EPAS1 (endothelial PAS domain protein 1) - Rat Genome Database

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Gene: EPAS1 (endothelial PAS domain protein 1) Canis lupus familiaris
Analyze
Symbol: EPAS1
Name: endothelial PAS domain protein 1
RGD ID: 12133234
Description: ENCODES a protein that exhibits cobalt ion binding (ortholog); DNA-binding transcription factor activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN angiogenesis (ortholog); blood vessel remodeling (ortholog); cell differentiation (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute kidney failure (ortholog); azoospermia (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (inferred); nuclear speck (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endothelial PAS domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,550,836 - 48,636,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,422,316 - 49,508,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:25403511   PMID:30032202   PMID:32384152  


Genomics

Comparative Map Data
EPAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,550,836 - 48,636,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,422,316 - 49,508,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBIUU_Cfam_GSD_1.0
EPAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,297,407 - 46,386,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,293,667 - 46,386,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37246,524,546 - 46,613,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,378,067 - 46,467,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34246,436,213 - 46,525,486NCBI
Celera246,363,267 - 46,452,583 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,262,570 - 46,351,445 (+)NCBIHuRef
CHM1_1246,455,122 - 46,544,416 (+)NCBICHM1_1
T2T-CHM13v2.0246,302,427 - 46,391,719 (+)NCBIT2T-CHM13v2.0
Epas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,061,292 - 87,140,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)EnsemblGRCm39 Ensembl
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBIMGSCv36mm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
Epas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,543,252 - 13,626,147 (-)NCBIGRCr8
mRatBN7.267,790,236 - 7,871,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,790,647 - 7,871,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,070,313 - 8,149,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,379,714 - 8,459,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,907,014 - 7,986,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
Epas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBIChiLan1.0ChiLan1.0
EPAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21280,015,546 - 80,104,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A80,019,514 - 80,108,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,403,411 - 46,492,734 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,332,286 - 47,421,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,332,308 - 47,421,560 (+)Ensemblpanpan1.1panPan2
Epas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,427,139 - 34,510,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,855,732 - 5,938,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,855,748 - 5,938,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,165,816 - 94,254,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,167,759 - 94,253,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,157,832 - 100,211,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,823,110 - 60,912,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,822,815 - 60,912,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604550,944,448 - 51,034,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473827,747,696 - 27,834,054 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473827,747,770 - 27,831,213 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EPAS1
1392 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 2
Medium 5 5 22 6 6 6 6 6 12 8 8 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004132   ⟹   ENSCAFP00000003819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088212   ⟹   ENSCAFP00000052188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1048,605,311 - 48,634,844 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048877   ⟹   ENSCAFP00845038343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1049,422,316 - 49,508,077 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048970   ⟹   ENSCAFP00845038415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1049,422,389 - 49,505,404 (+)Ensembl
RefSeq Acc Id: XM_022424681   ⟹   XP_022280389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11048,550,837 - 48,636,776 (+)NCBI
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038489201   ⟹   XP_038345129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBI
RefSeq Acc Id: XM_038551203   ⟹   XP_038407131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBI
RefSeq Acc Id: XM_038615102   ⟹   XP_038471030
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBI
RefSeq Acc Id: XM_038680486   ⟹   XP_038536414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022280389   ⟸   XM_022424681
- UniProtKB: A0A8C0LRG2 (UniProtKB/TrEMBL),   A0A8C0NAE9 (UniProtKB/TrEMBL),   A0A8C0YRR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000052188   ⟸   ENSCAFT00000088212
RefSeq Acc Id: ENSCAFP00000003819   ⟸   ENSCAFT00000004132
RefSeq Acc Id: XP_038345129   ⟸   XM_038489201
RefSeq Acc Id: XP_038471030   ⟸   XM_038615102
RefSeq Acc Id: XP_038536414   ⟸   XM_038680486
- UniProtKB: A0A8C0LRG2 (UniProtKB/TrEMBL),   A0A8C0NAE9 (UniProtKB/TrEMBL),   A0A8C0YRR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407131   ⟸   XM_038551203
- UniProtKB: A0A8C0LRG2 (UniProtKB/TrEMBL),   A0A8C0NAE9 (UniProtKB/TrEMBL),   A0A8C0YRR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038343   ⟸   ENSCAFT00845048877
RefSeq Acc Id: ENSCAFP00845038415   ⟸   ENSCAFT00845048970
Protein Domains
bHLH   PAS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002627 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011140 UniProtKB/TrEMBL
  ENSCAFG00040009099 UniProtKB/TrEMBL
  ENSCAFG00845027702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004132.5 UniProtKB/TrEMBL
  ENSCAFT00000088212.2 UniProtKB/TrEMBL
  ENSCAFT00030020616.1 UniProtKB/TrEMBL
  ENSCAFT00030020723.1 UniProtKB/TrEMBL
  ENSCAFT00030020835.1 UniProtKB/TrEMBL
  ENSCAFT00040016880.1 UniProtKB/TrEMBL
  ENSCAFT00845048877.1 UniProtKB/TrEMBL
  ENSCAFT00845048970 ENTREZGENE
  ENSCAFT00845048970.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HIF-1_TAD_C UniProtKB/TrEMBL
  HIF_alpha_subunit UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Nuc_translocat UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
NCBI Gene EPAS1 ENTREZGENE
PANTHER ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/TrEMBL
Pfam HIF-1 UniProtKB/TrEMBL
  HIF-1a_CTAD UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_11 UniProtKB/TrEMBL
PRINTS NCTRNSLOCATR UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A8C0LRG2 ENTREZGENE
  A0A8C0MZQ6_CANLF UniProtKB/TrEMBL
  A0A8C0N2K1_CANLF UniProtKB/TrEMBL
  A0A8C0NAE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YRR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PUG3_CANLF UniProtKB/TrEMBL
  A0A8I3PYE5_CANLF UniProtKB/TrEMBL
  A0A8P0N5N3_CANLF UniProtKB/TrEMBL
  A0A8P0P1Y8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40391 ENTREZGENE