Apoc2 (apolipoprotein C2) - Rat Genome Database

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Gene: Apoc2 (apolipoprotein C2) Ictidomys tridecemlineatus
Analyze
Symbol: Apoc2
Name: apolipoprotein C2
RGD ID: 12440545
Description: ENCODES a protein that exhibits identical protein binding (ortholog); lipase inhibitor activity (ortholog); lipid binding (ortholog); INVOLVED IN cholesterol efflux (ortholog); chylomicron remnant clearance (ortholog); chylomicron remodeling (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Coronary Disease (ortholog); diabetes mellitus (ortholog); FOUND IN chylomicron (ortholog); extracellular space (ortholog); intermediate-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apolipoprotein C-II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,531,219 - 1,531,921 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2SquirrelCoronary Disease susceptibilityISORGD:13520019068941 RGDPMID:7590197|REF_RGD_ID:1601205
Apoc2Squirreldiabetes mellitus  ISORGD:13520019068941protein:increased expression:serumRGDPMID:2352345|REF_RGD_ID:2313973
Apoc2Squirrelend stage renal disease  ISORGD:13520019068941associated with Diabetes Mellitus, Insulin-DependentRGDPMID:8139482|REF_RGD_ID:2313968
Apoc2Squirrelfamilial hyperlipidemia susceptibilityISORGD:13520019068941 RGDPMID:1782747|REF_RGD_ID:1599175
Apoc2Squirrelhepatocellular carcinoma  ISORGD:13520019068941associated with hepatitis B; mRNA:increased expression:liverRGDPMID:31211449|REF_RGD_ID:153350082
Apoc2SquirrelHypercholesterolemia susceptibilityISORGD:13520019068941associated with Hypertriglyceridemia;DNA:missense mutation: :p.K38Q (human)RGDPMID:8490626|REF_RGD_ID:1601207
Apoc2SquirrelHyperlipoproteinemias  ISORGD:13520019068941protein:increased expression:serumRGDPMID:1468157|REF_RGD_ID:1601208
Apoc2SquirrelHyperlipoproteinemias susceptibilityISORGD:13520019068941DNA:missense mutation: :p.L72P (human)RGDPMID:16153625|REF_RGD_ID:1601204
Apoc2SquirrelHypertriglyceridemia susceptibilityISORGD:13520019068941 RGDPMID:7590197|REF_RGD_ID:1601205
Apoc2SquirrelHypertriglyceridemia  ISORGD:13520019068941 RGDPMID:3944267|REF_RGD_ID:1601214
Apoc2Squirrelhypobetalipoproteinemia  ISORGD:13520019068941protein:decreased expression:plasmaRGDPMID:2242096|REF_RGD_ID:1601212
Apoc2Squirrellipid metabolism disorder no_associationISORGD:13520019068941DNA:missense mutation: :p.K19T (human)RGDPMID:7923858|REF_RGD_ID:1601206
Apoc2Squirrelmultiple sclerosis  ISORGD:13520019068941 RGDPMID:10335523|REF_RGD_ID:1358408
Apoc2Squirrelnephrotic syndrome  ISORGD:13520019068941protein:increased expression:serumRGDPMID:8366982|REF_RGD_ID:2313970
Apoc2Squirrelobesity  ISORGD:13520019068941protein:increased expression:serumRGDPMID:9002300|REF_RGD_ID:1601191
Apoc2Squirreltype 2 diabetes mellitus  ISORGD:13520019068941protein:increased expression:plasmaRGDPMID:12733353|PMID:3757210|REF_RGD_ID:2313953|REF_RGD_ID:2313966
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelfamilial apolipoprotein C-II deficiency  ISORGD:13520018554872ClinVar Annotator: match by term: Familial apolipoprotein C-II deficiencyClinVarPMID:12783430|PMID:1349286|PMID:1569385|PMID:1628605|PMID:1782747|PMID:1971748|PMID:1990844|PMID:213719|PMID:22135386|PMID:2477392|PMID:24788417|PMID:25741868|PMID:2592354|PMID:26772541|PMID:28492532|PMID:29100061|PMID:30197986|PMID:30686043|PMID:30793526|PMID:31538826|PMID:31589614|PMID:31619059|PMID:3192518|PMID:32041611|PMID:3225819|PMID:3263393|PMID:32861330|PMID:33111339|PMID:33116287|PMID:3467353|PMID:36152419|PMID:36325899|PMID:36555767|PMID:3680515|PMID:3944267|PMID:3944271|PMID:7815420|PMID:7923858|PMID:8323539|PMID:8490626
Apoc2Squirrelfamilial lipoprotein lipase deficiency  ISORGD:13520018554872ClinVar Annotator: match by term: C-II ANAPOLIPOPROTEINEMIAClinVarPMID:12783430|PMID:1349286|PMID:1628605|PMID:1782747|PMID:1971748|PMID:1990844|PMID:213719|PMID:22135386|PMID:2477392|PMID:24788417|PMID:25741868|PMID:2592354|PMID:28492532|PMID:29100061|PMID:30197986|PMID:30686043|PMID:30793526|PMID:31538826|PMID:31589614|PMID:31619059|PMID:32041611|PMID:3225819|PMID:3263393|PMID:32861330|PMID:33111339|PMID:33116287|PMID:3467353|PMID:36152419|PMID:36325899|PMID:36555767|PMID:3680515|PMID:3944267|PMID:3944271|PMID:7815420|PMID:7923858|PMID:8323539|PMID:8490626
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2SquirrelAcute Liver Failure  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:35172013
Apoc2SquirrelDrug Eruptions  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:21055120
Apoc2SquirrelExperimental Liver Neoplasms  ISORGD:13520019068941CTD Direct Evidence: marker/mechanismCTDPMID:11420682
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelfamilial apolipoprotein C-II deficiency  ISORGD:13520017240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelcholesterol efflux involved_inISORGD:13520019068941 PMID:11162594BHF-UCLPMID:11162594
Apoc2Squirrelchylomicron remnant clearance involved_inISORGD:13520019068941 PMID:4020294BHF-UCLPMID:4020294
Apoc2Squirrelchylomicron remodeling involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelhigh-density lipoprotein particle clearance involved_inISORGD:13520019068941 PMID:15778093BHF-UCLPMID:15778093
Apoc2Squirrellipoprotein transport  ISORGD:21359068941 RGDPMID:4020294|REF_RGD_ID:1599181
Apoc2Squirrelnegative regulation of cholesterol transport involved_inISORGD:13520019068941 PMID:15778093BHF-UCLPMID:15778093
Apoc2Squirrelnegative regulation of lipid metabolic process involved_inISORGD:13520019068941 PMID:182536BHF-UCLPMID:182536
Apoc2Squirrelnegative regulation of receptor-mediated endocytosis involved_inISORGD:13520019068941 PMID:1917954BHF-UCLPMID:1917954
Apoc2Squirrelnegative regulation of very-low-density lipoprotein particle clearance involved_inISORGD:13520019068941 PMID:1917954BHF-UCLPMID:1917954
Apoc2Squirrelphospholipid efflux involved_inISORGD:13520019068941 PMID:11162594BHF-UCLPMID:11162594
Apoc2Squirrelpositive regulation of fatty acid biosynthetic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelpositive regulation of phospholipid catabolic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelpositive regulation of triglyceride catabolic process involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelpositive regulation of very-low-density lipoprotein particle remodeling involved_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelresponse to xenobiotic stimulus  ISORGD:21359068941 RGDPMID:9888873|REF_RGD_ID:1599178
Apoc2Squirreltriglyceride homeostasis involved_inISORGD:13520019068941 PMID:17018885BHF-UCLPMID:17018885
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelchylomicron part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722
Apoc2Squirrelextracellular space located_inISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelintermediate-density lipoprotein particle part_ofISORGD:13520019068941 PMID:17336988BHF-UCLPMID:17336988
Apoc2Squirrellow-density lipoprotein particle part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722
Apoc2Squirrelspherical high-density lipoprotein particle part_ofISORGD:13520019068941 PMID:16682745BHF-UCLPMID:16682745
Apoc2Squirrelvery-low-density lipoprotein particle part_ofISORGD:13520019068941 PMID:8245722BHF-UCLPMID:8245722

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelidentical protein binding enablesISOUniProtKB:P02655-PRO_00000020249068941 PMID:28229588IntActPMID:28229588
Apoc2Squirrellipase inhibitor activity enablesISORGD:13520019068941 PMID:182536BHF-UCLPMID:182536
Apoc2Squirrellipid binding enablesISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrellipoprotein lipase activator activity enablesISORGD:13520019068941 PMID:10727238, PMID:15878877, PMID:270715CACAOPMID:10727238|PMID:15878877|PMID:270715
Apoc2Squirrelmolecular function activator activity enablesISORGD:13520019068941 PMID:15209504DisProtPMID:15209504
Apoc2Squirrelphospholipase activator activity enablesISORGD:13520019068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelphospholipase binding enablesISOUniProtKB:P111519068941 PMID:10727238BHF-UCLPMID:10727238
Apoc2Squirrelprotein binding enablesISOUniProtKB:P496389068941 PMID:32296183IntActPMID:32296183

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apoc2Squirrelaltered lipoprotein metabolic pathway  ISORGD:13520019068941 RGDPMID:10073946|REF_RGD_ID:1578471
Apoc2Squirrellipoprotein metabolic pathway  ISORGD:13520019068941 RGDPMID:10073946|REF_RGD_ID:1578471
PMID:22301074   PMID:30032202  



Apoc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,531,219 - 1,531,921 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,946,051 - 44,949,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,946,035 - 44,949,565 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,449,308 - 45,452,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,141,083 - 50,144,658 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,141,082 - 50,144,657NCBI
Celera1942,253,565 - 42,257,132 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,879,798 - 41,883,381 (+)NCBIHuRef
CHM1_11945,452,071 - 45,455,660 (+)NCBICHM1_1
T2T-CHM13v2.01947,770,875 - 47,774,393 (+)NCBIT2T-CHM13v2.0
Apoc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,405,504 - 19,411,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,405,504 - 19,411,866 (-)EnsemblGRCm39 Ensembl
GRCm38719,671,579 - 19,677,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,671,579 - 19,677,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,256,928 - 20,262,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,830,106 - 18,836,463 (-)NCBIMGSCv36mm8
Celera717,077,835 - 17,082,947 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,457,397 - 88,462,365 (-)NCBIGRCr8
mRatBN7.2179,329,429 - 79,334,397 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,329,428 - 79,334,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,724,358 - 84,729,330 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,275,674 - 93,280,670 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,479,464 - 86,484,436 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,589,023 - 80,593,991 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,589,023 - 80,594,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,854,610 - 81,859,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,979,034 - 78,984,002 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,788,729 - 73,793,701 (-)NCBICelera
Cytogenetic Map1q21NCBI
Apoc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,016,217 - 2,021,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,019,547 - 2,021,543 (+)NCBIChiLan1.0ChiLan1.0
APOC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,104,521 - 51,108,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,976,612 - 52,980,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,892,954 - 41,896,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,498,109 - 50,501,877 (+)NCBIpanpan1.1PanPan1.1panPan2
APOC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,504,806 - 110,506,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,504,815 - 110,506,961 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,985,886 - 109,987,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,034,576 - 111,036,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,034,585 - 111,036,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,709,344 - 110,711,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,344,763 - 110,346,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,213,632 - 111,215,715 (-)NCBIUU_Cfam_GSD_1.0
APOC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1651,404,219 - 51,406,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,285,954 - 47,288,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,406,829 - 38,411,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,409,641 - 38,410,927 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,985,436 - 17,990,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,765,481 - 1,769,781 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,765,467 - 1,769,786 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
RefSeq Transcripts XM_021735230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040279714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_021735230   ⟹   XP_021590905
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBI
SpeTri2.0NW_0049367061,531,219 - 1,531,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040279714   ⟹   XP_040135648
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBI
Protein RefSeqs XP_021590905 (Get FASTA)   NCBI Sequence Viewer  
  XP_040135648 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3256227 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021590905   ⟸   XM_021735230
- Sequence:
RefSeq Acc Id: XP_040135648   ⟸   XM_040279714



Database
Acc Id
Source(s)
NCBI Gene Apoc2 ENTREZGENE