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The carboxylation of glutamate (Glu) residues to gamma-carboxyglutamate (Gla) is an important posttranslational modification of proteins known as 'vitamin K-dependent proteins' (VKD). The modification allows for the reversible, calcium-dependent binding to negatively charged phospholipids (phosphatidylserine or phosphatidic acid) of membranes. This is particularly important for coagulation/clotting factors and natural anticoagulants, classic examples and better characterized systems of gamma-car

Pathway Diagram:

Elsevier Inc. protein C anticoagulant pathway coagulation cascade pathway Gla domain vitamin K-dependent proteins, anticoagulation vitamin K-dependent proteins, coagulation gamma-carboxyglutamic acid Vitamin K1 oxide phylloquinone glutamate vitamin K1 reduced vitamin K1 reduced ---> Vitamin K1 oxide Vitamin K1 oxide ---> phylloquinone Vkorc1 Ggcx Ggcx ---> vitamin K-dependent proteins, coagulation phylloquinone ---> vitamin K1 reduced vitamin K-dependent proteins, anticoagulation ---> protein C anticoagulant pathway vitamin K-dependent proteins, coagulation ---> coagulation cascade pathway Ggcx ---> vitamin K-dependent proteins, anticoagulation glutamate ---> gamma-carboxyglutamic acid

Genes in Pathway:

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vitamin K cycle pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ggcx gamma-glutamyl carboxylase JBrowse link 4 100,277,345 100,293,097 RGD:11344916
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 JBrowse link 1 199,338,785 199,341,306 RGD:11344916

Pathway Gene Annotations

Disease Annotations Associated with Genes in the vitamin K cycle pathway
Pathway Annotations Associated with Genes in the vitamin K cycle pathway

References Associated with the vitamin K cycle pathway:

Ontology Path Diagram:

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