Xrcc1 (X-ray repair cross complementing 1)

Gene: Xrcc1 (X-ray repair cross complementing 1) Chinchilla lanigera

Analyze

Symbol:

Xrcc1

Name:

X-ray repair cross complementing 1

RGD ID:

8865835

Description:

ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); cerebellum morphogenesis (ortholog); DNA damage response (ortholog); PARTICIPATES IN base excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 5 Alpha Fluorouracil Toxicity (ortholog); asphyxia neonatorum (ortholog); autosomal recessive spinocerebellar ataxia 26 (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); ERCC4-ERCC1 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	1,293,416 - 1,315,839 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	1,293,416 - 1,315,839 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

5 Alpha Fluorouracil Toxicity (ISO)

acute lymphoblastic leukemia (ISO)

asphyxia neonatorum (ISO)

autosomal recessive spinocerebellar ataxia 26 (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

Birth Weight (ISO)

brain glioma (ISO)

Breast Neoplasms (ISO)

cataract (ISO)

central nervous system cancer (ISO)

cervical cancer (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Hepatitis C (ISO)

chronic myeloid leukemia (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

contact dermatitis (ISO)

coronary artery disease (ISO)

diabetic retinopathy (ISO)

Erythema (ISO)

esophageal cancer (ISO)

esophagus squamous cell carcinoma (ISO)

ethylmalonic encephalopathy (ISO)

gallbladder cancer (ISO)

gastric cardia adenocarcinoma (ISO)

gastric cardia carcinoma (ISO)

genetic disease (ISO)

glioblastoma (ISO)

hepatitis A (ISO)

hepatitis B (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Human Viral Hepatitis (ISO)

hypertension (ISO)

impotence (ISO)

in situ carcinoma (ISO)

invasive ductal carcinoma (ISO)

laryngeal carcinoma (ISO)

laryngeal squamous cell carcinoma (ISO)

leiomyoma (ISO)

liver cancer (ISO)

liver cirrhosis (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung non-small cell carcinoma (ISO)

male infertility (ISO)

malignant mesothelioma (ISO)

meningioma (ISO)

Mesothelioma (ISO)

Micronuclei, Chromosome-Defective (ISO)

Mouth Neoplasms (ISO)

myelodysplastic syndrome (ISO)

nasopharynx carcinoma (ISO)

Neoplasm Metastasis (ISO)

Occupational Diseases (ISO)

oral mucosa leukoplakia (ISO)

pancreatic cancer (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

Salivary Gland Neoplasms (ISO)

schizophrenia (ISO)

seminoma (ISO)

senile cataract (ISO)

stomach cancer (ISO)

stomach carcinoma (ISO)

Stomach Neoplasms (ISO)

stomatitis (ISO)

thyroid gland papillary carcinoma (ISO)

transient cerebral ischemia (ISO)

transitional cell carcinoma (ISO)

type 2 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (ISO)

cerebellum morphogenesis (ISO)

DNA damage response (ISO)

DNA repair (ISO)

double-strand break repair via nonhomologous end joining (ISO)

hippocampus development (ISO)

negative regulation of protection from non-homologous end joining at telomere (ISO)

positive regulation of single strand break repair (ISO)

replication-born double-strand break repair via sister chromatid exchange (ISO)

response to hydroperoxide (ISO)

response to hypoxia (ISO)

response to organic substance (ISO)

response to xenobiotic stimulus (ISO)

telomeric DNA-containing double minutes formation (ISO)

voluntary musculoskeletal movement (ISO)

Cellular Component

chromatin (ISO)

chromosome, telomeric region (ISO)

ERCC4-ERCC1 complex (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

site of DNA damage (ISO)

Molecular Function

3' overhang single-stranded DNA endodeoxyribonuclease activity (ISO)

ADP-D-ribose modification-dependent protein binding (ISO)

enzyme binding (ISO)

oxidized DNA binding (ISO)

poly-ADP-D-ribose binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

base excision repair pathway (ISO)

nucleotide excision repair pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Xrcc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	1,293,416 - 1,315,839 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	1,293,416 - 1,315,839 (-)	NCBI	ChiLan1.0	ChiLan1.0

XRCC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	43,543,311 - 43,575,527 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	43,543,311 - 43,580,473 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	44,047,463 - 44,079,679 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	48,739,304 - 48,771,555 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	48,739,303 - 48,771,555	NCBI
Celera	19	40,850,091 - 40,882,209 (-)	NCBI		Celera
Cytogenetic Map	19	q13.31	NCBI
HuRef	19	40,478,136 - 40,510,489 (-)	NCBI		HuRef
CHM1_1	19	44,049,115 - 44,081,452 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	46,364,840 - 46,397,157 (-)	NCBI		T2T-CHM13v2.0

Xrcc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	24,246,124 - 24,272,863 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	24,245,714 - 24,272,865 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	24,546,699 - 24,573,438 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	24,546,289 - 24,573,440 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	25,332,169 - 25,358,457 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	24,255,049 - 24,282,192 (+)	NCBI		MGSCv36	mm8
Celera	7	19,161,255 - 19,187,540 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	11.42	NCBI

Xrcc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	89,268,721 - 89,296,619 (+)	NCBI		GRCr8
mRatBN7.2	1	80,140,495 - 80,168,705 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	80,141,207 - 80,168,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	85,534,876 - 85,562,653 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	94,084,721 - 94,112,152 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	87,290,702 - 87,318,402 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	81,412,635 - 81,441,680 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	81,413,353 - 81,441,678 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	82,673,571 - 82,701,082 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	79,834,167 - 79,860,300 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	79,912,277 - 79,938,411 (+)	NCBI
Celera	1	74,594,313 - 74,621,523 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

XRCC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	49,702,261 - 49,739,417 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	51,570,527 - 51,608,367 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	40,485,052 - 40,522,188 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	49,093,928 - 49,125,723 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	49,094,014 - 49,125,520 (-)	Ensembl	panpan1.1		panPan2

XRCC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	111,548,719 - 111,571,816 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	111,548,719 - 111,571,816 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	111,028,445 - 111,051,541 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	112,158,850 - 112,181,954 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	112,158,850 - 112,181,954 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	111,746,938 - 111,770,215 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	111,380,774 - 111,403,889 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	112,265,054 - 112,288,168 (+)	NCBI		UU_Cfam_GSD_1.0

Xrcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	16,407,084 - 16,436,413 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	751,108 - 783,777 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	752,571 - 783,746 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XRCC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	50,403,689 - 50,425,729 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	50,403,691 - 50,425,730 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	46,158,742 - 46,180,744 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XRCC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	37,062,149 - 37,095,138 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	37,060,439 - 37,095,094 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	16,603,474 - 16,637,686 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xrcc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	1,087,611 - 1,113,266 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624907	1,087,611 - 1,113,275 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005412443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005412444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01073070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01073071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01073072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01053241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000002319 ⟹ ENSCLAP00000002271

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955555	1,293,416 - 1,315,839 (-)	Ensembl

RefSeq Acc Id:

XM_005412443 ⟹ XP_005412500

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955555	1,293,416 - 1,315,839 (-)	NCBI

Sequence:

show sequence

GGAGAAGCTCGTCTGCGCTTGCGCTGAGTCGACGCTAGCGCCGCGCGCCGCGGTTTGAAAGGCC
CGAGCCTCGCGCGCTTGCGCACTGAAGCCCGCGCGGGGAGCTCCCCTTCCCCGCCCCCCAAACG
GGACCCTTCCTCACTCTCTAGTGTAGGTGAAGCCCACGACTTTGGCATGCCGGAGATCCGCCTC
CGCCACGTCGTGTCCTGCAGCAGCCAGGATTCGACCCACTGTGCGGAAAACCTCCTCAAGGCGG
ACACTTACCGGAAATGGCGGGCAGCCAAGGCGGGCGAGAAGTCCATCTCGGTGGTCCTACAGCT
GGAGAAGGAGGAGCAGATCCACAGTGTGGACATCGGGAACGACGGCTCGGCCTTTGTAGAGGTG
CTGGTGGGCAGCTCAGCCGGAGGGGCCGGCGAGCAGGACTACGAGGTGCTCCTGGTCACCTCAT
CTTTCATGTCCCCTGCCGAGAGCCGCAGTGGCTCAAACCCCAACCGTGTTCGCATTTTTGGGCC
TGACAAGCTGGTCCGGGCAGCAGCTGAGAAGCGCTGGGACCGAGTCAAAATTGTGTGCAGCCAG
CCCTACACCAAGGACTCTCCCTATGGCCTGAGTTTTATACGGCTTCATAGCCCTCCAGACAAAG
AGGAAGCAGAGGTCCCAACCCAGAAGGTGACAGTGACTAAGCTTGGCCAGTTCCGGGTGAAGGA
GGAAGACGAGAGCGCCAGCTCCCTGAGACCGGGAGCCCTCTTCTTTGGCAGGATAAACAAGACA
TCCCCAGCCACAGCCAGTGACCCAACAGGGCCCAGCTATGCAGCAGCTACACTCCAGGCCTCCA
GTGCCGCATCCTCCACCTCTCCACTCTCCAAGGCTGTGGGCAGCAGCTCTAAGCCTCAGGAGAC
CCCCAAAGGGAAGAGGAAGTTGGATTTGAATGTAGAAGAAAGGAAGACCCCCAGCAAACCGCCA
GCCCAGCTCTCATCTCCTGCCCTCAAGAGACCCAAATTGCCAGCTCCCACTCGCACCCCCACCG
CAGCCCCAGTCCCTGCTGTAGCACAGAAGGCTGGGCCAGAGAAGCCCCGCGGAGACGGCGACGA
GCCCAGGGGAGCCCGAGCCGGCCCTCAGGAGCTGGGGAAGATCCTTCAAGGTGTGGTGGTGGTG
CTGAGTGGCTTCCAGAACCCCTTCCGCTCGGAGCTCCGGGACAAGGCCCTGGAGCTGGGTGCCA
AGTATCGGCCAGACTGGACCCCGGACAGTACCCACCTCATCTGCGCCTTTGCGAACACCCCCAA
GTACAGCCAGGTCCTTGGCCTCGGAGGCCGCATTGTGCGCAAAGAGTGGGTGCTGGACTGTCAC
CGCATGCGACGGCGGCTGCCCTCCCGGAGGTACCTCATGGCAGGGCCCGACTCCAGCAGTGAGG
ATGAGGGGGGCGGTCCCAGCGGCAGCAGCGGGGATGAAGCCCCTAGGCCTCTAAGAAAGCGCCC
CCAGACCAAAACCAAGCCTCCCCTGGCATCTGGACCCAGCTCACCCCAGAAGCCCTTAAGCCCA
AAAGAGACCAAAGCAGCCTCAGTAGGACCCCAGGAAAATTCTGACACGGAGGAGGAAGAGTCAG
CAGGTCGGGACCGTGGGGAGGAGGAGTCTGGGGACACTGAGGATGAGCTGAGAAGGGTGGCTGA
GCAGAGGGAGCACAGGCCGCCCCCTGGCCAGGAGGAGAATGGCGAGGAGGACCCCTATGCGGGC
TCCACAGATGAGAACACGGACAGCGAGGATCGCCCTGAGCCTGCCGACCAGCCAATTCCTGAAC
TCCCAGACTTCTTCCAGGGCAAGCACTTCTTCCTGTACGGGGAGTTCCCTGGGGACGAGCGGCG
GAAGCTCATTCGATATGTCACTGCCTTCAACGGGGAGCTCGAGGACTATATGAGTGACCGTGTC
CAGTTTGTGATCACAGCACAGGAATGGGATCCGAGCTTCGAGGAGGCTCTGATGGACAACCCCT
CCCTGGCATTTGTTCGTCCCCGATGGATCTACAGTTGCAACGAGAAGCAGAAGTTACTTCCCCA
CCAGCTCTATGGGGTGGTGCCCCAGGCCTGAACCGTGCACTTGTGTGCACAGACGTGCACGGAC
ACACACACAGTTTAATAAAGGTGACCTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_005412444 ⟹ XP_005412501

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955555	1,293,416 - 1,315,838 (-)	NCBI

Sequence:

show sequence

GAGAAGCTCGTCTGCGCTTGCGCTGAGTCGACGCTAGCGCCGCGCGCCGCGGTTTGAAAGGCCC
GAGCCTCGCGCGCTTGCGCACTGAAGCCCGCGCGGGGAGCTCCCCTTCCCCGCCCCCCAAACGG
GACCCTTCCTCACTCTCTAGTGTAGGTGAAGCCCACGACTTTGGCATGCCGGAGATCCGCCTCC
GCCACGTCGTGTCCTGCAGCAGCCAGGATTCGACCCACTGTGCGGAAAACCTCCTCAAGGCGGA
CACTTACCGGAAATGGCGGGCAGCCAAGGCGGGCGAGAAGTCCATCTCGGTGGTCCTACAGCTG
GAGAAGGAGGAGCAGATCCACAGTGTGGACATCGGGAACGACGGCTCGGCCTTTGTAGAGGTGC
TGGTGGGCAGCTCAGCCGGAGGGGCCGGCGAGCAGGACTACGAGGTGCTCCTGGTCACCTCATC
TTTCATGTCCCCTGCCGAGAGCCGCAGTGGCTCAAACCCCAACCGTGTTCGCATTTTTGGGCCT
GACAAGCTGGTCCGGGCAGCAGCTGAGAAGCGCTGGGACCGAGTCAAAATTGTGTGCAGCCAGC
CCTACACCAAGGACTCTCCCTATGGCCTGAGTTTTATACGGCTTCATAGCCCTCCAGACAAAGA
GGAAGCAGAGGTCCCAACCCAGAAGGTGACAGTGACTAAGCTTGGCCAGTTCCGGGTGAAGGAG
GAAGACGAGAGCGCCAGCTCCCTGAGACCGGGAGCCCTCTTCTTTGGCAGGATAAACAAGACAT
CCCCAGCCACAGCCAGTGACCCAACAGGGCCCAGCTATGCAGCAGCTACACTCCAGGCCTCCAG
TGCCGCATCCTCCACCTCTCCACTCTCCAAGGCTGTGGGCAGCAGCTCTAAGCCTCAGGAGACC
CCCAAAGGGAAGAGGAAGTTGGATTTGAATGTAGAAGAAAGGAAGACCCCCAGCAAACCGCCAG
CCCAGCTCTCATCTCCTGCCCTCAAGAGACCCAAATTGCCAGCTCCCACTCGCACCCCCACCGC
AGCCCCAGTCCCTGCTGTAGCACAGAAGGCTGGGCCAGAGAAGCCCCGCGGAGACGGCGACGAG
CCCAGGGGAGCCCGAGCCGGCCCTCAGGAGCTGGGGAAGATCCTTCAAGGTGTGGTGGTGGTGC
TGAGTGGCTTCCAGAACCCCTTCCGCTCGGAGCTCCGGGACAAGGCCCTGGAGCTGGGTGCCAA
GTATCGGCCAGACTGGACCCCGGACAGTACCCACCTCATCTGCGCCTTTGCGAACACCCCCAAG
TACAGCCAGGTCCTTGGCCTCGGAGGCCGCATTGTGCGCAAAGAGTGGGTGCTGGACTGTCACC
GCATGCGACGGCGGCTGCCCTCCCGGAGGTACCTCATGGCAGGGCCCGACTCCAGCAGTGAGGA
TGAGGGGGGCGGTCCCAGCGGCAGCAGCGGGGATGAAGCCCCTAGGCCTCTAAGAAAGCGCCCC
CAGACCAAAACCAAGCCTCCCCTGGCATCTGGACCCAGCTCACCCCAGAAGCCCTTAAGCCCAA
AAGAGACCAAAGCAGCCTCAGTAGGACCCCAGGAAAATTCTGACACGGAGGAGGAAGAGTCAGG
TCGGGACCGTGGGGAGGAGGAGTCTGGGGACACTGAGGATGAGCTGAGAAGGGTGGCTGAGCAG
AGGGAGCACAGGCCGCCCCCTGGCCAGGAGGAGAATGGCGAGGAGGACCCCTATGCGGGCTCCA
CAGATGAGAACACGGACAGCGAGGATCGCCCTGAGCCTGCCGACCAGCCAATTCCTGAACTCCC
AGACTTCTTCCAGGGCAAGCACTTCTTCCTGTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAG
CTCATTCGATATGTCACTGCCTTCAACGGGGAGCTCGAGGACTATATGAGTGACCGTGTCCAGT
TTGTGATCACAGCACAGGAATGGGATCCGAGCTTCGAGGAGGCTCTGATGGACAACCCCTCCCT
GGCATTTGTTCGTCCCCGATGGATCTACAGTTGCAACGAGAAGCAGAAGTTACTTCCCCACCAG
CTCTATGGGGTGGTGCCCCAGGCCTGAACCGTGCACTTGTGTGCACAGACGTGCACGGACACAC
ACACAGTTTAATAAAGGTGACCTGCTTTGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005412500	(Get FASTA)	NCBI Sequence Viewer
	XP_005412501	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002271
	ENSCLAP00000002271.1

RefSeq Acc Id:

XP_005412501 ⟸ XM_005412444

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKSISVVLQLEKEEQIHSVDIGNDG
SAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPAESRSGSNPNRVRIFGPDKLVRAAAEKRWDRV
KIVCSQPYTKDSPYGLSFIRLHSPPDKEEAEVPTQKVTVTKLGQFRVKEEDESASSLRPGALFF
GRINKTSPATASDPTGPSYAAATLQASSAASSTSPLSKAVGSSSKPQETPKGKRKLDLNVEERK
TPSKPPAQLSSPALKRPKLPAPTRTPTAAPVPAVAQKAGPEKPRGDGDEPRGARAGPQELGKIL
QGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKE
WVLDCHRMRRRLPSRRYLMAGPDSSSEDEGGGPSGSSGDEAPRPLRKRPQTKTKPPLASGPSSP
QKPLSPKETKAASVGPQENSDTEEEESGRDRGEEESGDTEDELRRVAEQREHRPPPGQEENGEE
DPYAGSTDENTDSEDRPEPADQPIPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDY
MSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA

hide sequence

RefSeq Acc Id:	XP_005412500 ⟸ XM_005412443
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2URI2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKSISVVLQLEKEEQIHSVDIGNDG SAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPAESRSGSNPNRVRIFGPDKLVRAAAEKRWDRV KIVCSQPYTKDSPYGLSFIRLHSPPDKEEAEVPTQKVTVTKLGQFRVKEEDESASSLRPGALFF GRINKTSPATASDPTGPSYAAATLQASSAASSTSPLSKAVGSSSKPQETPKGKRKLDLNVEERK TPSKPPAQLSSPALKRPKLPAPTRTPTAAPVPAVAQKAGPEKPRGDGDEPRGARAGPQELGKIL QGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKE WVLDCHRMRRRLPSRRYLMAGPDSSSEDEGGGPSGSSGDEAPRPLRKRPQTKTKPPLASGPSSP QKPLSPKETKAASVGPQENSDTEEEESAGRDRGEEESGDTEDELRRVAEQREHRPPPGQEENGE EDPYAGSTDENTDSEDRPEPADQPIPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELED YMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA hide sequence

RefSeq Acc Id:

ENSCLAP00000002271 ⟸ ENSCLAT00000002319

Protein Domains

BRCT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001641	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002319	ENTREZGENE
	ENSCLAT00000002319.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10190	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
InterPro	BRCT_dom	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	BRCT_XRCC1_rpt1	UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/TrEMBL
	Xrcc1_N	UniProtKB/TrEMBL
NCBI Gene	Xrcc1	ENTREZGENE
PANTHER	DNA REPAIR PROTEIN XRCC1	UniProtKB/TrEMBL
	DNA-REPAIR PROTEIN XRCC1	UniProtKB/TrEMBL
Pfam	BRCT	UniProtKB/TrEMBL
	BRCT_2	UniProtKB/TrEMBL
	XRCC1_N	UniProtKB/TrEMBL
PROSITE	BRCT	UniProtKB/TrEMBL
SMART	BRCT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49785	UniProtKB/TrEMBL
	SSF52113	UniProtKB/TrEMBL
UniProt	A0A8C2URI2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Xrcc1	X-ray repair cross complementing 1		X-ray repair complementing defective repair in Chinese hamster cells 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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