Mef2c (myocyte enhancer factor 2C) - Rat Genome Database

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Gene: Mef2c (myocyte enhancer factor 2C) Chinchilla lanigera
Analyze
Symbol: Mef2c
Name: myocyte enhancer factor 2C
RGD ID: 8875214
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell proliferation (ortholog); B cell receptor signaling pathway (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); autosomal dominant mental retardation 20 (ortholog); FOUND IN cytoplasm (ortholog); intracellular membrane-bounded organelle (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: myocyte-specific enhancer factor 2C
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541822,537,285 - 22,701,434 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell homeostasis  (ISO)
B cell proliferation  (ISO)
B cell receptor signaling pathway  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac ventricle formation  (ISO)
cartilage morphogenesis  (ISO)
cell fate commitment  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chondrocyte differentiation  (ISO)
dentate gyrus development  (ISO)
embryonic heart tube development  (ISO)
embryonic skeletal system morphogenesis  (ISO)
embryonic viscerocranium morphogenesis  (ISO)
endochondral ossification  (ISO)
epithelial cell proliferation involved in renal tubule morphogenesis  (ISO)
excitatory postsynaptic potential  (ISO)
gene expression  (ISO)
germinal center formation  (ISO)
glomerulus morphogenesis  (ISO)
heart development  (ISO)
heart looping  (ISO)
humoral immune response  (ISO)
learning or memory  (ISO)
MAPK cascade  (ISO)
melanocyte differentiation  (ISO)
monocyte differentiation  (ISO)
muscle cell fate determination  (ISO)
myotube differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
nephron tubule epithelial cell differentiation  (ISO)
neural crest cell differentiation  (ISO)
neuron development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
platelet formation  (ISO)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of macrophage apoptotic process  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of skeletal muscle cell differentiation  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
primary heart field specification  (ISO)
regulation of AMPA receptor activity  (ISO)
regulation of dendritic spine development  (ISO)
regulation of germinal center formation  (ISO)
regulation of megakaryocyte differentiation  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of sarcomere organization  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic activity  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
regulation of transcription, DNA-templated  (ISO)
renal tubule morphogenesis  (ISO)
response to nutrient levels  (ISO)
response to vitamin E  (ISO)
roof of mouth development  (ISO)
secondary heart field specification  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
sinoatrial valve morphogenesis  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal muscle tissue development  (ISO)
smooth muscle cell differentiation  (ISO)
sympathetic neuron axon guidance  (ISO)
transdifferentiation  (ISO)
ventricular cardiac muscle cell differentiation  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Mef2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541822,537,285 - 22,701,434 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBIChiLan1.0ChiLan1.0
MEF2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl588,717,117 - 88,904,257 (-)EnsemblGRCh38hg38GRCh38
GRCh38588,717,117 - 88,904,105 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37588,012,934 - 88,199,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36588,051,922 - 88,214,780 (-)NCBINCBI36hg18NCBI36
Build 34588,051,921 - 88,214,780NCBI
Celera583,907,023 - 84,092,551 (-)NCBI
Cytogenetic Map5q14.3NCBI
HuRef583,218,989 - 83,404,187 (-)NCBIHuRef
CHM1_1587,447,103 - 87,632,656 (-)NCBICHM1_1
Mef2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391383,652,136 - 83,815,198 (+)NCBIGRCm39mm39
GRCm39 Ensembl1383,652,153 - 83,815,199 (+)Ensembl
GRCm381383,504,017 - 83,667,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1383,504,034 - 83,667,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371383,643,033 - 83,806,684 (+)NCBIGRCm37mm9NCBIm37
MGSCv361383,981,532 - 84,141,286 (+)NCBImm8
Celera1385,760,645 - 85,921,930 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1343.68NCBI
Mef2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2213,973,299 - 14,136,065 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl213,993,438 - 14,132,880 (+)Ensembl
Rnor_6.0211,658,534 - 11,822,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl211,658,568 - 11,822,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0211,521,053 - 11,684,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4212,331,078 - 12,346,520 (-)NCBIRGSC3.4rn4RGSC3.4
Celera210,288,159 - 10,449,731 (+)NCBICelera
Cytogenetic Map2q11NCBI
MEF2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1526,620,837 - 26,786,426 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl526,681,700 - 26,786,426 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0526,480,489 - 26,650,813 (+)NCBIMhudiblu_PPA_v0panPan3
MEF2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1319,778,997 - 19,948,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl319,779,007 - 19,943,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha321,145,574 - 21,314,826 (+)NCBI
ROS_Cfam_1.0319,687,661 - 19,856,893 (+)NCBI
UMICH_Zoey_3.1319,665,907 - 19,834,881 (+)NCBI
UNSW_CanFamBas_1.0319,629,618 - 19,798,838 (+)NCBI
UU_Cfam_GSD_1.0319,916,077 - 20,085,117 (+)NCBI
Mef2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213175,400,303 - 175,565,279 (+)NCBI
SpeTri2.0NW_0049364697,060,480 - 7,225,497 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl296,122,407 - 96,296,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1296,122,407 - 96,296,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2298,794,388 - 98,885,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEF2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1482,702,378 - 82,887,491 (-)NCBI
ChlSab1.1 Ensembl482,706,738 - 82,788,152 (-)Ensembl
Vero_WHO_p1.0NW_02366604931,746,488 - 31,916,073 (-)NCBI
Mef2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247438,072,871 - 8,235,174 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005382286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013512984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01019287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCB01005517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000004907   ⟹   ENSCLAP00000004816
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,537,285 - 22,701,240 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004908   ⟹   ENSCLAP00000004817
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,557,021 - 22,701,240 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004909   ⟹   ENSCLAP00000004818
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,558,046 - 22,701,240 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004910   ⟹   ENSCLAP00000004819
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,558,046 - 22,701,240 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004911   ⟹   ENSCLAP00000004820
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,611,353 - 22,701,434 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004912   ⟹   ENSCLAP00000004821
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,613,638 - 22,701,434 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004913   ⟹   ENSCLAP00000004822
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,613,638 - 22,701,240 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004914   ⟹   ENSCLAP00000004823
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541822,613,638 - 22,701,240 (+)Ensembl
RefSeq Acc Id: XM_005382286   ⟹   XP_005382343
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005382287   ⟹   XP_005382344
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,625 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005382288   ⟹   XP_005382345
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,625 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512975   ⟹   XP_013368429
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512976   ⟹   XP_013368430
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512977   ⟹   XP_013368431
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,557,151 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512978   ⟹   XP_013368432
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,557,385 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512979   ⟹   XP_013368433
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,618 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512980   ⟹   XP_013368434
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,632 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512981   ⟹   XP_013368435
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,624 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512982   ⟹   XP_013368436
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,630 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512983   ⟹   XP_013368437
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,635 - 22,701,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512984   ⟹   XP_013368438
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541822,558,630 - 22,701,434 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005382343   ⟸   XM_005382286
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005382345   ⟸   XM_005382288
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005382344   ⟸   XM_005382287
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368430   ⟸   XM_013512976
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368429   ⟸   XM_013512975
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368431   ⟸   XM_013512977
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368432   ⟸   XM_013512978
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368433   ⟸   XM_013512979
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013368435   ⟸   XM_013512981
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013368436   ⟸   XM_013512982
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013368438   ⟸   XM_013512984
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013368434   ⟸   XM_013512980
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013368437   ⟸   XM_013512983
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSCLAP00000004823   ⟸   ENSCLAT00000004914
RefSeq Acc Id: ENSCLAP00000004821   ⟸   ENSCLAT00000004912
RefSeq Acc Id: ENSCLAP00000004822   ⟸   ENSCLAT00000004913
RefSeq Acc Id: ENSCLAP00000004819   ⟸   ENSCLAT00000004910
RefSeq Acc Id: ENSCLAP00000004820   ⟸   ENSCLAT00000004911
RefSeq Acc Id: ENSCLAP00000004816   ⟸   ENSCLAT00000004907
RefSeq Acc Id: ENSCLAP00000004817   ⟸   ENSCLAT00000004908
RefSeq Acc Id: ENSCLAP00000004818   ⟸   ENSCLAT00000004909


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003422 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000004818 ENTREZGENE
  ENSCLAP00000004819 ENTREZGENE
  ENSCLAP00000004821 ENTREZGENE
  ENSCLAP00000004822 ENTREZGENE
Ensembl Transcript ENSCLAT00000004909 ENTREZGENE
  ENSCLAT00000004910 ENTREZGENE
  ENSCLAT00000004912 ENTREZGENE
  ENSCLAT00000004913 ENTREZGENE
NCBI Gene Mef2c ENTREZGENE