Bdnf (brain derived neurotrophic factor) - Rat Genome Database

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Gene: Bdnf (brain derived neurotrophic factor) Chinchilla lanigera
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Symbol: Bdnf
Name: brain derived neurotrophic factor
RGD ID: 8807547
Description: ENCODES a protein that exhibits neurotrophin TRKB receptor binding (ortholog); INVOLVED IN aging (ortholog); axon extension (ortholog); axon guidance (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH inner ear disease; acoustic neuroma (ortholog); alcohol use disorder (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: brain-derived neurotrophic factor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,772,088 - 6,822,588 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,773,244 - 6,822,201 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
alcohol use disorder  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
amphetamine abuse  (ISO)
Amyloid Plaques  (ISO)
asthma  (ISO)
Ataxia  (ISO)
atopic dermatitis  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Pain  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
color blindness  (ISO)
congenital central hypoventilation syndrome  (ISO)
cystitis  (ISO)
Deafness  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Drug Eruptions  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
hypertensive encephalopathy  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
inner ear disease  (IEP)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
keratoconus  (ISO)
Leukoencephalopathies  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
Nasal Polyps  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Degeneration  (ISO)
Nerve Injuries  (ISO)
nervous system disease  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
Pain, Referred  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (ISO)
post-traumatic stress disorder  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
psychotic disorder  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Injuries  (ISO)
Reperfusion Injury  (ISO)
Respiration Disorders  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tinnitus  (ISO)
Tobacco Use Disorder  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vascular dementia  (ISO)
Visceral Pain  (ISO)
visual epilepsy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
axon extension  (ISO)
axon guidance  (ISO)
axon target recognition  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (ISO)
circadian rhythm  (ISO)
cognition  (ISO)
collateral sprouting  (ISO)
conditioned place preference  (ISO)
dendrite development  (ISO)
dendrite extension  (ISO)
excitatory postsynaptic potential  (ISO)
fear response  (ISO)
feeding behavior  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glutamate secretion  (ISO)
inhibitory postsynaptic potential  (ISO)
inner ear development  (ISO)
learning  (ISO)
learning or memory  (ISO)
mechanoreceptor differentiation  (ISO)
mitochondrial electron transport, NADH to ubiquinone  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell death  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of synaptic transmission, GABAergic  (ISO)
nerve development  (ISO)
nervous system development  (ISO)
neuron projection extension  (ISO)
neuron recognition  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of collateral sprouting  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of synapse assembly  (ISO)
regeneration  (ISO)
regulation of axon extension  (ISO)
regulation of collateral sprouting  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of metabolic process  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of retinal cell programmed cell death  (ISO)
regulation of short-term neuronal synaptic plasticity  (ISO)
regulation of synaptic plasticity  (ISO)
response to activity  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to food  (ISO)
response to hormone  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to light intensity  (ISO)
response to light stimulus  (ISO)
response to nerve growth factor  (ISO)
response to nutrient levels  (ISO)
response to potassium ion  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin A  (ISO)
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (ISO)
synapse assembly  (ISO)
taste bud development  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Bdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,772,088 - 6,822,588 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,773,244 - 6,822,201 (-)NCBIChiLan1.0ChiLan1.0
BDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1127,654,893 - 27,722,058 (-)EnsemblGRCh38hg38GRCh38
GRCh381127,654,893 - 27,722,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371127,676,440 - 27,743,577 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,633,016 - 27,699,872 (-)NCBINCBI36hg18NCBI36
Build 341127,633,019 - 27,637,249NCBI
Celera1127,822,548 - 27,889,725 (-)NCBI
Cytogenetic Map11p14.1NCBI
HuRef1127,374,586 - 27,441,772 (-)NCBIHuRef
CHM1_11127,675,184 - 27,742,527 (-)NCBICHM1_1
Bdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,505,045 - 109,557,388 (+)NCBIGRCm39mm39
GRCm39 Ensembl2109,505,045 - 109,557,352 (+)Ensembl
GRCm382109,674,700 - 109,727,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,674,700 - 109,727,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,514,857 - 109,567,200 (+)NCBIGRCm37mm9NCBIm37
MGSCv362109,475,539 - 109,527,845 (+)NCBImm8
Celera2110,835,441 - 110,887,723 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.63NCBI
Bdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2396,165,042 - 96,215,621 (+)NCBI
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
BDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11127,520,306 - 27,589,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,520,312 - 27,589,239 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01127,618,322 - 27,687,661 (-)NCBIMhudiblu_PPA_v0panPan3
BDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12148,191,580 - 48,243,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2148,192,670 - 48,204,480 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,689,871 - 47,691,000 (-)NCBI
ROS_Cfam_1.02149,335,793 - 49,386,964 (-)NCBI
UMICH_Zoey_3.12148,338,131 - 48,339,260 (-)NCBI
UNSW_CanFamBas_1.02148,489,388 - 48,490,517 (-)NCBI
UU_Cfam_GSD_1.02149,083,467 - 49,084,596 (-)NCBI
Bdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,374,992 - 36,427,979 (+)NCBI
SpeTri2.0NW_0049365405,530,081 - 5,582,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,623,268 - 32,679,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,623,668 - 32,679,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,206,996 - 35,265,002 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDNF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,386,825 - 37,451,380 (+)NCBI
ChlSab1.1 Ensembl137,449,593 - 37,450,336 (+)Ensembl
Bdnf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476617,281,882 - 17,330,601 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000001432   ⟹   ENSCLAP00000001390
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554766,772,088 - 6,822,588 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001433   ⟹   ENSCLAP00000001391
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554766,776,094 - 6,788,519 (-)Ensembl
RefSeq Acc Id: XM_005401751   ⟹   XP_005401808
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554766,773,244 - 6,822,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005401752   ⟹   XP_005401809
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554766,773,244 - 6,804,024 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005401753   ⟹   XP_005401810
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554766,773,244 - 6,820,994 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503014   ⟹   XP_013358468
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554766,773,244 - 6,788,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503015   ⟹   XP_013358469
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554766,773,244 - 6,783,859 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005401808   ⟸   XM_005401751
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005401810   ⟸   XM_005401753
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005401809   ⟸   XM_005401752
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013358468   ⟸   XM_013503014
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013358469   ⟸   XM_013503015
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000001391   ⟸   ENSCLAT00000001433
RefSeq Acc Id: ENSCLAP00000001390   ⟸   ENSCLAT00000001432


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001053 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000001390 ENTREZGENE
Ensembl Transcript ENSCLAT00000001432 ENTREZGENE
NCBI Gene Bdnf ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Bdnf  brain derived neurotrophic factor    brain-derived neurotrophic factor  Symbol and/or name change 5135510 APPROVED