RGD Reference Report - Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients. - Rat Genome Database

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Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients.

Authors: Ekmekci, Y  Keven, K  Akar, N  Egin, Y  Sengul, S  Kutlay, S  Erturk, S  Erbay, B 
Citation: Ekmekci Y, etal., Nephrol Dial Transplant. 2006 Dec;21(12):3555-8. Epub 2006 Sep 12.
RGD ID: 6902907
Pubmed: (View Article at PubMed) PMID:16968732
DOI: Full-text: DOI:10.1093/ndt/gfl400

BACKGROUND: Thrombophilia has been implicated in the development of avascular necrosis (AVN) in various diseases. We aimed to search for the relation of both prothrombin gene G20210A mutation and factor V G1691A (factor V Leiden) mutation with AVN among kidney transplant recipients. METHODS: Nineteen patients with AVN and 38 control patients without AVN were included. Clinical information was collected, and gender, age, type of renal allograft, duration and type of dialysis, presence of acute rejection, and cumulative doses of ciclosporin and corticosteroid administration were taken into consideration. Genotypes of factor V G1691A and prothrombin G20210A were determined by direct sequencing of genomic DNA. RESULTS: Factor V Leiden mutation was detected in six patients (31.6%) among patients with AVN and in only three patients (7.9%) in the control group (P = 0.048). Two patients (10.5%) in the AVN group were determined to have prothrombin G20210A mutation, while no prothrombin G20210A mutation was detected in the control group. When both of the mutations causing thrombophilia were considered, a total of eight patients (42.1%) in the AVN group and three patients (7.9%) in the control group were identified (P = 0.004). CONCLUSION: Thrombophilia seems to be an important risk factor for development of AVN. More studies are needed to clarify the role of factor V G1691A and prothrombin G20210A mutation for AVN.

Annotation

Disease Annotations    
Femur Head Necrosis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II)
F5  (coagulation factor V)

Genes (Mus musculus)
F2  (coagulation factor II)
F5  (coagulation factor V)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)
F5  (coagulation factor V)


Additional Information