RGD Reference Report - Role of thrombin in chronic rhinosinusitis-associated tissue remodeling. - Rat Genome Database

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Role of thrombin in chronic rhinosinusitis-associated tissue remodeling.

Authors: Shimizu, S  Gabazza, EC  Ogawa, T  Tojima, I  Hoshi, E  Kouzaki, H  Shimizu, T 
Citation: Shimizu S, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):7-11.
RGD ID: 5147783
Pubmed: PMID:21711961   (View Abstract at PubMed)
DOI: DOI:10.2500/ajra.2011.25.3535   (Journal Full-text)

BACKGROUND: Thrombin, the effector enzyme of the coagulation system, has been reported to promote inflammatory responses in nasal diseases through its protease-activated receptors (PARs). Chronic rhinosinusitis (CRS) is characterized by increased deposition of extracellular matrix proteins, tissue remodeling, and formation of nasal polyps. The role of thrombin in chronic nasal inflammation-associated tissue remodeling still has not been appraised. This study was conducted to elucidate the role of thrombin in the pathogenesis of CRS. METHODS: Nasal secretion was collected from patients with CRS with nasal polyp (CRSwNP) with asthma (n = 9), CRSwNP without asthma (n = 10), allergic rhinitis (n = 7), and control patients (n = 3). The concentrations of thrombin, thrombin-antithrombin (TAT) complex, and vascular endothelial growth factor (VEGF) were evaluated by enzyme immunoassays. The concentration of thrombin and TAT complex was measured in nasal secretion from each group of patients, and VEGF was measured in culture medium from airway epithelial cells treated with thrombin or thrombin receptor agonist peptide. RESULTS: Thrombin and TAT complex were significantly increased in nasal secretion of patients with CRSwNPs with asthma compared with the control group. Thrombin and PAR-1 agonist peptide significantly stimulated VEGF secretion from cultured human airway epithelial cells. CONCLUSION: The results of this study showed that there is increased activation of the coagulation system in the nasal mucosa of CRS patients and that thrombin may play a role in nasal polyp formation by stimulating VEGF production from airway epithelial cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F2Ratallergic rhinitis  ISOF2 (Homo sapiens)protein:increased expression:nasal mucusRGD 
F2Mouseallergic rhinitis  ISOF2 (Homo sapiens)protein:increased expression:nasal mucusRGD 
F2Humanallergic rhinitis  IEP protein:increased expression:nasal mucusRGD 
F2Ratasthma  ISOF2 (Homo sapiens)associated with Rhinosinusitis more ...RGD 
F2Mouseasthma  ISOF2 (Homo sapiens)associated with Rhinosinusitis more ...RGD 
F2Humanasthma  IEP associated with Rhinosinusitis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II, thrombin)

Genes (Mus musculus)
F2  (coagulation factor II)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)


Additional Information