Mstn (myostatin) - Rat Genome Database

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Gene: Mstn (myostatin) Chinchilla lanigera
Analyze
Symbol: Mstn
Name: myostatin
RGD ID: 8730094
Description: ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to hypoxia (ortholog); muscle cell cellular homeostasis (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Burns (ortholog); Cachexia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth/differentiation factor 8
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mstn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
MSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,055,700 - 190,062,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,055,700 - 190,062,729 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,920,426 - 190,927,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,628,671 - 190,635,700 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,745,932 - 190,752,961NCBI
Celera2184,515,357 - 184,522,386 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,780,433 - 182,787,462 (-)NCBIHuRef
CHM1_12190,926,378 - 190,933,407 (-)NCBICHM1_1
T2T-CHM13v2.02190,545,060 - 190,552,089 (-)NCBIT2T-CHM13v2.0
Mstn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,100,799 - 53,107,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,100,799 - 53,107,238 (+)EnsemblGRCm39 Ensembl
GRCm38153,061,640 - 53,068,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,061,640 - 53,068,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv37153,118,507 - 53,124,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,006,208 - 53,012,624 (+)NCBIMGSCv36mm8
Celera153,601,512 - 53,607,928 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Mstn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
MSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensemblpanpan1.1panPan2
MSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137729,172 - 734,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37729,172 - 734,362 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,685,007 - 1,690,090 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037623,197 - 628,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37621,860 - 628,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137633,617 - 638,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037601,655 - 606,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037629,871 - 634,951 (-)NCBIUU_Cfam_GSD_1.0
Mstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,842,726 - 148,849,304 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,988,718 - 7,996,971 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,988,879 - 7,996,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,620,270 - 94,628,545 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,623,526 - 94,628,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,734,309 - 105,739,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,564,816 - 75,570,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,565,152 - 75,570,528 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040123,900,932 - 123,908,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mstn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,892,938 - 5,899,473 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,893,051 - 5,899,380 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000023063   ⟹   ENSCLAP00000022851
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)Ensembl
RefSeq Acc Id: XM_005373312   ⟹   XP_005373369
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005373369 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022851
  ENSCLAP00000022851.1
RefSeq Acc Id: XP_005373369   ⟸   XM_005373312
- UniProtKB: A0A8C2VZ96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000022851   ⟸   ENSCLAT00000023063
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015676 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023063 ENTREZGENE
  ENSCLAT00000023063.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Mstn ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
  PTHR11848:SF150 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C2VZ96 ENTREZGENE, UniProtKB/TrEMBL