F2 (coagulation factor II, thrombin)

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Gene: F2 (coagulation factor II, thrombin) Chinchilla lanigera

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Symbol:

Name:

coagulation factor II, thrombin

RGD ID:

9016445

Description:

ENCODES a protein that exhibits endopeptidase activity (ortholog); heparin binding (ortholog); lipopolysaccharide binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

coagulation factor II (thrombin); prothrombin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	1,356,769 - 1,367,517 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	1,356,675 - 1,367,788 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acquired angioedema (ISO)

Acute Coronary Syndrome (ISO)

Acute Lung Injury (ISO)

allergic rhinitis (ISO)

Alzheimer's disease (ISO)

appendicitis (ISO)

asthma (ISO)

atherosclerosis (ISO)

atopic dermatitis (ISO)

autoimmune hepatitis (ISO)

bacterial pneumonia (ISO)

blood coagulation disease (ISO)

brain edema (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

bullous pemphigoid (ISO)

calcium oxalate nephrolithiasis (ISO)

carotid stenosis (ISO)

celiac disease (ISO)

Cerebral Hemorrhage (ISO)

cerebral infarction (ISO)

cerebral palsy (ISO)

Chagas disease (ISO)

chronic obstructive pulmonary disease (ISO)

clear cell renal cell carcinoma (ISO)

congenital disorder of glycosylation type IIc (ISO)

Congenital Prothrombin Deficiency (ISO)

Contusions (ISO)

coronary artery disease (ISO)

COVID-19 (ISO)

Crohn's disease (ISO)

dengue disease (ISO)

Diabetic Nephropathies (ISO)

disseminated intravascular coagulation (ISO)

end stage renal disease (ISO)

Endotoxemia (ISO)

Experimental Arthritis (ISO)

Experimental Diabetes Mellitus (ISO)

eye disease (ISO)

factor VIII deficiency (ISO)

Familial Amyloid Polyneuropathies (ISO)

familial Mediterranean fever (ISO)

Femur Head Necrosis (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

Habitual Abortions (ISO)

hemolytic-uremic syndrome (ISO)

hemophilia B (ISO)

Hemorrhage (ISO)

Hemorrhagic Shock (ISO)

hepatitis C (ISO)

hepatocellular carcinoma (ISO)

hereditary angioedema (ISO)

herpes zoster (ISO)

high grade glioma (ISO)

Human Viral Hepatitis (ISO)

Huntington's disease (ISO)

Hyperalgesia (ISO)

hyperglycemia (ISO)

hyperhomocysteinemia (ISO)

Hypertrophy (ISO)

intellectual disability (ISO)

intracranial sinus thrombosis (ISO)

Kidney Calculi (ISO)

Knee Osteoarthritis (ISO)

leptospirosis (ISO)

liver cirrhosis (ISO)

Liver Failure (ISO)

Mesenteric Ischemia (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

middle cerebral artery infarction (ISO)

myocardial infarction (ISO)

Neoplasm Metastasis (ISO)

nephrosis (ISO)

Nerve Degeneration (ISO)

obesity (ISO)

ovarian cancer (ISO)

Paratuberculosis (ISO)

Pediatric Crohn's Disease (ISO)

portal vein thrombosis (ISO)

pre-eclampsia (ISO)

prostate cancer (ISO)

prothrombin deficiency (ISO)

pulmonary embolism (ISO)

pulmonary fibrosis (ISO)

Reperfusion Injury (ISO)

retinal vein occlusion (ISO)

rheumatoid arthritis (ISO)

schizophrenia (ISO)

sensorineural hearing loss (ISO)

Sepsis (ISO)

Septic Peritonitis (ISO)

sickle cell anemia (ISO)

Spinal Cord Injuries (ISO)

Spontaneous Abortions (ISO)

steatotic liver disease (ISO)

Stroke (ISO)

systemic lupus erythematosus (ISO)

systemic scleroderma (ISO)

Thromboembolism (ISO)

thrombophilia (ISO)

thrombophilia due to thrombin defect (ISO)

thrombosis (ISO)

toxic shock syndrome (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

urinary bladder cancer (ISO)

Urinary Calculi (ISO)

urticaria (ISO)

vascular skin disease (ISO)

Venous Thromboembolism (ISO)

Venous Thrombosis (ISO)

Ventricular Dysfunction, Left (ISO)

Ventricular Fibrillation (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

cell surface receptor signaling pathway (ISO)

cellular response to mechanical stimulus (ISO)

fibrinolysis (ISO)

G protein-coupled receptor signaling pathway (ISO)

ligand-gated ion channel signaling pathway (ISO)

negative regulation of astrocyte differentiation (ISO)

negative regulation of blood coagulation (ISO)

negative regulation of cytokine production involved in inflammatory response (ISO)

negative regulation of proteolysis (ISO)

platelet activation (ISO)

positive regulation of blood coagulation (ISO)

positive regulation of cell growth (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of collagen biosynthetic process (ISO)

positive regulation of insulin secretion (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of reactive oxygen species metabolic process (ISO)

positive regulation of release of sequestered calcium ion into cytosol (ISO)

regulation of cell shape (ISO)

regulation of cytosolic calcium ion concentration (ISO)

regulation of gene expression (ISO)

response to inactivity (ISO)

response to Thyroglobulin triiodothyronine (ISO)

response to thyrotropin-releasing hormone (ISO)

response to thyroxine (ISO)

response to wounding (ISO)

thrombin-activated receptor signaling pathway (ISO)

Cellular Component

collagen-containing extracellular matrix (ISO)

external side of plasma membrane (ISO)

extracellular space (ISO)

Molecular Function

endopeptidase activity (ISO)

heparin binding (ISO)

lipopolysaccharide binding (ISO)

peptidase activity (ISO)

protein binding (ISO)

receptor ligand activity (ISO)

serine-type endopeptidase activity (ISO)

signaling receptor binding (ISO)

thrombospondin receptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

coagulation cascade pathway (ISO)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

forkhead class A signaling pathway (ISO)

heparin pharmacodynamics pathway (ISO)

phenindione pharmacodynamics pathway (ISO)

protease mediated signaling via protease-activated receptor 1 (ISO)

protease mediated signaling via protease-activated receptor 3 (ISO)

protease mediated signaling via protease-activated receptor 4 (ISO)

protein C anticoagulant pathway (ISO)

reteplase pharmacodynamics pathway (ISO)

syndecan signaling pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

vitamin K metabolic pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

F2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	1,356,769 - 1,367,517 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	1,356,675 - 1,367,788 (-)	NCBI	ChiLan1.0	ChiLan1.0

F2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	46,719,213 - 46,739,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	46,719,196 - 46,739,506 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	46,740,763 - 46,761,056 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	46,697,331 - 46,717,631 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	46,697,330 - 46,717,631	NCBI
Celera	11	46,888,702 - 46,909,014 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,446,660 - 46,466,973 (+)	NCBI		HuRef
CHM1_1	11	46,739,149 - 46,759,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	46,875,235 - 46,896,332 (+)	NCBI		T2T-CHM13v2.0

F2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,442,742 - 91,466,799 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,455,665 - 91,466,759 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,612,397 - 91,636,457 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,625,320 - 91,636,414 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,465,477 - 91,476,571 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,426,159 - 91,437,253 (-)	NCBI		MGSCv36	mm8
Celera	2	93,014,831 - 93,025,920 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.63	NCBI

F2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	98,051,958 - 98,065,246 (-)	NCBI		GRCr8
mRatBN7.2	3	77,596,196 - 77,609,486 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,596,198 - 77,609,486 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,071,217 - 81,084,670 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,670,242 - 89,683,695 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,521,762 - 87,534,981 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,529,468 - 80,542,993 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,529,428 - 80,543,031 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,228,703 - 87,242,228 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,005,318 - 76,018,603 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,901,694 - 75,914,982 (-)	NCBI
Celera	3	76,801,000 - 76,814,280 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

F2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	48,912,486 - 48,945,313 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	48,943,307 - 48,965,006 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	46,669,925 - 46,690,391 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	47,227,891 - 47,249,157 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	47,227,891 - 47,249,157 (+)	Ensembl	panpan1.1		panPan2

F2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,782,744 - 42,799,531 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,782,751 - 42,799,459 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,511,662 - 41,528,485 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	43,438,760 - 43,455,850 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	43,438,759 - 43,455,806 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,924,063 - 42,940,888 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	42,479,219 - 42,496,510 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	43,208,980 - 43,225,802 (-)	NCBI		UU_Cfam_GSD_1.0

F2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	20,260,330 - 20,277,033 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	2,372,044 - 2,388,650 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	2,371,725 - 2,388,617 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

F2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,791,455 - 15,819,137 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	15,793,257 - 15,819,151 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	17,145,002 - 17,170,975 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,877,024 - 1,887,958 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,876,974 - 1,887,720 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005384007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01022456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01106150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022986 ⟹ ENSCLAP00000022777

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	1,356,769 - 1,367,517 (-)	Ensembl

RefSeq Acc Id:

XM_005384007 ⟹ XP_005384064

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	1,356,675 - 1,367,788 (-)	NCBI

Sequence:

show sequence

ACTCAGCAGGGTCAGGACAGGCCCGGGAGCCCGGCGAGACACACTCGTGCGATGGCGCACGTCG
CAGGCCTGCAGCTGCCTGGCTGCCTGGCCCTGGCCCTGGCCCTGCTCGGCCTCGCGCTCAGCCA
GGATGTGTTCCTGGCCCCACAGCGGGCACTGTCGCTGCTGCAGCGGGTGCGCCGGGCCAACAGC
GGCTTCCTGGAGGAGCTGCGCAAGGGCAACCTGGAGCGTGAGTGTGTGGAGGAGCAGTGCAGCT
ACGAGGAGGCCTTTGAGGCCCTGGAGTCATCCAGTGCCACGGACGCGTTCTGGGCCAAGTACAC
GGCATGCACGTCCGTGCGGAAGCCCCGGGAGACCTTCATGGAATGTCTGGAAGGTCACTGCGCC
AGGGACCTGGGCATGAACTACCGTGGGGACGTGAACGTCACCCGGTCGGGCATCGAGTGCCAGC
TGTGGAGCAGCCGCTACCCACACAGGCCCGAAGTGAACCACACCAGCCACCCCAACGCCGGCCT
GCTCGAGAACTTCTGCCGCAACCCCGATGGCAGCAGCGCGGGCCCCTGGTGCTACACCACCGAC
CCCACCGTGCGCAGGGAGGAGTGCAGCGTGCCTGTGTGTGGCGAGGCGCGCCTCACTGTGGAGA
TGATACCCCGTGCCAGGGGCACCGGGCTGGATGTGTCACCTTCACCAGAGGACTGTGTCCCTGA
GCGAGGCCGGCACTACCGAGGGCGCCTGGCGGTAACGTCACAGGGGTCTCCTTGCCTGCCCTGG
GCCGGTGAGCAGGCCAAGTCCCTGAGCCAGGACAAGGACTTCAGCCCGGAGGTGAAACTAGAGG
AGAACTTCTGCCGGAACCCCAATAAGGACGAGGAAGGTGCCTGGTGCTTTGTGGCTGGTGAGAA
CCGAGACTTCCAGTACTGCGACCTCAACTACTGTGAGGAGGTGTTGGAGGAGGAGGCGGCGGAC
GGGCTGGCCGAGGAGGCCATCGGTGGCCGTACCACGACAGAAGACTTCCAGCCCTTCTTCGACG
AGAAGACCTTCGGCTTGGGGGAGACCGACTGCGGGCTGCGGCCACTATTTGAGAAGAAGGGGGT
GAAGGACACGACGGAAGAGCAGCTGCTGGACTCCTACATCGACGGCCGCATCGTGGAGGGCTGG
GACGCGGAGACCGGCATCGCGCCCTGGCAGGTGATGCTCTTCCGCAAGACGCCCCAGGAGCTGC
TGTGTGGGGCCAGCCTCATCAGCGACCGCTGGGTGCTCACGGCTGCTCACTGCATTATGTATCC
GCCCTGGGACAAGAACTTCACCCACAATGACCTCCTGGTGCGCATTGGCAAGCACGCCCGCAGC
AGGTATGAGCGGAATATGGAGAAGATCTCCATGCTGGAGAAGATCTACATCCACCCCCGCTACA
ACTGGCGTGAGAACCTGGACCGCGACATCGCGCTGCTCAAGCTCAAGCGACCGCTGTCCTTCAG
CAACTACATCCACCCCGTGTGTCTGCCTGACAAGCAGACGGTGCTCAGCCTGCTCCAGGCGGGC
CATAAGGGCCGGGTGACGGGCTGGGGCAACCTGCGCGAGGTGTGGAAGAGCAGCCCGAACGAGG
TGCAGCCCAGCGTGCTGCAGGTGGTGAACCTGCCCATCGTGGACCGGCGCACCTGCAGGGCGTC
CACGCGGATCCGCATCACTGACAACATGTTCTGTGCCGGTTTCAAGCCTGAGGAAGGAAAGCGC
GGGGATGCTTGCGAAGGCGACAGCGGGGGACCCTTCGTCATGAAGAGCCCCTTCAACCACCGCT
GGTATCAAATGGGCATCGTGTCGTGGGGCGAGGGCTGCGACCGGGACGGGAAGTACGGCTTCTA
CACACACGTGTTCCGCCTGAAGAAGTGGATCCAGAAGGTCATCGAGCAGTCTGGGTAGCCTGCC
AGCCCCTCCTGCAGTCGCAGACAGTCGCCAGTGCGCCGAGTATTTCTGTGGTTTCTGAAACGAC
AGCTCCAATAAAAGCGCGTCGGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005384064	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022777
	ENSCLAP00000022777.1

RefSeq Acc Id:

XP_005384064 ⟸ XM_005384007

- UniProtKB:

A0A8C2W1W9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHVAGLQLPGCLALALALLGLALSQDVFLAPQRALSLLQRVRRANSGFLEELRKGNLERECVE
EQCSYEEAFEALESSSATDAFWAKYTACTSVRKPRETFMECLEGHCARDLGMNYRGDVNVTRSG
IECQLWSSRYPHRPEVNHTSHPNAGLLENFCRNPDGSSAGPWCYTTDPTVRREECSVPVCGEAR
LTVEMIPRARGTGLDVSPSPEDCVPERGRHYRGRLAVTSQGSPCLPWAGEQAKSLSQDKDFSPE
VKLEENFCRNPNKDEEGAWCFVAGENRDFQYCDLNYCEEVLEEEAADGLAEEAIGGRTTTEDFQ
PFFDEKTFGLGETDCGLRPLFEKKGVKDTTEEQLLDSYIDGRIVEGWDAETGIAPWQVMLFRKT
PQELLCGASLISDRWVLTAAHCIMYPPWDKNFTHNDLLVRIGKHARSRYERNMEKISMLEKIYI
HPRYNWRENLDRDIALLKLKRPLSFSNYIHPVCLPDKQTVLSLLQAGHKGRVTGWGNLREVWKS
SPNEVQPSVLQVVNLPIVDRRTCRASTRIRITDNMFCAGFKPEEGKRGDACEGDSGGPFVMKSP
FNHRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIEQSG

hide sequence

Ensembl Acc Id:

ENSCLAP00000022777 ⟸ ENSCLAT00000022986

Protein Domains

Kringle Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015618	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022986	ENTREZGENE
	ENSCLAT00000022986.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/TrEMBL
	4.10.140.10	UniProtKB/TrEMBL
InterPro	Kringle	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Prothrombin/thrombin	UniProtKB/TrEMBL
	Serine_Protease_S1-Domain	UniProtKB/TrEMBL
	Thrombin_light_chain	UniProtKB/TrEMBL
	Thrombin_light_chain_sf	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	F2	ENTREZGENE
PANTHER	PROTHROMBIN	UniProtKB/TrEMBL
	PTHR24254:SF10	UniProtKB/TrEMBL
Pfam	Kringle	UniProtKB/TrEMBL
	Thrombin_light	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
	KRINGLE	UniProtKB/TrEMBL
	PROTHROMBIN	UniProtKB/TrEMBL
PROSITE	KRINGLE_1	UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	SM00130	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
	SSF57440	UniProtKB/TrEMBL
UniProt	A0A8C2W1W9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	F2	coagulation factor II, thrombin		coagulation factor II (thrombin)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)