RGD Reference Report - Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases. - Rat Genome Database

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Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases.

Authors: Sun, Y  Wang, J  Wu, X  Xi, C  Gai, Y  Liu, H  Yuan, Q  Wang, E  Gao, L  Hu, J  Zhou, L 
Citation: Sun Y, etal., Br J Neurosurg. 2011 Jun;25(3):363-8. Epub 2011 Feb 28.
RGD ID: 5147766
Pubmed: PMID:21355766   (View Abstract at PubMed)
DOI: DOI:10.3109/02688697.2011.552650   (Journal Full-text)

OBJECTIVES: To estimate the incidence of coagulopathy and disseminated intravascular coagulation (DIC) in patients with traumatic brain injury (TBI) and to investigate its relationship to patient outcome. DESIGN: A prospective observational study. MEASUREMENTS AND MAIN RESULTS: From January 2007 to June 2009, 242 consecutive adult patients with TBI seen in three independent hospitals were recruited. Glasgow Coma Score (GCS) on admission, platelet counts (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-DT) and DIC scores were recorded for each case on admission. Clinical outcome was measured according to the Glasgow Outcome Scale (GOS) at 3 months after injury. Statistical analysis was carried using Student's t-test, one-way analysis of variance (ANOVA), and Tudey test. Coagulation abnormalities were present in approximately 50% of patients with TBI. Prolonged PT and increased D-DT and FIB levels occurred in patients with more severe brain injury and poorer outcome, and these findings were statistically significant. CONCLUSIONS: Coagulation changes, particularly the incidence of DIC, may occur within 6 h after TBI and are more pronounced in patients with severe injuries and poor outcome. PT, D-DT levels and more comprehensively a DIC scores may be useful prognostic indicators in patients with TBI.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F2RatBrain Injuries severityISOF2 (Homo sapiens) RGD 
F2MouseBrain Injuries severityISOF2 (Homo sapiens) RGD 
F2HumanBrain Injuries severityIDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II, thrombin)

Genes (Mus musculus)
F2  (coagulation factor II)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)


Additional Information