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Gene: Vkorc1 (vitamin K epoxide reductase complex, subunit 1) Rattus norvegicus
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Symbol: Vkorc1
Name: vitamin K epoxide reductase complex, subunit 1
Description: Exhibits vitamin-K-epoxide reductase (warfarin-insensitive) activity. Contributes to vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in several processes, including regulation of blood coagulation; response to antibiotic; and response to organonitrogen compound. Localizes to intracellular membrane-bounded organelle. Used to study warfarin sensitivity. Human ortholog(s) of this gene implicated in inherited blood coagulation disease and warfarin resistance. Orthologous to human VKORC1 (vitamin K epoxide reductase complex subunit 1); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: phylloquinone epoxide reductase; vitamin K epoxide reductase complex subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); Warfarin resistance
Orthologs:
Homo sapiens (human) : VKORC1 (vitamin K epoxide reductase complex subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Vkorc1 (vitamin K epoxide reductase complex, subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vkorc1 (vitamin K epoxide reductase complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Canis lupus familiaris (dog) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vkorc1 (vitamin K epoxide reductase complex subunit 1)
Sus scrofa (pig) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Chlorocebus sabaeus (African green monkey) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Heterocephalus glaber (naked mole-rat) : Vkorc1 (vitamin K epoxide reductase complex subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Celera1180,153,292 - 180,155,813 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Vkorc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1303107
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.