Apoc2 (apolipoprotein C2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Apoc2 (apolipoprotein C2) Chinchilla lanigera
Analyze
Symbol: Apoc2
Name: apolipoprotein C2
RGD ID: 8781812
Description: ENCODES a protein that exhibits identical protein binding (ortholog); lipase inhibitor activity (ortholog); lipid binding (ortholog); INVOLVED IN cholesterol efflux (ortholog); chylomicron remnant clearance (ortholog); chylomicron remodeling (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Coronary Disease (ortholog); diabetes mellitus (ortholog); FOUND IN chylomicron (ortholog); extracellular space (ortholog); intermediate-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apolipoprotein C-II
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,016,217 - 2,021,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,019,547 - 2,021,543 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2ChinchillaCoronary Disease susceptibilityISORGD:13520019068941 RGDPMID:7590197|REF_RGD_ID:1601205
Apoc2Chinchilladiabetes mellitus  ISORGD:13520019068941protein:increased expression:serumRGDPMID:2352345|REF_RGD_ID:2313973
Apoc2Chinchillaend stage renal disease  ISORGD:13520019068941associated with Diabetes Mellitus, Insulin-DependentRGDPMID:8139482|REF_RGD_ID:2313968
Apoc2Chinchillafamilial hyperlipidemia susceptibilityISORGD:13520019068941 RGDPMID:1782747|REF_RGD_ID:1599175
Apoc2Chinchillahepatocellular carcinoma  ISORGD:13520019068941associated with hepatitis B; mRNA:increased expression:liverRGDPMID:31211449|REF_RGD_ID:153350082
Apoc2ChinchillaHypercholesterolemia susceptibilityISORGD:13520019068941associated with Hypertriglyceridemia;DNA:missense mutation: :p.K38Q (human)RGDPMID:8490626|REF_RGD_ID:1601207
Apoc2ChinchillaHyperlipoproteinemias  ISORGD:13520019068941protein:increased expression:serumRGDPMID:1468157|REF_RGD_ID:1601208
Apoc2ChinchillaHyperlipoproteinemias susceptibilityISORGD:13520019068941DNA:missense mutation: :p.L72P (human)RGDPMID:16153625|REF_RGD_ID:1601204
Apoc2ChinchillaHypertriglyceridemia  ISORGD:13520019068941 RGDPMID:3944267|REF_RGD_ID:1601214
Apoc2ChinchillaHypertriglyceridemia susceptibilityISORGD:13520019068941 RGDPMID:7590197|REF_RGD_ID:1601205
Apoc2Chinchillahypobetalipoproteinemia  ISORGD:13520019068941protein:decreased expression:plasmaRGDPMID:2242096|REF_RGD_ID:1601212
Apoc2Chinchillalipid metabolism disorder no_associationISORGD:13520019068941DNA:missense mutation: :p.K19T (human)RGDPMID:7923858|REF_RGD_ID:1601206
Apoc2Chinchillamultiple sclerosis  ISORGD:13520019068941 RGDPMID:10335523|REF_RGD_ID:1358408
Apoc2Chinchillanephrotic syndrome  ISORGD:13520019068941protein:increased expression:serumRGDPMID:8366982|REF_RGD_ID:2313970
Apoc2Chinchillaobesity  ISORGD:13520019068941protein:increased expression:serumRGDPMID:9002300|REF_RGD_ID:1601191
Apoc2Chinchillatype 2 diabetes mellitus  ISORGD:13520019068941protein:increased expression:plasmaRGDPMID:12733353|PMID:3757210|REF_RGD_ID:2313953|REF_RGD_ID:2313966
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillafamilial apolipoprotein C-II deficiency  ISORGD:13520018554872ClinVar Annotator: match by term: Familial apolipoprotein C-II deficiencyClinVarPMID:12783430|PMID:1349286|PMID:1569385|PMID:1628605|PMID:1782747|PMID:1971748|PMID:1990844|PMID:213719|PMID:22135386|PMID:2477392|PMID:24788417|PMID:25741868|PMID:2592354|PMID:26772541|PMID:28492532|PMID:29100061|PMID:30197986|PMID:30686043|PMID:30793526|PMID:31538826|PMID:31589614|PMID:31619059|PMID:3192518|PMID:32041611|PMID:3225819|PMID:3263393|PMID:32861330|PMID:33111339|PMID:33116287|PMID:3467353|PMID:36152419|PMID:36325899|PMID:36555767|PMID:3680515|PMID:3944267|PMID:3944271|PMID:7815420|PMID:7923858|PMID:8323539|PMID:8490626
Apoc2Chinchillafamilial lipoprotein lipase deficiency  ISORGD:13520018554872ClinVar Annotator: match by term: C-II ANAPOLIPOPROTEINEMIAClinVarPMID:12783430|PMID:1349286|PMID:1628605|PMID:1782747|PMID:1971748|PMID:1990844|PMID:213719|PMID:22135386|PMID:2477392|PMID:24788417|PMID:25741868|PMID:2592354|PMID:28492532|PMID:29100061|PMID:30197986|PMID:30686043|PMID:30793526|PMID:31538826|PMID:31589614|PMID:31619059|PMID:32041611|PMID:3225819|PMID:3263393|PMID:32861330|PMID:33111339|PMID:33116287|PMID:3467353|PMID:36152419|PMID:36325899|PMID:36555767|PMID:3680515|PMID:3944267|PMID:3944271|PMID:7815420|PMID:7923858|PMID:8323539|PMID:8490626
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2ChinchillaAcute Liver Failure  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:35172013
Apoc2ChinchillaDrug Eruptions  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:21055120
Apoc2ChinchillaExperimental Liver Neoplasms  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:11420682
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillafamilial apolipoprotein C-II deficiency  ISORGD:13520017240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillacholesterol efflux involved_inISORGD:13520019068941 PMID:11162594BHF-UCLPMID:11162594
Apoc2Chinchillachylomicron remnant clearance involved_inISORGD:13520019068941 PMID:4020294BHF-UCLPMID:4020294
Apoc2Chinchillachylomicron remodeling involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillahigh-density lipoprotein particle clearance involved_inISORGD:13520019068941 PMID:15778093BHF-UCLPMID:15778093
Apoc2Chinchillalipoprotein transport  ISORGD:21359068941 RGDPMID:4020294|REF_RGD_ID:1599181
Apoc2Chinchillanegative regulation of cholesterol transport involved_inISORGD:13520019068941 PMID:15778093BHF-UCLPMID:15778093
Apoc2Chinchillanegative regulation of lipid metabolic process involved_inISORGD:13520019068941 PMID:182536BHF-UCLPMID:182536
Apoc2Chinchillanegative regulation of receptor-mediated endocytosis involved_inISORGD:13520019068941 PMID:1917954BHF-UCLPMID:1917954
Apoc2Chinchillanegative regulation of very-low-density lipoprotein particle clearance involved_inISORGD:13520019068941 PMID:1917954BHF-UCLPMID:1917954
Apoc2Chinchillaphospholipid efflux involved_inISORGD:13520019068941 PMID:11162594BHF-UCLPMID:11162594
Apoc2Chinchillapositive regulation of fatty acid biosynthetic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillapositive regulation of phospholipid catabolic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillapositive regulation of triglyceride catabolic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillapositive regulation of very-low-density lipoprotein particle remodeling involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillaresponse to xenobiotic stimulus  ISORGD:21359068941 RGDPMID:9888873|REF_RGD_ID:1599178
Apoc2Chinchillatriglyceride homeostasis involved_inISORGD:13520019068941 PMID:17018885BHF-UCLPMID:17018885
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillachylomicron part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722
Apoc2Chinchillaextracellular space located_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillaintermediate-density lipoprotein particle part_ofISORGD:13520019068941 PMID:17336988BHF-UCLPMID:17336988
Apoc2Chinchillalow-density lipoprotein particle part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722
Apoc2Chinchillaspherical high-density lipoprotein particle part_ofISORGD:13520019068941 PMID:16682745BHF-UCLPMID:16682745
Apoc2Chinchillavery-low-density lipoprotein particle part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillaidentical protein binding enablesISOUniProtKB:P02655-PRO_00000020249068941 PMID:28229588IntActPMID:28229588
Apoc2Chinchillalipase inhibitor activity enablesISORGD:13520019068941 PMID:182536BHF-UCLPMID:182536
Apoc2Chinchillalipid binding enablesISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillalipoprotein lipase activator activity enablesISORGD:13520019068941 PMID:10727238, PMID:15878877, PMID:270715CACAOPMID:10727238|PMID:15878877|PMID:270715
Apoc2Chinchillamolecular function activator activity enablesISORGD:13520019068941 PMID:15209504DisProtPMID:15209504
Apoc2Chinchillaphospholipase activator activity enablesISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillaphospholipase binding enablesISOUniProtKB:P111519068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Chinchillaprotein binding enablesISOUniProtKB:P496389068941 PMID:32296183IntActPMID:32296183

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Chinchillaaltered lipoprotein metabolic pathway  ISORGD:13520019068941 RGDPMID:10073946|REF_RGD_ID:1578471
Apoc2Chinchillalipoprotein metabolic pathway  ISORGD:13520019068941 RGDPMID:10073946|REF_RGD_ID:1578471

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Apoc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,016,217 - 2,021,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,019,547 - 2,021,543 (+)NCBIChiLan1.0ChiLan1.0
APOC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,946,051 - 44,949,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,946,035 - 44,949,565 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,449,308 - 45,452,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,141,083 - 50,144,658 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,141,082 - 50,144,657NCBI
Celera1942,253,565 - 42,257,132 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,879,798 - 41,883,381 (+)NCBIHuRef
CHM1_11945,452,071 - 45,455,660 (+)NCBICHM1_1
T2T-CHM13v2.01947,770,875 - 47,774,393 (+)NCBIT2T-CHM13v2.0
Apoc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,405,504 - 19,411,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,405,504 - 19,411,866 (-)EnsemblGRCm39 Ensembl
GRCm38719,671,579 - 19,677,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,671,579 - 19,677,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,256,928 - 20,262,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,830,106 - 18,836,463 (-)NCBIMGSCv36mm8
Celera717,077,835 - 17,082,947 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,457,397 - 88,462,365 (-)NCBIGRCr8
mRatBN7.2179,329,429 - 79,334,397 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,329,428 - 79,334,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,724,358 - 84,729,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,275,674 - 93,280,670 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,479,464 - 86,484,436 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,589,023 - 80,593,991 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,589,023 - 80,594,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,854,610 - 81,859,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,979,034 - 78,984,002 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,788,729 - 73,793,701 (-)NCBICelera
Cytogenetic Map1q21NCBI
APOC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,104,521 - 51,108,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,976,612 - 52,980,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,892,954 - 41,896,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,498,109 - 50,501,877 (+)NCBIpanpan1.1PanPan1.1panPan2
APOC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,504,806 - 110,506,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,504,815 - 110,506,961 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,985,886 - 109,987,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,034,576 - 111,036,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,034,585 - 111,036,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,709,344 - 110,711,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,344,763 - 110,346,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,213,632 - 111,215,715 (-)NCBIUU_Cfam_GSD_1.0
Apoc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,531,219 - 1,531,921 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1651,404,219 - 51,406,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,285,954 - 47,288,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,406,829 - 38,411,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,409,641 - 38,410,927 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,985,436 - 17,990,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,765,481 - 1,769,781 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,765,467 - 1,769,786 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
RefSeq Transcripts XM_005412482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01073125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01062692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000001566   ⟹   ENSCLAP00000001523
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555552,016,217 - 2,021,830 (+)Ensembl
RefSeq Acc Id: XM_005412482   ⟹   XP_005412539
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555552,019,547 - 2,021,543 (+)NCBI
Sequence:
Protein RefSeqs XP_005412539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001523
  ENSCLAP00000001523.1
RefSeq Acc Id: XP_005412539   ⟸   XM_005412482
- UniProtKB: A0A8C2UKH1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000001523   ⟸   ENSCLAT00000001566



1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000001142 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001566 ENTREZGENE
  ENSCLAT00000001566.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1440.10 UniProtKB/TrEMBL
InterPro Apo-CII UniProtKB/TrEMBL
  ApoC-II_dom_sf UniProtKB/TrEMBL
NCBI Gene Apoc2 ENTREZGENE
PANTHER APOLIPOPROTEIN C-II UniProtKB/TrEMBL
  PTHR16566 UniProtKB/TrEMBL
Pfam Apo-CII UniProtKB/TrEMBL
UniProt A0A8C2UKH1 ENTREZGENE, UniProtKB/TrEMBL
1 to 11 of 11 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Apoc2  apolipoprotein C2    apolipoprotein C-II  Symbol and/or name change 5135510 APPROVED