VKORC1 (vitamin K epoxide reductase complex subunit 1) - Rat Genome Database

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Gene: VKORC1 (vitamin K epoxide reductase complex subunit 1) Sus scrofa
Analyze
Symbol: VKORC1
Name: vitamin K epoxide reductase complex subunit 1
RGD ID: 14147466
Description: ENCODES a protein that exhibits vitamin-K-epoxide reductase (warfarin-insensitive) activity (ortholog); vitamin-K-epoxide reductase (warfarin-sensitive) activity (ortholog); INVOLVED IN peptidyl-glutamic acid carboxylation (ortholog); positive regulation of coagulation (ortholog); regulation of blood coagulation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Aortic Calcification (ortholog); Aortic Rupture (ortholog); blood coagulation disease (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,386,245 - 17,389,905 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,483,272 - 17,485,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VKORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,386,245 - 17,389,905 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,483,272 - 17,485,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VKORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,090,854 - 31,094,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,090,842 - 31,095,980 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,102,175 - 31,106,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,009,676 - 31,013,777 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,191,224 - 29,195,328 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,663,874 - 28,667,978 (-)NCBIHuRef
CHM1_11632,419,476 - 32,423,596 (-)NCBICHM1_1
T2T-CHM13v2.01631,478,282 - 31,482,234 (-)NCBIT2T-CHM13v2.0
Vkorc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,492,235 - 127,494,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,485,399 - 127,494,626 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl7127,492,235 - 127,494,789 (-)EnsemblGRCm39 Ensembl
GRCm387127,893,063 - 127,895,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,886,227 - 127,895,454 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,893,063 - 127,895,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,036,577 - 135,039,131 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,684,211 - 127,686,765 (-)NCBIMGSCv36mm8
Celera7127,728,262 - 127,730,816 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
Vkorc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,932,969 - 191,935,490 (-)NCBIGRCr8
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,853,032 - 190,855,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,039,126 - 198,041,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,709,541 - 190,712,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Celera1180,153,292 - 180,155,813 (-)NCBICelera
Cytogenetic Map1q37NCBI
Vkorc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBIChiLan1.0ChiLan1.0
VKORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,298,329 - 34,303,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,099,732 - 39,104,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,871,756 - 23,876,599 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,459,556 - 31,464,617 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,459,560 - 31,464,897 (-)Ensemblpanpan1.1panPan2
VKORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,140,565 - 17,142,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,140,633 - 17,142,547 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,715,931 - 18,717,978 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,271,459 - 17,273,505 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,271,517 - 17,273,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,071,856 - 17,073,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,990,716 - 16,992,762 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,303,101 - 17,305,147 (+)NCBIUU_Cfam_GSD_1.0
Vkorc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,361,540 - 125,363,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,459,022 - 13,462,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,459,400 - 13,461,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VKORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,778,553 - 27,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,776,416 - 27,782,640 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,685,255 - 1,689,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vkorc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,141,545 - 14,144,177 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,141,545 - 14,144,181 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VKORC1
70 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000043889   ⟹   ENSSSCP00000049733
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl317,386,441 - 17,396,840 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000094352   ⟹   ENSSSCP00000074957
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl317,386,245 - 17,389,802 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000105656   ⟹   ENSSSCP00000079381
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl317,386,376 - 17,389,905 (+)Ensembl
RefSeq Acc Id: XM_003124473   ⟹   XP_003124521
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021086403   ⟹   XP_020942062
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1317,386,386 - 17,389,162 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003124521   ⟸   XM_003124473
- Peptide Label: isoform X1
- UniProtKB: A0A287B0I6 (UniProtKB/TrEMBL),   A0A4X1TJA8 (UniProtKB/TrEMBL),   A0A8D0JA43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020942062   ⟸   XM_021086403
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSSSCP00000049733   ⟸   ENSSSCT00000043889
Ensembl Acc Id: ENSSSCP00000079381   ⟸   ENSSSCT00000105656
Ensembl Acc Id: ENSSSCP00000074957   ⟸   ENSSSCT00000094352
Protein Domains
Vitamin K epoxide reductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035364 Ensembl
  ENSSSCG00000057004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015018772 UniProtKB/TrEMBL
  ENSSSCG00025046732 UniProtKB/TrEMBL
  ENSSSCG00030066023 UniProtKB/TrEMBL
  ENSSSCG00035078823 UniProtKB/TrEMBL
  ENSSSCG00045036636 UniProtKB/TrEMBL
  ENSSSCG00050076355 UniProtKB/TrEMBL
  ENSSSCG00055029748 UniProtKB/TrEMBL
  ENSSSCG00060022557 UniProtKB/TrEMBL
  ENSSSCG00065078707 UniProtKB/TrEMBL
  ENSSSCG00070009326 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000094352.1 UniProtKB/TrEMBL
  ENSSSCT00000105656 ENTREZGENE
  ENSSSCT00000105656.1 UniProtKB/TrEMBL
  ENSSSCT00015024864.1 UniProtKB/TrEMBL
  ENSSSCT00015025007.1 UniProtKB/TrEMBL
  ENSSSCT00025063532.1 UniProtKB/TrEMBL
  ENSSSCT00025063739.1 UniProtKB/TrEMBL
  ENSSSCT00030092246.1 UniProtKB/TrEMBL
  ENSSSCT00035107701.1 UniProtKB/TrEMBL
  ENSSSCT00035107829.1 UniProtKB/TrEMBL
  ENSSSCT00035107857.1 UniProtKB/TrEMBL
  ENSSSCT00045063098.1 UniProtKB/TrEMBL
  ENSSSCT00045063168.1 UniProtKB/TrEMBL
  ENSSSCT00050104886.1 UniProtKB/TrEMBL
  ENSSSCT00050104895.1 UniProtKB/TrEMBL
  ENSSSCT00055059145.1 UniProtKB/TrEMBL
  ENSSSCT00055059175.1 UniProtKB/TrEMBL
  ENSSSCT00060030617.1 UniProtKB/TrEMBL
  ENSSSCT00065109272.1 UniProtKB/TrEMBL
  ENSSSCT00065109283.1 UniProtKB/TrEMBL
  ENSSSCT00065109286.1 UniProtKB/TrEMBL
  ENSSSCT00070018105.1 UniProtKB/TrEMBL
  ENSSSCT00070018225.1 UniProtKB/TrEMBL
  ENSSSCT00070018253.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.130 UniProtKB/TrEMBL
InterPro VKOR UniProtKB/TrEMBL
  VKOR_sf UniProtKB/TrEMBL
  VKORC1/VKORC1L1 UniProtKB/TrEMBL
KEGG Report ssc:100522924 UniProtKB/TrEMBL
NCBI Gene VKORC1 ENTREZGENE
PANTHER PTHR14519 UniProtKB/TrEMBL
  VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1 UniProtKB/TrEMBL
  VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1 UniProtKB/TrEMBL
Pfam VKOR UniProtKB/TrEMBL
SMART VKc UniProtKB/TrEMBL
UniProt A0A287B0I6 ENTREZGENE
  A0A4X1TJA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TJK6_PIG UniProtKB/TrEMBL
  A0A8D0JA43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1D613_PIG UniProtKB/TrEMBL
  A0A8D1S773_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287B0I6 UniProtKB/TrEMBL
  A0A8W4F6T7 UniProtKB/TrEMBL
VGNC ID VGNC:111775 ENTREZGENE