Vkorc1 (vitamin K epoxide reductase complex subunit 1) - Rat Genome Database

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Gene: Vkorc1 (vitamin K epoxide reductase complex subunit 1) Chinchilla lanigera
Analyze
Symbol: Vkorc1
Name: vitamin K epoxide reductase complex subunit 1
RGD ID: 8880262
Description: ENCODES a protein that exhibits vitamin-K-epoxide reductase (warfarin-insensitive) activity (ortholog); vitamin-K-epoxide reductase (warfarin-sensitive) activity (ortholog); INVOLVED IN blood coagulation (ortholog); bone development (ortholog); peptidyl-glutamic acid carboxylation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Aortic Calcification (ortholog); Aortic Rupture (ortholog); blood coagulation disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum lumen (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vitamin K epoxide reductase complex, subunit 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1ChinchillaAortic Calcification susceptibilityISOVkorc1 (Rattus norvegicus)9068941DNA:missense mutation: :p.Y139C (416A>G) (rat)RGDPMID:19884975 and REF_RGD_ID:2315841
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1Chinchillabranched-chain keto acid dehydrogenase kinase deficiency  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Branched-chain keto acid dehydrogenase kinase deficiencyClinVarPMID:25741868
Vkorc1Chinchillacombined deficiency of vitamin K-dependent clotting factors 2  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Vitamin K-dependent clotting factors more ...ClinVarPMID:11154138 more ...
Vkorc1ChinchillaCoumarin Sensitivity  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: COUMARIN SENSITIVITYClinVarPMID:14765194 more ...
Vkorc1Chinchilladilated cardiomyopathy  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and DominantClinVarPMID:28492532
Vkorc1Chinchillathrombosis  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: ThrombusClinVarPMID:15883587 more ...
Vkorc1ChinchillaVenous Thromboembolism  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Venous thromboembolismClinVarPMID:15883587 more ...
Vkorc1Chinchillawarfarin resistance  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Coumarin resistanceClinVarPMID:14765194 more ...
Vkorc1Chinchillawarfarin sensitivity  ISOVKORC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Warfarin sensitivityClinVarPMID:14765194 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1ChinchillaAortic Rupture  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16549638
Vkorc1Chinchillablood coagulation disease  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19141161
Vkorc1ChinchillaCoronary Disease  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16549638
Vkorc1ChinchillaDrug-Related Side Effects and Adverse Reactions  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26445138
Vkorc1ChinchillaHemorrhage  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20597268 and PMID:26445138
Vkorc1ChinchillaStroke  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16549638
Vkorc1Chinchillavascular disease  ISOVKORC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16549638
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1Chinchillacombined deficiency of vitamin K-dependent clotting factors 2  ISOVKORC1 (Homo sapiens)7240710 OMIM 
Vkorc1Chinchillawarfarin resistance  ISOVKORC1 (Homo sapiens)7240710 OMIM 


Biological Process
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1Chinchillaendoplasmic reticulum located_inISOVKORC1 (Homo sapiens)9068941 HPAGO_REF:0000052
Vkorc1Chinchillaendoplasmic reticulum lumen is_active_inISOVkorc1 (Mus musculus)9068941 PMID:23928358MGIPMID:23928358
Vkorc1Chinchillaendoplasmic reticulum membrane is_active_inISOVKORC1 (Homo sapiens)9068941 PMID:22923610UniProtPMID:22923610

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1Chinchillavitamin K cycle pathway   ISOVKORC1 (Homo sapiens)9068941 RGDPMID:26663892 and REF_RGD_ID:11344916
Vkorc1Chinchillawarfarin pharmacodynamics pathway   ISOVKORC1 (Homo sapiens)9068941 RGDPMID:26287237 and REF_RGD_ID:11354881

Imported Annotations - SMPDB

1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vkorc1Chinchillaacenocoumarol pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00269
Vkorc1Chinchillaalteplase pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00280
Vkorc1Chinchillaaminocaproic acid pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00286
Vkorc1Chinchillaanistreplase pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00281
Vkorc1Chinchillaaprotinin pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00288
Vkorc1Chinchillaargatroban pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00276
Vkorc1Chinchillabivalirudin pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00277
Vkorc1Chinchilladicoumarol pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00270 and SMP:00656
Vkorc1Chinchillaenoxaparin pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00272
Vkorc1Chinchillafondaparinux pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00273
Vkorc1Chinchillaheparin pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00274
Vkorc1Chinchillaphenindione pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00655
Vkorc1Chinchillareteplase pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00285
Vkorc1Chinchillatranexamic acid pharmacodynamics pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00287
Vkorc1Chinchillavitamin K metabolic pathway  ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00464
Vkorc1Chinchillawarfarin pharmacodynamics pathway   ISOVKORC1 (Homo sapiens)9068941 SMPDBSMP:00268
1 to 16 of 16 rows

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Vkorc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBIChiLan1.0ChiLan1.0
VKORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,090,854 - 31,094,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,090,842 - 31,095,980 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,102,175 - 31,106,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,009,676 - 31,013,777 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,191,224 - 29,195,328 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,663,874 - 28,667,978 (-)NCBIHuRef
CHM1_11632,419,476 - 32,423,596 (-)NCBICHM1_1
T2T-CHM13v2.01631,478,282 - 31,482,234 (-)NCBIT2T-CHM13v2.0
Vkorc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,492,235 - 127,494,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,485,399 - 127,494,626 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl7127,492,235 - 127,494,789 (-)EnsemblGRCm39 Ensembl
GRCm387127,893,063 - 127,895,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,886,227 - 127,895,454 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,893,063 - 127,895,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,036,577 - 135,039,131 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,684,211 - 127,686,765 (-)NCBIMGSCv36mm8
Celera7127,728,262 - 127,730,816 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
Vkorc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,932,969 - 191,935,490 (-)NCBIGRCr8
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,853,032 - 190,855,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,039,126 - 198,041,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,709,541 - 190,712,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Celera1180,153,292 - 180,155,813 (-)NCBICelera
Cytogenetic Map1q37NCBI
VKORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,298,329 - 34,303,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,099,732 - 39,104,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,871,756 - 23,876,599 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,459,556 - 31,464,617 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,459,560 - 31,464,897 (-)Ensemblpanpan1.1panPan2
VKORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,140,565 - 17,142,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,140,633 - 17,142,547 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,715,931 - 18,717,978 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,271,459 - 17,273,505 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,271,517 - 17,273,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,071,856 - 17,073,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,990,716 - 16,992,762 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,303,101 - 17,305,147 (+)NCBIUU_Cfam_GSD_1.0
Vkorc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,361,540 - 125,363,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,459,022 - 13,462,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,459,400 - 13,461,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VKORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,386,245 - 17,389,905 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,483,272 - 17,485,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VKORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,778,553 - 27,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,776,416 - 27,782,640 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,685,255 - 1,689,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vkorc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,141,545 - 14,144,177 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,141,545 - 14,144,181 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






RefSeq Acc Id: XM_005405300   ⟹   XP_005405357
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBI
Sequence:
Protein RefSeqs XP_005405357 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018294.1
RefSeq Acc Id: XP_005405357   ⟸   XM_005405300
- Sequence:
Vitamin K epoxide reductase



1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000012539 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018473.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.130 UniProtKB/TrEMBL
InterPro VKOR UniProtKB/TrEMBL
  VKOR_sf UniProtKB/TrEMBL
  VKORC1/VKORC1L1 UniProtKB/TrEMBL
NCBI Gene Vkorc1 ENTREZGENE
PANTHER PTHR14519 UniProtKB/TrEMBL
  VITAMIN-K-EPOXIDE REDUCTASE (WARFARIN-SENSITIVE) UniProtKB/TrEMBL
Pfam VKOR UniProtKB/TrEMBL
UniProt A0A8C2YRN1_CHILA UniProtKB/TrEMBL
1 to 11 of 11 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Vkorc1  vitamin K epoxide reductase complex subunit 1    vitamin K epoxide reductase complex, subunit 1  Symbol and/or name change 5135510 APPROVED