RGD Reference Report - Continuous Active State of Coagulation System in Patients With Nonthrombotic Inflammatory Bowel Disease. - Rat Genome Database

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Continuous Active State of Coagulation System in Patients With Nonthrombotic Inflammatory Bowel Disease.

Authors: Alkim, H  Ayaz, S  Alkim, C  Ulker, A  Sahin, B 
Citation: Alkim H, etal., Clin Appl Thromb Hemost. 2011 May 17.
RGD ID: 5147754
Pubmed: PMID:21593018   (View Abstract at PubMed)
DOI: DOI:10.1177/1076029611405034   (Journal Full-text)

This study was planned for searching possible changes of the total coagulation and fibrinolysis system in inflammatory bowel disease (IBD) in order to obtain some clues for explaining the relation between IBD and hypercoagulability. A total of 24 patients with ulcerative colitis, 12 patients with Crohn disease, and 20 healthy controls were studied. Platelets; prothrombin time (PT); partial thromboplastin time (PTT); fibrinozgen; D-dimer; fibrinogen degradation products; protein C; protein S; antithrombin; thrombin time; von Willebrand factor; coagulation factors V, VII, VIII, IX, XI, and XIII; plasminogen; antiplasmin; tissue plasminogen activator; plasminogen activator inhibitor 1; and prothrombin fragments 1 + 2 were studied. Most of the procoagulants (platelets, fibrinogen, von Willebrand factor, coagulation factor IX, and plasminogen activator inhibitor 1) were found increased together with decreases in some anticoagulants (protein S and antithrombin) in IBD. Also the activation markers of coagulation (D-dimer, fibrinogen degradation products, and prothrombin fragments 1 + 2) were all increased. The parameters of the total coagulation-fibrinolysis system were increased in IBD, regardless of the form and the activity of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Crohn's disease  ISOF2 (Homo sapiens)5147754; 5147754 RGD 
Crohn's disease  IEP 5147754 RGD 
ulcerative colitis  ISOF2 (Homo sapiens)5147754; 5147754 RGD 
ulcerative colitis  IEP 5147754 RGD 

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II, thrombin)

Genes (Mus musculus)
F2  (coagulation factor II)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)


Additional Information