Nfe2l2 (nuclear factor, erythroid 2 like 2) - Rat Genome Database
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Gene: Nfe2l2 (nuclear factor, erythroid 2 like 2) Chinchilla lanigera
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Symbol: Nfe2l2
Name: nuclear factor, erythroid 2 like 2
RGD ID: 8798257
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN aflatoxin catabolic process (ortholog); aging (ortholog); cell redox homeostasis (ortholog); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; ASSOCIATED WITH Acidoses (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN centrosome (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2-like 2
Orthologs:
Homo sapiens (human) : NFE2L2 (nuclear factor, erythroid 2 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Nfe2l2 (nuclear factor, erythroid derived 2, like 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfe2l2 (nuclear factor, erythroid 2-like 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Canis lupus familiaris (dog) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
Sus scrofa (pig) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Chlorocebus sabaeus (African green monkey) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Heterocephalus glaber (naked mole-rat) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acidoses  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiac Output, Low  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colorectal cancer  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
fatty liver disease  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
Gastrointestinal Diseases  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA  (ISO)
Insulin Resistance  (ISO)
keratosis  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macular degeneration  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
pancreatic ductal carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
pleurisy  (ISO)
Premature Aging  (ISO)
premature ovarian failure  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
sickle cell anemia  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sunburn  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular System Injuries  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin catabolic process  (ISO)
aging  (ISO)
cell redox homeostasis  (ISO)
cellular response to angiotensin  (ISO)
cellular response to copper ion  (ISO)
cellular response to drug  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to laminar fluid shear stress  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to tumor necrosis factor  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
inflammatory response  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of hematopoietic stem cell differentiation  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
PERK-mediated unfolded protein response  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glutathione biosynthetic process  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to stress  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
proteasomal ubiquitin-independent protein catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein ubiquitination  (ISO)
regulation of embryonic development  (ISO)
regulation of removal of superoxide radicals  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to drug  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to lithium ion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Nfe2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBIChiLan1.0ChiLan1.0
NFE2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2177,227,595 - 177,392,697 (-)EnsemblGRCh38hg38GRCh38
GRCh382177,230,303 - 177,265,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372178,095,031 - 178,129,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362177,803,282 - 177,837,663 (-)NCBINCBI36hg18NCBI36
Build 342177,920,542 - 177,954,924NCBI
Celera2171,697,459 - 171,732,295 (-)NCBI
Cytogenetic Map2q31.2NCBI
HuRef2169,966,324 - 170,001,125 (-)NCBIHuRef
CHM1_12178,100,863 - 178,135,685 (-)NCBICHM1_1
Nfe2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39275,505,857 - 75,535,007 (-)NCBI
GRCm38275,675,513 - 75,704,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl275,675,513 - 75,704,641 (-)EnsemblGRCm38mm10GRCm38
MGSCv37275,513,576 - 75,542,698 (-)NCBIGRCm37mm9NCBIm37
MGSCv36275,476,358 - 75,505,480 (-)NCBImm8
Celera277,336,615 - 77,365,680 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.75NCBI
Nfe2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
NFE2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B182,214,116 - 182,248,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B182,214,116 - 182,248,085 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B64,509,446 - 64,544,600 (-)NCBIMhudiblu_PPA_v0panPan3
NFE2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3620,989,360 - 21,012,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13620,989,205 - 21,087,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nfe2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365096,589,967 - 6,621,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFE2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1582,973,648 - 83,146,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11582,967,485 - 83,146,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21592,433,294 - 92,469,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFE2L2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)Ensembl
ChlSab1.11062,789,647 - 62,825,651 (-)NCBI
Nfe2l2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478714,355,330 - 14,381,353 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019330   ⟹   ENSCLAP00000019145
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)Ensembl
RefSeq Acc Id: XM_005373407   ⟹   XP_005373464
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512710   ⟹   XP_013368164
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540319,517,002 - 19,536,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512713   ⟹   XP_013368167
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540319,517,000 - 19,536,428 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005373464 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368164 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368167 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005373464   ⟸   XM_005373407
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013368167   ⟸   XM_013512713
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013368164   ⟸   XM_013512710
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000019145   ⟸   ENSCLAT00000019330


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013122 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000019145 ENTREZGENE
Ensembl Transcript ENSCLAT00000019330 ENTREZGENE
NCBI Gene Nfe2l2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nfe2l2  nuclear factor, erythroid 2 like 2    nuclear factor, erythroid 2-like 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Nfe2l2  nuclear factor, erythroid 2-like 2    nuclear factor (erythroid-derived 2)-like 2  Symbol and/or name change 5135510 APPROVED