTRNSLOCATR UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A8C2VEF4 ENTREZGENE, UniProtKB/TrEMBL