Plcb1 (phospholipase C beta 1) - Rat Genome Database

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Gene: Plcb1 (phospholipase C beta 1) Chinchilla lanigera
Analyze
Symbol: Plcb1
Name: phospholipase C beta 1
RGD ID: 8732395
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calmodulin binding (ortholog); enzyme binding (ortholog); INVOLVED IN activation of meiosis involved in egg activation (ortholog); brain development (ortholog); cellular response to fluoride (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; phospholipase C, beta 1 (phosphoinositide-specific)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541518,210,662 - 18,915,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541518,210,608 - 18,915,099 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of meiosis involved in egg activation  (ISO)
brain development  (ISO)
cellular response to fluoride  (ISO)
cellular response to glyceraldehyde  (ISO)
cellular response to ionomycin  (ISO)
cellular response to vasopressin  (ISO)
cerebral cortex development  (ISO)
fat cell differentiation  (ISO)
G protein-coupled acetylcholine receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
glutamate receptor signaling pathway  (ISO)
inositol trisphosphate metabolic process  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-12-mediated signaling pathway  (ISO)
interleukin-15-mediated signaling pathway  (ISO)
learning  (ISO)
memory  (ISO)
negative regulation of monocyte extravasation  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
phosphatidylinositol catabolic process  (ISO)
phosphatidylinositol metabolic process  (ISO)
positive regulation of acrosome reaction  (ISO)
positive regulation of CD24 production  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of embryonic development  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of fertilization  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of retrograde trans-synaptic signaling by endocanabinoid  (ISO)
response to monosaccharide  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
endothelin signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase C (PKC) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References


Genomics

Comparative Map Data
Plcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541518,210,662 - 18,915,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541518,210,608 - 18,915,099 (+)NCBIChiLan1.0ChiLan1.0
PLCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl208,077,251 - 8,968,360 (+)EnsemblGRCh38hg38GRCh38
GRCh38208,132,266 - 8,884,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37208,112,913 - 8,865,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36208,061,296 - 8,813,547 (+)NCBINCBI36hg18NCBI36
Build 34208,061,295 - 8,813,547NCBI
Celera208,182,881 - 8,935,778 (+)NCBI
Cytogenetic Map20p12.3NCBI
HuRef208,064,325 - 8,817,514 (+)NCBIHuRef
CHM1_1208,113,481 - 8,866,748 (+)NCBICHM1_1
Plcb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392134,628,084 - 135,317,178 (+)NCBIGRCm39mm39
GRCm39 Ensembl2134,627,987 - 135,317,178 (+)Ensembl
GRCm382134,786,164 - 135,475,258 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2134,786,067 - 135,475,258 (+)EnsemblGRCm38mm10GRCm38
MGSCv372134,611,900 - 135,300,994 (+)NCBIGRCm37mm9NCBIm37
MGSCv362134,477,971 - 135,163,863 (+)NCBImm8
Celera2135,990,426 - 136,678,579 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map265.66NCBI
Plcb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23122,059,968 - 122,772,896 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl3128,155,069 - 128,419,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03127,721,244 - 128,419,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03134,211,557 - 134,908,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43122,797,718 - 123,523,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13122,703,321 - 123,430,863 (+)NCBI
Celera3120,808,920 - 121,513,252 (+)NCBICelera
Cytogenetic Map3q36NCBI
PLCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1207,887,773 - 8,636,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl207,887,960 - 8,636,019 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0208,106,665 - 8,858,572 (+)NCBIMhudiblu_PPA_v0panPan3
PLCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12413,337,285 - 13,996,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2413,322,296 - 13,995,539 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2413,161,289 - 13,837,418 (-)NCBI
ROS_Cfam_1.02413,744,297 - 14,413,598 (-)NCBI
UMICH_Zoey_3.12413,354,731 - 14,024,546 (-)NCBI
UNSW_CanFamBas_1.02413,455,648 - 14,132,727 (-)NCBI
UU_Cfam_GSD_1.02413,793,592 - 14,463,037 (-)NCBI
Plcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640162,117,602 - 162,822,762 (-)NCBI
SpeTri2.0NW_00493648510,548,966 - 11,254,139 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1717,007,261 - 17,745,312 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11717,007,197 - 17,745,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21719,691,473 - 19,950,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,242,601 - 29,994,238 (-)NCBI
ChlSab1.1 Ensembl229,242,425 - 29,496,793 (-)Ensembl
Vero_WHO_p1.0NW_02366607114,560,873 - 15,334,958 (+)NCBI
Plcb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247419,030,817 - 9,859,597 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005380862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01016445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01016460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCB01041065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDI01190271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000019130   ⟹   ENSCLAP00000018945
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541518,210,662 - 18,912,077 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019131   ⟹   ENSCLAP00000018946
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541518,671,493 - 18,915,158 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019132   ⟹   ENSCLAP00000018947
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541518,671,493 - 18,915,158 (+)Ensembl
RefSeq Acc Id: XM_005380862   ⟹   XP_005380919
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541518,210,608 - 18,915,099 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380919 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005380919   ⟸   XM_005380862
- Sequence:
RefSeq Acc Id: ENSCLAP00000018947   ⟸   ENSCLAT00000019132
RefSeq Acc Id: ENSCLAP00000018945   ⟸   ENSCLAT00000019130
RefSeq Acc Id: ENSCLAP00000018946   ⟸   ENSCLAT00000019131


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012974 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000018945 ENTREZGENE
Ensembl Transcript ENSCLAT00000019130 ENTREZGENE
NCBI Gene Plcb1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Plcb1  phospholipase C beta 1    phospholipase C, beta 1 (phosphoinositide-specific)  Symbol and/or name change 5135510 APPROVED