Vkorc1 (vitamin K epoxide reductase complex, subunit 1) - Rat Genome Database

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Gene: Vkorc1 (vitamin K epoxide reductase complex, subunit 1) Rattus norvegicus
Analyze
Symbol: Vkorc1
Name: vitamin K epoxide reductase complex, subunit 1
RGD ID: 1303107
Description: Enables vitamin-K-epoxide reductase (warfarin-insensitive) activity. Contributes to vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in several processes, including regulation of blood coagulation; response to antibiotic; and response to organonitrogen compound. Located in intracellular membrane-bounded organelle. Used to study warfarin sensitivity. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 2 and warfarin resistance. Orthologous to human VKORC1 (vitamin K epoxide reductase complex subunit 1); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: phylloquinone epoxide reductase; vitamin K epoxide reductase complex subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); Warfarin resistance
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)Ensembl
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Celera1180,153,292 - 180,155,813 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxycoumarin  (ISO)
7-Hydroxywarfarin  (ISO)
acenocoumarol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
Bromadiolone  (EXP,ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
Chlorophacinone  (EXP)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Coumachlor  (ISO)
coumarin  (ISO)
coumarins  (ISO)
Coumatetralyl  (EXP,ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dehydroacetic acid  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicoumarol  (ISO)
Difenacoum  (EXP,ISO)
Difethialone  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
fipronil  (EXP)
fluindione  (ISO)
folic acid  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
paracetamol  (ISO)
phenindione  (ISO)
phenprocoumon  (ISO)
phylloquinone  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vitamin K epoxide  (EXP,ISO)
warfarin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:15879509   PMID:16270630   PMID:19200363   PMID:19492146   PMID:20978134   PMID:21127708   PMID:23018795   PMID:23918929   PMID:23928358   PMID:24611351   PMID:27846632  
PMID:29155484   PMID:30214074   PMID:31484376   PMID:32687688   PMID:33771253   PMID:35296766   PMID:35430058  


Genomics

Comparative Map Data
Vkorc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)Ensembl
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Celera1180,153,292 - 180,155,813 (-)NCBICelera
Cytogenetic Map1q37NCBI
VKORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,090,854 - 31,094,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1631,090,842 - 31,095,980 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,102,175 - 31,106,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,009,676 - 31,013,777 (-)NCBINCBI36hg18NCBI36
Celera1629,191,224 - 29,195,328 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,663,874 - 28,667,978 (-)NCBIHuRef
CHM1_11632,419,476 - 32,423,596 (-)NCBICHM1_1
T2T-CHM13v2.01631,478,282 - 31,482,234 (-)NCBI
Vkorc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,492,235 - 127,494,833 (-)NCBIGRCm39mm39
GRCm39 Ensembl7127,485,399 - 127,494,626 (-)Ensembl
GRCm39 Ensembl7127,492,235 - 127,494,789 (-)Ensembl
GRCm387127,893,063 - 127,895,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,886,227 - 127,895,454 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,893,063 - 127,895,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,036,577 - 135,039,131 (-)NCBIGRCm37mm9NCBIm37
MGSCv367127,684,211 - 127,686,765 (-)NCBImm8
Celera7127,728,262 - 127,730,816 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
Vkorc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBIChiLan1.0ChiLan1.0
VKORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11631,459,556 - 31,464,617 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,459,560 - 31,464,897 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01623,871,756 - 23,876,599 (+)NCBIMhudiblu_PPA_v0panPan3
VKORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,140,565 - 17,142,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,140,633 - 17,142,547 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,715,931 - 18,717,978 (+)NCBI
ROS_Cfam_1.0617,271,459 - 17,273,505 (+)NCBI
ROS_Cfam_1.0 Ensembl617,271,517 - 17,273,431 (+)Ensembl
UMICH_Zoey_3.1617,071,856 - 17,073,902 (+)NCBI
UNSW_CanFamBas_1.0616,990,716 - 16,992,762 (+)NCBI
UU_Cfam_GSD_1.0617,303,101 - 17,305,147 (+)NCBI
Vkorc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,361,540 - 125,363,993 (-)NCBI
SpeTri2.0NW_00493650113,459,400 - 13,461,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VKORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,386,441 - 17,396,840 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,483,272 - 17,485,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VKORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,778,553 - 27,782,639 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl527,776,416 - 27,782,640 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660681,685,255 - 1,689,345 (+)NCBIVero_WHO_p1.0
Vkorc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,141,545 - 14,144,177 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478214,141,545 - 14,144,181 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH128112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,502,683 - 182,502,877 (+)MAPPERmRatBN7.2
Rnor_6.01199,338,978 - 199,339,171NCBIRnor6.0
Rnor_5.01206,361,573 - 206,361,766UniSTSRnor5.0
RGSC_v3.41187,176,938 - 187,177,131UniSTSRGSC3.4
Celera1180,153,485 - 180,153,678UniSTS
Cytogenetic Map1q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383635Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:119
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000073596
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 25 48 41 3 41 1 2 56 35 32 11 1
Low 1 18 9 16 7 9 18 9 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_203335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW253787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY423047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB314647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000073596   ⟹   ENSRNOP00000063977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)Ensembl
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101446   ⟹   ENSRNOP00000087618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,500,844 - 182,504,595 (-)Ensembl
RefSeq Acc Id: NM_203335   ⟹   NP_976080
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,502,491 - 182,505,012 (-)NCBI
Rnor_6.01199,338,785 - 199,341,306 (-)NCBI
Rnor_5.01206,361,380 - 206,363,901 (-)NCBI
RGSC_v3.41187,176,745 - 187,179,266 (-)RGD
Celera1180,153,292 - 180,155,813 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_976080 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66413 (Get FASTA)   NCBI Sequence Viewer  
  AAR82917 (Get FASTA)   NCBI Sequence Viewer  
  BAX00317 (Get FASTA)   NCBI Sequence Viewer  
  BAX00318 (Get FASTA)   NCBI Sequence Viewer  
  BAX00319 (Get FASTA)   NCBI Sequence Viewer  
  BAX00320 (Get FASTA)   NCBI Sequence Viewer  
  BAX00321 (Get FASTA)   NCBI Sequence Viewer  
  BAX00322 (Get FASTA)   NCBI Sequence Viewer  
  BAX00323 (Get FASTA)   NCBI Sequence Viewer  
  BAX00324 (Get FASTA)   NCBI Sequence Viewer  
  BAX00325 (Get FASTA)   NCBI Sequence Viewer  
  BAX00326 (Get FASTA)   NCBI Sequence Viewer  
  BAX00327 (Get FASTA)   NCBI Sequence Viewer  
  BAX00328 (Get FASTA)   NCBI Sequence Viewer  
  BAX00329 (Get FASTA)   NCBI Sequence Viewer  
  BAX00330 (Get FASTA)   NCBI Sequence Viewer  
  BAX00331 (Get FASTA)   NCBI Sequence Viewer  
  BAX00332 (Get FASTA)   NCBI Sequence Viewer  
  BAX00333 (Get FASTA)   NCBI Sequence Viewer  
  EDM17218 (Get FASTA)   NCBI Sequence Viewer  
  EDM17219 (Get FASTA)   NCBI Sequence Viewer  
  Q6TEK4 (Get FASTA)   NCBI Sequence Viewer  
  QBB72906 (Get FASTA)   NCBI Sequence Viewer  
  QBB72907 (Get FASTA)   NCBI Sequence Viewer  
  QBB72908 (Get FASTA)   NCBI Sequence Viewer  
  QBB72909 (Get FASTA)   NCBI Sequence Viewer  
  QBB72910 (Get FASTA)   NCBI Sequence Viewer  
  QBB72911 (Get FASTA)   NCBI Sequence Viewer  
  QBB72912 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_976080   ⟸   NM_203335
- Peptide Label: precursor
- UniProtKB: Q6TEK4 (UniProtKB/Swiss-Prot),   B2GUU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063977   ⟸   ENSRNOT00000073596
RefSeq Acc Id: ENSRNOP00000087618   ⟸   ENSRNOT00000101446
Protein Domains
VKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TEK4-F1-model_v2 AlphaFold Q6TEK4 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690444
Promoter ID:EPDNEW_R969
Type:initiation region
Name:Vkorc1_1
Description:vitamin K epoxide reductase complex, subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,341,313 - 199,341,373EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303107 AgrOrtholog
BioCyc Gene G2FUF-57331 BioCyc
BioCyc Pathway PWY-7999 [vitamin K-epoxide cycle] BioCyc
Ensembl Genes ENSRNOG00000050828 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000063977 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073596 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9100951 IMAGE-MGC_LOAD
InterPro VKOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VKOR_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VKORC1/VKORC1L1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187297 IMAGE-MGC_LOAD
NCBI Gene 309004 ENTREZGENE
PANTHER PTHR14519 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam VKOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB VKORC1 RGD
PhenoGen Vkorc1 PhenoGen
SMART VKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1S7IVG9_RAT UniProtKB/TrEMBL
  A0A1S7IVH4_RAT UniProtKB/TrEMBL
  A0A1S7IVH6_RAT UniProtKB/TrEMBL
  A0A1S7IVH8_RAT UniProtKB/TrEMBL
  A0A1S7IVH9_RAT UniProtKB/TrEMBL
  A0A1S7IVI4_RAT UniProtKB/TrEMBL
  A0A1S7IVI8_RAT UniProtKB/TrEMBL
  A0A1S7IVJ5_RAT UniProtKB/TrEMBL
  A0A411HQX2_RAT UniProtKB/TrEMBL
  A0A411HQZ0_RAT UniProtKB/TrEMBL
  A0A411HR06_RAT UniProtKB/TrEMBL
  A0A411HR20_RAT UniProtKB/TrEMBL
  A0A411HR25_RAT UniProtKB/TrEMBL
  B2GUU6 ENTREZGENE, UniProtKB/TrEMBL
  Q6TEK4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Vkorc1  vitamin K epoxide reductase complex, subunit 1  Vkorc1  vitamin K epoxide reductase complex, subunit 1  Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Vkorc1  vitamin K epoxide reductase complex, subunit 1  Rw  Warfarin resistance  Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Rw  Warfarin resistance      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog are detected in individuals with combined deficiency of Vitamin K-dependent clotting factors type 2 (VKCFD2) and warfarin resistance (WR) 1303972
gene_mutations_overexpression Tyr139Cys mutation is associated with warfarin resistance in the Rw strain 1303972